Energy Metabolism (Homo sapiens)

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Imported to mitochondria= PPARGC1A induces expressionTranscription Nuclear Encoded Genes?P= PPARGC1A induced by external stimuliCYTOPLASM= Key regulatorNUCLEUS= PPARGC1A, PPARs and UCP2, 3Pre-initiation ComplexGenes of mitochondrial fatty acid oxidationenzymesP= Double positive feedback loop= family members of PPARGC1APost-transcriptional modificationPPPARGC1AP= PPARGC1A and muscle controlMuscular atrophyP= transcription factors for mtDNA= PPARGC1A co-activates nuclear receptors and transcription factorsPPP3CBPPARGEP300PRKAG2PPARGC1ATFB2MTFB2MPRMT1CREB1PPARGC1APPARGSIRT3SIRT1PPRC1Unknown Transcription FactorsPPARAATF2PPARGC1APPARGC1ATFB1MUnknown Transcription Factors UCP3PPARDNRF1PPARGC1APPARGC1BPPARAMEF2BCAMK4PPARGC1APPP3R1TFB1MPPARGC1APPARGC1APPARGC1AFOXO1Unknown Transcription FactorsMYBBP1AMEF2CPPARGC1ATFAMUCP2PPP3CCPPARGPPARGC1APPARGC1AUnknown Transcription FactorsHDAC1PRKAB1PPARGC1AAcetylPPARGC1APRKAA1GABPAPPARGC1AGSK3BPPARAMED1TFAMTFB1MCAMK4NCOA1PPP3CAUnknown Transcription FactorsMEF2DPRKAA2PRKAB2HDAC1PPARGC1APRKAG3RXRAPPARGC1APRKAG1MEF2APPARDCAMK2GFOXO3CREB1PPP3R2FOXO3ESRRATFB2MUnknown Transcription FactorsMAPK14Unknown Transcription Factors


Description

The PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Source: Wikipedia (wikipedia:PPARGC1A)

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History

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CompareRevisionActionTimeUserComment
106404view21:33, 28 August 2019KhanspersModified description
105585view04:43, 10 August 2019KhanspersModified description
94314view12:10, 1 September 2017Marvin M2Connected unconnected line
94237view12:49, 29 August 2017DeSlChanged ID for acetyl (which was an acetyl leaving group), added ID for CAMK4
94202view14:54, 25 August 2017DeSlAdded ID for acetaldehyde
91584view19:53, 18 March 2017AlexanderPicotweaked interactions
91583view19:49, 18 March 2017MaintBotremoving color and legend to enable general use
89375view06:28, 10 September 2016EgonwConnected lines.
80210view21:02, 22 May 2015KhanspersReverted to version '17:36, 8 July 2013' by Khanspers
80182view20:02, 18 May 2015Khanspersremoved node coloring
80167view22:28, 14 May 2015KhanspersAdded mir219 targeting of CAMK2G, removed node colors, added labels, added states
68947view17:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
45242view18:25, 7 October 2011AlexanderPicoOntology Term : 'energy metabolic pathway' added !
41103view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
38811view08:31, 24 September 2010Jildaucompartment
38121view01:34, 13 August 2010AlexanderPicofixed legend
38118view01:00, 13 August 2010AlexanderPicoModified categories
38117view00:59, 13 August 2010AlexanderPicoModified description
38116view00:53, 13 August 2010AlexanderPicofinished connecting datanodes and lines
38115view00:23, 13 August 2010AlexanderPicoPeriodical save, work in progress
38094view00:29, 12 August 2010AlexanderPicofixed arrows and datanodes in top third of pathway
38093view23:58, 11 August 2010AlexanderPicoConnecting genes to database, fixing lines and datanodes
38091view23:49, 11 August 2010AlexanderPicoPeriodical save, work in progress
38089view23:38, 11 August 2010AlexanderPicoadded pathway name
38021view14:06, 30 July 2010MXFKoshoPeriodical save, work in progress
38020view13:59, 30 July 2010MXFKoshoSpecify description
37913view09:34, 16 July 2010MXFKoshoSpecify description
37910view02:35, 16 July 2010MXFKoshoSpecify description
37909view02:32, 16 July 2010MXFKoshoSpecify description
37908view02:26, 16 July 2010MXFKoshoPeriodical save, work in progress
37907view02:24, 16 July 2010MXFKosho
37906view02:16, 16 July 2010MXFKoshoPeriodical save, work in progress
37905view02:04, 16 July 2010MXFKoshoSpecify description
37904view01:59, 16 July 2010MXFKoshoSpecify description
37903view01:54, 16 July 2010MXFKoshoPeriodical save, work in progress
37902view01:45, 16 July 2010MXFKoshoSpecify description
37563view17:12, 11 June 2010MXFKoshoSpecify description
37559view13:51, 11 June 2010MXFKoshoSpecify description
37558view13:46, 11 June 2010MXFKoshoSpecify description
37557view13:38, 11 June 2010MXFKoshoPeriodical save, work in progress
37556view12:57, 11 June 2010MXFKoshoPeriodical save, work in progress
37290view21:21, 24 May 2010MXFKoshoSpecify description
37285view19:20, 24 May 2010MXFKoshoPeriodical save, work in progress
37284view19:01, 24 May 2010MXFKoshoSpecify description
37283view18:01, 24 May 2010MXFKoshoSpecify description
37282view15:01, 24 May 2010MXFKoshoPeriodical save, work in progress
37281view14:49, 24 May 2010MXFKoshoSpecify description
37280view10:44, 24 May 2010MXFKoshoSpecify description
37278view21:35, 23 May 2010MXFKoshoSpecify description
37268view19:36, 23 May 2010MXFKoshoSpecify description

External references

DataNodes

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NameTypeDatabase referenceComment
ATF2GeneProduct1386 (Entrez Gene)
AcetylMetabolite
CAMK2GGeneProduct818 (Entrez Gene)
CAMK4GeneProduct
CAMK4GeneProduct814 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
ESRRAGeneProduct2101 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO3GeneProduct2309 (Entrez Gene)
GABPAGeneProduct2551 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MED1GeneProduct5469 (Entrez Gene)
MEF2AGeneProduct4205 (Entrez Gene)
MEF2BGeneProduct100271849 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MEF2DGeneProduct4209 (Entrez Gene)
MYBBP1AGeneProduct10514 (Entrez Gene)
NCOA1GeneProduct8648 (Entrez Gene)
NRF1GeneProduct4899 (Entrez Gene)
PPARAGeneProduct5465 (Entrez Gene)
PPARDGeneProduct5467 (Entrez Gene)
PPARGGeneProduct5468 (Entrez Gene)
PPARGC1AGeneProduct10891 (Entrez Gene)
PPARGC1BGeneProduct133522 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CBGeneProduct5532 (Entrez Gene)
PPP3CCGeneProduct5533 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
PPP3R2GeneProduct5535 (Entrez Gene)
PPRC1GeneProduct23082 (Entrez Gene)
PRKAA1GeneProduct5562 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRKAB1GeneProduct5564 (Entrez Gene)
PRKAB2GeneProduct5565 (Entrez Gene)
PRKAG1GeneProduct5571 (Entrez Gene)
PRKAG2GeneProduct51422 (Entrez Gene)
PRKAG3GeneProduct53632 (Entrez Gene)
PRMT1GeneProduct3276 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
SIRT1GeneProduct23411 (Entrez Gene)
SIRT3GeneProduct23410 (Entrez Gene)
TFAMGeneProduct7019 (Entrez Gene)
TFB1MGeneProduct51106 (Entrez Gene)
TFB2MGeneProduct64216 (Entrez Gene)
UCP2GeneProduct7351 (Entrez Gene)
UCP3GeneProduct7352 (Entrez Gene)
Unknown Transcription FactorsGeneProduct
Unknown Transcription Factors GeneProduct

Annotated Interactions

No annotated interactions

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