Citrate cycle (TCA cycle) (Mycobacterium tuberculosis)

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Isocitrate lyaseSuccinyl-CoAsynthetaseKetoglutarate ferrodoxinoxidoreductaseAconitaseMalate synthasePyruvate dehyrdrogenaseFumarateIsocitrateGlycolysisPhosphoenolpyruvate (PEP)Methylisocitrate lyaseSuccinatedehydrogenasePyruvate kinaseCitrate synthaseMethylcitratealpha-ketoglutarateMethylisocitrateMalateAconitaseMalatedehydrogenaseMethylcitrate synthaseFumaraseIsocitratedehydrogenaseSuccinyl-CoAOxaloacetateAcetyl-CoAPyruvateGlyoxylateSuccinateCitrate


Description

The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011]. Source: KEGG (http://www.genome.jp/kegg-bin/highlight_pathway?scale=1.0&map=map00020)

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History

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40202view18:02, 17 February 2011KhanspersDeleted pathway: delete requested by author
40173view21:11, 14 February 2011Madhun
40172view21:08, 14 February 2011Madhun
40171view21:05, 14 February 2011Madhun
40170view21:04, 14 February 2011MadhunSpecify description
40126view15:17, 11 February 2011Madhun
40125view03:54, 11 February 2011Madhun
40124view03:43, 11 February 2011MadhunPeriodical save, work in progress
40123view00:11, 11 February 2011Madhun
40122view00:10, 11 February 2011Madhun
40121view00:07, 11 February 2011MadhunPeriodical save, work in progress
40120view00:04, 11 February 2011Madhun
40119view00:03, 11 February 2011Madhun
40118view23:57, 10 February 2011MadhunPeriodical save, work in progress
40117view23:57, 10 February 2011Madhun
40116view23:52, 10 February 2011Madhun
40115view23:35, 10 February 2011Madhun
40114view23:33, 10 February 2011Madhun
40111view20:56, 10 February 2011Madhun1
40110view20:54, 10 February 2011Madhunnew
40109view20:49, 10 February 2011MadhunPeriodical save, work in progress
40108view20:37, 10 February 2011MadhunPeriodical save, work in progress
39472view21:25, 3 December 2010MadhunModified categories
39275view22:36, 9 November 2010AlexanderPicoModified categories
39031view22:26, 27 September 2010Madhun1
39030view22:25, 27 September 2010MadhunModified categories
39029view22:24, 27 September 2010Madhun1
39028view22:15, 27 September 2010Madhun1
39027view22:15, 27 September 2010Madhun1
39026view22:14, 27 September 2010Madhun1
39025view22:13, 27 September 2010Madhuntest
39024view22:00, 27 September 2010Madhun1
39023view21:59, 27 September 2010Madhun1
39022view21:53, 27 September 2010MadhunPeriodical save, work in progress
39021view21:46, 27 September 2010Madhun1
39020view21:43, 27 September 2010Madhun1
39019view21:37, 27 September 2010Madhun1
39018view21:33, 27 September 2010MadhunPeriodical save, work in progress
39017view21:13, 27 September 2010MadhunPeriodical save, work in progress
39016view21:07, 27 September 2010Madhun1
39015view20:30, 27 September 2010Madhuntest
39014view20:26, 27 September 2010MadhunNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Acetyl-CoAMetabolite
AconitaseGeneProduct
CitrateMetabolite
Citrate synthaseGeneProduct
FumaraseGeneProductRv0198c (TubercuList)
FumarateMetabolite
GlycolysisPathway
GlyoxylateMetabolite
IsocitrateMetabolite
Isocitrate dehydrogenaseGeneProduct
Isocitrate lyaseGeneProduct
Ketoglutarate ferrodoxin oxidoreductaseGeneProduct
MalateMetabolite
Malate dehydrogenaseGeneProduct
Malate synthaseGeneProduct
MethylcitrateMetabolite
Methylcitrate synthaseGeneProduct
MethylisocitrateMetabolite
Methylisocitrate lyaseGeneProduct
OxaloacetateMetabolite
Phosphoenolpyruvate (PEP)Metabolite
PyruvateMetabolite
Pyruvate dehyrdrogenaseGeneProduct
Pyruvate kinaseGeneProduct
SuccinateMetabolite
Succinate dehydrogenaseGeneProduct
Succinyl-CoAMetabolite
Succinyl-CoA synthetaseGeneProduct
alpha-ketoglutarateMetabolite

Annotated Interactions

No annotated interactions

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