Eicosanoid synthesis (Homo sapiens)

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21Cell Membrane15-HETE5-HPETEPGD2 11-ketoreducPTGES2GSH peroxidasePTGISPGE2 9-ketoreducLeukotriene D4Prostaglandin I2TBXAS1PTGDS5-HETEPLA2G6DPEP1Leukotriene E4PNPLA8Leukotriene A4ALOX15ALOX5Prostaglandin F2aLTA4HThromboxane B2ALOX5APPNPLA3PTGS1ALOX15ALOX12ALOX15BArachidonic acidPTGESPLA2G2A12-HETEPTGS2Per-oxidaseLeukotriene B4LTC4SGGT1PGD2Leukotriene C4Thromboxane A2Prostaglandin H2Prostaglandin D2ALOX5APALOX512-HPETE15-HPETEProstaglandin E215-Dehydro-prostaglandin I2dehydrogenase1Thromboxane A3Pla2g5GPPla2g6Pla2g4aPla2g4bPtgs1Ptgs2Ptgs1Ptgs2PGG2Arachidonic acid11-HETEALOX5PGJ215-deoxy-PGJ215-deoxy-PGD2


In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia.

This pathway has been updated with information from LIPID MAPS>Eicosanoids [1]. Metabolites and proteins from this pathway are orange coloured and have an rounded rectangle shape (where an rectangle shape indicates that the node only occures in the LIPIDM APS pathway). Reactions occurring in the LIPID MAPS pathways are coloured orange (where a dashed line indicates that the reaction only occures in the LIPID MAPS pathway).

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms



  1. Korff JM, Jarabak J; ''''; , PubMed Europe PMC Scholia
  2. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia


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120547view17:50, 14 December 2021Conroy lipidsupdate most lipids to lipidmaps identifiers
117707view12:26, 22 May 2021EweitzModified title
106700view13:09, 17 September 2019MaintBotHMDB identifier normalization
106398view21:30, 28 August 2019KhanspersModified description
105578view06:32, 9 August 2019KhanspersModified description
102907view10:58, 28 January 2019DeSlModified description
102906view10:56, 28 January 2019DeSlChanged layout slightly, and annotated 2 missing metabolites.
98574view15:40, 17 September 2018DeSlModified description
98571view15:39, 17 September 2018DeSlChanged layout, coloured outside of node orange.
98564view13:36, 17 September 2018DeSlModified description
98563view13:32, 17 September 2018DeSlChanged layout, removed node colour.
98452view12:49, 7 September 2018DeSlRemoved "last modified" item
98451view12:49, 7 September 2018DeSlModified description
98450view12:48, 7 September 2018DeSlSLight layout change
98449view12:47, 7 September 2018DeSlOne more ID.
98448view12:45, 7 September 2018DeSlAnnotated more nodes.
98447view12:41, 7 September 2018DeSlAdded more IDs to new LipidMaps content
98431view15:39, 6 September 2018DeSlAdded remaining lipids from lipidmaps
98430view15:24, 6 September 2018DeSlModified description
98429view15:23, 6 September 2018DeSlReverted to version '15:22, 6 September 2018' by DeSl
98428view15:23, 6 September 2018DeSlModified description
98427view15:22, 6 September 2018DeSlModified description
98426view15:22, 6 September 2018DeSlModified description
98425view15:21, 6 September 2018DeSlModified description
98424view15:19, 6 September 2018DeSlModified description
98423view15:18, 6 September 2018DeSlModified description
98422view15:13, 6 September 2018DeSlModified description
98421view15:10, 6 September 2018DeSlAdded info from LipidMaps PW.
89514view10:45, 16 September 2016Mkutmonontology tag fix
89469view13:39, 15 September 2016Mkutmonremove space from ontology term id
82702view07:46, 23 October 2015EgonwReplaced to CAS numbers with the ChEBI identifiers: 70608-72-9 cannot be 5-HETE, 12-HETE, and 15-HETE at the same time.
79809view16:44, 16 April 2015Mkutmonfixed unconnected line
71381view18:40, 17 October 2013MaintBotAutomated update of data sources
67184view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
63178view20:30, 8 May 2013MaintBotUpdating gpml version
45234view17:44, 7 October 2011AlexanderPicoOntology Term : 'epithelial cell' added !
45226view17:36, 7 October 2011AlexanderPicoOntology Term : 'inflammatory response pathway' added !
45138view01:00, 7 October 2011AlexanderPicofixed reaction
45103view22:21, 6 October 2011AlexanderPicofixed reactions
45099view21:51, 6 October 2011AlexanderPicoupdated reactions
45098view21:46, 6 October 2011AlexanderPicoupdated refs and reactions
45095view21:16, 6 October 2011AlexanderPicodb refs
41942view18:41, 2 March 2011CarlospirolaPNPLA3 added
41939view17:39, 2 March 2011CarlospirolaPeriodical save, work in progress
41143view23:39, 1 March 2011MaintBotRemoved redundant pathway information and comments
35467view12:07, 12 February 2010Thomasadded literature
35466view12:06, 12 February 2010ThomasModified description
34433view18:14, 10 December 2009MaintBotAutomatic update of empty xrefs
31982view13:11, 14 August 2009MaintBotFixed group labels
21031view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Eicosanoid Synthesis]] moved to [[Pathway:WP167]]: Moved to stable identifier

External references


View all...
NameTypeDatabase referenceComment
11-HETEMetaboliteLMFA03060085 (LIPID MAPS)
12-HETEMetaboliteCHEBI:19138 (ChEBI)
12-HPETEMetabolite71030-35-8 (CAS)
15-Dehydro-prostaglandin I2MetaboliteLMFA03010205 (LIPID MAPS) Changed 15-oxo-prostaglandin I2 to 15-Dehydro-prostaglandin I2, since the enzyme listed mentions dehydrogenase, and pubchem mentions 15-Dehydro-prostaglandin I2 is created from Prostaglandin I2.
15-HETEMetaboliteCHEBI:64017 (ChEBI)
15-HPETEMetabolite70981-96-3 (CAS)
15-deoxy-PGD2MetaboliteLMFA03010051 (LIPID MAPS)
15-deoxy-PGJ2MetaboliteLMFA03010021 (LIPID MAPS)
5-HETEMetabolite70608-72-9 (CAS)
5-HPETEMetaboliteLMFA03060108 (LIPID MAPS)
ALOX12GeneProduct239 (Entrez Gene)
ALOX15GeneProduct246 (Entrez Gene)
ALOX15BGeneProduct247 (Entrez Gene)
ALOX5GeneProduct240 (Entrez Gene)
ALOX5APGeneProduct241 (Entrez Gene)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
DPEP1GeneProduct1800 (Entrez Gene)
GGT1GeneProduct2678 (Entrez Gene)
GPMetaboliteCHEBI:37739 (ChEBI) AKA glycerophospholipids
GSH peroxidaseGeneProduct1.11.1.9 (Enzyme Nomenclature)
LTA4HGeneProduct4048 (Entrez Gene)
LTC4SGeneProduct4056 (Entrez Gene)
Leukotriene A4MetaboliteLMFA03020023 (LIPID MAPS)
Leukotriene B4MetaboliteLMFA03020001 (LIPID MAPS)
Leukotriene C4MetaboliteLMFA03020003 (LIPID MAPS)
Leukotriene D4MetaboliteLMFA03020006 (LIPID MAPS)
Leukotriene E4MetaboliteLMFA03020002 (LIPID MAPS)
PGD2 11-ketoreducGeneProduct1.1.1.188 (Enzyme Nomenclature)
PGD2MetaboliteLMFA03010004 (LIPID MAPS)
PGE2 9-ketoreducGeneProduct1.1.1.189 (Enzyme Nomenclature)
PGG2MetaboliteLMFA03010009 (LIPID MAPS)
PGJ2MetaboliteLMFA03010019 (LIPID MAPS)
PLA2G2AGeneProduct5320 (Entrez Gene)
PLA2G6GeneProduct8398 (Entrez Gene)
PNPLA8GeneProduct50640 (Entrez Gene)
PTGDSGeneProduct5730 (Entrez Gene)
PTGES2GeneProduct80142 (Entrez Gene)
PTGESGeneProduct9536 (Entrez Gene)
PTGISGeneProduct5740 (Entrez Gene)
PTGS1GeneProduct5742 (Entrez Gene)
PTGS2GeneProduct5743 (Entrez Gene)
Per- oxidaseGeneProduct1.11.1.7 (Enzyme Nomenclature)
Pla2g4aProtein5321 (Entrez Gene)
Pla2g4bProtein100137049 (Entrez Gene)
Pla2g5Protein5322 (Entrez Gene)
Pla2g6Protein8398 (Entrez Gene)
Prostaglandin D2MetaboliteLMFA03010004 (LIPID MAPS)
Prostaglandin E2MetaboliteLMFA03010003 (LIPID MAPS)
Prostaglandin F2aMetaboliteLMFA03010002 (LIPID MAPS)
Prostaglandin H2MetaboliteLMFA03010010 (LIPID MAPS)
Prostaglandin I2MetaboliteLMFA03010087 (LIPID MAPS)
Ptgs1Protein5742 (Entrez Gene)
Ptgs2Protein5743 (Entrez Gene)
TBXAS1GeneProduct6916 (Entrez Gene)
Thromboxane A2MetaboliteLMFA03030001 (LIPID MAPS)
Thromboxane A3MetaboliteLMFA03030005 (LIPID MAPS)
Thromboxane B2MetaboliteLMFA03030002 (LIPID MAPS)
dehydrogenaseGeneProduct1.1.1.231 (Enzyme Nomenclature)

Annotated Interactions

No annotated interactions

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