MicroRNAs in cardiomyocyte hypertrophy (Homo sapiens)

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(Modified description)
(HMDB identifier normalization)
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This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP1544 CPTAC Assay Portal].</Comment>
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP1544 CPTAC Assay Portal].</Comment>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molkentin JD</bp:AUTHORS>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Regulation of cardiac hypertrophy by intracellular signalling pathways.</bp:TITLE>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molkentin JD</bp:AUTHORS>
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Line 2,150: Line 2,195:
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Line 2,159: Line 2,209:
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Calcineurin and beyond: cardiac hypertrophic signaling.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart.</bp:TITLE>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molkentin JD</bp:AUTHORS>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy.</bp:TITLE>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molkentin JD</bp:AUTHORS>
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Line 2,214: Line 2,296:
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      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
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      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1996</bp:YEAR>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chien KR</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ebd">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ebd">
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">9253712</bp:ID>
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">9253712</bp:ID>
Line 2,239: Line 2,334:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hilfiker-Kleiner D</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hilfiker-Kleiner D</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c5f">
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       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Small guanine nucleotide-binding proteins and myocardial hypertrophy.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cardiovasc Res</bp:SOURCE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Circ Res</bp:SOURCE>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2000</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jalili T</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clerk A</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Takeishi Y</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sugden PH</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Walsh RA</bp:AUTHORS>
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    </bp:PublicationXref>
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      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hypertrophic cardimyopathy pathway</bp:TERM>
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-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000296</bp:ID>
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-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
+
-
    </bp:openControlledVocabulary>
+
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    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
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-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">miRNA pathway</bp:TERM>
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      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000808</bp:ID>
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      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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    </bp:openControlledVocabulary>
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      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pennica D</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="be1">
Line 2,291: Line 2,357:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Grant SR</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Grant SR</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Olson EN</bp:AUTHORS>
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-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart.</bp:TITLE>
 
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      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cardiology</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR>
 
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-
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-
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-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang S</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang G</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hu S</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zheng Z</bp:AUTHORS>
 
-
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-
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-
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-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.</bp:TITLE>
 
-
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-
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-
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-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hoit BD</bp:AUTHORS>
 
-
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-
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-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.</bp:TITLE>
 
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EMBO J</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2000</bp:YEAR>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bueno OF</bp:AUTHORS>
 
-
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-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Witt SA</bp:AUTHORS>
 
-
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-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Klevitsky R</bp:AUTHORS>
 
-
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-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jones SP</bp:AUTHORS>
 
-
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-
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-
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-
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-
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-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy.</bp:TITLE>
 
-
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-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
 
-
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-
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-
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-
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     </bp:PublicationXref>
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Line 2,357: Line 2,366:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vanhaesebroeck B</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vanhaesebroeck B</bp:AUTHORS>
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-
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-
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-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2000</bp:YEAR>
 
-
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     </bp:PublicationXref>
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   </Biopax>
   </Biopax>
</Pathway>
</Pathway>

Revision as of 12:09, 16 August 2019

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
106646view21:07, 12 September 2019KhanspersModified description
106194view12:09, 16 August 2019MaintBotHMDB identifier normalization
105649view05:11, 10 August 2019KhanspersModified description
104849view14:44, 20 June 2019Fehrhartgraphical line between PI3K and complex
104848view14:39, 20 June 2019Fehrhart
102988view13:20, 31 January 2019SusanUpdated microRNA genes from RNA to GeneProduct
102987view13:06, 31 January 2019SusanRe-annotated microRNAs
98337view13:27, 23 August 2018EgonwUpdated the MIR21 identifier.
89794view10:54, 6 October 2016Mkutmonfixed special character in datanode label
84696view21:04, 15 March 2016KhanspersQuick edit to datanode annotation or property
84695view21:03, 15 March 2016KhanspersQuick edit to datanode annotation or property
75258view21:11, 13 May 2014Khansperschanged data nodes from gene product to rna
75252view20:57, 13 May 2014Khanspersupdated xrefs for mirs
74529view21:45, 29 April 2014AlexanderPicofixed unsupported characters in datanode labels
73325view20:39, 20 January 2014MaintBotFixed GraphId that incidentally overlapped with a GroupId!?
72027view12:54, 24 October 2013Mkutmonfixed unconnected lines
70090view18:00, 12 July 2013MaintBotupdating to 2013 schema
67463view11:05, 26 June 2013DdiglesOntology Term : 'hypertrophic cardimyopathy pathway' added !
59101view22:12, 21 February 2013MaintBotUpdated Ensembl data source
45381view21:47, 7 October 2011KhanspersOntology Term : 'heart disease' added !
44907view10:26, 6 October 2011MartijnVanIerselOntology Term : 'miRNA pathway' added !
41050view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
37611view11:02, 14 June 2010MLevelsModified description
37610view10:59, 14 June 2010MLevelsChanged Lines
37553view12:58, 10 June 2010MLevelsMoved some microRNAs
37552view12:56, 10 June 2010MLevelsAdded some microRNAs
37551view12:46, 10 June 2010MLevelsPeriodical save, work in progress
37541view10:54, 10 June 2010MLevelsDeleted non-canonical wnt
37534view13:14, 9 June 2010MLevelsNon-Canonical Wnt Pathway
37438view09:20, 4 June 2010MLevelsMicroRNAs added
37407view12:04, 1 June 2010MLevelsMinor Changes
37406view11:57, 1 June 2010MLevelsPeriodical save, work in progress
37399view11:28, 1 June 2010MLevelsPeriodical save, work in progress
37395view10:45, 1 June 2010MLevelsAdded WNT pathway
37393view10:38, 1 June 2010MLevelsModified description
37392view10:12, 1 June 2010MLevelsPeriodical save, work in progress
37391view10:01, 1 June 2010MLevelsPeriodical save, work in progress
37388view09:51, 1 June 2010MLevelsPeriodical save, work in progress
37387view09:12, 1 June 2010MLevelsModified description
37345view08:49, 28 May 2010MLevelsPeriodical save, work in progress
37344view08:35, 28 May 2010MLevelsPeriodical save, work in progress
37343view08:22, 28 May 2010MLevelsPeriodical save, work in progress
37342view08:12, 28 May 2010MLevelsPeriodical save, work in progress
37341view08:02, 28 May 2010MLevelsPeriodical save, work in progress
37340view07:51, 28 May 2010MLevelsPeriodical save, work in progress
37336view14:16, 27 May 2010MLevelsMicroRNAs added
37335view14:06, 27 May 2010MLevelsPeriodical save, work in progress
37334view13:56, 27 May 2010MLevelsPeriodical save, work in progress
37333view13:46, 27 May 2010MLevelsPeriodical save, work in progress
37332view13:34, 27 May 2010MLevelsPeriodical save, work in progress

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/3/3b/WP1544_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/3/3b/WP1544_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106194)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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