Folate Metabolism (Homo sapiens)

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(Modified description)
(HMDB identifier normalization)
Line 4: Line 4:
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP176 CPTAC Assay Portal].</Comment>
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP176 CPTAC Assay Portal].</Comment>
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   <DataNode TextLabel="NFkB1" GraphId="a48fd" Type="GeneProduct" GroupRef="ec079">
   <DataNode TextLabel="NFkB1" GraphId="a48fd" Type="GeneProduct" GroupRef="ec079">
     <Comment>nuclear factor NF-kappa-B p50 subunit</Comment>
     <Comment>nuclear factor NF-kappa-B p50 subunit</Comment>
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     <Xref Database="Entrez Gene" ID="4790"/>
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     <Xref Database="Entrez Gene" ID="4790" />
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   </DataNode>
   <DataNode TextLabel="FOLR1" GraphId="a7532" Type="GeneProduct">
   <DataNode TextLabel="FOLR1" GraphId="a7532" Type="GeneProduct">
     <Comment>folate receptor 1 (adult)</Comment>
     <Comment>folate receptor 1 (adult)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="2348"/>
+
     <Xref Database="Entrez Gene" ID="2348" />
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   </DataNode>
   <DataNode TextLabel="PGE1" GraphId="b3ff0" Type="Metabolite">
   <DataNode TextLabel="PGE1" GraphId="b3ff0" Type="Metabolite">
Line 20: Line 20:
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01442"/>
+
     <Xref Database="HMDB" ID="HMDB0001442" />
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   </DataNode>
   <DataNode TextLabel="F2-Isoprostane" GraphId="b4b3a" Type="Metabolite">
   <DataNode TextLabel="F2-Isoprostane" GraphId="b4b3a" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="Wikidata" ID="Q33659470" />
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   </DataNode>
   <DataNode TextLabel="RELA" GraphId="b84bc" Type="GeneProduct" GroupRef="ec079">
   <DataNode TextLabel="RELA" GraphId="b84bc" Type="GeneProduct" GroupRef="ec079">
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65</Comment>
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65</Comment>
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     <Xref Database="Entrez Gene" ID="5970"/>
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     <Xref Database="Entrez Gene" ID="5970" />
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   <DataNode TextLabel="F2-Isoprostane" GraphId="bdfc9" Type="Metabolite">
   <DataNode TextLabel="F2-Isoprostane" GraphId="bdfc9" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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   <DataNode TextLabel="MCP1" GraphId="c3fd6" Type="GeneProduct">
   <DataNode TextLabel="MCP1" GraphId="c3fd6" Type="GeneProduct">
Line 42: Line 42:
     <Comment>CCL2</Comment>
     <Comment>CCL2</Comment>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="6347"/>
+
     <Xref Database="Entrez Gene" ID="6347" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="c5524" Type="Metabolite">
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="c5524" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB05083"/>
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     <Xref Database="HMDB" ID="HMDB0005083" />
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   <DataNode TextLabel="MCP1" GraphId="c9530" Type="GeneProduct">
   <DataNode TextLabel="MCP1" GraphId="c9530" Type="GeneProduct">
Line 54: Line 54:
     <Comment>CCL2</Comment>
     <Comment>CCL2</Comment>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="6347"/>
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     <Xref Database="Entrez Gene" ID="6347" />
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   <DataNode TextLabel="p53" GraphId="cf80f" Type="GeneProduct">
   <DataNode TextLabel="p53" GraphId="cf80f" Type="GeneProduct">
Line 65: Line 65:
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>fa0</BiopaxRef>
     <BiopaxRef>fa0</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="7157" />
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   </DataNode>
   <DataNode TextLabel="FOLR4" GraphId="d1353" Type="GeneProduct">
   <DataNode TextLabel="FOLR4" GraphId="d1353" Type="GeneProduct">
     <Comment>folate receptor 4 (delta) homolog (mouse)</Comment>
     <Comment>folate receptor 4 (delta) homolog (mouse)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="390243"/>
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     <Xref Database="Entrez Gene" ID="390243" />
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   </DataNode>
   <DataNode TextLabel="PGE1" GraphId="dc15d" Type="Metabolite">
   <DataNode TextLabel="PGE1" GraphId="dc15d" Type="Metabolite">
     <Comment>Prostaglandin E1</Comment>
     <Comment>Prostaglandin E1</Comment>
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>e06</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0001442" />
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   </DataNode>
   <DataNode TextLabel="FOLR3" GraphId="dd56f" Type="GeneProduct">
   <DataNode TextLabel="FOLR3" GraphId="dd56f" Type="GeneProduct">
     <Comment>folate receptor 3 (gamma)</Comment>
     <Comment>folate receptor 3 (gamma)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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   </DataNode>
   <DataNode TextLabel="SLC19A1" GraphId="ddcdc" Type="GeneProduct">
   <DataNode TextLabel="SLC19A1" GraphId="ddcdc" Type="GeneProduct">
     <Comment>solute carrier family 19 (folate transporter), member 1</Comment>
     <Comment>solute carrier family 19 (folate transporter), member 1</Comment>
     <BiopaxRef>ef8</BiopaxRef>
     <BiopaxRef>ef8</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="6573"/>
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     <Xref Database="Entrez Gene" ID="6573" />
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   </DataNode>
   <DataNode TextLabel="PGE2" GraphId="e2a77" Type="Metabolite">
   <DataNode TextLabel="PGE2" GraphId="e2a77" Type="Metabolite">
Line 96: Line 96:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
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   <DataNode TextLabel="NFkB2" GraphId="e3a3b" Type="GeneProduct" GroupRef="ec079">
   <DataNode TextLabel="NFkB2" GraphId="e3a3b" Type="GeneProduct" GroupRef="ec079">
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 2</Comment>
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 2</Comment>
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     <Xref Database="Entrez Gene" ID="4791" />
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   </DataNode>
   <DataNode TextLabel="Thromboxane B2" GraphId="e3b53" Type="Metabolite">
   <DataNode TextLabel="Thromboxane B2" GraphId="e3b53" Type="Metabolite">
     <BiopaxRef>f21</BiopaxRef>
     <BiopaxRef>f21</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB03252"/>
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     <Xref Database="HMDB" ID="HMDB0003252" />
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   </DataNode>
   <DataNode TextLabel="Thromboxane A2" GraphId="e5c10" Type="Metabolite">
   <DataNode TextLabel="Thromboxane A2" GraphId="e5c10" Type="Metabolite">
Line 113: Line 113:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>d18</BiopaxRef>
     <BiopaxRef>d18</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01452"/>
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     <Xref Database="HMDB" ID="HMDB0001452" />
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   <DataNode TextLabel="PGF2a" GraphId="e63e6" Type="Metabolite">
   <DataNode TextLabel="PGF2a" GraphId="e63e6" Type="Metabolite">
Line 120: Line 120:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01139"/>
+
     <Xref Database="HMDB" ID="HMDB0001139" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="e70db" Type="Metabolite">
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="e70db" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB05083"/>
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     <Xref Database="HMDB" ID="HMDB0005083" />
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   </DataNode>
   <DataNode TextLabel="FOLR2" GraphId="f27f3" Type="GeneProduct">
   <DataNode TextLabel="FOLR2" GraphId="f27f3" Type="GeneProduct">
     <Comment>folate receptor 2 (fetal)</Comment>
     <Comment>folate receptor 2 (fetal)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="2350"/>
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     <Xref Database="Entrez Gene" ID="2350" />
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   <DataNode TextLabel="PGF2a" GraphId="f3420" Type="Metabolite">
   <DataNode TextLabel="PGF2a" GraphId="f3420" Type="Metabolite">
Line 138: Line 138:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0001139" />
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   </DataNode>
   <DataNode TextLabel="SLC46A1" GraphId="f4789" Type="GeneProduct">
   <DataNode TextLabel="SLC46A1" GraphId="f4789" Type="GeneProduct">
     <Comment>solute carrier family 46 (folate transporter), member 1</Comment>
     <Comment>solute carrier family 46 (folate transporter), member 1</Comment>
     <BiopaxRef>ef8</BiopaxRef>
     <BiopaxRef>ef8</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="113235"/>
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     <Xref Database="Entrez Gene" ID="113235" />
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   <DataNode TextLabel="PGE2" GraphId="f52fa" Type="Metabolite">
   <DataNode TextLabel="PGE2" GraphId="f52fa" Type="Metabolite">
Line 151: Line 151:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01220"/>
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     <Xref Database="HMDB" ID="HMDB0001220" />
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   </DataNode>
   <DataNode TextLabel="Thromboxane B2" GraphId="f80f8" Type="Metabolite">
   <DataNode TextLabel="Thromboxane B2" GraphId="f80f8" Type="Metabolite">
     <BiopaxRef>f21</BiopaxRef>
     <BiopaxRef>f21</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB03252"/>
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     <Xref Database="HMDB" ID="HMDB0003252" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFD2" GraphId="aa511" Type="Protein">
   <DataNode TextLabel="MTHFD2" GraphId="aa511" Type="Protein">
Line 163: Line 163:
     <Comment>methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase</Comment>
     <Comment>methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="10797"/>
+
     <Xref Database="Entrez Gene" ID="10797" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MSR*" GraphId="abcce" Type="Protein">
   <DataNode TextLabel="MSR*" GraphId="abcce" Type="Protein">
Line 171: Line 171:
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
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     <Graphics CenterX="1546.3333333333333" CenterY="540.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="1546.3333333333333" CenterY="540.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4552"/>
+
     <Xref Database="Entrez Gene" ID="4552" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAT" GraphId="d16de" Type="Protein">
   <DataNode TextLabel="MAT" GraphId="d16de" Type="Protein">
Line 178: Line 178:
     <Comment>Methionine adenosyltransferase</Comment>
     <Comment>Methionine adenosyltransferase</Comment>
     <BiopaxRef>e4d</BiopaxRef>
     <BiopaxRef>e4d</BiopaxRef>
-
     <Graphics CenterX="2017.0" CenterY="424.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="2017.0" CenterY="424.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4143"/>
+
     <Xref Database="Entrez Gene" ID="4143" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFD1*" GraphId="e1c42" Type="Protein">
   <DataNode TextLabel="MTHFD1*" GraphId="e1c42" Type="Protein">
Line 186: Line 186:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>aa9</BiopaxRef>
     <BiopaxRef>aa9</BiopaxRef>
-
     <Graphics CenterX="2367.3333333333335" CenterY="580.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="2367.3333333333335" CenterY="580.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4522"/>
+
     <Xref Database="Entrez Gene" ID="4522" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTR*" GraphId="e44d5" Type="Protein">
   <DataNode TextLabel="MTR*" GraphId="e44d5" Type="Protein">
Line 197: Line 197:
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
-
     <Graphics CenterX="1766.3333333333333" CenterY="857.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="1766.3333333333333" CenterY="857.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4548"/>
+
     <Xref Database="Entrez Gene" ID="4548" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="AHCY" GraphId="f949e" Type="Protein">
   <DataNode TextLabel="AHCY" GraphId="f949e" Type="Protein">
Line 204: Line 204:
     <Comment>Adenosylhomocysteinase</Comment>
     <Comment>Adenosylhomocysteinase</Comment>
     <BiopaxRef>e10</BiopaxRef>
     <BiopaxRef>e10</BiopaxRef>
-
     <Graphics CenterX="1489.3333333333333" CenterY="500.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="1489.3333333333333" CenterY="500.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="191"/>
+
     <Xref Database="Entrez Gene" ID="191" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SHMT" GraphId="fa33e" Type="Protein">
   <DataNode TextLabel="SHMT" GraphId="fa33e" Type="Protein">
Line 212: Line 212:
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
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     <Graphics CenterX="2375.3333333333335" CenterY="730.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="6472"/>
+
     <Xref Database="Entrez Gene" ID="6472" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DHFR" GraphId="fb4fe" Type="Protein">
   <DataNode TextLabel="DHFR" GraphId="fb4fe" Type="Protein">
Line 221: Line 221:
     <BiopaxRef>ad8</BiopaxRef>
     <BiopaxRef>ad8</BiopaxRef>
     <BiopaxRef>ef2</BiopaxRef>
     <BiopaxRef>ef2</BiopaxRef>
-
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     <Graphics CenterX="2365.3333333333335" CenterY="874.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="1719"/>
+
     <Xref Database="Entrez Gene" ID="1719" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CBS" GraphId="e0635" Type="Protein">
   <DataNode TextLabel="CBS" GraphId="e0635" Type="Protein">
Line 229: Line 229:
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
-
     <Graphics CenterX="1538.3333333333333" CenterY="755.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32776" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="1538.3333333333333" CenterY="755.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32776" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="875"/>
+
     <Xref Database="Entrez Gene" ID="875" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="c2767" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="c2767" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2284.4999999999995" CenterY="555.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
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     <Graphics CenterX="2284.4999999999995" CenterY="555.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB0000217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="cbdd9" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="cbdd9" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2284.4999999999995" CenterY="259.81666666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
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     <Graphics CenterX="2284.4999999999995" CenterY="259.81666666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB0000217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="d895a" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="d895a" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2291.4999999999995" CenterY="848.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
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-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB0000217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="ddda2" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="ddda2" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2163.1666666666665" CenterY="2219.8166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
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-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB0000217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="f85b1" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="f85b1" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="919.1666666666666" CenterY="653.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
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     <Graphics CenterX="919.1666666666666" CenterY="653.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB0000217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="fb622" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="fb622" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2163.1666666666665" CenterY="705.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
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-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB0000217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="ffaaa" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="ffaaa" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="1756.5000000000002" CenterY="632.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
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     <Graphics CenterX="1756.5000000000002" CenterY="632.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB0000217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MPO" GraphId="a2b1b" Type="Protein">
   <DataNode TextLabel="MPO" GraphId="a2b1b" Type="Protein">
Line 274: Line 274:
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
-
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     <Graphics CenterX="1293.6666666666667" CenterY="2365.483333333333" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4353"/>
+
     <Xref Database="Entrez Gene" ID="4353" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NOS" GraphId="aec15" Type="Protein">
   <DataNode TextLabel="NOS" GraphId="aec15" Type="Protein">
     <Comment>Nitric oxide synthase</Comment>
     <Comment>Nitric oxide synthase</Comment>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
-
     <Graphics CenterX="876.3333333333334" CenterY="583.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="876.3333333333334" CenterY="583.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Uniprot-TrEMBL" ID="C9J5P6"/>
+
     <Xref Database="Uniprot-TrEMBL" ID="C9J5P6" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Catalase" GraphId="b2d6c" Type="Protein">
   <DataNode TextLabel="Catalase" GraphId="b2d6c" Type="Protein">
Line 287: Line 287:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>de0</BiopaxRef>
     <BiopaxRef>de0</BiopaxRef>
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     <Graphics CenterX="1213.3333333333333" CenterY="707.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="1213.3333333333333" CenterY="707.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="847"/>
+
     <Xref Database="Entrez Gene" ID="847" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MPO" GraphId="e56d6" Type="Protein">
   <DataNode TextLabel="MPO" GraphId="e56d6" Type="Protein">
Line 297: Line 297:
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
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     <Graphics CenterX="1293.6666666666667" CenterY="635.4833333333333" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4353"/>
+
     <Xref Database="Entrez Gene" ID="4353" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cysteine" GraphId="c0e86" Type="Metabolite">
   <DataNode TextLabel="Cysteine" GraphId="c0e86" Type="Metabolite">
-
     <Graphics CenterX="1349.0" CenterY="815.8333333333334" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1349.0" CenterY="815.8333333333334" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00574"/>
+
     <Xref Database="HMDB" ID="HMDB0000574" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cysteine" GraphId="f5359" Type="Metabolite">
   <DataNode TextLabel="Cysteine" GraphId="f5359" Type="Metabolite">
-
     <Graphics CenterX="1349.0" CenterY="2321.8333333333335" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="1349.0" CenterY="2321.8333333333335" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00574"/>
+
     <Xref Database="HMDB" ID="HMDB0000574" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="tPA" GraphId="ae193" Type="Protein">
   <DataNode TextLabel="tPA" GraphId="ae193" Type="Protein">
Line 312: Line 312:
     <Comment>plasminogen activator, tissue</Comment>
     <Comment>plasminogen activator, tissue</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2734.483333333333" CenterY="2235.741646321615" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="5327"/>
+
     <Xref Database="Entrez Gene" ID="5327" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Factor VII" GraphId="b5988" Type="Protein">
   <DataNode TextLabel="Factor VII" GraphId="b5988" Type="Protein">
Line 320: Line 320:
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
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     <Graphics CenterX="2568.8166666666666" CenterY="1175.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2155"/>
+
     <Xref Database="Entrez Gene" ID="2155" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PLG" GraphId="c70ad" Type="Protein">
   <DataNode TextLabel="PLG" GraphId="c70ad" Type="Protein">
Line 327: Line 327:
     <Comment>Plasminogen</Comment>
     <Comment>Plasminogen</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2569.8166666666666" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="5340"/>
+
     <Xref Database="Entrez Gene" ID="5340" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="tPA" GraphId="ce47c" Type="Protein">
   <DataNode TextLabel="tPA" GraphId="ce47c" Type="Protein">
Line 334: Line 334:
     <Comment>plasminogen activator, tissue</Comment>
     <Comment>plasminogen activator, tissue</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2732.483333333333" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="5327"/>
+
     <Xref Database="Entrez Gene" ID="5327" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thrombin" GraphId="d3b1c" Type="Protein">
   <DataNode TextLabel="Thrombin" GraphId="d3b1c" Type="Protein">
Line 342: Line 342:
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
-
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     <Graphics CenterX="2568.15" CenterY="1259.7086994291394" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2147"/>
+
     <Xref Database="Entrez Gene" ID="2147" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thrombin" GraphId="d843d" Type="Protein">
   <DataNode TextLabel="Thrombin" GraphId="d843d" Type="Protein">
Line 350: Line 350:
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
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     <Graphics CenterX="2568.8166666666666" CenterY="2246.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="2568.8166666666666" CenterY="2246.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2147"/>
+
     <Xref Database="Entrez Gene" ID="2147" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAI-1" GraphId="db3d2" Type="Protein">
   <DataNode TextLabel="PAI-1" GraphId="db3d2" Type="Protein">
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2887.483333333333" CenterY="2235.7416463216146" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00"/>
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     <Graphics CenterX="2887.483333333333" CenterY="2235.7416463216146" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="5054"/>
+
     <Xref Database="Entrez Gene" ID="5054" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Factor VII" GraphId="db5db" Type="Protein">
   <DataNode TextLabel="Factor VII" GraphId="db5db" Type="Protein">
Line 364: Line 364:
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
-
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     <Graphics CenterX="2568.8166666666666" CenterY="2280.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2155"/>
+
     <Xref Database="Entrez Gene" ID="2155" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAI-1" GraphId="dda8d" Type="Protein">
   <DataNode TextLabel="PAI-1" GraphId="dda8d" Type="Protein">
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2887.483333333333" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00"/>
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     <Graphics CenterX="2887.483333333333" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="5054"/>
+
     <Xref Database="Entrez Gene" ID="5054" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PLG" GraphId="ffac8" Type="Protein">
   <DataNode TextLabel="PLG" GraphId="ffac8" Type="Protein">
Line 377: Line 377:
     <Comment>Plasminogen</Comment>
     <Comment>Plasminogen</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2568.8166666666666" CenterY="2215.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="2568.8166666666666" CenterY="2215.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="5340"/>
+
     <Xref Database="Entrez Gene" ID="5340" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 4" GraphId="bcee4" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 4" GraphId="bcee4" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.12</Comment>
     <Comment>EC 1.11.1.12</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 4</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 4</Comment>
-
     <Graphics CenterX="1262.5" CenterY="423.0833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32794" FontSize="10" Valign="Middle" Color="ff0000"/>
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     <Graphics CenterX="1262.5" CenterY="423.0833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32794" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2879"/>
+
     <Xref Database="Entrez Gene" ID="2879" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="H2O2" GraphId="e312e" Type="Metabolite">
   <DataNode TextLabel="H2O2" GraphId="e312e" Type="Metabolite">
     <Comment>Hydrogen peroxide</Comment>
     <Comment>Hydrogen peroxide</Comment>
-
     <Graphics CenterX="1124.0" CenterY="597.4554707379133" Width="80.0" Height="30.0" ZOrder="32802" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1124.0" CenterY="597.4554707379133" Width="80.0" Height="30.0" ZOrder="32802" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03125"/>
+
     <Xref Database="HMDB" ID="HMDB0003125" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="(11S)-hydroxymethylene-THF" GraphId="b4e68" Type="Metabolite">
   <DataNode TextLabel="(11S)-hydroxymethylene-THF" GraphId="b4e68" Type="Metabolite">
     <Comment>(11S)-hydroxymethylenetetrahydrofolate</Comment>
     <Comment>(11S)-hydroxymethylenetetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2403.991666666667" CenterY="400.31666666666666" Width="144.01666666666668" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
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-
     <Xref Database="" ID=""/>
+
     <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5,10-Methylene-THF" GraphId="b5a53" Type="Metabolite">
   <DataNode TextLabel="5,10-Methylene-THF" GraphId="b5a53" Type="Metabolite">
Line 401: Line 401:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2246.7202751368486" CenterY="655.3166666666659" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="2246.7202751368486" CenterY="655.3166666666659" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01533"/>
+
     <Xref Database="HMDB" ID="HMDB0001533" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5,10-Methenyl-THF" GraphId="c8a9d" Type="Metabolite">
   <DataNode TextLabel="5,10-Methenyl-THF" GraphId="c8a9d" Type="Metabolite">
     <Comment>5,10-Methenyltetrahydrofolic acid</Comment>
     <Comment>5,10-Methenyltetrahydrofolic acid</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2247.991666666667" CenterY="468.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2247.991666666667" CenterY="468.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01354"/>
+
     <Xref Database="HMDB" ID="HMDB0001354" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-Formyl-THF" GraphId="cf0a2" Type="Metabolite">
   <DataNode TextLabel="5-Formyl-THF" GraphId="cf0a2" Type="Metabolite">
     <Comment>5-Formyltetrahydrofolate</Comment>
     <Comment>5-Formyltetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2647.991666666667" CenterY="502.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2647.991666666667" CenterY="502.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01562"/>
+
     <Xref Database="HMDB" ID="HMDB0001562" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="10-Formyl-THF" GraphId="d0bb5" Type="Metabolite">
   <DataNode TextLabel="10-Formyl-THF" GraphId="d0bb5" Type="Metabolite">
     <Comment>10-formyltetrahydrofolate</Comment>
     <Comment>10-formyltetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2247.991666666667" CenterY="223.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2247.991666666667" CenterY="223.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00972"/>
+
     <Xref Database="HMDB" ID="HMDB0000972" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="(11R)-hydroxymethylene-THF" GraphId="d1eb6" Type="Metabolite">
   <DataNode TextLabel="(11R)-hydroxymethylene-THF" GraphId="d1eb6" Type="Metabolite">
     <Comment>(11R)-hydroxymethylenetetrahydrofolate</Comment>
     <Comment>(11R)-hydroxymethylenetetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2647.991666666667" CenterY="400.31666666666666" Width="144.01666666666668" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="2647.991666666667" CenterY="400.31666666666666" Width="144.01666666666668" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
-
     <Xref Database="" ID=""/>
+
     <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GAR" GraphId="d61a5" Type="Metabolite">
   <DataNode TextLabel="GAR" GraphId="d61a5" Type="Metabolite">
Line 432: Line 432:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
-
     <Graphics CenterX="2573.991666666667" CenterY="643.3166666666667" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2573.991666666667" CenterY="643.3166666666667" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02022"/>
+
     <Xref Database="HMDB" ID="HMDB0002022" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FGAR" GraphId="ead14" Type="Metabolite">
   <DataNode TextLabel="FGAR" GraphId="ead14" Type="Metabolite">
Line 439: Line 439:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
-
     <Graphics CenterX="2755.991666666667" CenterY="643.65" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2755.991666666667" CenterY="643.65" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="18272"/>
+
     <Xref Database="ChEBI" ID="18272" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Dihydrofolate" GraphId="ff915" Type="Metabolite">
   <DataNode TextLabel="Dihydrofolate" GraphId="ff915" Type="Metabolite">
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
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-
     <Xref Database="HMDB" ID="HMDB01056"/>
+
     <Xref Database="HMDB" ID="HMDB0001056" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-methyl-THF" GraphId="c48e4" Type="Metabolite">
   <DataNode TextLabel="5-methyl-THF" GraphId="c48e4" Type="Metabolite">
Line 452: Line 452:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
-
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-
     <Xref Database="HMDB" ID="HMDB01396"/>
+
     <Xref Database="HMDB" ID="HMDB0001396" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folate" GraphId="c9215" Type="Metabolite">
   <DataNode TextLabel="Folate" GraphId="c9215" Type="Metabolite">
     <Comment>Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).</Comment>
     <Comment>Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).</Comment>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
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     <Graphics CenterX="2095.579166666667" CenterY="2347.3166666666666" Width="129.50833333333333" Height="73.36666666666666" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="ChEBI" ID="37445"/>
+
     <Xref Database="ChEBI" ID="37445" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folate" GraphId="f5e5d" Type="Metabolite">
   <DataNode TextLabel="Folate" GraphId="f5e5d" Type="Metabolite">
Line 474: Line 474:
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
-
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     <Graphics CenterX="2112.2458333333343" CenterY="1150.761419581714" Width="129.50833333333333" Height="73.36666666666666" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="ChEBI" ID="37445"/>
+
     <Xref Database="ChEBI" ID="37445" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-methyl-THF" GraphId="fb8f4" Type="Metabolite">
   <DataNode TextLabel="5-methyl-THF" GraphId="fb8f4" Type="Metabolite">
     <Comment>5-methyltetrahydrofolate</Comment>
     <Comment>5-methyltetrahydrofolate</Comment>
     <Comment>Predominant food folate</Comment>
     <Comment>Predominant food folate</Comment>
-
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+
     <Graphics CenterX="1911.5" CenterY="2369.3166666666666" Width="106.01666666666688" Height="21.366666666666674" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01396"/>
+
     <Xref Database="HMDB" ID="HMDB0001396" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD3" GraphId="b2954" Type="Protein">
   <DataNode TextLabel="SOD3" GraphId="b2954" Type="Protein">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
-
     <Graphics CenterX="1059.15" CenterY="2235.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="1059.15" CenterY="2235.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="6649"/>
+
     <Xref Database="Entrez Gene" ID="6649" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD3" GraphId="dbcff" Type="Protein" GroupRef="c56ac">
   <DataNode TextLabel="SOD3" GraphId="dbcff" Type="Protein" GroupRef="c56ac">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
-
     <Graphics CenterX="1059.15" CenterY="533.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998"/>
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     <Graphics CenterX="1059.15" CenterY="533.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="6649"/>
+
     <Xref Database="Entrez Gene" ID="6649" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RFK" GraphId="bce08" Type="Protein">
   <DataNode TextLabel="RFK" GraphId="bce08" Type="Protein">
Line 499: Line 499:
     <Comment>riboflavin kinase</Comment>
     <Comment>riboflavin kinase</Comment>
     <BiopaxRef>a22</BiopaxRef>
     <BiopaxRef>a22</BiopaxRef>
-
     <Graphics CenterX="1823.3333333333333" CenterY="276.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32824" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="1823.3333333333333" CenterY="276.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32824" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="55312"/>
+
     <Xref Database="Entrez Gene" ID="55312" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="H2O" GraphId="e023f" Type="Metabolite">
   <DataNode TextLabel="H2O" GraphId="e023f" Type="Metabolite">
     <Comment>Glutathione disulfide</Comment>
     <Comment>Glutathione disulfide</Comment>
-
     <Graphics CenterX="1142.185825410544" CenterY="344.18582541054445" Width="80.0" Height="30.0" ZOrder="32826" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1142.185825410544" CenterY="344.18582541054445" Width="80.0" Height="30.0" ZOrder="32826" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02111"/>
+
     <Xref Database="HMDB" ID="HMDB0002111" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 3" GraphId="a99ae" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 3" GraphId="a99ae" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
-
     <Graphics CenterX="1262.5" CenterY="408.3833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1262.5" CenterY="408.3833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2878"/>
+
     <Xref Database="Entrez Gene" ID="2878" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 3" GraphId="f2daa" Type="Protein">
   <DataNode TextLabel="GPX 3" GraphId="f2daa" Type="Protein">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
-
     <Graphics CenterX="1467.5" CenterY="2418.383333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1467.5" CenterY="2418.383333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2878"/>
+
     <Xref Database="Entrez Gene" ID="2878" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CTH" GraphId="b3fc3" Type="Protein">
   <DataNode TextLabel="CTH" GraphId="b3fc3" Type="Protein">
Line 523: Line 523:
     <Comment>cystathionase</Comment>
     <Comment>cystathionase</Comment>
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
-
     <Graphics CenterX="1413.3333333333333" CenterY="756.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32832" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="1413.3333333333333" CenterY="756.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32832" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="1491"/>
+
     <Xref Database="Entrez Gene" ID="1491" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Heme" GraphId="a07e7" Type="Metabolite">
   <DataNode TextLabel="Heme" GraphId="a07e7" Type="Metabolite">
Line 530: Line 530:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
-
     <Graphics CenterX="1346.3166666666666" CenterY="706.3166666666667" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32836" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1346.3166666666666" CenterY="706.3166666666667" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32836" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03178"/>
+
     <Xref Database="HMDB" ID="HMDB0003178" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="THF" GraphId="e5400" Type="Metabolite">
   <DataNode TextLabel="THF" GraphId="e5400" Type="Metabolite">
     <Comment>Tetrahydrofolic acid</Comment>
     <Comment>Tetrahydrofolic acid</Comment>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
     <Graphics CenterX="2243.325000000006" CenterY="812.8594497263035" Width="106.01666666666688" Height="21.366666666666788" ZOrder="32858" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2243.325000000006" CenterY="812.8594497263035" Width="106.01666666666688" Height="21.366666666666788" ZOrder="32858" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01846"/>
+
     <Xref Database="HMDB" ID="HMDB0001846" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="a1df1" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="a1df1" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="1756.5" CenterY="700.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1756.5" CenterY="700.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB0000221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="b6c81" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="b6c81" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="846.5" CenterY="653.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="846.5" CenterY="653.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB0000221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="b848b" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="b848b" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2066.5" CenterY="706.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="2066.5" CenterY="706.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB0000221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="c222f" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="c222f" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2291.5" CenterY="899.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="2291.5" CenterY="899.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB0000221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="d656e" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="d656e" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2066.5" CenterY="2217.3166666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="2066.5" CenterY="2217.3166666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB0000221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="e0aa2" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="e0aa2" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2283.5" CenterY="604.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="2283.5" CenterY="604.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB0000221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="e3d0e" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="e3d0e" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2284.5" CenterY="313.31666666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="2284.5" CenterY="313.31666666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB0000221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 6" GraphId="c9baf" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 6" GraphId="c9baf" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 6</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 6</Comment>
-
     <Graphics CenterX="1262.5" CenterY="437.7833333333332" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32872" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1262.5" CenterY="437.7833333333332" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32872" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="257202"/>
+
     <Xref Database="Entrez Gene" ID="257202" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Manganese" GraphId="c4516" Type="Metabolite">
   <DataNode TextLabel="Manganese" GraphId="c4516" Type="Metabolite">
-
     <Graphics CenterX="1177.0" CenterY="2320.5" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833"/>
+
     <Graphics CenterX="1177.0" CenterY="2320.5" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833" />
-
     <Xref Database="HMDB" ID="HMDB01333"/>
+
     <Xref Database="HMDB" ID="HMDB0001333" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Manganese" GraphId="f238e" Type="Metabolite">
   <DataNode TextLabel="Manganese" GraphId="f238e" Type="Metabolite">
-
     <Graphics CenterX="1177.0" CenterY="509.4999999999999" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833"/>
+
     <Graphics CenterX="1177.0" CenterY="509.4999999999999" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833" />
-
     <Xref Database="HMDB" ID="HMDB01333"/>
+
     <Xref Database="HMDB" ID="HMDB0001333" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folic acid" GraphId="f5c49" Type="Metabolite">
   <DataNode TextLabel="Folic acid" GraphId="f5c49" Type="Metabolite">
Line 593: Line 593:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
-
     <Graphics CenterX="2245.0" CenterY="2380.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="2245.0" CenterY="2380.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00121"/>
+
     <Xref Database="HMDB" ID="HMDB0000121" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folic acid" GraphId="fdd61" Type="Metabolite">
   <DataNode TextLabel="Folic acid" GraphId="fdd61" Type="Metabolite">
Line 601: Line 601:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
-
     <Graphics CenterX="2243.0" CenterY="1000.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="2243.0" CenterY="1000.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00121"/>
+
     <Xref Database="HMDB" ID="HMDB0000121" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 2" GraphId="ee09f" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 2" GraphId="ee09f" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 2</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 2</Comment>
-
     <Graphics CenterX="1262.5" CenterY="393.68333333333334" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32902" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1262.5" CenterY="393.68333333333334" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32902" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2877"/>
+
     <Xref Database="Entrez Gene" ID="2877" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 1" GraphId="cc013" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 1" GraphId="cc013" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 1</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 1</Comment>
-
     <Graphics CenterX="1262.5" CenterY="378.98333333333335" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32914" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1262.5" CenterY="378.98333333333335" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32914" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2876"/>
+
     <Xref Database="Entrez Gene" ID="2876" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RNS" GraphId="ac095" Type="Metabolite">
   <DataNode TextLabel="RNS" GraphId="ac095" Type="Metabolite">
Line 621: Line 621:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
-
     <Graphics CenterX="972.3166666666667" CenterY="884.3333333333334" Width="70.70000000000005" Height="30.0" ZOrder="32920" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="972.3166666666667" CenterY="884.3333333333334" Width="70.70000000000005" Height="30.0" ZOrder="32920" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="CHEBI:62764"/>
+
     <Xref Database="ChEBI" ID="CHEBI:62764" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFR*" GraphId="aa7fc" Type="Protein">
   <DataNode TextLabel="MTHFR*" GraphId="aa7fc" Type="Protein">
Line 630: Line 630:
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
     <Graphics CenterX="2100.0" CenterY="736.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="2100.0" CenterY="736.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4524"/>
+
     <Xref Database="Entrez Gene" ID="4524" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GART" GraphId="b1cf5" Type="Protein">
   <DataNode TextLabel="GART" GraphId="b1cf5" Type="Protein">
Line 638: Line 638:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
-
     <Graphics CenterX="2729.0" CenterY="570.4999999999998" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="2729.0" CenterY="570.4999999999998" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2618"/>
+
     <Xref Database="Entrez Gene" ID="2618" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFS" GraphId="b9e0d" Type="Protein">
   <DataNode TextLabel="MTHFS" GraphId="b9e0d" Type="Protein">
Line 645: Line 645:
     <Comment>5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)</Comment>
     <Comment>5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2487.0" CenterY="560.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="2487.0" CenterY="560.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="10588"/>
+
     <Xref Database="Entrez Gene" ID="10588" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SHMT" GraphId="effec" Type="Protein">
   <DataNode TextLabel="SHMT" GraphId="effec" Type="Protein">
Line 652: Line 652:
     <Comment>Serine hydroxymethyltransferase 1 (soluble)</Comment>
     <Comment>Serine hydroxymethyltransferase 1 (soluble)</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2767.0" CenterY="451.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="2767.0" CenterY="451.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="6470"/>
+
     <Xref Database="Entrez Gene" ID="6470" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Homocysteine" GraphId="e963d" Type="Metabolite">
   <DataNode TextLabel="Homocysteine" GraphId="e963d" Type="Metabolite">
     <BiopaxRef>c0b</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
-
     <Graphics CenterX="1603.0" CenterY="2329.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1603.0" CenterY="2329.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00742"/>
+
     <Xref Database="HMDB" ID="HMDB0000742" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Homocysteine" GraphId="f7b96" Type="Metabolite">
   <DataNode TextLabel="Homocysteine" GraphId="f7b96" Type="Metabolite">
Line 670: Line 670:
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
-
     <Graphics CenterX="1603.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1603.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00742"/>
+
     <Xref Database="HMDB" ID="HMDB0000742" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD1" GraphId="c0bee" Type="Protein" GroupRef="c56ac">
   <DataNode TextLabel="SOD1" GraphId="c0bee" Type="Protein" GroupRef="c56ac">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 1, soluble</Comment>
     <Comment>superoxide dismutase 1, soluble</Comment>
-
     <Graphics CenterX="1059.15" CenterY="505.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32932" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="1059.15" CenterY="505.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32932" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="6647"/>
+
     <Xref Database="Entrez Gene" ID="6647" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="a379c" Type="Metabolite">
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="a379c" Type="Metabolite">
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>cda</BiopaxRef>
     <BiopaxRef>cda</BiopaxRef>
-
     <Graphics CenterX="1630.3333333333333" CenterY="2392.1666666666665" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1630.3333333333333" CenterY="2392.1666666666665" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01491"/>
+
     <Xref Database="HMDB" ID="HMDB0001491" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="f536b" Type="Metabolite">
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="f536b" Type="Metabolite">
Line 690: Line 690:
     <BiopaxRef>cda</BiopaxRef>
     <BiopaxRef>cda</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
-
     <Graphics CenterX="1602.3333333333333" CenterY="900.1666666666666" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1602.3333333333333" CenterY="900.1666666666666" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01491"/>
+
     <Xref Database="HMDB" ID="HMDB0001491" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Glycine" GraphId="a2828" Type="Metabolite">
   <DataNode TextLabel="Glycine" GraphId="a2828" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1312.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1312.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00123"/>
+
     <Xref Database="HMDB" ID="HMDB0000123" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Glycine" GraphId="cc841" Type="Metabolite">
   <DataNode TextLabel="Glycine" GraphId="cc841" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1330.0" CenterY="2226.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1330.0" CenterY="2226.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00123"/>
+
     <Xref Database="HMDB" ID="HMDB0000123" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="L-Arginine" GraphId="cd5bc" Type="Metabolite">
   <DataNode TextLabel="L-Arginine" GraphId="cd5bc" Type="Metabolite">
     <BiopaxRef>ac7</BiopaxRef>
     <BiopaxRef>ac7</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
     <Graphics CenterX="768.0" CenterY="747.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="768.0" CenterY="747.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00517"/>
+
     <Xref Database="HMDB" ID="HMDB0000517" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Serine" GraphId="d12af" Type="Metabolite">
   <DataNode TextLabel="Serine" GraphId="d12af" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
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+
     <Graphics CenterX="1475.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00187"/>
+
     <Xref Database="HMDB" ID="HMDB0000187" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDL" GraphId="a6262" Type="Metabolite">
   <DataNode TextLabel="LDL" GraphId="a6262" Type="Metabolite">
Line 724: Line 724:
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
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+
     <Graphics CenterX="792.0" CenterY="1004.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39026"/>
+
     <Xref Database="ChEBI" ID="39026" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACT" GraphId="a6906" Type="Protein">
   <DataNode TextLabel="ACT" GraphId="a6906" Type="Protein">
Line 732: Line 732:
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
-
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+
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-
     <Xref Database="Entrez Gene" ID="12"/>
+
     <Xref Database="Entrez Gene" ID="12" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOB" GraphId="a8ce8" Type="Protein">
   <DataNode TextLabel="APOB" GraphId="a8ce8" Type="Protein">
     <Comment>apolipoprotein B</Comment>
     <Comment>apolipoprotein B</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
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     <Graphics CenterX="809.3333333333334" CenterY="1376.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="338"/>
+
     <Xref Database="Entrez Gene" ID="338" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL/APOA1" GraphId="a971b" Type="Metabolite">
   <DataNode TextLabel="HDL/APOA1" GraphId="a971b" Type="Metabolite">
Line 745: Line 745:
     <Comment>ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles</Comment>
     <Comment>ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="1286.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="898.3333333333334" CenterY="1286.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39025"/>
+
     <Xref Database="ChEBI" ID="39025" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1" GraphId="ae262" Type="Protein">
   <DataNode TextLabel="APOA1" GraphId="ae262" Type="Protein">
     <Comment>apolipoprotein A-I</Comment>
     <Comment>apolipoprotein A-I</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
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     <Graphics CenterX="898.3333333333334" CenterY="1203.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="335"/>
+
     <Xref Database="Entrez Gene" ID="335" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1" GraphId="aec06" Type="Protein">
   <DataNode TextLabel="APOA1" GraphId="aec06" Type="Protein">
     <Comment>apolipoprotein A-I</Comment>
     <Comment>apolipoprotein A-I</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
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     <Graphics CenterX="898.3333333333334" CenterY="2371.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="335"/>
+
     <Xref Database="Entrez Gene" ID="335" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDL" GraphId="b163e" Type="Metabolite">
   <DataNode TextLabel="LDL" GraphId="b163e" Type="Metabolite">
Line 767: Line 767:
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
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+
     <Graphics CenterX="791.0" CenterY="2283.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39026"/>
+
     <Xref Database="ChEBI" ID="39026" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TAG" GraphId="b35b8" Type="Metabolite">
   <DataNode TextLabel="TAG" GraphId="b35b8" Type="Metabolite">
Line 774: Line 774:
     <Comment>Triacylglycerol</Comment>
     <Comment>Triacylglycerol</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="687.3333333333334" CenterY="2279.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="687.3333333333334" CenterY="2279.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="17855"/>
+
     <Xref Database="ChEBI" ID="17855" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOB" GraphId="b4497" Type="Protein">
   <DataNode TextLabel="APOB" GraphId="b4497" Type="Protein">
     <Comment>apolipoprotein B</Comment>
     <Comment>apolipoprotein B</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
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+
     <Graphics CenterX="687.3333333333334" CenterY="2346.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="338"/>
+
     <Xref Database="Entrez Gene" ID="338" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cholesterol" GraphId="bf019" Type="Metabolite">
   <DataNode TextLabel="Cholesterol" GraphId="bf019" Type="Metabolite">
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="977.3333333333334" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="977.3333333333334" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00067"/>
+
     <Xref Database="HMDB" ID="HMDB0000067" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL/SAA" GraphId="bfd83" Type="Metabolite">
   <DataNode TextLabel="HDL/SAA" GraphId="bfd83" Type="Metabolite">
Line 794: Line 794:
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
     <Graphics CenterX="589.3333333333334" CenterY="1291.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="589.3333333333334" CenterY="1291.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39025"/>
+
     <Xref Database="ChEBI" ID="39025" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL" GraphId="c013c" Type="Metabolite">
   <DataNode TextLabel="HDL" GraphId="c013c" Type="Metabolite">
Line 801: Line 801:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="2485.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="898.3333333333334" CenterY="2485.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39025"/>
+
     <Xref Database="ChEBI" ID="39025" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA1" GraphId="c1059" Type="Protein">
   <DataNode TextLabel="SAA1" GraphId="c1059" Type="Protein">
Line 808: Line 808:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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+
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-
     <Xref Database="Entrez Gene" ID="6288"/>
+
     <Xref Database="Entrez Gene" ID="6288" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="oxLDL" GraphId="c2ce6" Type="Metabolite">
   <DataNode TextLabel="oxLDL" GraphId="c2ce6" Type="Metabolite">
Line 817: Line 817:
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
-
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+
     <Graphics CenterX="791.0" CenterY="2245.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="CHEBI:60151"/>
+
     <Xref Database="ChEBI" ID="CHEBI:60151" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TAG" GraphId="c3879" Type="Metabolite">
   <DataNode TextLabel="TAG" GraphId="c3879" Type="Metabolite">
Line 824: Line 824:
     <Comment>Triacylglycerol</Comment>
     <Comment>Triacylglycerol</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
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     <Graphics CenterX="734.3333333333334" CenterY="1464.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="17855"/>
+
     <Xref Database="ChEBI" ID="17855" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ABCA1" GraphId="c4c25" Type="Protein">
   <DataNode TextLabel="ABCA1" GraphId="c4c25" Type="Protein">
Line 831: Line 831:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="19"/>
+
     <Xref Database="Entrez Gene" ID="19" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA4" GraphId="c4c97" Type="Protein">
   <DataNode TextLabel="SAA4" GraphId="c4c97" Type="Protein">
Line 838: Line 838:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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     <Graphics CenterX="711.3333333333334" CenterY="1219.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="6291"/>
+
     <Xref Database="Entrez Gene" ID="6291" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA2" GraphId="c5808" Type="Protein">
   <DataNode TextLabel="SAA2" GraphId="c5808" Type="Protein">
Line 845: Line 845:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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     <Graphics CenterX="563.3333333333334" CenterY="1219.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="6289"/>
+
     <Xref Database="Entrez Gene" ID="6289" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SRB1" GraphId="d2c4e" Type="Protein">
   <DataNode TextLabel="SRB1" GraphId="d2c4e" Type="Protein">
     <Comment>scavenger receptor class B, member 1</Comment>
     <Comment>scavenger receptor class B, member 1</Comment>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="949"/>
+
     <Xref Database="Entrez Gene" ID="949" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA3" GraphId="de80e" Type="Protein">
   <DataNode TextLabel="SAA3" GraphId="de80e" Type="Protein">
Line 858: Line 858:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="6290"/>
+
     <Xref Database="Entrez Gene" ID="6290" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL" GraphId="df758" Type="Metabolite">
   <DataNode TextLabel="VLDL" GraphId="df758" Type="Metabolite">
Line 865: Line 865:
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
     <Graphics CenterX="687.3333333333334" CenterY="2314.983333333333" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="687.3333333333334" CenterY="2314.983333333333" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39027"/>
+
     <Xref Database="ChEBI" ID="39027" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FMN" GraphId="e42a5" Type="Metabolite">
   <DataNode TextLabel="FMN" GraphId="e42a5" Type="Metabolite">
     <Comment>Flavin Mononucleotide</Comment>
     <Comment>Flavin Mononucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="1928.3333333333333" CenterY="337.31666666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1928.3333333333333" CenterY="337.31666666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01520"/>
+
     <Xref Database="HMDB" ID="HMDB0001520" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1-NO2Tyr" GraphId="e4372" Type="Protein">
   <DataNode TextLabel="APOA1-NO2Tyr" GraphId="e4372" Type="Protein">
     <Comment>Nitrotyrosinated apolipoprotein A-I</Comment>
     <Comment>Nitrotyrosinated apolipoprotein A-I</Comment>
     <BiopaxRef>c65</BiopaxRef>
     <BiopaxRef>c65</BiopaxRef>
-
     <Graphics CenterX="897.9916666666667" CenterY="973.3166666666667" Width="86.01666666666667" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="897.9916666666667" CenterY="973.3166666666667" Width="86.01666666666667" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="335"/>
+
     <Xref Database="Entrez Gene" ID="335" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL" GraphId="e69a0" Type="Metabolite">
   <DataNode TextLabel="HDL" GraphId="e69a0" Type="Metabolite">
Line 884: Line 884:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
     <Graphics CenterX="979.3333333333334" CenterY="1237.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="979.3333333333334" CenterY="1237.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39025"/>
+
     <Xref Database="ChEBI" ID="39025" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL-C" GraphId="ede1f" Type="Metabolite">
   <DataNode TextLabel="HDL-C" GraphId="ede1f" Type="Metabolite">
Line 891: Line 891:
     <Comment>Cholesterol transport</Comment>
     <Comment>Cholesterol transport</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="1355.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="898.3333333333334" CenterY="1355.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="47775"/>
+
     <Xref Database="ChEBI" ID="47775" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL-C" GraphId="f3b52" Type="Metabolite">
   <DataNode TextLabel="HDL-C" GraphId="f3b52" Type="Metabolite">
Line 898: Line 898:
     <Comment>Cholesterol transport</Comment>
     <Comment>Cholesterol transport</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="2407.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="898.3333333333334" CenterY="2407.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="47775"/>
+
     <Xref Database="ChEBI" ID="47775" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACT" GraphId="f58a9" Type="Protein">
   <DataNode TextLabel="ACT" GraphId="f58a9" Type="Protein">
Line 906: Line 906:
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="860.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="791.0" CenterY="860.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="12"/>
+
     <Xref Database="Entrez Gene" ID="12" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL" GraphId="f5e1f" Type="Metabolite">
   <DataNode TextLabel="VLDL" GraphId="f5e1f" Type="Metabolite">
Line 913: Line 913:
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
     <Graphics CenterX="732.3333333333334" CenterY="1403.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="732.3333333333334" CenterY="1403.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39027"/>
+
     <Xref Database="ChEBI" ID="39027" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL-TAG" GraphId="f97c7" Type="Metabolite">
   <DataNode TextLabel="VLDL-TAG" GraphId="f97c7" Type="Metabolite">
Line 920: Line 920:
     <Comment>Triglyceride transport</Comment>
     <Comment>Triglyceride transport</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="687.3333333333334" CenterY="2243.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="687.3333333333334" CenterY="2243.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="47776"/>
+
     <Xref Database="ChEBI" ID="47776" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="oxLDL" GraphId="fa1dc" Type="Metabolite">
   <DataNode TextLabel="oxLDL" GraphId="fa1dc" Type="Metabolite">
Line 929: Line 929:
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="1095.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="791.0" CenterY="1095.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="CHEBI:60151"/>
+
     <Xref Database="ChEBI" ID="CHEBI:60151" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cholesterol" GraphId="fa941" Type="Metabolite">
   <DataNode TextLabel="Cholesterol" GraphId="fa941" Type="Metabolite">
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="2442.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="898.3333333333334" CenterY="2442.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00067"/>
+
     <Xref Database="HMDB" ID="HMDB0000067" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL/APOB" GraphId="fbb71" Type="Metabolite">
   <DataNode TextLabel="VLDL/APOB" GraphId="fbb71" Type="Metabolite">
Line 941: Line 941:
     <Comment>The VLDL is produced in the liver, contains one molecule of apoB100</Comment>
     <Comment>The VLDL is produced in the liver, contains one molecule of apoB100</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="809.3333333333334" CenterY="1437.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="809.3333333333334" CenterY="1437.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39027"/>
+
     <Xref Database="ChEBI" ID="39027" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDLR" GraphId="fca6e" Type="Protein">
   <DataNode TextLabel="LDLR" GraphId="fca6e" Type="Protein">
     <Comment>low density lipoprotein receptor</Comment>
     <Comment>low density lipoprotein receptor</Comment>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
-
     <Graphics CenterX="792.0" CenterY="913.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="792.0" CenterY="913.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3949"/>
+
     <Xref Database="Entrez Gene" ID="3949" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL-TAG" GraphId="fcc5d" Type="Metabolite">
   <DataNode TextLabel="VLDL-TAG" GraphId="fcc5d" Type="Metabolite">
Line 954: Line 954:
     <Comment>Triglyceride transport</Comment>
     <Comment>Triglyceride transport</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="809.3333333333334" CenterY="1499.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="809.3333333333334" CenterY="1499.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="47776"/>
+
     <Xref Database="ChEBI" ID="47776" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O2" GraphId="bc4c4" Type="Metabolite">
   <DataNode TextLabel="O2" GraphId="bc4c4" Type="Metabolite">
     <BiopaxRef>d63</BiopaxRef>
     <BiopaxRef>d63</BiopaxRef>
-
     <Graphics CenterX="1291.0" CenterY="599.0" Width="80.0" Height="30.0" ZOrder="32948" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1291.0" CenterY="599.0" Width="80.0" Height="30.0" ZOrder="32948" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01377"/>
+
     <Xref Database="HMDB" ID="HMDB0001377" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cob(I)alamin" GraphId="aebe4" Type="Metabolite">
   <DataNode TextLabel="Cob(I)alamin" GraphId="aebe4" Type="Metabolite">
Line 967: Line 967:
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
-
     <Graphics CenterX="1700.3333333333333" CenterY="573.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1700.3333333333333" CenterY="573.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02174"/>
+
     <Xref Database="HMDB" ID="HMDB0002174" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="b57a6" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="b57a6" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="2066.3333333333335" CenterY="612.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2066.3333333333335" CenterY="612.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01248"/>
+
     <Xref Database="HMDB" ID="HMDB0001248" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cob(I)alamin" GraphId="de2a9" Type="Metabolite">
   <DataNode TextLabel="Cob(I)alamin" GraphId="de2a9" Type="Metabolite">
Line 981: Line 981:
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
-
     <Graphics CenterX="1702.3333333333333" CenterY="2271.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1702.3333333333333" CenterY="2271.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02174"/>
+
     <Xref Database="HMDB" ID="HMDB0002174" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-OHdG" GraphId="eeb89" Type="Metabolite">
   <DataNode TextLabel="8-OHdG" GraphId="eeb89" Type="Metabolite">
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <BiopaxRef>be4</BiopaxRef>
     <BiopaxRef>be4</BiopaxRef>
-
     <Graphics CenterX="680.3333333333334" CenterY="560.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="680.3333333333334" CenterY="560.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03333"/>
+
     <Xref Database="HMDB" ID="HMDB0003333" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="f468f" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="f468f" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
-
     <Graphics CenterX="1828.3333333333333" CenterY="698.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1828.3333333333333" CenterY="698.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01248"/>
+
     <Xref Database="HMDB" ID="HMDB0001248" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cob(II)alamin" GraphId="f4b4d" Type="Metabolite">
   <DataNode TextLabel="Cob(II)alamin" GraphId="f4b4d" Type="Metabolite">
Line 1,000: Line 1,000:
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
-
     <Graphics CenterX="1700.3333333333333" CenterY="762.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1700.3333333333333" CenterY="762.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02174"/>
+
     <Xref Database="HMDB" ID="HMDB0002174" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-OHdG" GraphId="f4ca6" Type="Metabolite">
   <DataNode TextLabel="8-OHdG" GraphId="f4ca6" Type="Metabolite">
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <BiopaxRef>be4</BiopaxRef>
     <BiopaxRef>be4</BiopaxRef>
-
     <Graphics CenterX="537.6666666666666" CenterY="2220.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="537.6666666666666" CenterY="2220.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03333"/>
+
     <Xref Database="HMDB" ID="HMDB0003333" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ADP" GraphId="b52e8" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="b52e8" Type="Metabolite">
     <Comment>Adenosine diphosphate</Comment>
     <Comment>Adenosine diphosphate</Comment>
-
     <Graphics CenterX="2039.0" CenterY="367.98333333333335" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="2039.0" CenterY="367.98333333333335" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB01341"/>
+
     <Xref Database="HMDB" ID="HMDB0001341" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ADP" GraphId="cd72a" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="cd72a" Type="Metabolite">
     <Comment>Adenosine diphosphate</Comment>
     <Comment>Adenosine diphosphate</Comment>
-
     <Graphics CenterX="2531.0" CenterY="522.9833333333333" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="2531.0" CenterY="522.9833333333333" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB01341"/>
+
     <Xref Database="HMDB" ID="HMDB0001341" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Magnesium" GraphId="ab890" Type="Metabolite">
   <DataNode TextLabel="Magnesium" GraphId="ab890" Type="Metabolite">
-
     <Graphics CenterX="2182.0" CenterY="2272.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="2182.0" CenterY="2272.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00547"/>
+
     <Xref Database="HMDB" ID="HMDB0000547" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Chlorine" GraphId="b7263" Type="Metabolite">
   <DataNode TextLabel="Chlorine" GraphId="b7263" Type="Metabolite">
-
     <Graphics CenterX="1115.0" CenterY="2262.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1115.0" CenterY="2262.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00492"/>
+
     <Xref Database="HMDB" ID="HMDB0000492" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Chlorine" GraphId="c0f46" Type="Metabolite">
   <DataNode TextLabel="Chlorine" GraphId="c0f46" Type="Metabolite">
-
     <Graphics CenterX="1053.0" CenterY="708.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1053.0" CenterY="708.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00492"/>
+
     <Xref Database="HMDB" ID="HMDB0000492" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Magnesium" GraphId="f4fec" Type="Metabolite">
   <DataNode TextLabel="Magnesium" GraphId="f4fec" Type="Metabolite">
-
     <Graphics CenterX="2182.0" CenterY="285.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="2182.0" CenterY="285.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00547"/>
+
     <Xref Database="HMDB" ID="HMDB0000547" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="S-nitrosohomocysteine" GraphId="c8bf3" Type="Metabolite">
   <DataNode TextLabel="S-nitrosohomocysteine" GraphId="c8bf3" Type="Metabolite">
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
     <Graphics CenterX="1306.5" CenterY="527.5" Width="123.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1306.5" CenterY="527.5" Width="123.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle" />
-
     <Xref Database="PubChem-compound" ID="3035701"/>
+
     <Xref Database="PubChem-compound" ID="3035701" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cystathionine" GraphId="cb485" Type="Metabolite">
   <DataNode TextLabel="Cystathionine" GraphId="cb485" Type="Metabolite">
-
     <Graphics CenterX="1468.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1468.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00099"/>
+
     <Xref Database="HMDB" ID="HMDB0000099" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD2" GraphId="ed5ed" Type="Protein" GroupRef="c56ac">
   <DataNode TextLabel="SOD2" GraphId="ed5ed" Type="Protein" GroupRef="c56ac">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 2, mitochondrial</Comment>
     <Comment>superoxide dismutase 2, mitochondrial</Comment>
-
     <Graphics CenterX="1059.15" CenterY="519.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32966" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="1059.15" CenterY="519.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32966" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="6648"/>
+
     <Xref Database="Entrez Gene" ID="6648" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Serine" GraphId="f3084" Type="Metabolite">
   <DataNode TextLabel="Serine" GraphId="f3084" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1475.0" CenterY="2227.816619873047" Width="72.0" Height="21.33333333333337" ZOrder="32970" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1475.0" CenterY="2227.816619873047" Width="72.0" Height="21.33333333333337" ZOrder="32970" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00187"/>
+
     <Xref Database="HMDB" ID="HMDB0000187" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ATP" GraphId="e2d51" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="e2d51" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
-
     <Graphics CenterX="1789.4916666666666" CenterY="368.98333333333335" Width="51.0" Height="14.7" ZOrder="32974" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1789.4916666666666" CenterY="368.98333333333335" Width="51.0" Height="14.7" ZOrder="32974" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00538"/>
+
     <Xref Database="HMDB" ID="HMDB0000538" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Zinc" GraphId="e1371" Type="Metabolite">
   <DataNode TextLabel="Zinc" GraphId="e1371" Type="Metabolite">
-
     <Graphics CenterX="1828.0" CenterY="574.8333333333334" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1828.0" CenterY="574.8333333333334" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01303"/>
+
     <Xref Database="HMDB" ID="HMDB0001303" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Zinc" GraphId="fc87c" Type="Metabolite">
   <DataNode TextLabel="Zinc" GraphId="fc87c" Type="Metabolite">
-
     <Graphics CenterX="1828.0" CenterY="2264.8333333333335" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1828.0" CenterY="2264.8333333333335" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01303"/>
+
     <Xref Database="HMDB" ID="HMDB0001303" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO" GraphId="a2c0e" Type="Metabolite">
   <DataNode TextLabel="NO" GraphId="a2c0e" Type="Metabolite">
Line 1,077: Line 1,077:
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
     <Graphics CenterX="1017.3333333333334" CenterY="754.6666666666666" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1017.3333333333334" CenterY="754.6666666666666" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03378"/>
+
     <Xref Database="HMDB" ID="HMDB0003378" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HOCl" GraphId="aeb17" Type="Metabolite">
   <DataNode TextLabel="HOCl" GraphId="aeb17" Type="Metabolite">
     <Comment>Hypochlorite</Comment>
     <Comment>Hypochlorite</Comment>
-
     <Graphics CenterX="1126.3333333333333" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1126.3333333333333" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01050"/>
+
     <Xref Database="HMDB" ID="HMDB0001050" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO" GraphId="b9847" Type="Metabolite">
   <DataNode TextLabel="NO" GraphId="b9847" Type="Metabolite">
Line 1,089: Line 1,089:
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
-
     <Graphics CenterX="1017.3333333333334" CenterY="2208.6666666666665" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1017.3333333333334" CenterY="2208.6666666666665" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03378"/>
+
     <Xref Database="HMDB" ID="HMDB0003378" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O3" GraphId="c177c" Type="Metabolite">
   <DataNode TextLabel="O3" GraphId="c177c" Type="Metabolite">
     <Comment>ozone</Comment>
     <Comment>ozone</Comment>
-
     <Graphics CenterX="1020.3333333333334" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1020.3333333333334" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="25812"/>
+
     <Xref Database="ChEBI" ID="25812" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO2" GraphId="d599e" Type="Metabolite">
   <DataNode TextLabel="NO2" GraphId="d599e" Type="Metabolite">
     <Comment>Nitrogen dioxide</Comment>
     <Comment>Nitrogen dioxide</Comment>
-
     <Graphics CenterX="1100.3333333333333" CenterY="756.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1100.3333333333333" CenterY="756.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="33101"/>
+
     <Xref Database="ChEBI" ID="33101" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HNO2" GraphId="e4fb0" Type="Metabolite">
   <DataNode TextLabel="HNO2" GraphId="e4fb0" Type="Metabolite">
     <Comment>Nitrous acid</Comment>
     <Comment>Nitrous acid</Comment>
-
     <Graphics CenterX="1103.3333333333333" CenterY="800.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1103.3333333333333" CenterY="800.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="25567"/>
+
     <Xref Database="ChEBI" ID="25567" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL1B" GraphId="a0188" Type="Protein">
   <DataNode TextLabel="IL1B" GraphId="a0188" Type="Protein">
     <Comment>interleukin 1, beta</Comment>
     <Comment>interleukin 1, beta</Comment>
     <BiopaxRef>b78</BiopaxRef>
     <BiopaxRef>b78</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2499.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1145.8166666666666" CenterY="2499.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3553"/>
+
     <Xref Database="Entrez Gene" ID="3553" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL2" GraphId="a36b0" Type="Protein">
   <DataNode TextLabel="IL2" GraphId="a36b0" Type="Protein">
Line 1,117: Line 1,117:
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2566.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1145.8166666666666" CenterY="2566.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3558"/>
+
     <Xref Database="Entrez Gene" ID="3558" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrinogen" GraphId="a741c" Type="Protein" GroupRef="d5ce7">
   <DataNode TextLabel="Fibrinogen" GraphId="a741c" Type="Protein" GroupRef="d5ce7">
-
     <Graphics CenterX="2394.961729643253" CenterY="1210.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2394.961729643253" CenterY="1210.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Wikidata" ID="Q381899"/>
+
     <Xref Database="Wikidata" ID="Q381899" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL1B" GraphId="a8c2d" Type="Protein">
   <DataNode TextLabel="IL1B" GraphId="a8c2d" Type="Protein">
Line 1,128: Line 1,128:
     <BiopaxRef>b78</BiopaxRef>
     <BiopaxRef>b78</BiopaxRef>
     <BiopaxRef>d77</BiopaxRef>
     <BiopaxRef>d77</BiopaxRef>
-
     <Graphics CenterX="1245.8166666666666" CenterY="1324.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1245.8166666666666" CenterY="1324.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3553"/>
+
     <Xref Database="Entrez Gene" ID="3553" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CRP" GraphId="aa691" Type="Protein">
   <DataNode TextLabel="CRP" GraphId="aa691" Type="Protein">
Line 1,139: Line 1,139:
     <BiopaxRef>be5</BiopaxRef>
     <BiopaxRef>be5</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
-
     <Graphics CenterX="1501.8166666666666" CenterY="1115.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1501.8166666666666" CenterY="1115.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="1401"/>
+
     <Xref Database="Entrez Gene" ID="1401" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HBB" GraphId="acb2b" Type="Protein">
   <DataNode TextLabel="HBB" GraphId="acb2b" Type="Protein">
     <Comment>hemoglobin, beta</Comment>
     <Comment>hemoglobin, beta</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2032.8166666666666" CenterY="1710.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2032.8166666666666" CenterY="1710.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3043"/>
+
     <Xref Database="Entrez Gene" ID="3043" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INSR" GraphId="b05cc" Type="Protein">
   <DataNode TextLabel="INSR" GraphId="b05cc" Type="Protein">
Line 1,152: Line 1,152:
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>e66</BiopaxRef>
     <BiopaxRef>e66</BiopaxRef>
-
     <Graphics CenterX="1738.8166666666666" CenterY="1788.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1738.8166666666666" CenterY="1788.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3643"/>
+
     <Xref Database="Entrez Gene" ID="3643" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HBA1" GraphId="b31e0" Type="Protein">
   <DataNode TextLabel="HBA1" GraphId="b31e0" Type="Protein">
     <Comment>hemoglobin, alpha 1</Comment>
     <Comment>hemoglobin, alpha 1</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2032.8166666666666" CenterY="1654.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2032.8166666666666" CenterY="1654.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3039"/>
+
     <Xref Database="Entrez Gene" ID="3039" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrin" GraphId="b5d1d" Type="Protein">
   <DataNode TextLabel="Fibrin" GraphId="b5d1d" Type="Protein">
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2394.483333333333" CenterY="2253.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2394.483333333333" CenterY="2253.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Wikidata" ID="Q27205"/>
+
     <Xref Database="Wikidata" ID="Q27205" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL10" GraphId="b696d" Type="Protein">
   <DataNode TextLabel="IL10" GraphId="b696d" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>bd7</BiopaxRef>
     <BiopaxRef>bd7</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1403.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1244.8166666666666" CenterY="1403.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3458"/>
+
     <Xref Database="Entrez Gene" ID="3458" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HbA1c" GraphId="b7344" Type="Protein">
   <DataNode TextLabel="HbA1c" GraphId="b7344" Type="Protein">
Line 1,177: Line 1,177:
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2301.483333333333" CenterY="2572.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2301.483333333333" CenterY="2572.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Wikidata" ID="Q311213"/>
+
     <Xref Database="Wikidata" ID="Q311213" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL2" GraphId="b8177" Type="Protein">
   <DataNode TextLabel="IL2" GraphId="b8177" Type="Protein">
Line 1,184: Line 1,184:
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1246.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1244.8166666666666" CenterY="1246.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3558"/>
+
     <Xref Database="Entrez Gene" ID="3558" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL4" GraphId="ba6d9" Type="Protein">
   <DataNode TextLabel="IL4" GraphId="ba6d9" Type="Protein">
     <Comment>interleukin 4</Comment>
     <Comment>interleukin 4</Comment>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1206.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1244.8166666666666" CenterY="1206.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3565"/>
+
     <Xref Database="Entrez Gene" ID="3565" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CSF1" GraphId="bd2f6" Type="Protein">
   <DataNode TextLabel="CSF1" GraphId="bd2f6" Type="Protein">
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
-
     <Graphics CenterX="1246.8166666666666" CenterY="1449.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1246.8166666666666" CenterY="1449.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="1435"/>
+
     <Xref Database="Entrez Gene" ID="1435" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALB" GraphId="be83d" Type="Protein">
   <DataNode TextLabel="ALB" GraphId="be83d" Type="Protein">
     <Comment>albumin</Comment>
     <Comment>albumin</Comment>
     <BiopaxRef>c31</BiopaxRef>
     <BiopaxRef>c31</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="213"/>
+
     <Xref Database="Entrez Gene" ID="213" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="D-dimer" GraphId="bfe70" Type="Protein">
   <DataNode TextLabel="D-dimer" GraphId="bfe70" Type="Protein">
Line 1,209: Line 1,209:
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
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-
     <Xref Database="Wikidata" ID="Q2162109"/>
+
     <Xref Database="Wikidata" ID="Q2162109" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INS" GraphId="c2c56" Type="Protein">
   <DataNode TextLabel="INS" GraphId="c2c56" Type="Protein">
Line 1,218: Line 1,218:
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
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-
     <Xref Database="Entrez Gene" ID="3630"/>
+
     <Xref Database="Entrez Gene" ID="3630" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IFNg" GraphId="c7788" Type="Protein">
   <DataNode TextLabel="IFNg" GraphId="c7788" Type="Protein">
Line 1,225: Line 1,225:
     <BiopaxRef>b42</BiopaxRef>
     <BiopaxRef>b42</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="3458"/>
+
     <Xref Database="Entrez Gene" ID="3458" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrinogen" GraphId="c7ee6" Type="Protein">
   <DataNode TextLabel="Fibrinogen" GraphId="c7ee6" Type="Protein">
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
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-
     <Xref Database="Wikidata" ID="Q381899"/>
+
     <Xref Database="Wikidata" ID="Q381899" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="sICAM-1" GraphId="cbdfe" Type="Protein">
   <DataNode TextLabel="sICAM-1" GraphId="cbdfe" Type="Protein">
Line 1,239: Line 1,239:
     <BiopaxRef>cd0</BiopaxRef>
     <BiopaxRef>cd0</BiopaxRef>
     <BiopaxRef>c22</BiopaxRef>
     <BiopaxRef>c22</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="3383"/>
+
     <Xref Database="Entrez Gene" ID="3383" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL10" GraphId="cbe08" Type="Protein">
   <DataNode TextLabel="IL10" GraphId="cbe08" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>bd7</BiopaxRef>
     <BiopaxRef>bd7</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="3458"/>
+
     <Xref Database="Entrez Gene" ID="3458" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL4" GraphId="cd348" Type="Protein">
   <DataNode TextLabel="IL4" GraphId="cd348" Type="Protein">
     <Comment>interleukin 4</Comment>
     <Comment>interleukin 4</Comment>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2596.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
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-
     <Xref Database="Entrez Gene" ID="3565"/>
+
     <Xref Database="Entrez Gene" ID="3565" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IFNg" GraphId="d2268" Type="Protein">
   <DataNode TextLabel="IFNg" GraphId="d2268" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>b42</BiopaxRef>
     <BiopaxRef>b42</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="3458"/>
+
     <Xref Database="Entrez Gene" ID="3458" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TNFa" GraphId="d2dd6" Type="Protein">
   <DataNode TextLabel="TNFa" GraphId="d2dd6" Type="Protein">
Line 1,266: Line 1,266:
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="7124"/>
+
     <Xref Database="Entrez Gene" ID="7124" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TNFa" GraphId="dc833" Type="Protein">
   <DataNode TextLabel="TNFa" GraphId="dc833" Type="Protein">
     <Comment>tumor necrosis factor (TNF superfamily, member 2)</Comment>
     <Comment>tumor necrosis factor (TNF superfamily, member 2)</Comment>
     <BiopaxRef>dde</BiopaxRef>
     <BiopaxRef>dde</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="7124"/>
+
     <Xref Database="Entrez Gene" ID="7124" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="D-dimer" GraphId="e43dd" Type="Protein">
   <DataNode TextLabel="D-dimer" GraphId="e43dd" Type="Protein">
Line 1,279: Line 1,279:
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
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-
     <Xref Database="Wikidata" ID="Q2162109"/>
+
     <Xref Database="Wikidata" ID="Q2162109" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrin" GraphId="e86dd" Type="Metabolite">
   <DataNode TextLabel="Fibrin" GraphId="e86dd" Type="Metabolite">
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2394.961729643253" CenterY="1291.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc33" />
-
     <Xref Database="Wikidata" ID="Q27205"/>
+
     <Xref Database="Wikidata" ID="Q27205" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CSF1" GraphId="ee610" Type="Protein">
   <DataNode TextLabel="CSF1" GraphId="ee610" Type="Protein">
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="1435"/>
+
     <Xref Database="Entrez Gene" ID="1435" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL6" GraphId="f72a3" Type="Protein">
   <DataNode TextLabel="IL6" GraphId="f72a3" Type="Protein">
Line 1,298: Line 1,298:
     <BiopaxRef>fc9</BiopaxRef>
     <BiopaxRef>fc9</BiopaxRef>
     <BiopaxRef>d53</BiopaxRef>
     <BiopaxRef>d53</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="3569"/>
+
     <Xref Database="Entrez Gene" ID="3569" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INS" GraphId="fae15" Type="Protein">
   <DataNode TextLabel="INS" GraphId="fae15" Type="Protein">
Line 1,306: Line 1,306:
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="3630"/>
+
     <Xref Database="Entrez Gene" ID="3630" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALB" GraphId="fb407" Type="Protein">
   <DataNode TextLabel="ALB" GraphId="fb407" Type="Protein">
     <Comment>albumin</Comment>
     <Comment>albumin</Comment>
     <BiopaxRef>c31</BiopaxRef>
     <BiopaxRef>c31</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="213"/>
+
     <Xref Database="Entrez Gene" ID="213" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HbA1c" GraphId="fd377" Type="Protein">
   <DataNode TextLabel="HbA1c" GraphId="fd377" Type="Protein">
Line 1,319: Line 1,319:
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
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-
     <Xref Database="" ID=""/>
+
     <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL6" GraphId="ffd35" Type="Protein">
   <DataNode TextLabel="IL6" GraphId="ffd35" Type="Protein">
Line 1,328: Line 1,328:
     <BiopaxRef>d77</BiopaxRef>
     <BiopaxRef>d77</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="3569"/>
+
     <Xref Database="Entrez Gene" ID="3569" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Riboflavin" GraphId="b78d1" Type="Metabolite">
   <DataNode TextLabel="Riboflavin" GraphId="b78d1" Type="Metabolite">
     <BiopaxRef>ca9</BiopaxRef>
     <BiopaxRef>ca9</BiopaxRef>
-
     <Graphics CenterX="1723.3166666666666" CenterY="337.31666666666666" Width="70.7" Height="21.333333333333346" ZOrder="33006" FontSize="10" Valign="Middle" Color="009933"/>
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-
     <Xref Database="HMDB" ID="HMDB00244"/>
+
     <Xref Database="HMDB" ID="HMDB0000244" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O2" GraphId="ff48f" Type="Metabolite">
   <DataNode TextLabel="O2" GraphId="ff48f" Type="Metabolite">
     <Comment>Superoxide</Comment>
     <Comment>Superoxide</Comment>
-
     <Graphics CenterX="1017.0" CenterY="600.0" Width="48.0" Height="18.0" ZOrder="33014" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1017.0" CenterY="600.0" Width="48.0" Height="18.0" ZOrder="33014" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02168"/>
+
     <Xref Database="HMDB" ID="HMDB0002168" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="a0e9a" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="a0e9a" Type="Metabolite">
Line 1,346: Line 1,346:
     <BiopaxRef>b54</BiopaxRef>
     <BiopaxRef>b54</BiopaxRef>
     <BiopaxRef>e4d</BiopaxRef>
     <BiopaxRef>e4d</BiopaxRef>
-
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+
     <Graphics CenterX="1757.0" CenterY="448.5" Width="122.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01185"/>
+
     <Xref Database="HMDB" ID="HMDB0001185" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Methionine" GraphId="a47a5" Type="Metabolite">
   <DataNode TextLabel="Methionine" GraphId="a47a5" Type="Metabolite">
Line 1,353: Line 1,353:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
-
     <Graphics CenterX="1935.0" CenterY="522.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1935.0" CenterY="522.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00696"/>
+
     <Xref Database="HMDB" ID="HMDB0000696" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="bbd30" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="bbd30" Type="Metabolite">
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
-
     <Graphics CenterX="1442.5" CenterY="2277.5" Width="125.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1442.5" CenterY="2277.5" Width="125.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00939"/>
+
     <Xref Database="HMDB" ID="HMDB0000939" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Methionine" GraphId="d8487" Type="Metabolite">
   <DataNode TextLabel="Methionine" GraphId="d8487" Type="Metabolite">
     <BiopaxRef>aa7</BiopaxRef>
     <BiopaxRef>aa7</BiopaxRef>
-
     <Graphics CenterX="1922.0" CenterY="2288.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1922.0" CenterY="2288.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00696"/>
+
     <Xref Database="HMDB" ID="HMDB0000696" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="de0ee" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="de0ee" Type="Metabolite">
Line 1,371: Line 1,371:
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>b54</BiopaxRef>
     <BiopaxRef>b54</BiopaxRef>
-
     <Graphics CenterX="1757.0" CenterY="2326.5" Width="122.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1757.0" CenterY="2326.5" Width="122.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01185"/>
+
     <Xref Database="HMDB" ID="HMDB0001185" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="f12e8" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="f12e8" Type="Metabolite">
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB00939"/>
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     <Xref Database="HMDB" ID="HMDB0000939" />
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   <DataNode TextLabel="ADP" GraphId="d0d40" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="d0d40" Type="Metabolite">
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     <Comment>Adenosine diphosphate</Comment>
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     <Xref Database="HMDB" ID="HMDB0001341" />
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   <DataNode TextLabel="ONOO/ONOOH" GraphId="a23e3" Type="Metabolite">
   <DataNode TextLabel="ONOO/ONOOH" GraphId="a23e3" Type="Metabolite">
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     <Comment>Peroxynitrite</Comment>
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     <Xref Database="HMDB" ID="HMDB0002179" />
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   <DataNode TextLabel="Nitrotyrosine" GraphId="b950b" Type="Metabolite">
   <DataNode TextLabel="Nitrotyrosine" GraphId="b950b" Type="Metabolite">
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     <BiopaxRef>f11</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0001904" />
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   <DataNode TextLabel="Nitrotyrosine" GraphId="d35d3" Type="Metabolite">
   <DataNode TextLabel="Nitrotyrosine" GraphId="d35d3" Type="Metabolite">
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     <BiopaxRef>f11</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01904"/>
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     <Xref Database="HMDB" ID="HMDB0001904" />
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   <DataNode TextLabel="Tetrahydrobiopterin" GraphId="dd14d" Type="Metabolite">
   <DataNode TextLabel="Tetrahydrobiopterin" GraphId="dd14d" Type="Metabolite">
Line 1,404: Line 1,404:
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     <Xref Database="HMDB" ID="HMDB0000027" />
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   <DataNode TextLabel="ATP" GraphId="a1aad" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="a1aad" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
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     <Xref Database="HMDB" ID="HMDB0000538" />
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   </DataNode>
   <DataNode TextLabel="ATP" GraphId="de676" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="de676" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
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     <Xref Database="HMDB" ID="HMDB0000538" />
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   </DataNode>
   <DataNode TextLabel="Glucose" GraphId="bbc0b" Type="Metabolite">
   <DataNode TextLabel="Glucose" GraphId="bbc0b" Type="Metabolite">
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0000122" />
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   <DataNode TextLabel="Glucose" GraphId="bc2dc" Type="Metabolite">
   <DataNode TextLabel="Glucose" GraphId="bc2dc" Type="Metabolite">
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
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   <DataNode TextLabel="Fructosamine" GraphId="cb21d" Type="Metabolite">
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   <DataNode TextLabel="Fructosamine" GraphId="cb8ee" Type="Metabolite">
   <DataNode TextLabel="Fructosamine" GraphId="cb8ee" Type="Metabolite">
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   <DataNode TextLabel="Iron" GraphId="a6473" Type="Metabolite">
   <DataNode TextLabel="Iron" GraphId="a6473" Type="Metabolite">
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     <Xref Database="HMDB" ID="HMDB0000692" />
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   <DataNode TextLabel="Iron" GraphId="fef7a" Type="Metabolite">
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     <Xref Database="HMDB" ID="HMDB0000692" />
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   <DataNode TextLabel="FLAD1" GraphId="ae58b" Type="Protein">
Line 1,454: Line 1,454:
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     <Xref Database="Entrez Gene" ID="80308"/>
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     <Xref Database="Entrez Gene" ID="80308" />
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     <Xref Database="Ensembl" ID="ENSG00000171560" />
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     <Xref Database="Ensembl" ID="ENSG00000171564" />
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     <Xref Database="Ensembl" ID="ENSG00000171557" />
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     <Comment>From intracellular part to the plasma</Comment>
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="a9e4a">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="a9f6c">
   <Interaction GraphId="a9f6c">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="aabd6">
   <Interaction GraphId="aabd6">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
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   <Interaction GraphId="aad44">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
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   <Interaction GraphId="abefe">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="ad82b">
   <Interaction GraphId="ad82b">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="adba7">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="ae60e">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="af294">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="af7a6">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="b2a6d">
   <Interaction GraphId="b2a6d">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="b2ae1">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="b318a">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="bd2d2">
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     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="bf21a">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="c172a">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="c625f">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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