miRNA regulation of DNA damage response (Homo sapiens)

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452348486, 11, 12, 17, 21...9, 32156, 11, 12, 17, 21...34362639141948338163932483313313414848484486, 11, 12, 17, 21...484648453, 163744201828266, 11, 12, 17, 21...1, 6, 10, 31, 3515156, 11, 12, 17, 21...6, 11, 12, 17, 21...47303548403, 1674248153, 1620183315203, 1641, 433483920183345323, 166, 11, 12, 17, 21...Blocked transcriptionG2/M checkpointEndogenous:Collapsed replication forksSingle stranded DNA replication breaksFree radicals (ROS)Cell-cycle progressionChromatin alterationDouble-strand breaksDNA adductDNA damage sourceAlkylating agentsmiR polycistronDifferent pathwayBulky DNA lesionG2/MCheckpointTextDNA repair and damage preventionChange in the Cell conditionTextReplication stressPathway LinkROSG2/M transitionTextCell membraneSpecialized:Somatic hypermutaionV(D)J recombinationClass switchingDNA repairChromatinremodellingExogenous:Cigarette SmokeCaffeineRadiation (UV)ClastogenesHypoxiaGenotoxic drugsG1/S transitionCellDNA damage ATM dependentInhibitionBlocked replicationActivationMetabolitemicroRNAMitochondrial membraneCaption:Extral cellularSpaceROSGene productCell survivalRAD51hsa-mir-21Estradiolhsa-mir-16CASP9TLK2CCNB2GADD45BCCND3CDK5CHEK1NBNRPA2CCNG1hsa-mir-222hsa-mir-15b/16-2PRKDCApoptosisE2F1BIDhsa-mir-34bhsa-mir-330BAXH2AFXCCNE2RRM2BPMAIP1BRCA1hsa-mir-373CASP8hsa-mir-424FANCD2CDC25ASFNCDK6CCNB3hsa-mir-34b/34cSESN1CCNB1hsa-mir-17HUS1hsa-miR-106b/25hsa-mir-449ahsa-mir-106bhsa-miR-17/92a-1hsa-mir-16DDB2CDK4hsa-mir-203hsa-mir-145RB1hsa-mir-24hsa-mir-143/145CDK1hsa-mir-15a/16-1GADD45GSMC1AMDM2hsa-mir-221TNFRSF10BABL1ATMCREB1CDK2BBC3ATRMRE11has-miR-195/497hsa-miR-449c/449aRFCCell Cyclehsa-mir-29cCDC25CGADD45ARAD9ATP53AIP1RAD52CASP3hsa-mir-181ahsa-mir-210hsa-mir-17hsa-mir-16PMLE2F17-hydroxystaurosporinehsa-mir-15aATRIPhsa-mir-449aCCND1hsa-let-7a-1/7dhsa-mir-29aRB1CDKN1ACaffeineTLK1miR-143/145 polycistronGADD45GGADD45ARAD17hsa-mir-421hsa-mir-15b/16-2CCNE1Senescencehsa-mir-29bGADD45Bhsa-mir-122PIDDCYCSAPAF1CHEK2hsa-mir-20aCDKN1BRAD50FASRAD1hsa-miR-29b-1/29aCCND2hsa-mir-223hsa-mir-195c-Mychsa-mir-449bTP53


This is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The two central genes can both be divides into their most important genes. For the ATM pathway these are TP53 and CHEK2, while CHEK1 is most important for the ATR pathway.

The goal of this first pathway is to provide an overview of the most important gene products, processes and changes in cell condition elicited by the DNA damage response while keeping it clear and understandable. Also some microRNAs are implemented to visualize the possible effects they can induce. By doing so a better understanding of the role microRNA play in the DNA damage response might arise.

All processes take place in the cytoplasm, except when mentioned differently.

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118120view11:08, 24 May 2021EweitzModified description
116539view12:09, 7 May 2021EweitzModified title
113793view09:04, 24 November 2020Finterlysmall graphical update
107119view14:19, 17 September 2019MaintBotChEBI identifier normalization
105862view23:21, 15 August 2019KhanspersModified description
103023view15:52, 31 January 2019Mkutmonupdated ensembl ids
102986view12:46, 31 January 2019SusanRe-annotated microRNAs
98336view13:26, 23 August 2018EgonwUpdated the MIR21 identifier.
94738view15:05, 5 October 2017Ryanmillerconnected lines
84694view21:01, 15 March 2016KhanspersQuick edit to datanode annotation or property
79564view17:47, 25 March 2015Zarichanged ID for PRKDC
78503view10:29, 7 January 2015MaintBotadded missing graphIds
75268view21:48, 13 May 2014Khanspersupdated miRNAs and lines
71711view20:03, 17 October 2013MaintBotremoved data source from nodes without identifier
70992view21:04, 21 September 2013EgonwAdded the missing DB names.
70112view19:09, 12 July 2013MaintBotupdated to 2013 schema
70023view01:52, 12 July 2013AlexanderPicoModified title
68400view08:12, 5 July 2013EgonwConverted the "alkylating agent" label into a DataNode with ChEBI identifier.
59081view21:57, 21 February 2013MaintBotUpdated Ensembl data source
45379view21:45, 7 October 2011KhanspersOntology Term : 'DNA repair pathway' added !
44908view10:26, 6 October 2011MartijnVanIerselOntology Term : 'miRNA pathway' added !
41096view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
40043view15:20, 1 February 2011AndraPeriodical save, work in progress
39801view15:52, 20 January 2011Stan.gaj
39800view15:51, 20 January 2011Stan.gaj
39799view15:48, 20 January 2011Stan.gaj
39717view11:00, 14 January 2011Stan.gaj
38644view12:16, 23 September 2010Mkutmonadded some pathway links
38435view08:40, 13 September 2010Stan.gajAdded miRNA-122/Cyclin G1/MDM2/p53 regulatory network
38434view08:10, 13 September 2010Stan.gajSpecify description
38432view08:00, 13 September 2010Stan.gajPeriodical save, work in progress
37425view15:16, 1 June 2010J.krumeichSpecify description
37424view15:14, 1 June 2010J.krumeichSpecify description
37423view15:04, 1 June 2010J.krumeichPeriodical save, work in progress
37422view14:34, 1 June 2010J.krumeichPeriodical save, work in progress
37296view09:18, 25 May 2010J.krumeichPeriodical save, work in progress
37195view09:25, 21 May 2010J.krumeichPeriodical save, work in progress
37189view11:30, 20 May 2010J.krumeichModified description
37188view11:23, 20 May 2010J.krumeichPeriodical save, work in progress
37187view11:12, 20 May 2010J.krumeichPeriodical save, work in progress
37186view10:02, 20 May 2010J.krumeichSpecify description
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37183view09:39, 20 May 2010J.krumeichPeriodical save, work in progress
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External references


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NameTypeDatabase referenceComment
7-hydroxystaurosporineMetabolite65225 (Chemspider)
ABL1GeneProductENSG00000097007 (Ensembl Human)
APAF1GeneProductENSG00000120868 (Ensembl Human)
ATMGeneProductENSG00000149311 (Ensembl Human)
ATRGeneProductENSG00000175054 (Ensembl Human)
ATRIPGeneProduct84126 (Entrez Gene)
ApoptosisPathwayWP254 (WikiPathways)
BAXGeneProductENSG00000087088 (Ensembl Human)
BBC3GeneProductENSG00000105327 (Ensembl Human)
BIDGeneProductENSG00000015475 (Ensembl Human)
BRCA1GeneProductENSG00000012048 (Ensembl Human)
CASP3GeneProductENSG00000164305 (Ensembl Human)
CASP8GeneProductENSG00000064012 (Ensembl Human)
CASP9GeneProductENSG00000132906 (Ensembl Human)
CCNB1GeneProductENSG00000134057 (Ensembl Human)
CCNB2GeneProductENSG00000157456 (Ensembl Human)
CCNB3GeneProductENSG00000147082 (Ensembl Human)
CCND1GeneProductENSG00000110092 (Ensembl Human)
CCND2GeneProductENSG00000118971 (Ensembl Human)
CCND3GeneProductENSG00000112576 (Ensembl Human)
CCNE1GeneProductENSG00000105173 (Ensembl Human)
CCNE2GeneProductENSG00000175305 (Ensembl Human)
CCNG1GeneProductENSG00000113328 (Ensembl Human)
CDC25AGeneProductENSG00000164045 (Ensembl Human)
CDC25CGeneProductENSG00000158402 (Ensembl Human)
CDK1GeneProductENSG00000170312 (Ensembl Human)
CDK2GeneProductENSG00000123374 (Ensembl Human)
CDK4GeneProductENSG00000135446 (Ensembl Human)
CDK5GeneProductENSG00000164885 (Ensembl Human)
CDK6GeneProductENSG00000105810 (Ensembl Human)
CDKN1AGeneProductENSG00000124762 (Ensembl Human)
CDKN1BGeneProductENSG00000111276 (Ensembl Human)
CHEK1GeneProductENSG00000149554 (Ensembl Human)
CHEK2GeneProductENSG00000183765 (Ensembl Human)
CREB1GeneProduct1385 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl Human)
CaffeineMetabolite2424 (Chemspider)
Cell CyclePathwayWP179
DDB2GeneProductENSG00000134574 (Ensembl Human)
E2F1GeneProductENSG00000101412 (Ensembl Human)
EstradiolMetabolite16469 (ChEBI)
FANCD2GeneProductENSG00000144554 (Ensembl Human)
FASGeneProductENSG00000026103 (Ensembl Human)
GADD45AGeneProductENSG00000116717 (Ensembl Human)
GADD45BGeneProductENSG00000099860 (Ensembl Human)
GADD45GGeneProductENSG00000130222 (Ensembl Human)
H2AFXGeneProductENSG00000188486 (Ensembl Human)
HUS1GeneProductENSG00000188996 (Ensembl Human)
MDM2GeneProductENSG00000135679 (Ensembl Human)
MRE11GeneProduct4361 (Entrez Gene)
NBNGeneProduct4683 (Entrez Gene)
PIDDGeneProduct55367 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl Human)
PMLGeneProductENSG00000140464 (Ensembl Human)
PRKDCGeneProductENSG00000121031 (Ensembl Human)
RAD17GeneProductENSG00000152942 (Ensembl Human)
RAD1GeneProductENSG00000113456 (Ensembl Human)
RAD50GeneProductENSG00000113522 (Ensembl Human)
RAD51GeneProductENSG00000051180 (Ensembl Human)
RAD52GeneProductENSG00000002016 (Ensembl Human)
RAD9AGeneProductENSG00000172613 (Ensembl Human)
RB1GeneProductENSG00000139687 (Ensembl Human)
RFCGeneProduct5981 (Entrez Gene)
RPA2GeneProductENSG00000117748 (Ensembl Human)
RRM2BGeneProductENSG00000048392 (Ensembl Human)
SESN1GeneProductENSG00000080546 (Ensembl Human)
SFNGeneProductENSG00000175793 (Ensembl Human)
SMC1AGeneProductENSG00000072501 (Ensembl Human)
TLK1GeneProductENSG00000198586 (Ensembl Human)
TLK2GeneProductENSG00000146872 (Ensembl Human)
TNFRSF10BGeneProductENSG00000120889 (Ensembl Human)
TP53AIP1GeneProductENSG00000120471 (Ensembl Human)
TP53GeneProductENSG00000141510 (Ensembl Human)
c-MycGeneProduct4609 (Entrez Gene)
hsa-miR-106b/25GeneProduct4176 (Entrez Gene)
hsa-miR-17/92a-1GeneProductENSG00000215417 (Ensembl Human)
hsa-miR-449c/449aGeneProduct166979 (Entrez Gene)
hsa-mir-106bRnaENSG00000208036 (Ensembl Human)
hsa-mir-122GeneProductENSG00000207778 (Ensembl Human)
hsa-mir-145RnaENSG00000207700 (Ensembl Human)
hsa-mir-15aRnaENSG00000207718 (Ensembl Human)
hsa-mir-16RnaENSG00000208006 (Ensembl Human)
hsa-mir-17RnaENSG00000207745 (Ensembl Human)
hsa-mir-181aRnaENSG00000207759 (Ensembl Human)
hsa-mir-195RnaENSG00000207929 (Ensembl Human)
hsa-mir-203GeneProductENSG00000207568 (Ensembl Human)
hsa-mir-20aGeneProductENSG00000199149 (Ensembl Human)
hsa-mir-210GeneProductENSG00000199038 (Ensembl Human)
hsa-mir-21RnaENSG00000199004 (Ensembl Human)
hsa-mir-221RnaENSG00000207870 (Ensembl Human)
hsa-mir-222RnaENSG00000207725 (Ensembl Human)
hsa-mir-223GeneProductENSG00000207939 (Ensembl Human)
hsa-mir-24GeneProductENSG00000207617 (Ensembl Human)
hsa-mir-29aRnaENSG00000198981 (Ensembl Human)
hsa-mir-29bRnaENSG00000207748 (Ensembl Human)
hsa-mir-29cRnaENSG00000207966 (Ensembl Human)
hsa-mir-330GeneProductENSG00000199066 (Ensembl Human)
hsa-mir-34bRnaENSG00000207811 (Ensembl Human)
hsa-mir-373GeneProductENSG00000199143 (Ensembl Human)
hsa-mir-421RnaENSG00000202566 (Ensembl Human)
hsa-mir-424RnaENSG00000199097 (Ensembl Human)
hsa-mir-449aRnaENSG00000198983 (Ensembl Human)
hsa-mir-449bRnaENSG00000207728 (Ensembl Human)
miR-143/145 polycistronGeneProduct

Annotated Interactions

No annotated interactions

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