Energy Metabolism (Homo sapiens)

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?Pre-initiation Complex= PPARGC1A induces expression= transcription factors for mtDNAImported to mitochondria= family members of PPARGC1A= PPARGC1A and muscle controlNUCLEUSPP= PPARGC1A induced by external stimuli= PPARGC1A co-activates nuclear receptors and transcription factorsPPARGC1A Genes of mitochondrial fatty acid oxidationenzymes= Double positive feedback loopNUCLEUSPPost-transcriptional modificationPMuscular atrophyCYTOPLASMTranscription Nuclear Encoded Genes= Key regulator= PPARGC1A, PPARs and UCP2, 3CYTOPLASMPTFB2MPPARGC1AMYBBP1APPARGC1AHDAC1GABPATFB1MMEF2BPPARGC1AGSK3BSIRT1TFB2MUnknown Transcription Factors MAPK14UCP3RXRATFAMCAMK2GPPARGC1AUnknown Transcription FactorsPPP3CAPPARGC1ACREB1PRKAB2PPARGC1ACAMK4PPARDPPARGC1ACAMK4CREB1PPP3R1PPP3CBPRMT1EP300PRKAA2Unknown Transcription FactorsPRKAG1MEF2AFOXO1PPARGFOXO3PPARGC1AMEF2CTFB1MPPARDATF2PPARGC1APPP3CCPPARGPPARGC1ASIRT3TFB1MUCP2PPARGPPP3R2Unknown Transcription FactorsESRRAUnknown Transcription FactorsTFAMNCOA1Unknown Transcription FactorsPRKAG2PPARAAcetylPRKAG3FOXO3PPARGC1AHDAC1PPRC1PPARGC1BPRKAB1TFB2MPPARGC1ANRF1MED1PPARGC1APPARAPPARGC1APPARGC1APPARAMEF2DUnknown Transcription FactorsPPARGC1APRKAA1PPARGC1APPARGC1A


Description

The PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Source: Wikipedia (wikipedia:PPARGC1A)

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Bibliography

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History

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CompareRevisionActionTimeUserComment
106404view21:33, 28 August 2019KhanspersModified description
105585view04:43, 10 August 2019KhanspersModified description
94314view12:10, 1 September 2017Marvin M2Connected unconnected line
94237view12:49, 29 August 2017DeSlChanged ID for acetyl (which was an acetyl leaving group), added ID for CAMK4
94202view14:54, 25 August 2017DeSlAdded ID for acetaldehyde
91584view19:53, 18 March 2017AlexanderPicotweaked interactions
91583view19:49, 18 March 2017MaintBotremoving color and legend to enable general use
89375view06:28, 10 September 2016EgonwConnected lines.
80210view21:02, 22 May 2015KhanspersReverted to version '17:36, 8 July 2013' by Khanspers
80182view20:02, 18 May 2015Khanspersremoved node coloring
80167view22:28, 14 May 2015KhanspersAdded mir219 targeting of CAMK2G, removed node colors, added labels, added states
68947view17:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
45242view18:25, 7 October 2011AlexanderPicoOntology Term : 'energy metabolic pathway' added !
41103view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
38811view08:31, 24 September 2010Jildaucompartment
38121view01:34, 13 August 2010AlexanderPicofixed legend
38118view01:00, 13 August 2010AlexanderPicoModified categories
38117view00:59, 13 August 2010AlexanderPicoModified description
38116view00:53, 13 August 2010AlexanderPicofinished connecting datanodes and lines
38115view00:23, 13 August 2010AlexanderPicoPeriodical save, work in progress
38094view00:29, 12 August 2010AlexanderPicofixed arrows and datanodes in top third of pathway
38093view23:58, 11 August 2010AlexanderPicoConnecting genes to database, fixing lines and datanodes
38091view23:49, 11 August 2010AlexanderPicoPeriodical save, work in progress
38089view23:38, 11 August 2010AlexanderPicoadded pathway name
38021view14:06, 30 July 2010MXFKoshoPeriodical save, work in progress
38020view13:59, 30 July 2010MXFKoshoSpecify description
37913view09:34, 16 July 2010MXFKoshoSpecify description
37910view02:35, 16 July 2010MXFKoshoSpecify description
37909view02:32, 16 July 2010MXFKoshoSpecify description
37908view02:26, 16 July 2010MXFKoshoPeriodical save, work in progress
37907view02:24, 16 July 2010MXFKosho
37906view02:16, 16 July 2010MXFKoshoPeriodical save, work in progress
37905view02:04, 16 July 2010MXFKoshoSpecify description
37904view01:59, 16 July 2010MXFKoshoSpecify description
37903view01:54, 16 July 2010MXFKoshoPeriodical save, work in progress
37902view01:45, 16 July 2010MXFKoshoSpecify description
37563view17:12, 11 June 2010MXFKoshoSpecify description
37559view13:51, 11 June 2010MXFKoshoSpecify description
37558view13:46, 11 June 2010MXFKoshoSpecify description
37557view13:38, 11 June 2010MXFKoshoPeriodical save, work in progress
37556view12:57, 11 June 2010MXFKoshoPeriodical save, work in progress
37290view21:21, 24 May 2010MXFKoshoSpecify description
37285view19:20, 24 May 2010MXFKoshoPeriodical save, work in progress
37284view19:01, 24 May 2010MXFKoshoSpecify description
37283view18:01, 24 May 2010MXFKoshoSpecify description
37282view15:01, 24 May 2010MXFKoshoPeriodical save, work in progress
37281view14:49, 24 May 2010MXFKoshoSpecify description
37280view10:44, 24 May 2010MXFKoshoSpecify description
37278view21:35, 23 May 2010MXFKoshoSpecify description
37268view19:36, 23 May 2010MXFKoshoSpecify description

External references

DataNodes

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NameTypeDatabase referenceComment
GeneProduct
ATF2GeneProduct1386 (Entrez Gene)
AcetylMetabolite
CAMK2GGeneProduct818 (Entrez Gene)
CAMK4GeneProduct
CAMK4GeneProduct814 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
ESRRAGeneProduct2101 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO3GeneProduct2309 (Entrez Gene)
GABPAGeneProduct2551 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MED1GeneProduct5469 (Entrez Gene)
MEF2AGeneProduct4205 (Entrez Gene)
MEF2BGeneProduct100271849 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MEF2DGeneProduct4209 (Entrez Gene)
MYBBP1AGeneProduct10514 (Entrez Gene)
NCOA1GeneProduct8648 (Entrez Gene)
NRF1GeneProduct4899 (Entrez Gene)
PPARAGeneProduct5465 (Entrez Gene)
PPARDGeneProduct5467 (Entrez Gene)
PPARGGeneProduct5468 (Entrez Gene)
PPARGC1AGeneProduct
PPARGC1AGeneProduct10891 (Entrez Gene)
PPARGC1BGeneProduct133522 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CBGeneProduct5532 (Entrez Gene)
PPP3CCGeneProduct5533 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
PPP3R2GeneProduct5535 (Entrez Gene)
PPRC1GeneProduct23082 (Entrez Gene)
PRKAA1GeneProduct5562 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRKAB1GeneProduct5564 (Entrez Gene)
PRKAB2GeneProduct5565 (Entrez Gene)
PRKAG1GeneProduct5571 (Entrez Gene)
PRKAG2GeneProduct51422 (Entrez Gene)
PRKAG3GeneProduct53632 (Entrez Gene)
PRMT1GeneProduct3276 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
SIRT1GeneProduct23411 (Entrez Gene)
SIRT3GeneProduct23410 (Entrez Gene)
TFAMGeneProduct7019 (Entrez Gene)
TFB1MGeneProduct51106 (Entrez Gene)
TFB2MGeneProduct64216 (Entrez Gene)
UCP2GeneProduct7351 (Entrez Gene)
UCP3GeneProduct7352 (Entrez Gene)
Unknown Transcription FactorsGeneProduct
Unknown Transcription Factors GeneProduct

Annotated Interactions

No annotated interactions

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