MicroRNAs in cardiomyocyte hypertrophy (Homo sapiens)

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MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lines.
MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lines.
MicroRNAs are shown as purple rounded rectangles.
MicroRNAs are shown as purple rounded rectangles.
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It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done.</Comment>
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It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done.
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This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP1544 CPTAC Assay Portal].</Comment>
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Revision as of 05:11, 10 August 2019

516288515151558155125156158Hypertrophic gene transcriptionRTKsStressTranscription FactorsProtein SynthesisPol IIRhoNucleusSarcomere organizationTGFR/ActivinGPCRCell MembraneGC-ACatecholaminesPI3KTNFRGPCRG-beta-gammaStretchRASStressCellular ProteinsRCAN1 promotorGq/11hsa-mir-15bhsa-mir-30eIKKahsa-mir-15bhsa-mir-195MEK7hsa-mir-15bIKKbhsa-mir-30eMEK4hsa-mir-133bPIK3CBRhoAPLChsa-mir-15bCalciumhsa-mir-21FGFR2EGFWNT3AGATA4hsa-mir-125b-2hsa-let-7bNF-kappa-BANPhsa-mir-195STAT3hsa-mir-125b-1ERK1hsa-mir-208aTNF-alphaMEK5hsa-mir-199a-2hsa-mir-199a-1hsa-mir-15bhsa-mir-199a-2hsa-mir-195hsa-mir-103-1-asIGFIhsa-mir-23ahsa-mir-27bFGF2hsa-mir-208ahsa-mir-195hsa-mir-130bSOCShsa-mir-130bAKT1p38hsa-let-7bERK1hsa-let-7bhsa-mir-30eCalNAhsa-mir-27bMAPKKKGSK3-betahsa-mir-23ahsa-mir-199a-1HDAC 7MEK3hsa-mir-23ahsa-mir-133a-1hsa-mir-133bCalmodulinTGF-betaPDKhsa-mir-23aNFAT3hsa-mir-30ehsa-mir-133a-1hsa-mir-133a-2NIKhsa-mir-199a-2mTORMEK1Ang IIHDAC 5HDAC 9ERK5MEK6hsa-mir-185MAPKKKCalciumhsa-mir-15bJNKLRP6hsa-mir-21hsa-mir-23ahsa-mir-15bhsa-mir-27bhsa-mir-27bPIK3R1PIK3CDp38Rac1hsa-mir-195IGF-1 RBeta-cateninCDK 7