Glycolysis and gluconeogenesis (Mus musculus)

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1GluconeogenesisGlycolysisMitochondrionCytosol* Only the controlled, irreversible steps of each pathway are coloredAldoaGot1GapdhMdh1Hk33P-GlycerateDihydroxyacetone-PFbp1G6pcPdha2GckPgk2PklrAcetyl-CoAPdhbGlucoseEno2Slc2a1Pgam1MPC1Gpi1MalateGlyceraldehyde 3PLdhal6bGot2Slc2a21,3BP-GlyceratePcxSlc2a5Glucose-6PPyruvateFbp2LdhaEno1PfklPyruvatePck1Eno3GlucoseMdh2PfkpMalateFructose-1,6BPAldocHk2Gm13882Pentose Phosphate PathwayDldGlycogen MetabolismAspartate2P-GlycerateFructose 6PLdhcAldobTpi1AspartatePkm2TCA cyclePkm2OxaloacetatePdha1DlatPgk1Pgam2Triglyceride synthesisSlc2a3LactateP-enolpyruvateHk1LdhbPfkmPdhxOxaloacetateGapdhsSlc2a4MPC2


Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the ATP and NADH.

Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids.

Description adapted from Wikipedia.


This pathway was inferred from Homo sapiens pathway WP534(r28564) with a 76% conversion rate.

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Ontology Terms



  1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed Europe PMC Scholia


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116837view10:31, 14 May 2021EweitzModified title
113904view06:48, 8 December 2020EgonwFour more pathway datanodes clickable
106856view13:33, 17 September 2019MaintBotHMDB identifier normalization
90167view14:14, 20 October 2016Mkutmonfix unconnected lines
85675view02:05, 5 June 2016AlexanderPicoReverted to version '03:33, 10 April 2016' by AlexanderPico
85519view08:58, 25 May 2016Ghardingtest
85051view10:33, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
81906view22:09, 5 September 2015AlexanderPicoModified description
81903view22:04, 5 September 2015AlexanderPicoReverted to version '03:26, 7 January 2015' by AlexanderPico
81873view09:22, 4 September 2015Liisa18Quick edit to datanode annotation or property
81872view09:17, 4 September 2015Liisa18Quick edit to datanode annotation or property
78433view10:26, 7 January 2015MaintBotadded missing graphIds
69361view18:54, 8 July 2013EgonwReplaced an HMDB identifier of a charged species (removed in 3.5) with the uncharged one.
69169view18:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
67315view10:35, 26 June 2013Christine ChichesterOntology Term : 'glycolysis/gluconeogenesis pathway' added !
51735view08:41, 20 September 2012Thomasadded recently identified pyruvate transporters
43573view14:34, 1 July 2011AdrienDefayadd database ID to others pathway
43570view14:24, 1 July 2011AdrienDefayadd reference to the TCA cycle (DATABASE ID)
41358view00:27, 2 March 2011MaintBotRemoved redundant pathway information and comments
37467view15:46, 6 June 2010MartijnVanIerseladded link to triglycerides
36676view20:55, 11 April 2010MartijnVanIerselreversibility of aldolase reaction
36675view20:51, 11 April 2010MartijnVanIerselCorrected triose reactions, added glucose transporters
34413view23:10, 9 December 2009MaintBotAutomatic update of empty xrefs
32966view22:30, 28 September 2009MaintBotadded xrefs
32965view22:19, 28 September 2009MaintBotadded xrefs
32351view13:38, 15 August 2009MaintBotFixed text labels
31976view13:10, 14 August 2009MaintBotFixed group labels
31400view20:49, 13 August 2009MaintBotFixed text labels
30864view00:12, 30 July 2009MaintBotConverted from Homo sapiens
21011view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Glycolysis and Gluconeogenesis]] moved to [[Pathway:WP157]]: Moved to stable identifier
8098view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Glycolysis and Gluconeogenesis]] moved to [[Pathway:Mus musculus:Glycolysis and Gluconeogenesis]]: Renaming species
7671view16:08, 18 December 2007MaintBotfixed category names
7370view12:42, 4 November 2007MaintBotAdded categories to GPML
19483view22:19, 22 May 2007M.Braymergpml file for [[Mouse:Glycolysis_and_Gluconeogenesis]]
6453view22:19, 22 May 2007Kdahlquistgpml file for [[Mouse:Glycolysis_and_Gluconeogenesis]]

External references


View all...
NameTypeDatabase referenceComment
1,3BP-GlycerateMetaboliteHMDB01270 (HMDB)
2P-GlycerateMetaboliteHMDB00362 (HMDB)
3P-GlycerateMetaboliteHMDB00807 (HMDB)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
AldoaGeneProduct11674 (Entrez Gene)
AldobGeneProduct230163 (Entrez Gene)
AldocGeneProduct11676 (Entrez Gene)
AspartateMetaboliteHMDB00191 (HMDB)
Dihydroxyacetone-PMetaboliteHMDB01473 (HMDB)
DlatGeneProduct235339 (Entrez Gene)
DldGeneProduct13382 (Entrez Gene)
Eno1GeneProduct13806 (Entrez Gene)
Eno2GeneProduct13807 (Entrez Gene)
Eno3GeneProduct13808 (Entrez Gene)
Fbp1GeneProduct14121 (Entrez Gene)
Fbp2GeneProduct14120 (Entrez Gene)
Fructose 6PMetaboliteHMDB00124 (HMDB)
Fructose-1,6BPMetaboliteHMDB01058 (HMDB)
G6pcGeneProduct14377 (Entrez Gene) Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway
GapdhGeneProduct14433 (Entrez Gene)
GapdhsGeneProduct14447 (Entrez Gene)
GckGeneProduct103988 (Entrez Gene) Gck is mainly active in liver
Glucose-6PMetaboliteHMDB01401 (HMDB)
GlucoseMetaboliteHMDB00122 (HMDB)
Glyceraldehyde 3PMetaboliteHMDB01112 (HMDB)
Glycogen MetabolismPathwayWP317 (WikiPathways)
Gm13882GeneProduct100043349 (Entrez Gene)
Got1GeneProduct14718 (Entrez Gene)
Got2GeneProduct14719 (Entrez Gene)
Gpi1GeneProduct14751 (Entrez Gene)
Hk1GeneProduct15275 (Entrez Gene)
Hk2GeneProduct15277 (Entrez Gene)
Hk3GeneProduct212032 (Entrez Gene)
LactateMetaboliteLactate (Wikipedia)
LdhaGeneProduct16828 (Entrez Gene)
Ldhal6bGeneProduct106557 (Entrez Gene)
LdhbGeneProduct16832 (Entrez Gene)
LdhcGeneProduct16833 (Entrez Gene)
MPC1GeneProduct55951 (Entrez Gene)
MPC2GeneProduct70456 (Entrez Gene)
MalateMetaboliteHMDB00744 (HMDB)
Mdh1GeneProduct17449 (Entrez Gene)
Mdh2GeneProduct17448 (Entrez Gene)
OxaloacetateMetaboliteHMDB00223 (HMDB)
P-enolpyruvateMetaboliteHMDB00263 (HMDB)
Pck1GeneProduct18534 (Entrez Gene)
PcxGeneProduct18563 (Entrez Gene)
Pdha1GeneProduct18597 (Entrez Gene)
Pdha2GeneProduct18598 (Entrez Gene)
PdhbGeneProduct68263 (Entrez Gene)
PdhxGeneProduct27402 (Entrez Gene)
Pentose Phosphate PathwayPathwayWP63 (WikiPathways)
PfklGeneProduct18641 (Entrez Gene)
PfkmGeneProduct18642 (Entrez Gene)
PfkpGeneProduct56421 (Entrez Gene)
Pgam1GeneProduct18648 (Entrez Gene)
Pgam2GeneProduct56012 (Entrez Gene)
Pgk1GeneProduct18655 (Entrez Gene)
Pgk2GeneProduct18663 (Entrez Gene)
PklrGeneProduct18770 (Entrez Gene)
Pkm2GeneProduct18746 (Entrez Gene)
PyruvateMetaboliteHMDB00243 (HMDB)
Slc2a1GeneProduct20525 (Entrez Gene)
Slc2a2GeneProduct20526 (Entrez Gene)
Slc2a3GeneProduct20527 (Entrez Gene)
Slc2a4GeneProduct20528 (Entrez Gene)
Slc2a5GeneProduct56485 (Entrez Gene)
TCA cyclePathwayWP434 (WikiPathways)
Tpi1GeneProduct21991 (Entrez Gene)
Triglyceride synthesisPathwayWP386 (WikiPathways)

Annotated Interactions

No annotated interactions
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