Nuclear Receptors (Homo sapiens)

From WikiPathways

(Difference between revisions)
Jump to: navigation, search
(Added the typical metabolites for some of the receptors.)
(Modified description)
Line 3: Line 3:
   <Comment Source="WikiPathways-category">Molecular Function</Comment>
   <Comment Source="WikiPathways-category">Molecular Function</Comment>
   <Comment Source="WikiPathways-description">Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis.
   <Comment Source="WikiPathways-description">Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis.
-
Source: Wikipedia ([[wikipedia:Nuclear_receptor]])</Comment>
+
Source: Wikipedia ([[wikipedia:Nuclear_receptor]])
 +
 
 +
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP170 CPTAC Assay Portal].</Comment>
   <BiopaxRef>d1f</BiopaxRef>
   <BiopaxRef>d1f</BiopaxRef>
-
   <Graphics BoardWidth="1003.1666666666667" BoardHeight="815.7142857142857" />
+
   <Graphics BoardWidth="1003.1666666666667" BoardHeight="815.7142857142857"/>
   <DataNode TextLabel="THRA" GraphId="c8b" Type="GeneProduct" GroupRef="e9bc1">
   <DataNode TextLabel="THRA" GraphId="c8b" Type="GeneProduct" GroupRef="e9bc1">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="THRA | thyroid hormone receptor alpha (erythro..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="THRA | thyroid hormone receptor alpha (erythro..."/>
-
     <Graphics CenterX="83.33333333333333" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="83.33333333333333" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="7067" />
+
     <Xref Database="Entrez Gene" ID="7067"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="THRB" GraphId="db9" Type="GeneProduct" GroupRef="e9bc1">
   <DataNode TextLabel="THRB" GraphId="db9" Type="GeneProduct" GroupRef="e9bc1">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="THRB | thyroid hormone receptor beta (erythrob..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="THRB | thyroid hormone receptor beta (erythrob..."/>
-
     <Graphics CenterX="83.33333333333333" CenterY="166.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="83.33333333333333" CenterY="166.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="7068" />
+
     <Xref Database="Entrez Gene" ID="7068"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="THRB" GraphId="c5e" Type="GeneProduct" GroupRef="e9bc1">
   <DataNode TextLabel="THRB" GraphId="c5e" Type="GeneProduct" GroupRef="e9bc1">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="THRB | thyroid hormone receptor beta (erythrob..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="THRB | thyroid hormone receptor beta (erythrob..."/>
-
     <Graphics CenterX="83.33333333333333" CenterY="186.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="83.33333333333333" CenterY="186.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="7068" />
+
     <Xref Database="Entrez Gene" ID="7068"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RARA" GraphId="ec8" Type="GeneProduct" GroupRef="f82df">
   <DataNode TextLabel="RARA" GraphId="ec8" Type="GeneProduct" GroupRef="f82df">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RARA | retinoic acid receptor alpha" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RARA | retinoic acid receptor alpha"/>
-
     <Graphics CenterX="316.6666666666667" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="316.6666666666667" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5914" />
+
     <Xref Database="Entrez Gene" ID="5914"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RARB" GraphId="a3b" Type="GeneProduct" GroupRef="f82df">
   <DataNode TextLabel="RARB" GraphId="a3b" Type="GeneProduct" GroupRef="f82df">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RARB | retinoic acid receptor beta" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RARB | retinoic acid receptor beta"/>
-
     <Graphics CenterX="316.6666666666667" CenterY="166.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="316.6666666666667" CenterY="166.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5915" />
+
     <Xref Database="Entrez Gene" ID="5915"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RARG" GraphId="e14" Type="GeneProduct" GroupRef="f82df">
   <DataNode TextLabel="RARG" GraphId="e14" Type="GeneProduct" GroupRef="f82df">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RARG | retinoic acid receptor gamma" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RARG | retinoic acid receptor gamma"/>
-
     <Graphics CenterX="316.6666666666667" CenterY="186.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="316.6666666666667" CenterY="186.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5916" />
+
     <Xref Database="Entrez Gene" ID="5916"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RARG" GraphId="b12" Type="GeneProduct" GroupRef="f82df">
   <DataNode TextLabel="RARG" GraphId="b12" Type="GeneProduct" GroupRef="f82df">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RARG | retinoic acid receptor gamma" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RARG | retinoic acid receptor gamma"/>
-
     <Graphics CenterX="316.6666666666667" CenterY="206.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="316.6666666666667" CenterY="206.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5916" />
+
     <Xref Database="Entrez Gene" ID="5916"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PPARA" GraphId="f19" Type="GeneProduct" GroupRef="c10c6">
   <DataNode TextLabel="PPARA" GraphId="f19" Type="GeneProduct" GroupRef="c10c6">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPARA | peroxisome proliferative activated rece..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPARA | peroxisome proliferative activated rece..."/>
-
     <Graphics CenterX="553.3333333333334" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="553.3333333333334" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5465" />
+
     <Xref Database="Entrez Gene" ID="5465"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PPARD" GraphId="cf2" Type="GeneProduct" GroupRef="c10c6">
   <DataNode TextLabel="PPARD" GraphId="cf2" Type="GeneProduct" GroupRef="c10c6">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPARD | peroxisome proliferative activated rece..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPARD | peroxisome proliferative activated rece..."/>
-
     <Graphics CenterX="553.3333333333334" CenterY="166.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="553.3333333333334" CenterY="166.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5467" />
+
     <Xref Database="Entrez Gene" ID="5467"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PPARG" GraphId="fbc" Type="GeneProduct" GroupRef="c10c6">
   <DataNode TextLabel="PPARG" GraphId="fbc" Type="GeneProduct" GroupRef="c10c6">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPARG | peroxisome proliferative activated rece..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPARG | peroxisome proliferative activated rece..."/>
-
     <Graphics CenterX="553.3333333333334" CenterY="186.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="553.3333333333334" CenterY="186.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5468" />
+
     <Xref Database="Entrez Gene" ID="5468"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PPARG" GraphId="d7c" Type="GeneProduct" GroupRef="c10c6">
   <DataNode TextLabel="PPARG" GraphId="d7c" Type="GeneProduct" GroupRef="c10c6">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPARG | peroxisome proliferative activated rece..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPARG | peroxisome proliferative activated rece..."/>
-
     <Graphics CenterX="553.3333333333334" CenterY="206.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="553.3333333333334" CenterY="206.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5468" />
+
     <Xref Database="Entrez Gene" ID="5468"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR1D2" GraphId="c6d" Type="GeneProduct">
   <DataNode TextLabel="NR1D2" GraphId="c6d" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1D2 | nuclear receptor subfamily 1 group D ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1D2 | nuclear receptor subfamily 1 group D ..."/>
-
     <Graphics CenterX="733.3333333333334" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="733.3333333333334" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="9975" />
+
     <Xref Database="Entrez Gene" ID="9975"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR0B1" GraphId="d7f" Type="GeneProduct">
   <DataNode TextLabel="NR0B1" GraphId="d7f" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR0B1 | nuclear receptor subfamily 0 group B ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR0B1 | nuclear receptor subfamily 0 group B ..."/>
-
     <Graphics CenterX="893.3333333333334" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="893.3333333333334" CenterY="146.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="190" />
+
     <Xref Database="Entrez Gene" ID="190"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ROR1" GraphId="d7d" Type="GeneProduct" GroupRef="ca73c">
   <DataNode TextLabel="ROR1" GraphId="d7d" Type="GeneProduct" GroupRef="ca73c">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ROR1 | receptor tyrosine kinase-like orphan rec..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ROR1 | receptor tyrosine kinase-like orphan rec..."/>
-
     <Graphics CenterX="150.0" CenterY="283.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="150.0" CenterY="283.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="4919" />
+
     <Xref Database="Entrez Gene" ID="4919"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RORA" GraphId="cd4" Type="GeneProduct" GroupRef="ca73c">
   <DataNode TextLabel="RORA" GraphId="cd4" Type="GeneProduct" GroupRef="ca73c">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RORA | RAR-related orphan receptor A" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RORA | RAR-related orphan receptor A"/>
-
     <Graphics CenterX="150.0" CenterY="303.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="150.0" CenterY="303.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="6095" />
+
     <Xref Database="Entrez Gene" ID="6095"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RORC" GraphId="c98" Type="GeneProduct" GroupRef="ca73c">
   <DataNode TextLabel="RORC" GraphId="c98" Type="GeneProduct" GroupRef="ca73c">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RORC | RAR-related orphan receptor C" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RORC | RAR-related orphan receptor C"/>
-
     <Graphics CenterX="150.0" CenterY="323.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="150.0" CenterY="323.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="6097" />
+
     <Xref Database="Entrez Gene" ID="6097"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR1H2" GraphId="e39" Type="GeneProduct" GroupRef="c0325">
   <DataNode TextLabel="NR1H2" GraphId="e39" Type="GeneProduct" GroupRef="c0325">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1H2 | nuclear receptor subfamily 1 group H ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1H2 | nuclear receptor subfamily 1 group H ..."/>
-
     <Graphics CenterX="386.6666666666667" CenterY="283.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="386.6666666666667" CenterY="283.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="7376" />
+
     <Xref Database="Entrez Gene" ID="7376"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR1H3" GraphId="e7c" Type="GeneProduct" GroupRef="c0325">
   <DataNode TextLabel="NR1H3" GraphId="e7c" Type="GeneProduct" GroupRef="c0325">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1H3 | nuclear receptor subfamily 1 group H ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1H3 | nuclear receptor subfamily 1 group H ..."/>
-
     <Graphics CenterX="386.6666666666667" CenterY="303.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="386.6666666666667" CenterY="303.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="10062" />
+
     <Xref Database="Entrez Gene" ID="10062"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VDR" GraphId="c07" Type="GeneProduct" GroupRef="e72ee">
   <DataNode TextLabel="VDR" GraphId="c07" Type="GeneProduct" GroupRef="e72ee">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="VDR | vitamin D (125- dihydroxyvitamin D3) rec..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="VDR | vitamin D (125- dihydroxyvitamin D3) rec..."/>
-
     <Graphics CenterX="600.0" CenterY="283.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="600.0" CenterY="283.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="7421" />
+
     <Xref Database="Entrez Gene" ID="7421"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HNF4A" GraphId="f78" Type="GeneProduct">
   <DataNode TextLabel="HNF4A" GraphId="f78" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="HNF4A | hepatocyte nuclear factor 4 alpha" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="HNF4A | hepatocyte nuclear factor 4 alpha"/>
-
     <Graphics CenterX="123.33333333333333" CenterY="450.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="123.33333333333333" CenterY="450.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="3172" />
+
     <Xref Database="Entrez Gene" ID="3172"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RXRA" GraphId="db6" Type="GeneProduct" GroupRef="e957e">
   <DataNode TextLabel="RXRA" GraphId="db6" Type="GeneProduct" GroupRef="e957e">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RXRA | retinoid X receptor alpha" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RXRA | retinoid X receptor alpha"/>
-
     <Graphics CenterX="350.0" CenterY="450.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="350.0" CenterY="450.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="6256" />
+
     <Xref Database="Entrez Gene" ID="6256"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RXRB" GraphId="a09" Type="GeneProduct" GroupRef="e957e">
   <DataNode TextLabel="RXRB" GraphId="a09" Type="GeneProduct" GroupRef="e957e">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RXRB | retinoid X receptor beta" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RXRB | retinoid X receptor beta"/>
-
     <Graphics CenterX="350.0" CenterY="470.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="350.0" CenterY="470.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="6257" />
+
     <Xref Database="Entrez Gene" ID="6257"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RXRG" GraphId="ca3" Type="GeneProduct" GroupRef="e957e">
   <DataNode TextLabel="RXRG" GraphId="ca3" Type="GeneProduct" GroupRef="e957e">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RXRG | retinoid X receptor gamma" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RXRG | retinoid X receptor gamma"/>
-
     <Graphics CenterX="350.0" CenterY="490.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="350.0" CenterY="490.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="6258" />
+
     <Xref Database="Entrez Gene" ID="6258"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR2C2" GraphId="ac1" Type="GeneProduct">
   <DataNode TextLabel="NR2C2" GraphId="ac1" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2C2 | nuclear receptor subfamily 2 group C ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2C2 | nuclear receptor subfamily 2 group C ..."/>
-
     <Graphics CenterX="576.6666666666666" CenterY="450.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="576.6666666666666" CenterY="450.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="7182" />
+
     <Xref Database="Entrez Gene" ID="7182"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR2F1" GraphId="d0c" Type="GeneProduct" GroupRef="e8fcd">
   <DataNode TextLabel="NR2F1" GraphId="d0c" Type="GeneProduct" GroupRef="e8fcd">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2F1 | nuclear receptor subfamily 2 group F ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2F1 | nuclear receptor subfamily 2 group F ..."/>
-
     <Graphics CenterX="796.6666666666666" CenterY="450.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="796.6666666666666" CenterY="450.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="7025" />
+
     <Xref Database="Entrez Gene" ID="7025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR2F2" GraphId="be9" Type="GeneProduct" GroupRef="e8fcd">
   <DataNode TextLabel="NR2F2" GraphId="be9" Type="GeneProduct" GroupRef="e8fcd">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2F2 | nuclear receptor subfamily 2 group F ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2F2 | nuclear receptor subfamily 2 group F ..."/>
-
     <Graphics CenterX="796.6666666666666" CenterY="470.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="796.6666666666666" CenterY="470.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="7026" />
+
     <Xref Database="Entrez Gene" ID="7026"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR2F6" GraphId="f18" Type="GeneProduct" GroupRef="e8fcd">
   <DataNode TextLabel="NR2F6" GraphId="f18" Type="GeneProduct" GroupRef="e8fcd">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2F6 | nuclear receptor subfamily 2 group F ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2F6 | nuclear receptor subfamily 2 group F ..."/>
-
     <Graphics CenterX="796.6666666666666" CenterY="490.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="796.6666666666666" CenterY="490.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2063" />
+
     <Xref Database="Entrez Gene" ID="2063"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR2E1" GraphId="bde" Type="GeneProduct">
   <DataNode TextLabel="NR2E1" GraphId="bde" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2E1 | nuclear receptor subfamily 2 group E ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR2E1 | nuclear receptor subfamily 2 group E ..."/>
-
     <Graphics CenterX="123.33333333333333" CenterY="520.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="123.33333333333333" CenterY="520.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="7101" />
+
     <Xref Database="Entrez Gene" ID="7101"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ESR1" GraphId="ed2" Type="GeneProduct" GroupRef="d285f">
   <DataNode TextLabel="ESR1" GraphId="ed2" Type="GeneProduct" GroupRef="d285f">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ESR1 | estrogen receptor 1" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ESR1 | estrogen receptor 1"/>
-
     <Graphics CenterX="76.66666666666667" CenterY="650.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="76.66666666666667" CenterY="650.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2099" />
+
     <Xref Database="Entrez Gene" ID="2099"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ESR2" GraphId="df6" Type="GeneProduct" GroupRef="d285f">
   <DataNode TextLabel="ESR2" GraphId="df6" Type="GeneProduct" GroupRef="d285f">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ESR2 | estrogen receptor 2 (ER beta)" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ESR2 | estrogen receptor 2 (ER beta)"/>
-
     <Graphics CenterX="76.66666666666667" CenterY="670.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="76.66666666666667" CenterY="670.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2100" />
+
     <Xref Database="Entrez Gene" ID="2100"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ESRRA" GraphId="a34" Type="GeneProduct" GroupRef="baf7a">
   <DataNode TextLabel="ESRRA" GraphId="a34" Type="GeneProduct" GroupRef="baf7a">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ESRRA | estrogen-related receptor alpha" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ESRRA | estrogen-related receptor alpha"/>
-
     <Graphics CenterX="270.0" CenterY="650.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="270.0" CenterY="650.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2101" />
+
     <Xref Database="Entrez Gene" ID="2101"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ESRRB" GraphId="fbe" Type="GeneProduct" GroupRef="baf7a">
   <DataNode TextLabel="ESRRB" GraphId="fbe" Type="GeneProduct" GroupRef="baf7a">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ESRRB | estrogen-related receptor beta" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ESRRB | estrogen-related receptor beta"/>
-
     <Graphics CenterX="270.0" CenterY="670.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="270.0" CenterY="670.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2103" />
+
     <Xref Database="Entrez Gene" ID="2103"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR3C1" GraphId="a53" Type="GeneProduct">
   <DataNode TextLabel="NR3C1" GraphId="a53" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR3C1 | nuclear receptor subfamily 3 group C ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR3C1 | nuclear receptor subfamily 3 group C ..."/>
-
     <Graphics CenterX="483.3333333333333" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="483.3333333333333" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2908" />
+
     <Xref Database="Entrez Gene" ID="2908"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGR" GraphId="bc1" Type="GeneProduct">
   <DataNode TextLabel="PGR" GraphId="bc1" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PGR | progesterone receptor" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PGR | progesterone receptor"/>
-
     <Graphics CenterX="483.3333333333333" CenterY="710.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="483.3333333333333" CenterY="710.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5241" />
+
     <Xref Database="Entrez Gene" ID="5241"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="AR" GraphId="b83" Type="GeneProduct">
   <DataNode TextLabel="AR" GraphId="b83" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AR | androgen receptor (dihydrotestosterone rec..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AR | androgen receptor (dihydrotestosterone rec..."/>
-
     <Graphics CenterX="483.3333333333333" CenterY="770.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="483.3333333333333" CenterY="770.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="367" />
+
     <Xref Database="Entrez Gene" ID="367"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR4A1" GraphId="d8d" Type="GeneProduct" GroupRef="ad669">
   <DataNode TextLabel="NR4A1" GraphId="d8d" Type="GeneProduct" GroupRef="ad669">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR4A1 | nuclear receptor subfamily 4 group A ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR4A1 | nuclear receptor subfamily 4 group A ..."/>
-
     <Graphics CenterX="700.0" CenterY="643.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="700.0" CenterY="643.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="3164" />
+
     <Xref Database="Entrez Gene" ID="3164"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR4A2" GraphId="b33" Type="GeneProduct" GroupRef="ad669">
   <DataNode TextLabel="NR4A2" GraphId="b33" Type="GeneProduct" GroupRef="ad669">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR4A2 | nuclear receptor subfamily 4 group A ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR4A2 | nuclear receptor subfamily 4 group A ..."/>
-
     <Graphics CenterX="700.0" CenterY="663.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="700.0" CenterY="663.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="4929" />
+
     <Xref Database="Entrez Gene" ID="4929"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR5A1" GraphId="c43" Type="GeneProduct" GroupRef="cb7b1">
   <DataNode TextLabel="NR5A1" GraphId="c43" Type="GeneProduct" GroupRef="cb7b1">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR5A1 | nuclear receptor subfamily 5 group A ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR5A1 | nuclear receptor subfamily 5 group A ..."/>
-
     <Graphics CenterX="880.0" CenterY="643.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="880.0" CenterY="643.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2516" />
+
     <Xref Database="Entrez Gene" ID="2516"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR5A2" GraphId="abf" Type="GeneProduct" GroupRef="cb7b1">
   <DataNode TextLabel="NR5A2" GraphId="abf" Type="GeneProduct" GroupRef="cb7b1">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR5A2 | nuclear receptor subfamily 5 group A ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR5A2 | nuclear receptor subfamily 5 group A ..."/>
-
     <Graphics CenterX="880.0" CenterY="663.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="880.0" CenterY="663.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2494" />
+
     <Xref Database="Entrez Gene" ID="2494"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR1I2" GraphId="ee5" Type="GeneProduct" GroupRef="e72ee">
   <DataNode TextLabel="NR1I2" GraphId="ee5" Type="GeneProduct" GroupRef="e72ee">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1I2 | nuclear receptor subfamily 1 group I ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1I2 | nuclear receptor subfamily 1 group I ..."/>
-
     <Graphics CenterX="600.0" CenterY="303.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="600.0" CenterY="303.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="8856" />
+
     <Xref Database="Entrez Gene" ID="8856"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NR1I3" GraphId="fcc" Type="GeneProduct" GroupRef="e72ee">
   <DataNode TextLabel="NR1I3" GraphId="fcc" Type="GeneProduct" GroupRef="e72ee">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1I3 | nuclear receptor subfamily 1 group I ..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NR1I3 | nuclear receptor subfamily 1 group I ..."/>
-
     <Graphics CenterX="600.0" CenterY="323.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="600.0" CenterY="323.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="9970" />
+
     <Xref Database="Entrez Gene" ID="9970"/>
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="retinoic&#xA;acid" GraphId="b2dcf" Type="Metabolite">
+
   <DataNode TextLabel="retinoic&#10;acid" GraphId="b2dcf" Type="Metabolite">
-
     <Graphics CenterX="214.69387755102036" CenterY="176.12244897959184" Width="50.204081632653015" Height="30.408163265306143" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="214.69387755102036" CenterY="176.12244897959184" Width="50.204081632653015" Height="30.408163265306143" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:26536" />
+
     <Xref Database="ChEBI" ID="CHEBI:26536"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Oxysterols" GraphId="bbc2c" Type="Metabolite">
   <DataNode TextLabel="Oxysterols" GraphId="bbc2c" Type="Metabolite">
-
     <Graphics CenterX="281.02040816326524" CenterY="292.09183673469386" Width="60.408163265306186" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="281.02040816326524" CenterY="292.09183673469386" Width="60.408163265306186" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:53030" />
+
     <Xref Database="ChEBI" ID="CHEBI:53030"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="d3 vitamins" GraphId="e8321" Type="Metabolite">
   <DataNode TextLabel="d3 vitamins" GraphId="e8321" Type="Metabolite">
-
     <Graphics CenterX="728.7244897959191" CenterY="302.29591836734687" Width="65.51020408163181" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="728.7244897959191" CenterY="302.29591836734687" Width="65.51020408163181" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:73558" />
+
     <Xref Database="ChEBI" ID="CHEBI:73558"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="estrogen" GraphId="b8ba2" Type="Metabolite">
   <DataNode TextLabel="estrogen" GraphId="b8ba2" Type="Metabolite">
-
     <Graphics CenterX="76.53061224489795" CenterY="752.5510204081633" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="76.53061224489795" CenterY="752.5510204081633" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:50114" />
+
     <Xref Database="ChEBI" ID="CHEBI:50114"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="progesterone" GraphId="d7c69" Type="Metabolite">
   <DataNode TextLabel="progesterone" GraphId="d7c69" Type="Metabolite">
-
     <Graphics CenterX="589.2857142857142" CenterY="709.1836734693877" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="589.2857142857142" CenterY="709.1836734693877" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:17026" />
+
     <Xref Database="ChEBI" ID="CHEBI:17026"/>
   </DataNode>
   </DataNode>
   <Interaction>
   <Interaction>
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="239.79591836734687" Y="176.12244897959184" GraphRef="b2dcf" RelX="1.0" RelY="0.0" />
+
       <Point X="239.79591836734687" Y="176.12244897959184" GraphRef="b2dcf" RelX="1.0" RelY="0.0"/>
-
       <Point X="278.6666666666667" Y="176.66666666666666" GraphRef="a9c4a" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding" />
+
       <Point X="278.6666666666667" Y="176.66666666666666" GraphRef="a9c4a" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction>
   <Interaction>
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="311.2244897959183" Y="292.09183673469386" GraphRef="bbc2c" RelX="1.0" RelY="0.0" />
+
       <Point X="311.2244897959183" Y="292.09183673469386" GraphRef="bbc2c" RelX="1.0" RelY="0.0"/>
-
       <Point X="348.6666666666667" Y="293.3333333333333" GraphRef="b7469" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding" />
+
       <Point X="348.6666666666667" Y="293.3333333333333" GraphRef="b7469" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction>
   <Interaction>
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="695.9693877551032" Y="302.29591836734687" GraphRef="e8321" RelX="-1.0" RelY="0.0" />
+
       <Point X="695.9693877551032" Y="302.29591836734687" GraphRef="e8321" RelX="-1.0" RelY="0.0"/>
-
       <Point X="638.0" Y="303.3333333333333" GraphRef="c22e3" RelX="1.0" RelY="0.0" ArrowHead="mim-binding" />
+
       <Point X="638.0" Y="303.3333333333333" GraphRef="c22e3" RelX="1.0" RelY="0.0" ArrowHead="mim-binding"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction>
   <Interaction>
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="76.53061224489795" Y="742.5510204081633" GraphRef="b8ba2" RelX="0.0" RelY="-1.0" />
+
       <Point X="76.53061224489795" Y="742.5510204081633" GraphRef="b8ba2" RelX="0.0" RelY="-1.0"/>
-
       <Point X="76.66666666666667" Y="688.0" GraphRef="dcef5" RelX="0.0" RelY="1.0" ArrowHead="mim-binding" />
+
       <Point X="76.66666666666667" Y="688.0" GraphRef="dcef5" RelX="0.0" RelY="1.0" ArrowHead="mim-binding"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction>
   <Interaction>
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="549.2857142857142" Y="709.1836734693877" GraphRef="d7c69" RelX="-1.0" RelY="0.0" />
+
       <Point X="549.2857142857142" Y="709.1836734693877" GraphRef="d7c69" RelX="-1.0" RelY="0.0"/>
-
       <Point X="513.3333333333333" Y="710.0" GraphRef="bc1" RelX="1.0" RelY="0.0" ArrowHead="mim-binding" />
+
       <Point X="513.3333333333333" Y="710.0" GraphRef="bc1" RelX="1.0" RelY="0.0" ArrowHead="mim-binding"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Label TextLabel="Thyroid Receptor" GraphId="a28">
   <Label TextLabel="Thyroid Receptor" GraphId="a28">
-
     <Graphics CenterX="83.33333333333333" CenterY="106.66666666666667" Width="138.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="83.33333333333333" CenterY="106.66666666666667" Width="138.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
-
   <Label TextLabel="Peroxisome Proliferator&#xA;Activated Receptor" GraphId="ec4">
+
   <Label TextLabel="Peroxisome Proliferator&#10;Activated Receptor" GraphId="ec4">
-
     <Graphics CenterX="553.1666666666666" CenterY="108.08333333333333" Width="157.66666666666666" Height="33.833333333333336" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="553.1666666666666" CenterY="108.08333333333333" Width="157.66666666666666" Height="33.833333333333336" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Nuclear Receptor ROR" GraphId="bec">
   <Label TextLabel="Nuclear Receptor ROR" GraphId="bec">
-
     <Graphics CenterX="150.0" CenterY="250.0" Width="178.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="150.0" CenterY="250.0" Width="178.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Oxysterols Receptor" GraphId="eca">
   <Label TextLabel="Oxysterols Receptor" GraphId="eca">
-
     <Graphics CenterX="383.3333333333333" CenterY="250.0" Width="161.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="383.3333333333333" CenterY="250.0" Width="161.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Vitamin D3 Receptor" GraphId="a63">
   <Label TextLabel="Vitamin D3 Receptor" GraphId="a63">
-
     <Graphics CenterX="596.6666666666666" CenterY="250.0" Width="161.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="596.6666666666666" CenterY="250.0" Width="161.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Hepatocyte Nuclear Factor" GraphId="eab">
   <Label TextLabel="Hepatocyte Nuclear Factor" GraphId="eab">
-
     <Graphics CenterX="123.33333333333333" CenterY="416.6666666666667" Width="208.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="123.33333333333333" CenterY="416.6666666666667" Width="208.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Retinoic Acid Receptor RXR" GraphId="c8f">
   <Label TextLabel="Retinoic Acid Receptor RXR" GraphId="c8f">
-
     <Graphics CenterX="350.0" CenterY="416.6666666666667" Width="219.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="350.0" CenterY="416.6666666666667" Width="219.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Orphan Nuclear Receptor" GraphId="a6f">
   <Label TextLabel="Orphan Nuclear Receptor" GraphId="a6f">
-
     <Graphics CenterX="576.6666666666666" CenterY="416.6666666666667" Width="199.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="576.6666666666666" CenterY="416.6666666666667" Width="199.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Nuclear receptor TLX" GraphId="d46">
   <Label TextLabel="Nuclear receptor TLX" GraphId="d46">
-
     <Graphics CenterX="123.33333333333333" CenterY="490.0" Width="167.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="123.33333333333333" CenterY="490.0" Width="167.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Coup Transcription Factor" GraphId="a05">
   <Label TextLabel="Coup Transcription Factor" GraphId="a05">
-
     <Graphics CenterX="796.6666666666666" CenterY="416.6666666666667" Width="206.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="796.6666666666666" CenterY="416.6666666666667" Width="206.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Estrogen Receptor" GraphId="e80">
   <Label TextLabel="Estrogen Receptor" GraphId="e80">
-
     <Graphics CenterX="80.0" CenterY="615.6666666666666" Width="149.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="80.0" CenterY="615.6666666666666" Width="149.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Steroid Hormone Receptor" GraphId="ab2">
   <Label TextLabel="Steroid Hormone Receptor" GraphId="ab2">
-
     <Graphics CenterX="270.0" CenterY="615.6666666666666" Width="209.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="270.0" CenterY="615.6666666666666" Width="209.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Glucocorticoid Receptor" GraphId="a89">
   <Label TextLabel="Glucocorticoid Receptor" GraphId="a89">
-
     <Graphics CenterX="485.3333333333333" CenterY="612.6666666666666" Width="191.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="485.3333333333333" CenterY="612.6666666666666" Width="191.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Progesterone Receptor" GraphId="a8a">
   <Label TextLabel="Progesterone Receptor" GraphId="a8a">
-
     <Graphics CenterX="483.3333333333333" CenterY="681.6666666666666" Width="183.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="483.3333333333333" CenterY="681.6666666666666" Width="183.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Androgen Receptor" GraphId="fde">
   <Label TextLabel="Androgen Receptor" GraphId="fde">
-
     <Graphics CenterX="483.3333333333333" CenterY="745.0" Width="155.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="483.3333333333333" CenterY="745.0" Width="155.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="NR5 SUPERFAMILY" GraphId="b1e">
   <Label TextLabel="NR5 SUPERFAMILY" GraphId="b1e">
-
     <Graphics CenterX="880.3333333333334" CenterY="572.0833333333334" Width="142.66666666666666" Height="29.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle" />
+
     <Graphics CenterX="880.3333333333334" CenterY="572.0833333333334" Width="142.66666666666666" Height="29.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle"/>
   </Label>
   </Label>
   <Label TextLabel="Steroidogenic Receptor" GraphId="d42">
   <Label TextLabel="Steroidogenic Receptor" GraphId="d42">
-
     <Graphics CenterX="880.0" CenterY="606.6666666666666" Width="186.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="880.0" CenterY="606.6666666666666" Width="186.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Orphan Receptor" GraphId="e07">
   <Label TextLabel="Orphan Receptor" GraphId="e07">
-
     <Graphics CenterX="893.3333333333334" CenterY="106.66666666666667" Width="136.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="893.3333333333334" CenterY="106.66666666666667" Width="136.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="NR0 SUPERFAMILY" GraphId="a4d">
   <Label TextLabel="NR0 SUPERFAMILY" GraphId="a4d">
-
     <Graphics CenterX="888.6598639455784" CenterY="32.43367346938772" Width="140.33333333333334" Height="25.5" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle" />
+
     <Graphics CenterX="888.6598639455784" CenterY="32.43367346938772" Width="140.33333333333334" Height="25.5" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle"/>
   </Label>
   </Label>
   <Label TextLabel="NR1 SUPERFAMILY" GraphId="fd0">
   <Label TextLabel="NR1 SUPERFAMILY" GraphId="fd0">
-
     <Graphics CenterX="391.71768707482994" CenterY="32.70918367346936" Width="135.66666666666666" Height="25.5" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle" />
+
     <Graphics CenterX="391.71768707482994" CenterY="32.70918367346936" Width="135.66666666666666" Height="25.5" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle"/>
   </Label>
   </Label>
   <Label TextLabel="NR2 SUPERFAMILY" GraphId="cde">
   <Label TextLabel="NR2 SUPERFAMILY" GraphId="cde">
-
     <Graphics CenterX="460.0" CenterY="380.0833333333333" Width="157.33333333333334" Height="25.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle" />
+
     <Graphics CenterX="460.0" CenterY="380.0833333333333" Width="157.33333333333334" Height="25.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle"/>
   </Label>
   </Label>
   <Label TextLabel="NR3 SUPERFAMILY" GraphId="f8d">
   <Label TextLabel="NR3 SUPERFAMILY" GraphId="f8d">
-
     <Graphics CenterX="282.6666666666667" CenterY="571.0833333333334" Width="142.66666666666666" Height="27.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle" />
+
     <Graphics CenterX="282.6666666666667" CenterY="571.0833333333334" Width="142.66666666666666" Height="27.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle"/>
   </Label>
   </Label>
   <Label TextLabel="NR4 SUPERFAMILY" GraphId="d37">
   <Label TextLabel="NR4 SUPERFAMILY" GraphId="d37">
-
     <Graphics CenterX="699.1666666666666" CenterY="572.5833333333334" Width="139.66666666666666" Height="26.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle" />
+
     <Graphics CenterX="699.1666666666666" CenterY="572.5833333333334" Width="139.66666666666666" Height="26.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="Rectangle"/>
   </Label>
   </Label>
   <Label TextLabel="Orphan Receptor" GraphId="a62">
   <Label TextLabel="Orphan Receptor" GraphId="a62">
-
     <Graphics CenterX="700.0" CenterY="606.6666666666666" Width="136.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="700.0" CenterY="606.6666666666666" Width="136.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
-
   <Label TextLabel="Orphan Nuclear&#xA;Receptor" GraphId="fc2">
+
   <Label TextLabel="Orphan Nuclear&#10;Receptor" GraphId="fc2">
-
     <Graphics CenterX="733.0" CenterY="112.91666666666667" Width="116.0" Height="31.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="733.0" CenterY="112.91666666666667" Width="116.0" Height="31.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Retinoic Acid Receptor" GraphId="d53">
   <Label TextLabel="Retinoic Acid Receptor" GraphId="d53">
-
     <Graphics CenterX="316.6666666666667" CenterY="106.66666666666667" Width="180.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="316.6666666666667" CenterY="106.66666666666667" Width="180.33333333333334" Height="19.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
-
   <Group GroupId="d285f" GraphId="dcef5" />
+
   <Group GroupId="d285f" GraphId="dcef5"/>
-
   <Group GroupId="baf7a" GraphId="fc4ef" />
+
   <Group GroupId="baf7a" GraphId="fc4ef"/>
-
   <Group GroupId="ad669" GraphId="dc68c" />
+
   <Group GroupId="ad669" GraphId="dc68c"/>
-
   <Group GroupId="cb7b1" GraphId="e16fd" />
+
   <Group GroupId="cb7b1" GraphId="e16fd"/>
-
   <Group GroupId="e8fcd" GraphId="d8159" />
+
   <Group GroupId="e8fcd" GraphId="d8159"/>
-
   <Group GroupId="e957e" GraphId="a563d" />
+
   <Group GroupId="e957e" GraphId="a563d"/>
-
   <Group GroupId="ca73c" GraphId="e37a4" />
+
   <Group GroupId="ca73c" GraphId="e37a4"/>
-
   <Group GroupId="e9bc1" GraphId="db9ff" />
+
   <Group GroupId="e9bc1" GraphId="db9ff"/>
-
   <Group GroupId="f82df" GraphId="a9c4a" />
+
   <Group GroupId="f82df" GraphId="a9c4a"/>
-
   <Group GroupId="c10c6" GraphId="cf6b4" />
+
   <Group GroupId="c10c6" GraphId="cf6b4"/>
-
   <Group GroupId="e72ee" GraphId="c22e3" />
+
   <Group GroupId="e72ee" GraphId="c22e3"/>
-
   <Group GroupId="c0325" GraphId="b7469" />
+
   <Group GroupId="c0325" GraphId="b7469"/>
-
   <InfoBox CenterX="705.4" CenterY="235.26666666666668" />
+
   <InfoBox CenterX="705.4" CenterY="235.26666666666668"/>
   <Biopax>
   <Biopax>
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">

Revision as of 18:08, 15 August 2019

1Retinoic Acid Receptor RXRProgesterone ReceptorOxysterols ReceptorAndrogen ReceptorOrphan Nuclear ReceptorEstrogen ReceptorSteroid Hormone ReceptorVitamin D3 ReceptorGlucocorticoid ReceptorThyroid ReceptorOrphan NuclearReceptorCoup Transcription FactorOrphan ReceptorNuclear receptor TLXNR5 SUPERFAMILYNR3 SUPERFAMILYNuclear Receptor RORNR1 SUPERFAMILYHepatocyte Nuclear FactorSteroidogenic ReceptorPeroxisome ProliferatorActivated ReceptorRetinoic Acid ReceptorNR0 SUPERFAMILYNR4 SUPERFAMILYNR2 SUPERFAMILYOrphan Receptorestrogend3 vitaminsPPARGARNR1I2OxysterolsRARGNR2F6NR5A2RXRGHNF4ATHRBNR1H2NR1H3RORCTHRANR4A1ESRRBRARAPPARGNR4A2NR2C2RXRANR2F1NR5A1PPARDretinoicacidTHRBNR1D2RORAprogesteroneNR2F2RARGRARBNR0B1PPARANR3C1PGRESR1ESRRAROR1VDRESR2NR2E1NR1I3RXRB


Description

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis.

Source: Wikipedia (wikipedia:Nuclear_receptor)

This pathway is part the CPTAC Assay Portal.

Quality Tags

Ontology Terms

 

Bibliography

  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106664view21:26, 12 September 2019KhanspersModified description
105759view18:08, 15 August 2019KhanspersModified description
71083view11:57, 3 October 2013EgonwAdded the typical metabolites for some of the receptors.
69977view21:17, 11 July 2013MaintBot
69976view21:17, 11 July 2013MaintBotupdated to 2013 schema
67531view11:21, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
45340view20:22, 7 October 2011Khansperscleaned up description and removed old comment
45337view20:21, 7 October 2011KhanspersModified description
41225view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
38864view18:19, 24 September 2010Khanspers
35765view00:09, 13 February 2010AlexanderPicoModified description
35763view00:09, 13 February 2010AlexanderPicoModified description
35476view12:13, 12 February 2010MichielModified description
35473view12:11, 12 February 2010MichielAdded ref
34550view20:14, 21 December 2009KhanspersLayout
31984view13:12, 14 August 2009MaintBotFixed group labels
21037view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Nuclear Receptors]] moved to [[Pathway:WP170]]: Moved to stable identifier
14000view16:15, 20 May 2008Thomasgrouped genes
12973view10:58, 17 May 2008MaintBotSticky edges patch by Sjoerd
8284view13:46, 7 January 2008MaintBot[[Pathway:Human:Nuclear Receptors]] moved to [[Pathway:Homo sapiens:Nuclear Receptors]]: Renaming species
7762view16:16, 18 December 2007MaintBotfixed category names
7434view12:42, 4 November 2007MaintBotAdded categories to GPML
6355view22:18, 22 May 2007E.Tuninskygpml file for [[Human:Nuclear_Receptors]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARGeneProduct367 (Entrez Gene)
ESR1GeneProduct2099 (Entrez Gene)
ESR2GeneProduct2100 (Entrez Gene)
ESRRAGeneProduct2101 (Entrez Gene)
ESRRBGeneProduct2103 (Entrez Gene)
HNF4AGeneProduct3172 (Entrez Gene)
NR0B1GeneProduct190 (Entrez Gene)
NR1D2GeneProduct9975 (Entrez Gene)
NR1H2GeneProduct7376 (Entrez Gene)
NR1H3GeneProduct10062 (Entrez Gene)
NR1I2GeneProduct8856 (Entrez Gene)
NR1I3GeneProduct9970 (Entrez Gene)
NR2C2GeneProduct7182 (Entrez Gene)
NR2E1GeneProduct7101 (Entrez Gene)
NR2F1GeneProduct7025 (Entrez Gene)
NR2F2GeneProduct7026 (Entrez Gene)
NR2F6GeneProduct2063 (Entrez Gene)
NR3C1GeneProduct2908 (Entrez Gene)
NR4A1GeneProduct3164 (Entrez Gene)
NR4A2GeneProduct4929 (Entrez Gene)
NR5A1GeneProduct2516 (Entrez Gene)
NR5A2GeneProduct2494 (Entrez Gene)
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
PGRGeneProduct5241 (Entrez Gene)
PPARAGeneProduct5465 (Entrez Gene)
PPARDGeneProduct5467 (Entrez Gene)
PPARGGeneProduct5468 (Entrez Gene)
RARAGeneProduct5914 (Entrez Gene)
RARBGeneProduct5915 (Entrez Gene)
RARGGeneProduct5916 (Entrez Gene)
ROR1GeneProduct4919 (Entrez Gene)
RORAGeneProduct6095 (Entrez Gene)
RORCGeneProduct6097 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
RXRBGeneProduct6257 (Entrez Gene)
RXRGGeneProduct6258 (Entrez Gene)
THRAGeneProduct7067 (Entrez Gene)
THRBGeneProduct7068 (Entrez Gene)
VDRGeneProduct7421 (Entrez Gene)
d3 vitaminsMetaboliteCHEBI:73558 (ChEBI)
estrogenMetaboliteCHEBI:50114 (ChEBI)
progesteroneMetaboliteCHEBI:17026 (ChEBI)
retinoic acidMetaboliteCHEBI:26536 (ChEBI)

Annotated Interactions

No annotated interactions

Personal tools