Vitamin B12 Metabolism (Homo sapiens)

From WikiPathways

Revision as of 07:40, 5 March 2018 by Egonw (Talk | contribs)
Jump to: navigation, search
4592, 111, 125, 244, 266...125, 132, 137, 22649, 243ConversionCofactorsMetabolitesReactionOverarching processFrom intracellular part to the plasmaNitrogen CompundsSelenoproteinsTranscription factorBindingCatalysisCleavageSelenium statusProcess or metabolism involved in Se PathwayCofactor conversionOther proteinsInhibitionMicronutrientsBiomarker forNegative EffectStimulationLEGENDNecessary stimulationis composed ofProtein*Protein with polymorphismEnzymesIntracellularPlasmaPGF2aThromboxane A2PGE1CUBNIF*Thromboxane B2Thromboxane B2PGE1MegalinPGE2MCP1HCLipid peroxidationF2-IsoprostanePGF2aThromboxane B2PGE2F2-IsoprostaneNFkB1Protein tyrosine nitrationDNA OxidationLipoprotein metabolismProstaglandin metabolismTCN2*TCN2*8-Isoprostaglandin F2a8-Isoprostaglandin F2aa-TocopherolNFkB2MCP1a-TocopherolRELA77, 288, 29312140, 12412121, 48, 98, 100, 191...12177, 288, 2938898, 100, 155, 260, 265...246, 28417621, 39, 48, 98, 100...108, 13310, 155, 18616, 98, 100, 27010, 186840, 1243001, 66, 83, 158, 165...8, 31, 288200, 2881211, 66, 83, 158, 165...100, 260, 281200, 28898, 100, 270SHMTMM-CoA-HMATMSR*MUTMMABCBRMTR*MCEE72219100, 1079870, 26743, 60, 98, 146, 28618, 5739, 70CBS258NADP+NADP+NADHNADP+MPO137, 180, 269CysteinetPAPAI-1Factor VIIThrombinPLGPLGThrombintPAPAI-1Factor VII209, 27914814814814854, 209209, 27954, 209148148H2O25,10-Methylene-THF57, 106Creatinine5-methyl-THFCreatinine5-methyl-THF49, 60, 85, 96, 106...49, 60, 85, 96, 106...48, 11648, 116SOD3SOD3CTHTHF106NADPHNADPHNADNADPHMTHFR*43, 106HomocysteineHomocysteine10, 12, 40, 46, 60...10, 12, 40, 46, 60...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate40, 85, 9640, 85, 96SerineSerine18, 5718, 57ABCA1HDLVLDL-TAGCholesterolAPOA1-NO2TyrSAA1VLDLVLDL/APOBHDLAPOEAPOBACTLDLLDL/APOBHDL-CTAGoxLDLLDLVLDL-TAGCholesterolSAA2HDL-CSAA3TAGAPOA1oxLDLSRB1APOBSAA4HDL/APOA1VLDLLDLRLDL-CAPOA1LDL-CACTHDL/SAA872, 478793, 2292179, 20733165, 186, 2849, 130, 1752, 186, 26587130, 175165, 186, 2842, 47, 2726, 876, 872165, 186, 284287, 207165, 186, 2842722, 2728722, 2652179, 2292, 472879, 130, 1752, 47293, 2292, 4787, 2078-OHdG8-OHdGCob(II)alaminMethylcob(III)alaminAdenosylcobalaminVitamin B12/CobalaminFADAdenosylcobalaminVitamin B12/CobalaminCob(I)alaminMethylcob(III)alamin9, 23, 46, 48, 85...49, 70, 98, 24317698, 10798, 10749, 70, 98, 24336, 70, 989, 46, 48, 85, 96...17670, 98vitamin DChlorinevitamin DChlorine99CystathionineSOD2ZincZincHOClNO3-NOO3N2OHNO2NO2146, 286146, 180, 269, 290TNFaINSD-dimerALBIL6TNFaD-dimerIL6RANTESHBBIL10INSRINSFibrinFibrinRANTESFibrinogenIL1BFibrinogenHBA1ALBHbA1cCRPHbA1cIL10IL1BsICAM-1120, 125, 163, 227244125, 295150, 260148, 202155, 26620824454, 148148, 20217, 96, 1637, 134134, 172, 273134, 172, 273125, 293, 29523, 125, 134, 208, 293125, 16375, 96, 133, 165, 208...150, 26010917, 96, 16354, 148109109109155, 266125, 134, 208RiboflavinRiboflavin9, 199, 19O2 Methylmalonic acidCbl/TC S-Adenosylmethionine S-AdenosylhomocysteineCbl/TCCbl/HC S-AdenosylmethionineL-Methylmalonyl-CoAD-Methylmalonyl-CoA S-Adenosylhomocysteine Methylmalonic acid Succinyl-CoAMethionineMethionineCbl/IF48, 98, 100, 270106, 184106, 184100, 10798, 100, 27010760, 106, 12398, 100, 27060, 106, 12329, 70, 72, 106100, 10746, 10798, 100, 27029, 70, 72, 106100, 107ONOO-ONOOHNitrotyrosine300GlucoseGlucoseFructosamineFructosamine150109, 273109, 273150Ascorbic acidAscorbic acidAscorbic acid1, 158, 2641, 158, 2641, 158, 264


Description

Vitamin B12 is a water soluble, organic compound and essential nutrient involved in the everyday functioning of the nervous system and the brain.

Vitamin B12 is involved in the preservation and regeneration of the myelin shealth - the protective fatty layer that acts as an insulator in nerve axons.

Animals store vitamin B12 in liver and muscle and therefore eggs, milk, meat, liver are sources of the vitamin.

Problems in metabolism of vitamin B12 lead to "persistent" lack of energy to perform every day tasks.

The genes and pathways highlighted above describe several routes through which genes and metabolites involved in B12 metabolism are interconnected.

Central B12 metabolism nodes include folate metabolism and the synthesis of the citric acid cycle intermediates and succinyl-CoA, cyanocobalamin into methylcobalamin conversion, tyrosine nitration and riboflavin pathways.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Schumm K, Rocha S, Caamano J, Perkins ND; ''Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit.''; EMBO J, 2006 PubMed Europe PMC
  2. Momoi T, Ben-Yoseph Y, Nadler HL; ''Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls.''; Biochem J, 1982 PubMed Europe PMC
  3. Mayer O Jr, Simon J, Rosolová H, Hromádka M, Subrt I, Vobrubová I; ''The effects of folate supplementation on some coagulation parameters and oxidative status surrogates.''; Eur J Clin Pharmacol, 2002 PubMed Europe PMC
  4. Banning A, Florian S, Deubel S, Thalmann S, Müller-Schmehl K, Jacobasch G, Brigelius-Flohé R; ''GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  5. Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J; ''NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.''; J Biol Chem, 2006 PubMed Europe PMC
  6. Kosco MH, Gray D; ''Signals involved in germinal center reactions.''; Immunol Rev, 1992 PubMed Europe PMC
  7. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM; ''Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide.''; Biochemistry, 2006 PubMed Europe PMC
  8. Hammarström S; ''Leukotrienes.''; Annu Rev Biochem, 1983 PubMed Europe PMC
  9. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.''; J Biol Chem, 1992 PubMed Europe PMC
  10. Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev V; ''Structure-function relationships, physiological roles and evolution of mammalian ER-resident selenoproteins.''; Antioxid Redox Signal, 2009 PubMed Europe PMC
  11. Anderson ME, Allison RD, Meister A; ''Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.''; Proc Natl Acad Sci U S A, 1982 PubMed Europe PMC
  12. Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M; ''Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.''; Blood, 2006 PubMed Europe PMC
  13. Ahlberg J, Angelin B, Björkhem I, Einarsson K, Leijd B; ''Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.''; J Lipid Res, 1979 PubMed Europe PMC
  14. Betsholtz IH, Wikvall K; ''Cytochrome P450 CYP27-catalyzed oxidation of C27-steroid into C27-acid.''; J Steroid Biochem Mol Biol, 1995 PubMed Europe PMC
  15. Jakubowski H; ''Molecular basis of homocysteine toxicity in humans.''; Cell Mol Life Sci, 2004 PubMed Europe PMC
  16. Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S; ''Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.''; J Biol Chem, 2001 PubMed Europe PMC
  17. Johnson MR, Barnes S, Diasio RB; ''Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedure.''; Anal Biochem, 1989 PubMed Europe PMC
  18. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, Lane DA; ''Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.''; Circulation, 2000 PubMed Europe PMC
  19. Helgerud P, Saarem K, Norum KR; ''Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction.''; J Lipid Res, 1981 PubMed Europe PMC
  20. Hoyos B, Ballard DW, Böhnlein E, Siekevitz M, Greene WC; ''Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression.''; Science, 1989 PubMed Europe PMC
  21. Hooper PL, Hooper EM, Hunt WC, Garry PJ, Goodwin JS; ''Vitamins, lipids and lipoproteins in a healthy elderly population.''; Int J Vitam Nutr Res, 1983 PubMed Europe PMC
  22. Erickson SK, Bösterling B; ''Cholesterol 7 alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles.''; J Lipid Res, 1981 PubMed Europe PMC
  23. Clifton PM, Mackinnon AM, Barter PJ; ''Effects of serum amyloid A protein (SAA) on composition, size, and density of high density lipoproteins in subjects with myocardial infarction.''; J Lipid Res, 1985 PubMed Europe PMC
  24. Heirman I, Ginneberge D, Brigelius-Flohé R, Hendrickx N, Agostinis P, Brouckaert P, Rottiers P, Grooten J; ''Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy.''; Free Radic Biol Med, 2006 PubMed Europe PMC
  25. Remoli ME, Ragimbeau J, Giacomini E, Gafa V, Severa M, Lande R, Pellegrini S, Coccia EM; ''NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation.''; J Leukoc Biol, 2007 PubMed Europe PMC
  26. Lykidis A, Jackson PD, Rock CO, Jackowski S; ''The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content.''; J Biol Chem, 1997 PubMed Europe PMC
  27. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y; ''A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.''; J Biol Chem, 1997 PubMed Europe PMC
  28. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr, 1999 PubMed Europe PMC
  29. Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox PL, Ischiropoulos H, Smith JD, Kinter M, Hazen SL; ''Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.''; J Clin Invest, 2004 PubMed Europe PMC
  30. Bianco AC, Kim BW; ''Deiodinases: implications of the local control of thyroid hormone action.''; J Clin Invest, 2006 PubMed Europe PMC
  31. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.''; Bioessays, 1998 PubMed Europe PMC
  32. Cheng JB, Jacquemin E, Gerhardt M, Nazer H, Cresteil D, Heubi JE, Setchell KD, Russell DW; ''Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease.''; J Clin Endocrinol Metab, 2003 PubMed Europe PMC
  33. Agaugué S, Perrin-Cocon L, Coutant F, André P, Lotteau V; ''1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity.''; J Immunol, 2006 PubMed Europe PMC
  34. Lu C, Qiu F, Zhou H, Peng Y, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett, 2006 PubMed Europe PMC
  35. MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV; ''Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.''; Appl Environ Microbiol, 1982 PubMed Europe PMC
  36. Isseroff RR, Ziboh VA, Chapkin RS, Martinez DT; ''Conversion of linoleic acid into arachidonic acid by cultured murine and human keratinocytes.''; J Lipid Res, 1987 PubMed Europe PMC
  37. Yamauchi Y, Reid PC, Sperry JB, Furukawa K, Takeya M, Chang CC, Chang TY; ''Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.''; J Biol Chem, 2007 PubMed Europe PMC
  38. Nakamura MT, Nara TY; ''Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases.''; Annu Rev Nutr, 2004 PubMed Europe PMC
  39. Walker GA, Murphy S, Huennekens FM; ''Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems.''; Arch Biochem Biophys, 1969 PubMed Europe PMC
  40. Bates CJ, Schneede J, Mishra G, Prentice A, Mansoor MA; ''Relationship between methylmalonic acid, homocysteine, vitamin B12 intake and status and socio-economic indices, in a subset of participants in the British National Diet and Nutrition Survey of people aged 65 y and over.''; Eur J Clin Nutr, 2003 PubMed Europe PMC
  41. Pedretti A, Bocci E, Maggi R, Vistoli G; ''Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations.''; Steroids, 2008 PubMed Europe PMC
  42. Lu B, Xu FY, Jiang YJ, Choy PC, Hatch GM, Grunfeld C, Feingold KR; ''Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1).''; J Lipid Res, 2006 PubMed Europe PMC
  43. Kim YI; ''Role of the MTHFR polymorphisms in cancer risk modification and treatment.''; Future Oncol, 2009 PubMed Europe PMC
  44. Gustafsson J; ''Bile acid synthesis during development. Mitochondrial 12 alpha-hydroxylation in human fetal liver.''; J Clin Invest, 1985 PubMed Europe PMC
  45. Singh S, Madzelan P, Banerjee R; ''Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.''; Nat Prod Rep, 2007 PubMed Europe PMC
  46. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  47. Sica A, Tan TH, Rice N, Kretzschmar M, Ghosh P, Young HA; ''The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.''; Proc Natl Acad Sci U S A, 1992 PubMed Europe PMC
  48. Huerta C, Borek D, Machius M, Grishin NV, Zhang H; ''Structure and mechanism of a eukaryotic FMN adenylyltransferase.''; J Mol Biol, 2009 PubMed Europe PMC
  49. Gaughan DJ, Kluijtmans LA, Barbaux S, McMaster D, Young IS, Yarnell JW, Evans A, Whitehead AS; ''The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations.''; Atherosclerosis, 2001 PubMed Europe PMC
  50. Hoey L, Strain JJ, McNulty H; ''Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.''; Am J Clin Nutr, 2009 PubMed Europe PMC
  51. Zhai XY, Nielsen R, Birn H, Drumm K, Mildenberger S, Freudinger R, Moestrup SK, Verroust PJ, Christensen EI, Gekle M; ''Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney.''; Kidney Int, 2000 PubMed Europe PMC
  52. Lucock M; ''Folic acid: nutritional biochemistry, molecular biology, and role in disease processes.''; Mol Genet Metab, 2000 PubMed Europe PMC
  53. Schaap D, de Widt J, van der Wal J, Vandekerckhove J, van Damme J, Gussow D, Ploegh HL, van Blitterswijk WJ, van der Bend RL; ''Purification, cDNA-cloning and expression of human diacylglycerol kinase.''; FEBS Lett, 1990 PubMed Europe PMC
  54. Pesch J, Brehm U, Staib C, Grummt F; ''Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53.''; J Interferon Cytokine Res, 1996 PubMed Europe PMC
  55. Sala A, Voelkel N, Maclouf J, Murphy RC; ''Leukotriene E4 elimination and metabolism in normal human subjects.''; J Biol Chem, 1990 PubMed Europe PMC
  56. Jackowski S, Fagone P; ''CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.''; J Biol Chem, 2005 PubMed Europe PMC
  57. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN; ''Characterization of mammalian selenoproteomes.''; Science, 2003 PubMed Europe PMC
  58. Schnedl WJ, Liebminger A, Roller RE, Lipp RW, Krejs GJ; ''Hemoglobin variants and determination of glycated hemoglobin (HbA1c).''; Diabetes Metab Res Rev, 2001 PubMed Europe PMC
  59. Zamocky M, Furtmüller PG, Obinger C; ''Evolution of catalases from bacteria to humans.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  60. Gordon MM, Brada N, Remacha A, Badell I, del Río E, Baiget M, Santer R, Quadros EV, Rothenberg SP, Alpers DH; ''A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency.''; Hum Mutat, 2004 PubMed Europe PMC
  61. Bowser PA, Gray GM; ''Sphingomyelinase in pig and human epidermis.''; J Invest Dermatol, 1978 PubMed Europe PMC
  62. Burk RF, Hill KE, Motley AK; ''Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P.''; J Nutr, 2003 PubMed Europe PMC
  63. Murakami M, Nakatani Y, Tanioka T, Kudo I; ''Prostaglandin E synthase.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC
  64. Hammad SM, Stefansson S, Twal WO, Drake CJ, Fleming P, Remaley A, Brewer HB Jr, Argraves WS; ''Cubilin, the endocytic receptor for intrinsic factor-vitamin B(12) complex, mediates high-density lipoprotein holoparticle endocytosis.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC
  65. Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo J Jr; ''Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy.''; Biol Trace Elem Res, 2008 PubMed Europe PMC
  66. Kypreos KE, van Dijk KW, van Der Zee A, Havekes LM, Zannis VI; ''Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion.''; J Biol Chem, 2001 PubMed Europe PMC
  67. Riedel B, Fiskerstrand T, Refsum H, Ueland PM; ''Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase.''; Biochem J, 1999 PubMed Europe PMC
  68. Deo AK, Bandiera SM; ''Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.''; Drug Metab Dispos, 2008 PubMed Europe PMC
  69. Bohnenkamp HR, Papazisis KT, Burchell JM, Taylor-Papadimitriou J; ''Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.''; Cell Immunol, 2007 PubMed Europe PMC
  70. Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P; ''A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.''; J Exp Med, 2005 PubMed Europe PMC
  71. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.''; Clin Rev Allergy Immunol, 2009 PubMed Europe PMC
  72. Leonard S, Arbogast D, Geyer D, Jones C, Sinensky M; ''Localization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome 5.''; Proc Natl Acad Sci U S A, 1986 PubMed Europe PMC
  73. Wang LH, Kulmacz RJ; ''Thromboxane synthase: structure and function of protein and gene.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC
  74. Krishnaveni GV, Hill JC, Veena SR, Bhat DS, Wills AK, Karat CL, Yajnik CS, Fall CH; ''Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes.''; Diabetologia, 2009 PubMed Europe PMC
  75. Borzutzky A, Crompton B, Bergmann AK, Giliani S, Baxi S, Martin M, Neufeld EJ, Notarangelo LD; ''Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter.''; Clin Immunol, 2009 PubMed Europe PMC
  76. Bose R, Kolesnick R; ''Measurement of ceramide synthase activity.''; Methods Enzymol, 2000 PubMed Europe PMC
  77. Birn H, Willnow TE, Nielsen R, Norden AG, Bönsch C, Moestrup SK, Nexø E, Christensen EI; ''Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12).''; Am J Physiol Renal Physiol, 2002 PubMed Europe PMC
  78. Hoey L, McNulty H, Strain JJ; ''Studies of biomarker responses to intervention with riboflavin: a systematic review.''; Am J Clin Nutr, 2009 PubMed Europe PMC
  79. Bosschaerts T, Guilliams M, Noel W, Hérin M, Burk RF, Hill KE, Brys L, Raes G, Ghassabeh GH, De Baetselier P, Beschin A; ''Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.''; J Immunol, 2008 PubMed Europe PMC
  80. Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID; ''The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.''; Mol Pharmacol, 2008 PubMed Europe PMC
  81. Lewis GF, Rader DJ; ''New insights into the regulation of HDL metabolism and reverse cholesterol transport.''; Circ Res, 2005 PubMed Europe PMC
  82. Rampersaud GC, Kauwell GP, Bailey LB; ''Folate: a key to optimizing health and reducing disease risk in the elderly.''; J Am Coll Nutr, 2003 PubMed Europe PMC
  83. Engels F, Nijkamp FP; ''Pharmacological inhibition of leukotriene actions.''; Pharm World Sci, 1998 PubMed Europe PMC
  84. Esmon CT; ''Does inflammation contribute to thrombotic events?''; Haemostasis, 2000 PubMed Europe PMC
  85. Mudd JO, Borlaug BA, Johnston PV, Kral BG, Rouf R, Blumenthal RS, Kwiterovich PO Jr; ''Beyond low-density lipoprotein cholesterol: defining the role of low-density lipoprotein heterogeneity in coronary artery disease.''; J Am Coll Cardiol, 2007 PubMed Europe PMC
  86. Chatterjee S, Castiglione E; ''UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.''; Biochim Biophys Acta, 1987 PubMed Europe PMC
  87. Hahn FM, Xuan JW, Chambers AF, Poulter CD; ''Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization.''; Arch Biochem Biophys, 1996 PubMed Europe PMC
  88. Amaral JD, Castro RE, Steer CJ, Rodrigues CM; ''p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.''; Trends Mol Med, 2009 PubMed Europe PMC
  89. Bleys J, Navas-Acien A, Guallar E; ''Serum selenium and diabetes in U.S. adults.''; Diabetes Care, 2007 PubMed Europe PMC
  90. Schöneich C; ''Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.''; Biochim Biophys Acta, 2005 PubMed Europe PMC
  91. Paradisi G, Cucinelli F, Mele MC, Barini A, Lanzone A, Caruso A; ''Endothelial function in post-menopausal women: effect of folic acid supplementation.''; Hum Reprod, 2004 PubMed Europe PMC
  92. Mahley RW; ''Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.''; Science, 1988 PubMed Europe PMC
  93. Hansel A, Heinemann SH, Hoshi T; ''Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.''; Biochim Biophys Acta, 2005 PubMed Europe PMC
  94. Brigelius-Flohé R; ''Tissue-specific functions of individual glutathione peroxidases.''; Free Radic Biol Med, 1999 PubMed Europe PMC
  95. Wu C, Bates SM; ''Should D-dimer testing be used to predict the risk of recurrence after discontinuation of anticoagulant therapy for a first unprovoked episode of venous thromboembolism?''; Pol Arch Med Wewn, 2009 PubMed Europe PMC
  96. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.''; J Immunol, 1991 PubMed Europe PMC
  97. Giera M, Renard D, Plössl F, Bracher F; ''Lathosterol side chain amides: a new class of human lathosterol oxidase inhibitors.''; Steroids, 2008 PubMed Europe PMC
  98. Verrax J, Calderon PB; ''The controversial place of vitamin C in cancer treatment.''; Biochem Pharmacol, 2008 PubMed Europe PMC
  99. Chanarin I; ''Cobalamins and nitrous oxide: a review.''; J Clin Pathol, 1980 PubMed Europe PMC
  100. Whitaker MO, Wyche A, Fitzpatrick F, Sprecher H, Needleman P; ''Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  101. Sniderman AD; ''How, when, and why to use apolipoprotein B in clinical practice.''; Am J Cardiol, 2002 PubMed Europe PMC
  102. Manieri W, Moore ME, Soellner MB, Tsang P, Caperelli CA; ''Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes.''; Biochemistry, 2007 PubMed Europe PMC
  103. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC
  104. Gao Y, Hannan NR, Wanyonyi S, Konstantopolous N, Pagnon J, Feng HC, Jowett JB, Kim KH, Walder K, Collier GR; ''Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells.''; Cytokine, 2006 PubMed Europe PMC
  105. Edmondson DE, Newton-Vinson P; ''The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction.''; Antioxid Redox Signal, 2001 PubMed Europe PMC
  106. Arbogast S, Beuvin M, Fraysse B, Zhou H, Muntoni F, Ferreiro A; ''Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment.''; Ann Neurol, 2009 PubMed Europe PMC
  107. Watanabe F, Oki Y, Nakano Y, Kitaoka S; ''Occurrence and characterization of cyanocobalamin reductase (NADPH; CN-eliminating) involved in decyanation of cyanocobalamin in Euglena gracilis.''; J Nutr Sci Vitaminol (Tokyo), 1988 PubMed Europe PMC
  108. Bjørke Monsen AL, Ueland PM, Vollset SE, Guttormsen AB, Markestad T, Solheim E, Refsum H; ''Determinants of cobalamin status in newborns.''; Pediatrics, 2001 PubMed Europe PMC
  109. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL; ''A new human selenium-containing protein. Purification, characterization, and cDNA sequence.''; J Biol Chem, 1998 PubMed Europe PMC
  110. Moore SA, Hurt E, Yoder E, Sprecher H, Spector AA; ''Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid.''; J Lipid Res, 1995 PubMed Europe PMC
  111. Bills TK, Smith JB, Silver MJ; ''Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.''; J Clin Invest, 1977 PubMed Europe PMC
  112. Videla LA, Rodrigo R, Araya J, Poniachik J; ''Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease.''; Trends Mol Med, 2006 PubMed Europe PMC
  113. Stoffel W, LeKim D, Sticht G; ''Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one).''; Hoppe Seylers Z Physiol Chem, 1968 PubMed Europe PMC
  114. Becker BF; ''Towards the physiological function of uric acid.''; Free Radic Biol Med, 1993 PubMed Europe PMC
  115. Youssef D, El Abbassi A, Jordan RM, Peiris AN; ''Fructosamine--an underutilized tool in diabetes management: case report and literature review.''; Tenn Med, 2008 PubMed Europe PMC
  116. Jakobsson A, Westerberg R, Jacobsson A; ''Fatty acid elongases in mammals: their regulation and roles in metabolism.''; Prog Lipid Res, 2006 PubMed Europe PMC
  117. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, Radermacher P, Calzia E; ''Glucose metabolism and catecholamines.''; Crit Care Med, 2007 PubMed Europe PMC
  118. Lööf L, Wengle B; ''Enzymatic sulphation of bile salts in human liver.''; Biochim Biophys Acta, 1978 PubMed Europe PMC
  119. Abate A, Yang G, Dennery PA, Oberle S, Schröder H; ''Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin.''; Free Radic Biol Med, 2000 PubMed Europe PMC
  120. Santhanam U, Ray A, Sehgal PB; ''Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.''; Proc Natl Acad Sci U S A, 1991 PubMed Europe PMC
  121. Holleran WM, Williams ML, Gao WN, Elias PM; ''Serine-palmitoyl transferase activity in cultured human keratinocytes.''; J Lipid Res, 1990 PubMed Europe PMC
  122. Packer L, Witt EH, Tritschler HJ; ''alpha-Lipoic acid as a biological antioxidant.''; Free Radic Biol Med, 1995 PubMed Europe PMC
  123. Das UN; ''Folic acid says NO to vascular diseases.''; Nutrition, 2003 PubMed Europe PMC
  124. van der Westhuyzen DR, Cai L, de Beer MC, de Beer FC; ''Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.''; J Biol Chem, 2005 PubMed Europe PMC
  125. Kwak SE, Kim JE, Kim DW, Kwon OS, Choi SY, Kang TC; ''Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.''; Hippocampus, 2009 PubMed Europe PMC
  126. Kamagate A, Dong HH; ''FoxO1 integrates insulin signaling to VLDL production.''; Cell Cycle, 2008 PubMed Europe PMC
  127. Schäfer M, Werner S; ''Oxidative stress in normal and impaired wound repair.''; Pharmacol Res, 2008 PubMed Europe PMC
  128. Chen D, Zhang XY, Shi Y; ''Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria.''; Biochem J, 2006 PubMed Europe PMC
  129. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed Europe PMC
  130. Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN; ''Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.''; Biochem Soc Trans, 2007 PubMed Europe PMC
  131. Cuebas DA, Phillips C, Schmitz W, Conzelmann E, Novikov DK; ''The role of alpha-methylacyl-CoA racemase in bile acid synthesis.''; Biochem J, 2002 PubMed Europe PMC
  132. Serhan CN; ''Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity?''; Prostaglandins, 1997 PubMed Europe PMC
  133. Fowler B, Leonard JV, Baumgartner MR; ''Causes of and diagnostic approach to methylmalonic acidurias.''; J Inherit Metab Dis, 2008 PubMed Europe PMC
  134. el Attar TM, Lin HS; ''Effect of vitamin C and vitamin E on prostaglandin synthesis by fibroblasts and squamous carcinoma cells.''; Prostaglandins Leukot Essent Fatty Acids, 1992 PubMed Europe PMC
  135. Fernandes-Costa F, Metz J; ''Vitamin B12 binders (transcobalamins) in serum.''; Crit Rev Clin Lab Sci., 1982 PubMed Europe PMC
  136. Shen W, Stone K, Jales A, Leitenberg D, Ladisch S; ''Inhibition of TLR activation and up-regulation of IL-1R-associated kinase-M expression by exogenous gangliosides.''; J Immunol, 2008 PubMed Europe PMC
  137. Proctor PH.; ''Free radicals, uric acid, and human disease.''; Free Radic Biol Med., 1996 PubMed Europe PMC
  138. Guimarães MJ, Peterson D, Vicari A, Cocks BG, Copeland NG, Gilbert DJ, Jenkins NA, Ferrick DA, Kastelein RA, Bazan JF, Zlotnik A; ''Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC
  139. Ferré P; ''The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity.''; Diabetes, 2004 PubMed Europe PMC
  140. Nitahara Y, Aoyama Y, Horiuchi T, Noshiro M, Yoshida Y; ''Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli.''; J Biochem, 1999 PubMed Europe PMC
  141. Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ; ''Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.''; J Biol Chem, 1997 PubMed Europe PMC
  142. Molnár I, Balázs C, Szegedi G, Sipka S; ''Inhibition of type 2,5'-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue.''; Immunol Lett, 2002 PubMed Europe PMC
  143. Shields DJ, Lehner R, Agellon LB, Vance DE; ''Membrane topography of human phosphatidylethanolamine N-methyltransferase.''; J Biol Chem, 2003 PubMed Europe PMC
  144. Ogawa H, Gomi T, Fujioka M; ''Serine hydroxymethyltransferase and threonine aldolase: are they identical?''; Int J Biochem Cell Biol, 2000 PubMed Europe PMC
  145. Taki T, Kanfer JN; ''Phospholipase D from rat brain.''; Methods Enzymol, 1981 PubMed Europe PMC
  146. Lund EG, Kerr TA, Sakai J, Li WP, Russell DW; ''cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.''; J Biol Chem, 1998 PubMed Europe PMC
  147. Feghali CA, Wright TM; ''Cytokines in acute and chronic inflammation.''; Front Biosci, 1997 PubMed Europe PMC
  148. Puig-Kröger A, Sierra-Filardi E, Domí­nguez-Soto A, Samaniego R, Corcuera MT, Gómez-Aguado F, Ratnam M, Sánchez-Mateos P, Corbí­ AL; ''Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages.''; Cancer Res, 2009 PubMed Europe PMC
  149. Häberle J, Pauli S, Berning C, Koch HG, Linnebank M; ''TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations.''; J Hum Genet, 2009 PubMed Europe PMC
  150. Reilly IA, FitzGerald GA; ''Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.''; Blood, 1987 PubMed Europe PMC
  151. Whitehead VM; ''Acquired and inherited disorders of cobalamin and folate in children.''; Br J Haematol, 2006 PubMed Europe PMC
  152. Marnett LJ; ''Lipid peroxidation-DNA damage by malondialdehyde.''; Mutat Res, 1999 PubMed Europe PMC
  153. Voelker DR; ''Phosphatidylserine decarboxylase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  154. Refsum H, Johnston C, Guttormsen AB, Nexo E; ''Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults.''; Clin Chem, 2006 PubMed Europe PMC
  155. Huwyler J, Bürgin M, Zeugin T, Gut J; ''Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione.''; Mol Pharmacol, 1991 PubMed Europe PMC
  156. Zetterberg H, Nexö E, Regland B, Minthon L, Boson R, Palmér M, Rymo L, Blennow K; ''The transcobalamin (TC) codon 259 genetic polymorphism influences holo-TC concentration in cerebrospinal fluid from patients with Alzheimer disease.''; Clin Chem, 2003 PubMed Europe PMC
  157. Morrow JD, Roberts LJ 2nd.; ''The isoprostanes. Current knowledge and directions for future research.''; Biochem Pharmacol., 1996 PubMed Europe PMC
  158. Bütikofer P, Yee MC, Schott MA, Lubin BH, Kuypers FA; ''Generation of phosphatidic acid during calcium-loading of human erythrocytes. Evidence for a phosphatidylcholine-hydrolyzing phospholipase D.''; Eur J Biochem, 1993 PubMed Europe PMC
  159. Levin G, Duffin KL, Obukowicz MG, Hummert SL, Fujiwara H, Needleman P, Raz A; ''Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.''; Biochem J, 2002 PubMed Europe PMC
  160. Ho TC, Chen SL, Yang YC, Chen CY, Feng FP, Hsieh JW, Cheng HC, Tsao YP; ''15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.''; J Biol Chem, 2008 PubMed Europe PMC
  161. Waterham HR, Wijburg FA, Hennekam RC, Vreken P, Poll-The BT, Dorland L, Duran M, Jira PE, Smeitink JA, Wevers RA, Wanders RJ; ''Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.''; Am J Hum Genet, 1998 PubMed Europe PMC
  162. Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C, Obeid LM; ''Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.''; J Biol Chem, 2003 PubMed Europe PMC
  163. Shigenaga MK, Gimeno CJ, Ames BN; ''Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.''; Proc Natl Acad Sci U S A, 1989 PubMed Europe PMC
  164. Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T; ''Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.''; J Biol Chem, 2004 PubMed Europe PMC
  165. Jeong D, Kim TS, Chung YW, Lee BJ, Kim IY; ''Selenoprotein W is a glutathione-dependent antioxidant in vivo.''; FEBS Lett, 2002 PubMed Europe PMC
  166. Bierbach H; ''Studies on long chain fatty acid:CoA ligase from human small intestine.''; Gut, 1980 PubMed Europe PMC
  167. Neumann D, Kollewe C, Resch K, Martin MU.; ''The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC
  168. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.''; Prostaglandins., 1982 PubMed Europe PMC
  169. Karthikeyan S, Zhou Q, Osterman AL, Zhang H; ''Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism.''; Biochemistry, 2003 PubMed Europe PMC
  170. Brigelius-Flohé R; ''Glutathione peroxidases and redox-regulated transcription factors.''; Biol Chem, 2006 PubMed Europe PMC
  171. Franken PA, Van den Berg L, Huang J, Gunyuzlu P, Lugtigheid RB, Verheij HM, De Haas GH; ''Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Cleavage of a fusion protein with cyanogen bromide.''; Eur J Biochem, 1992 PubMed Europe PMC
  172. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, Lipsky PE; ''Cyclooxygenase in biology and disease.''; FASEB J, 1998 PubMed Europe PMC
  173. Chen Y, Dennis EA; ''Expression and characterization of human group V phospholipase A2.''; Biochim Biophys Acta, 1998 PubMed Europe PMC
  174. Hussein O, Rosenblat M, Refael G, Aviram M; ''Dietary selenium increases cellular glutathione peroxidase activity and reduces the enhanced susceptibility to lipid peroxidation of plasma and low-density lipoprotein in kidney transplant recipients.''; Transplantation, 1997 PubMed Europe PMC
  175. Basu S; ''F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  176. Fowler B; ''Genetic defects of folate and cobalamin metabolism.''; Eur J Pediatr, 1998 PubMed Europe PMC
  177. Powis G, Montfort WR; ''Properties and biological activities of thioredoxins.''; Annu Rev Pharmacol Toxicol, 2001 PubMed Europe PMC
  178. Kainou T, Kawamura K, Tanaka K, Matsuda H, Kawamukai M; ''Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.''; Biochim Biophys Acta, 1999 PubMed Europe PMC
  179. Choi SW, Mason JB; ''Folate and carcinogenesis: an integrated scheme.''; J Nutr, 2000 PubMed Europe PMC
  180. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone''; Prostaglandins., 1982 PubMed Europe PMC
  181. Banerjee R; ''B12 trafficking in mammals: A for coenzyme escort service.''; ACS Chem Biol, 2006 PubMed Europe PMC
  182. Abu-Soud HM, Hazen SL; ''Nitric oxide is a physiological substrate for mammalian peroxidases.''; J Biol Chem, 2000 PubMed Europe PMC
  183. Navab M, Anantharamaiah GM, Reddy ST, Van Lenten BJ, Fogelman AM; ''HDL as a biomarker, potential therapeutic target, and therapy.''; Diabetes, 2009 PubMed Europe PMC
  184. Izzo AA, Piscitelli F, Capasso R, Marini P, Cristino L, Petrosino S, Di Marzo V; ''Basal and Fasting/Refeeding-regulated Tissue Levels of Endogenous PPAR-alpha Ligands in Zucker Rats.''; Obesity (Silver Spring), 2009 PubMed Europe PMC
  185. Labunskyy VM, Hatfield DL, Gladyshev VN; ''The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.''; IUBMB Life, 2007 PubMed Europe PMC
  186. Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O; ''Purification and characterization of human phosphatidylserine synthase 1 and 2.''; Biochem J, 2008 PubMed Europe PMC
  187. Schnurr K, Belkner J, Ursini F, Schewe T, Kühn H; ''The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.''; J Biol Chem, 1996 PubMed Europe PMC
  188. Yun J, Kim JY, Kim OY, Jang Y, Chae JS, Kwak JH, Lim HH, Park HY, Lee SH, Lee JH; ''Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men.''; Nutr Metab Cardiovasc Dis, 2009 PubMed Europe PMC
  189. Cipollone F, Cicolini G, Bucci M; ''Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives.''; Pharmacol Ther, 2008 PubMed Europe PMC
  190. Bailey JM, Bryant RW, Whiting J, Salata K; ''Characterization of 11-HETE and 15-HETE, together with prostacyclin, as major products of the cyclooxygenase pathway in cultured rat aorta smooth muscle cells.''; J Lipid Res, 1983 PubMed Europe PMC
  191. Xie S, Wang Q, Wu H, Cogswell J, Lu L, Jhanwar-Uniyal M, Dai W; ''Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.''; J Biol Chem, 2001 PubMed Europe PMC
  192. Aksoy E, Vanden Berghe W, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M, Willems F; ''Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.''; Eur J Immunol, 2005 PubMed Europe PMC
  193. Malle E, Marsche G, Arnhold J, Davies MJ; ''Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.''; Biochim Biophys Acta, 2006 PubMed Europe PMC
  194. Eklund CM; ''Proinflammatory cytokines in CRP baseline regulation.''; Adv Clin Chem, 2009 PubMed Europe PMC
  195. Cao S, Zhang X, Edwards JP, Mosser DM; ''NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages.''; J Biol Chem, 2006 PubMed Europe PMC
  196. Liu YY, Han TY, Giuliano AE, Cabot MC; ''Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.''; J Biol Chem, 1999 PubMed Europe PMC
  197. Guan ZZ, Wang YN, Xiao KQ, Hu PS, Liu JL; ''Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by