Citrate cycle (TCA cycle) (Mycobacterium tuberculosis)

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lpdsdhCGlyoxylateFatty acid elongation in mitochondriaGlycolysis / GluconeogenesisglcBfrdA2-(alpha-Hydroxyethyl)thiamine diphosphatefrdBValine, leucine and isoleucine degradationicd12-Hydroxy-3-OxoadipateFatty acid metabolismFumaratecitEfrdDicd1Tyrosine metabolismdlaTSuccinyl-CoAicd2aceEAlanine, aspartate and glutamate metabolism(S)-MalatehoasmqoiclThiamin diphosphateEnzyme N6-(lipoyl)lysinegltA1korSuccinateAscorbate and aldarate metabolismmdhPyruvateaceEacn[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysineCitrateIsocitrateOxaloacetatepckAcitAAlanine, aspartate and glutamate metabolismacn5-HydroxylevulinateFatty acid biosynthesisArginine and proline metabolismicd2pcaD-Glutamine and D-glutamate metabolismfumOxalosuccinateGlyoxylate and dicarboxylate metabolismfrdCAcetyl-CoAValine, leucine and isoleucine degradationPhosphoenolpyruvatesdhBEnzyme N6-(dihydrolipoyl)lysinesdhAsdhDmezcis-AconitategltApykA2-Oxoglutarate


Description

The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011]. Source: KEGG (http://www.genome.jp/kegg-bin/highlight_pathway?scale=1.0&map=map00020)

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History

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CompareRevisionActionTimeUserComment
40202view18:02, 17 February 2011KhanspersDeleted pathway: delete requested by author
40173view21:11, 14 February 2011Madhun
40172view21:08, 14 February 2011Madhun
40171view21:05, 14 February 2011Madhun
40170view21:04, 14 February 2011MadhunSpecify description
40126view15:17, 11 February 2011Madhun
40125view03:54, 11 February 2011Madhun
40124view03:43, 11 February 2011MadhunPeriodical save, work in progress
40123view00:11, 11 February 2011Madhun
40122view00:10, 11 February 2011Madhun
40121view00:07, 11 February 2011MadhunPeriodical save, work in progress
40120view00:04, 11 February 2011Madhun
40119view00:03, 11 February 2011Madhun
40118view23:57, 10 February 2011MadhunPeriodical save, work in progress
40117view23:57, 10 February 2011Madhun
40116view23:52, 10 February 2011Madhun
40115view23:35, 10 February 2011Madhun
40114view23:33, 10 February 2011Madhun
40111view20:56, 10 February 2011Madhun1
40110view20:54, 10 February 2011Madhunnew
40109view20:49, 10 February 2011MadhunPeriodical save, work in progress
40108view20:37, 10 February 2011MadhunPeriodical save, work in progress
39472view21:25, 3 December 2010MadhunModified categories
39275view22:36, 9 November 2010AlexanderPicoModified categories
39031view22:26, 27 September 2010Madhun1
39030view22:25, 27 September 2010MadhunModified categories
39029view22:24, 27 September 2010Madhun1
39028view22:15, 27 September 2010Madhun1
39027view22:15, 27 September 2010Madhun1
39026view22:14, 27 September 2010Madhun1
39025view22:13, 27 September 2010Madhuntest
39024view22:00, 27 September 2010Madhun1
39023view21:59, 27 September 2010Madhun1
39022view21:53, 27 September 2010MadhunPeriodical save, work in progress
39021view21:46, 27 September 2010Madhun1
39020view21:43, 27 September 2010Madhun1
39019view21:37, 27 September 2010Madhun1
39018view21:33, 27 September 2010MadhunPeriodical save, work in progress
39017view21:13, 27 September 2010MadhunPeriodical save, work in progress
39016view21:07, 27 September 2010Madhun1
39015view20:30, 27 September 2010Madhuntest
39014view20:26, 27 September 2010MadhunNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-MalateMetaboliteC00149 (Kegg Compound)
2-(alpha-Hydroxyethyl)thiamine diphosphateMetaboliteC05125 (Kegg Compound)
2-Hydroxy-3-OxoadipateMetabolite
2-OxoglutarateMetaboliteC00026 (Kegg Compound)
5-HydroxylevulinateMetabolite
Acetyl-CoAMetaboliteC00024 (Kegg Compound)
Alanine, aspartate and glutamate metabolismPathwayWP1617 (WikiPathways)
Arginine and proline metabolismPathwayWP1621 (WikiPathways)
Ascorbate and aldarate metabolismPathwayWP1622 (WikiPathways)
CitrateMetaboliteC00158 (Kegg Compound)
D-Glutamine and D-glutamate metabolismPathwayWP1643 (WikiPathways)
Enzyme N6-(dihydrolipoyl)lysineMetaboliteC15973 (Kegg Compound)
Enzyme N6-(lipoyl)lysineMetaboliteC15972 (Kegg Compound)
Fatty acid biosynthesisPathwayWP1647 (WikiPathways)
Fatty acid elongation in mitochondriaPathway
Fatty acid metabolismPathwayWP1648 (WikiPathways)
FumarateMetaboliteC00122 (Kegg Compound)
Glycolysis / GluconeogenesisPathwayWP1660 (WikiPathways)
GlyoxylateMetabolite
Glyoxylate and dicarboxylate metabolismPathwayWP1661 (WikiPathways)
IsocitrateMetaboliteC00311 (Kegg Compound)
OxaloacetateMetaboliteC00036 (Kegg Compound)
OxalosuccinateMetaboliteC05379 (Kegg Compound)
PhosphoenolpyruvateMetaboliteC00074 (Kegg Compound)
PyruvateMetaboliteC00022 (Kegg Compound)
SuccinateMetaboliteC00042 (Kegg Compound)
Succinyl-CoAMetaboliteC00091 (Kegg Compound)
Thiamin diphosphateMetaboliteC00068 (Kegg Compound)
Tyrosine metabolismPathwayWP1714 (WikiPathways)
Valine, leucine and isoleucine degradationPathwayWP1717 (WikiPathways)
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysineMetaboliteC16255 (Kegg Compound)
aceEGeneProductRv2241 (TubercuList) Original kegg element: gene;51;mtu:Rv0843 mtu:Rv2241 mtu:Rv2496c mtu:Rv2497c
acnGeneProductRv1475c (TubercuList) Original kegg element: gene;15;mtu:Rv1475c
cis-AconitateMetaboliteC00417 (Kegg Compound)
citAGeneProductRv0889c (TubercuList) Original kegg element: gene;17;mtu:Rv0889c mtu:Rv0896 mtu:Rv1131
citEGeneProductRv2498c (TubercuList) Original kegg element: gene;60;mtu:Rv2498c mtu:Rv3075c
dlaTGeneProductRv2215Original kegg element: gene;57;mtu:Rv2495c
frdAGeneProductRv1552 (TubercuList) Original kegg element: gene;1;mtu:Rv0247c mtu:Rv0248c mtu:Rv1552 mtu:Rv1553 mtu:Rv1554 mtu:Rv1555 mtu:Rv3316 mtu:Rv3317 mtu:Rv3318 mtu:Rv3319
frdBGeneProductRv1553 (TubercuList) Original kegg element: gene;1;mtu:Rv0247c mtu:Rv0248c mtu:Rv1552 mtu:Rv1553 mtu:Rv1554 mtu:Rv1555 mtu:Rv3316 mtu:Rv3317 mtu:Rv3318 mtu:Rv3319
frdCGeneProductRv1554 (TubercuList) Original kegg element: gene;1;mtu:Rv0247c mtu:Rv0248c mtu:Rv1552 mtu:Rv1553 mtu:Rv1554 mtu:Rv1555 mtu:Rv3316 mtu:Rv3317 mtu:Rv3318 mtu:Rv3319
frdDGeneProductRv1555 (TubercuList) Original kegg element: gene;1;mtu:Rv0247c mtu:Rv0248c mtu:Rv1552 mtu:Rv1553 mtu:Rv1554 mtu:Rv1555 mtu:Rv3316 mtu:Rv3317 mtu:Rv3318 mtu:Rv3319
fumGeneProductRv1098cOriginal kegg element: gene;14;mtu:Rv1098c
glcBGeneProductRv1837c
gltA1GeneProductRv1131 (TubercuList) Original kegg element: gene;17;mtu:Rv0889c mtu:Rv0896 mtu:Rv1131
gltAGeneProductRv0896 (TubercuList) Original kegg element: gene;17;mtu:Rv0889c mtu:Rv0896 mtu:Rv1131
hoasGeneProductOriginal kegg element: gene;60;mtu:Rv2498c mtu:Rv3075c
icd1GeneProductRv3339c (TubercuList) Original kegg element: gene;9;mtu:Rv0066c mtu:Rv3339c
icd2GeneProductRv0066c (TubercuList) Original kegg element: gene;9;mtu:Rv0066c mtu:Rv3339c
iclGeneProductRv0467
korGeneProduct
lpdGeneProductRv0462 (TubercuList) Original kegg element: gene;55;mtu:Rv0462 mtu:Rv0794c mtu:Rv3303c
mdhGeneProductRv1240 (TubercuList) Original kegg element: gene;18;mtu:Rv1240
mezGeneProductRv2332Original kegg element: gene;19;mtu:Rv2967c
mqoGeneProductRv2852cOriginal kegg element: gene;18;mtu:Rv1240
pcaGeneProductRv2967c (TubercuList) Original kegg element: gene;19;mtu:Rv2967c
pckAGeneProductRv0211 (TubercuList) Original kegg element: gene;62;mtu:Rv0211
pykAGeneProductRv1617
sdhAGeneProductRv3318 (TubercuList) Original kegg element: gene;1;mtu:Rv0247c mtu:Rv0248c mtu:Rv1552 mtu:Rv1553 mtu:Rv1554 mtu:Rv1555 mtu:Rv3316 mtu:Rv3317 mtu:Rv3318 mtu:Rv3319
sdhBGeneProductRv3319 (TubercuList) Original kegg element: gene;1;mtu:Rv0247c mtu:Rv0248c mtu:Rv1552 mtu:Rv1553 mtu:Rv1554 mtu:Rv1555 mtu:Rv3316 mtu:Rv3317 mtu:Rv3318 mtu:Rv3319
sdhCGeneProductRv3316 (TubercuList) Original kegg element: gene;1;mtu:Rv0247c mtu:Rv0248c mtu:Rv1552 mtu:Rv1553 mtu:Rv1554 mtu:Rv1555 mtu:Rv3316 mtu:Rv3317 mtu:Rv3318 mtu:Rv3319
sdhDGeneProductRv3317 (TubercuList) Original kegg element: gene;1;mtu:Rv0247c mtu:Rv0248c mtu:Rv1552 mtu:Rv1553 mtu:Rv1554 mtu:Rv1555 mtu:Rv3316 mtu:Rv3317 mtu:Rv3318 mtu:Rv3319

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