Selenium Micronutrient Network (Homo sapiens)

From WikiPathways

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(Replace a PubChem SID with a Wikidata ID (which has more links out).)
(Updated Fibrinogen as complex with 3 subunits, changed fibrin datanode type from protein to metabolite.)
Line 2: Line 2:
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Selenium Micronutrient Network" Organism="Homo sapiens">
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Selenium Micronutrient Network" Organism="Homo sapiens">
   <Comment Source="WikiPathways-description">The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at:  http://www.selenodb.org</Comment>
   <Comment Source="WikiPathways-description">The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at:  http://www.selenodb.org</Comment>
-
   <Graphics BoardWidth="3725.9999999999995" BoardHeight="2671.0"/>
+
   <Graphics BoardWidth="3725.9999999999995" BoardHeight="2671.0" />
   <DataNode TextLabel="Lipoxin A4" GraphId="a438a" Type="Metabolite">
   <DataNode TextLabel="Lipoxin A4" GraphId="a438a" Type="Metabolite">
     <BiopaxRef>d95</BiopaxRef>
     <BiopaxRef>d95</BiopaxRef>
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     <Graphics CenterX="2642.0" CenterY="2349.3166666666666" Width="62.0" Height="16.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB04385"/>
+
     <Xref Database="HMDB" ID="HMDB04385" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGD2" GraphId="a79b9" Type="Metabolite">
   <DataNode TextLabel="PGD2" GraphId="a79b9" Type="Metabolite">
Line 12: Line 12:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>c9c</BiopaxRef>
     <BiopaxRef>c9c</BiopaxRef>
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-
     <Xref Database="HMDB" ID="HMDB01403"/>
+
     <Xref Database="HMDB" ID="HMDB01403" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Arachidonic acid" GraphId="a7bc6" Type="Metabolite">
   <DataNode TextLabel="Arachidonic acid" GraphId="a7bc6" Type="Metabolite">
Line 21: Line 21:
     <BiopaxRef>d00</BiopaxRef>
     <BiopaxRef>d00</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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-
     <Xref Database="HMDB" ID="HMDB01043"/>
+
     <Xref Database="HMDB" ID="HMDB01043" />
 +
  </DataNode>
 +
  <DataNode TextLabel="FGA" GraphId="ae014" Type="Protein" GroupRef="e46d6">
 +
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 +
    <Xref Database="Ensembl" ID="ENSG00000171560" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE1" GraphId="ae558" Type="Metabolite">
   <DataNode TextLabel="PGE1" GraphId="ae558" Type="Metabolite">
Line 28: Line 32:
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>b1f</BiopaxRef>
     <BiopaxRef>b1f</BiopaxRef>
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-
     <Xref Database="HMDB" ID="HMDB01442"/>
+
     <Xref Database="HMDB" ID="HMDB01442" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thromboxane B2" GraphId="b71db" Type="Metabolite">
   <DataNode TextLabel="Thromboxane B2" GraphId="b71db" Type="Metabolite">
     <BiopaxRef>f21</BiopaxRef>
     <BiopaxRef>f21</BiopaxRef>
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     <Graphics CenterX="1991.5" CenterY="2310.3166666666666" Width="83.0" Height="18.7" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="HMDB" ID="HMDB03252"/>
+
     <Xref Database="HMDB" ID="HMDB03252" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Lipoxin B4" GraphId="b8717" Type="Metabolite">
   <DataNode TextLabel="Lipoxin B4" GraphId="b8717" Type="Metabolite">
     <BiopaxRef>d95</BiopaxRef>
     <BiopaxRef>d95</BiopaxRef>
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     <Graphics CenterX="2760.0" CenterY="933.3166666666667" Width="62.0" Height="16.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB05082"/>
+
     <Xref Database="HMDB" ID="HMDB05082" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thromboxane A2" GraphId="b948f" Type="Metabolite">
   <DataNode TextLabel="Thromboxane A2" GraphId="b948f" Type="Metabolite">
Line 45: Line 49:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>d18</BiopaxRef>
     <BiopaxRef>d18</BiopaxRef>
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     <Graphics CenterX="1991.5" CenterY="1673.3166666666666" Width="83.0" Height="16.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01452"/>
+
     <Xref Database="HMDB" ID="HMDB01452" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Linoleic acid" GraphId="bb33d" Type="Metabolite">
   <DataNode TextLabel="Linoleic acid" GraphId="bb33d" Type="Metabolite">
     <BiopaxRef>fcb</BiopaxRef>
     <BiopaxRef>fcb</BiopaxRef>
     <BiopaxRef>e68</BiopaxRef>
     <BiopaxRef>e68</BiopaxRef>
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-
     <Xref Database="HMDB" ID="HMDB00673"/>
+
     <Xref Database="HMDB" ID="HMDB00673" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="a-Tocopherol" GraphId="bc4fd" Type="Metabolite">
   <DataNode TextLabel="a-Tocopherol" GraphId="bc4fd" Type="Metabolite">
Line 61: Line 65:
     <BiopaxRef>fb5</BiopaxRef>
     <BiopaxRef>fb5</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
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-
     <Xref Database="HMDB" ID="HMDB01893"/>
+
     <Xref Database="HMDB" ID="HMDB01893" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Arachidonic acid" GraphId="c2c40" Type="Metabolite">
   <DataNode TextLabel="Arachidonic acid" GraphId="c2c40" Type="Metabolite">
     <BiopaxRef>b30</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
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     <Graphics CenterX="1880.5" CenterY="2146.3166666666666" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01043"/>
+
     <Xref Database="HMDB" ID="HMDB01043" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Lipoxin A4" GraphId="c358a" Type="Metabolite">
   <DataNode TextLabel="Lipoxin A4" GraphId="c358a" Type="Metabolite">
     <BiopaxRef>d95</BiopaxRef>
     <BiopaxRef>d95</BiopaxRef>
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-
     <Xref Database="HMDB" ID="HMDB04385"/>
+
     <Xref Database="HMDB" ID="HMDB04385" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="F2-Isoprostane" GraphId="c38a5" Type="Metabolite">
   <DataNode TextLabel="F2-Isoprostane" GraphId="c38a5" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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-
     <Xref Database="Wikidata" ID="Q33659470"/>
+
     <Xref Database="Wikidata" ID="Q33659470" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DHA" GraphId="c468d" Type="Metabolite">
   <DataNode TextLabel="DHA" GraphId="c468d" Type="Metabolite">
Line 83: Line 87:
     <BiopaxRef>f8d</BiopaxRef>
     <BiopaxRef>f8d</BiopaxRef>
     <BiopaxRef>fe6</BiopaxRef>
     <BiopaxRef>fe6</BiopaxRef>
-
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     <Graphics CenterX="1849.0" CenterY="1087.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02183"/>
+
     <Xref Database="HMDB" ID="HMDB02183" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="c75f4" Type="Metabolite">
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="c75f4" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
-
     <Graphics CenterX="2245.65" CenterY="1450.0" Width="114.7" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="2245.65" CenterY="1450.0" Width="114.7" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB05083"/>
+
     <Xref Database="HMDB" ID="HMDB05083" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGI2" GraphId="c8082" Type="Metabolite">
   <DataNode TextLabel="PGI2" GraphId="c8082" Type="Metabolite">
     <Comment>Prostaglandin I2</Comment>
     <Comment>Prostaglandin I2</Comment>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
-
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     <Graphics CenterX="1837.0" CenterY="2310.3166666666666" Width="47.333333333333336" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01335"/>
+
     <Xref Database="HMDB" ID="HMDB01335" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE2" GraphId="c8c2d" Type="Metabolite">
   <DataNode TextLabel="PGE2" GraphId="c8c2d" Type="Metabolite">
     <Comment>Prostaglandin E2</Comment>
     <Comment>Prostaglandin E2</Comment>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
-
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-
     <Xref Database="HMDB" ID="HMDB01220"/>
+
     <Xref Database="HMDB" ID="HMDB01220" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thromboxane B2" GraphId="cb799" Type="Metabolite">
   <DataNode TextLabel="Thromboxane B2" GraphId="cb799" Type="Metabolite">
     <BiopaxRef>f21</BiopaxRef>
     <BiopaxRef>f21</BiopaxRef>
-
     <Graphics CenterX="1991.5" CenterY="1758.3166666666666" Width="83.0" Height="18.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="1991.5" CenterY="1758.3166666666666" Width="83.0" Height="18.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03252"/>
+
     <Xref Database="HMDB" ID="HMDB03252" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RELA" GraphId="cbb48" Type="GeneProduct" GroupRef="c57bc">
   <DataNode TextLabel="RELA" GraphId="cbb48" Type="GeneProduct" GroupRef="c57bc">
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65</Comment>
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65</Comment>
-
     <Graphics CenterX="1550.6666666666667" CenterY="1461.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff00ff"/>
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     <Graphics CenterX="1550.6666666666667" CenterY="1461.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff00ff" />
-
     <Xref Database="Entrez Gene" ID="5970"/>
+
     <Xref Database="Entrez Gene" ID="5970" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MDA" GraphId="cda46" Type="Metabolite">
   <DataNode TextLabel="MDA" GraphId="cda46" Type="Metabolite">
     <Comment>Malondialdehyde</Comment>
     <Comment>Malondialdehyde</Comment>
     <BiopaxRef>d63</BiopaxRef>
     <BiopaxRef>d63</BiopaxRef>
-
     <Graphics CenterX="2003.0" CenterY="2417.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="2003.0" CenterY="2417.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB06112"/>
+
     <Xref Database="HMDB" ID="HMDB06112" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE2" GraphId="ce534" Type="Metabolite">
   <DataNode TextLabel="PGE2" GraphId="ce534" Type="Metabolite">
Line 123: Line 127:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
-
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-
     <Xref Database="HMDB" ID="HMDB01220"/>
+
     <Xref Database="HMDB" ID="HMDB01220" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="a-Tocopherol" GraphId="ce5f2" Type="Metabolite">
   <DataNode TextLabel="a-Tocopherol" GraphId="ce5f2" Type="Metabolite">
Line 132: Line 136:
     <BiopaxRef>fb3</BiopaxRef>
     <BiopaxRef>fb3</BiopaxRef>
     <BiopaxRef>fb5</BiopaxRef>
     <BiopaxRef>fb5</BiopaxRef>
-
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     <Graphics CenterX="2256.8166666666666" CenterY="2224.8333333333335" Width="107.03333333333333" Height="25.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01893"/>
+
     <Xref Database="HMDB" ID="HMDB01893" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGI2" GraphId="ceac0" Type="Metabolite">
   <DataNode TextLabel="PGI2" GraphId="ceac0" Type="Metabolite">
     <Comment>Prostaglandin I2</Comment>
     <Comment>Prostaglandin I2</Comment>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
-
     <Graphics CenterX="1837.0" CenterY="1673.3166666666668" Width="47.333333333333336" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="1837.0" CenterY="1673.3166666666668" Width="47.333333333333336" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01335"/>
+
     <Xref Database="HMDB" ID="HMDB01335" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGF2a" GraphId="d16da" Type="Metabolite">
   <DataNode TextLabel="PGF2a" GraphId="d16da" Type="Metabolite">
     <Comment>Prostaglandin F2a</Comment>
     <Comment>Prostaglandin F2a</Comment>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
-
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-
     <Xref Database="HMDB" ID="HMDB01139"/>
+
     <Xref Database="HMDB" ID="HMDB01139" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DHA" GraphId="d3705" Type="Metabolite">
   <DataNode TextLabel="DHA" GraphId="d3705" Type="Metabolite">
Line 151: Line 155:
     <BiopaxRef>f8d</BiopaxRef>
     <BiopaxRef>f8d</BiopaxRef>
     <BiopaxRef>fe6</BiopaxRef>
     <BiopaxRef>fe6</BiopaxRef>
-
     <Graphics CenterX="1849.0" CenterY="2371.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1849.0" CenterY="2371.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02183"/>
+
     <Xref Database="HMDB" ID="HMDB02183" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="COX2" GraphId="d63c5" Type="Protein">
   <DataNode TextLabel="COX2" GraphId="d63c5" Type="Protein">
Line 169: Line 173:
     <BiopaxRef>eb5</BiopaxRef>
     <BiopaxRef>eb5</BiopaxRef>
     <BiopaxRef>b1f</BiopaxRef>
     <BiopaxRef>b1f</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="5743"/>
+
     <Xref Database="Entrez Gene" ID="5743" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="COX1" GraphId="d657b" Type="Protein">
   <DataNode TextLabel="COX1" GraphId="d657b" Type="Protein">
Line 180: Line 184:
     <BiopaxRef>c8e</BiopaxRef>
     <BiopaxRef>c8e</BiopaxRef>
     <BiopaxRef>eb5</BiopaxRef>
     <BiopaxRef>eb5</BiopaxRef>
-
     <Graphics CenterX="1787.8166666666666" CenterY="1242.4833333333333" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32768" FontSize="10" Valign="Middle" Color="999996"/>
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     <Graphics CenterX="1787.8166666666666" CenterY="1242.4833333333333" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32768" FontSize="10" Valign="Middle" Color="999996" />
-
     <Xref Database="Entrez Gene" ID="5742"/>
+
     <Xref Database="Entrez Gene" ID="5742" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALA" GraphId="d6ac0" Type="Metabolite">
   <DataNode TextLabel="ALA" GraphId="d6ac0" Type="Metabolite">
     <Comment>Alpha-Linolenic acid</Comment>
     <Comment>Alpha-Linolenic acid</Comment>
     <BiopaxRef>f8d</BiopaxRef>
     <BiopaxRef>f8d</BiopaxRef>
-
     <Graphics CenterX="1732.0" CenterY="2363.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1732.0" CenterY="2363.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01388"/>
+
     <Xref Database="HMDB" ID="HMDB01388" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGF2a" GraphId="d78db" Type="Metabolite">
   <DataNode TextLabel="PGF2a" GraphId="d78db" Type="Metabolite">
Line 193: Line 197:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
-
     <Graphics CenterX="1904.8333333333333" CenterY="1673.3166666666664" Width="53.0" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1904.8333333333333" CenterY="1673.3166666666664" Width="53.0" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01139"/>
+
     <Xref Database="HMDB" ID="HMDB01139" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="EPA" GraphId="d832d" Type="Metabolite">
   <DataNode TextLabel="EPA" GraphId="d832d" Type="Metabolite">
     <Comment>Eicosapentaenoic acid</Comment>
     <Comment>Eicosapentaenoic acid</Comment>
     <BiopaxRef>c8e</BiopaxRef>
     <BiopaxRef>c8e</BiopaxRef>
-
     <Graphics CenterX="1976.0" CenterY="999.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1976.0" CenterY="999.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01999"/>
+
     <Xref Database="HMDB" ID="HMDB01999" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGD2" GraphId="d8720" Type="Metabolite">
   <DataNode TextLabel="PGD2" GraphId="d8720" Type="Metabolite">
     <Comment>Prostaglandin D2</Comment>
     <Comment>Prostaglandin D2</Comment>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
-
     <Graphics CenterX="1770.9833333333333" CenterY="2310.3166666666666" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1770.9833333333333" CenterY="2310.3166666666666" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01403"/>
+
     <Xref Database="HMDB" ID="HMDB01403" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Linoleic acid" GraphId="dc083" Type="Metabolite">
   <DataNode TextLabel="Linoleic acid" GraphId="dc083" Type="Metabolite">
     <BiopaxRef>fcb</BiopaxRef>
     <BiopaxRef>fcb</BiopaxRef>
     <BiopaxRef>e68</BiopaxRef>
     <BiopaxRef>e68</BiopaxRef>
-
     <Graphics CenterX="1667.6666666666667" CenterY="2258.3166666666666" Width="73.33333333333333" Height="19.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1667.6666666666667" CenterY="2258.3166666666666" Width="73.33333333333333" Height="19.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00673"/>
+
     <Xref Database="HMDB" ID="HMDB00673" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE1" GraphId="dc9f7" Type="Metabolite">
   <DataNode TextLabel="PGE1" GraphId="dc9f7" Type="Metabolite">
Line 218: Line 222:
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>b1f</BiopaxRef>
     <BiopaxRef>b1f</BiopaxRef>
-
     <Graphics CenterX="1639.3166666666666" CenterY="1673.3166666666668" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1639.3166666666666" CenterY="1673.3166666666668" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01442"/>
+
     <Xref Database="HMDB" ID="HMDB01442" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DGLA" GraphId="de8da" Type="Metabolite">
   <DataNode TextLabel="DGLA" GraphId="de8da" Type="Metabolite">
Line 226: Line 230:
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>b1f</BiopaxRef>
     <BiopaxRef>b1f</BiopaxRef>
-
     <Graphics CenterX="1676.6666666666667" CenterY="1272.5" Width="73.33333333333333" Height="19.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1676.6666666666667" CenterY="1272.5" Width="73.33333333333333" Height="19.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02925"/>
+
     <Xref Database="HMDB" ID="HMDB02925" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NFkB1" GraphId="dee1e" Type="GeneProduct" GroupRef="c57bc">
   <DataNode TextLabel="NFkB1" GraphId="dee1e" Type="GeneProduct" GroupRef="c57bc">
     <Comment>nuclear factor NF-kappa-B p50 subunit</Comment>
     <Comment>nuclear factor NF-kappa-B p50 subunit</Comment>
-
     <Graphics CenterX="1550.6666666666667" CenterY="1421.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff00ff"/>
+
     <Graphics CenterX="1550.6666666666667" CenterY="1421.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff00ff" />
-
     <Xref Database="Entrez Gene" ID="4790"/>
+
     <Xref Database="Entrez Gene" ID="4790" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="F2-Isoprostane" GraphId="e3d61" Type="Metabolite">
   <DataNode TextLabel="F2-Isoprostane" GraphId="e3d61" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
-
     <Graphics CenterX="2151.3166666666666" CenterY="1368.8172157279491" Width="86.03333333333333" Height="29.634431455897943" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2151.3166666666666" CenterY="1368.8172157279491" Width="86.03333333333333" Height="29.634431455897943" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="Wikidata" ID="Q33659470"/>
+
     <Xref Database="Wikidata" ID="Q33659470" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DPA" GraphId="e6845" Type="Metabolite">
   <DataNode TextLabel="DPA" GraphId="e6845" Type="Metabolite">
     <Comment>Docosapentaenoic acid</Comment>
     <Comment>Docosapentaenoic acid</Comment>
     <BiopaxRef>fe6</BiopaxRef>
     <BiopaxRef>fe6</BiopaxRef>
-
     <Graphics CenterX="1969.0" CenterY="2371.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1969.0" CenterY="2371.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01976"/>
+
     <Xref Database="HMDB" ID="HMDB01976" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Lipoxin B4" GraphId="e6f1f" Type="Metabolite">
   <DataNode TextLabel="Lipoxin B4" GraphId="e6f1f" Type="Metabolite">
     <BiopaxRef>d95</BiopaxRef>
     <BiopaxRef>d95</BiopaxRef>
-
     <Graphics CenterX="2760.0" CenterY="2257.3166666666666" Width="62.0" Height="16.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2760.0" CenterY="2257.3166666666666" Width="62.0" Height="16.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB05082"/>
+
     <Xref Database="HMDB" ID="HMDB05082" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGH3" GraphId="e848a" Type="Metabolite">
   <DataNode TextLabel="PGH3" GraphId="e848a" Type="Metabolite">
Line 254: Line 258:
     <BiopaxRef>c8e</BiopaxRef>
     <BiopaxRef>c8e</BiopaxRef>
     <BiopaxRef>d9c</BiopaxRef>
     <BiopaxRef>d9c</BiopaxRef>
-
     <Graphics CenterX="1976.65" CenterY="1492.9833333333333" Width="91.0" Height="21.36666666666656" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1976.65" CenterY="1492.9833333333333" Width="91.0" Height="21.36666666666656" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB13040"/>
+
     <Xref Database="HMDB" ID="HMDB13040" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGG2" GraphId="e92a2" Type="Metabolite">
   <DataNode TextLabel="PGG2" GraphId="e92a2" Type="Metabolite">
     <Comment>Prostaglandin G2</Comment>
     <Comment>Prostaglandin G2</Comment>
     <BiopaxRef>eb5</BiopaxRef>
     <BiopaxRef>eb5</BiopaxRef>
-
     <Graphics CenterX="1902.65" CenterY="1348.9833333333333" Width="91.0" Height="21.36666666666656" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1902.65" CenterY="1348.9833333333333" Width="91.0" Height="21.36666666666656" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03235"/>
+
     <Xref Database="HMDB" ID="HMDB03235" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="e93f4" Type="Metabolite">
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="e93f4" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
-
     <Graphics CenterX="2244.65" CenterY="2420.0" Width="114.7" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2244.65" CenterY="2420.0" Width="114.7" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB05083"/>
+
     <Xref Database="HMDB" ID="HMDB05083" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DPA" GraphId="ea849" Type="Metabolite">
   <DataNode TextLabel="DPA" GraphId="ea849" Type="Metabolite">
     <Comment>Docosapentaenoic acid</Comment>
     <Comment>Docosapentaenoic acid</Comment>
     <BiopaxRef>fe6</BiopaxRef>
     <BiopaxRef>fe6</BiopaxRef>
-
     <Graphics CenterX="1969.0" CenterY="1087.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1969.0" CenterY="1087.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01976"/>
+
     <Xref Database="HMDB" ID="HMDB01976" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="EPA" GraphId="f3cc5" Type="Metabolite">
   <DataNode TextLabel="EPA" GraphId="f3cc5" Type="Metabolite">
     <Comment>Eicosapentaenoic acid</Comment>
     <Comment>Eicosapentaenoic acid</Comment>
     <BiopaxRef>c8e</BiopaxRef>
     <BiopaxRef>c8e</BiopaxRef>
-
     <Graphics CenterX="2169.0" CenterY="2386.3166666666666" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2169.0" CenterY="2386.3166666666666" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01999"/>
+
     <Xref Database="HMDB" ID="HMDB01999" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALA" GraphId="f7a72" Type="Metabolite">
   <DataNode TextLabel="ALA" GraphId="f7a72" Type="Metabolite">
     <Comment>Alpha-Linolenic acid</Comment>
     <Comment>Alpha-Linolenic acid</Comment>
     <BiopaxRef>f8d</BiopaxRef>
     <BiopaxRef>f8d</BiopaxRef>
-
     <Graphics CenterX="1732.0" CenterY="1087.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1732.0" CenterY="1087.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01388"/>
+
     <Xref Database="HMDB" ID="HMDB01388" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NFkB2" GraphId="f9052" Type="GeneProduct" GroupRef="c57bc">
   <DataNode TextLabel="NFkB2" GraphId="f9052" Type="GeneProduct" GroupRef="c57bc">
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 2</Comment>
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 2</Comment>
-
     <Graphics CenterX="1550.6666666666667" CenterY="1441.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff00ff"/>
+
     <Graphics CenterX="1550.6666666666667" CenterY="1441.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff00ff" />
-
     <Xref Database="Entrez Gene" ID="4791"/>
+
     <Xref Database="Entrez Gene" ID="4791" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MDA" GraphId="fd626" Type="Metabolite">
   <DataNode TextLabel="MDA" GraphId="fd626" Type="Metabolite">
     <Comment>Malondialdehyde</Comment>
     <Comment>Malondialdehyde</Comment>
     <BiopaxRef>d63</BiopaxRef>
     <BiopaxRef>d63</BiopaxRef>
-
     <Graphics CenterX="2003.0" CenterY="1217.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2003.0" CenterY="1217.5" Width="91.0" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB06112"/>
+
     <Xref Database="HMDB" ID="HMDB06112" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGH2" GraphId="feb41" Type="Metabolite">
   <DataNode TextLabel="PGH2" GraphId="feb41" Type="Metabolite">
     <Comment>Prostaglandin H2</Comment>
     <Comment>Prostaglandin H2</Comment>
     <BiopaxRef>d00</BiopaxRef>
     <BiopaxRef>d00</BiopaxRef>
-
     <Graphics CenterX="1903.65" CenterY="1441.9833333333333" Width="91.0" Height="21.36666666666656" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1903.65" CenterY="1441.9833333333333" Width="91.0" Height="21.36666666666656" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01381"/>
+
     <Xref Database="HMDB" ID="HMDB01381" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE3" GraphId="ffaea" Type="Metabolite">
   <DataNode TextLabel="PGE3" GraphId="ffaea" Type="Metabolite">
     <Comment>Prostaglandin E3</Comment>
     <Comment>Prostaglandin E3</Comment>
     <BiopaxRef>c8e</BiopaxRef>
     <BiopaxRef>c8e</BiopaxRef>
-
     <Graphics CenterX="2081.3166666666666" CenterY="1673.3166666666666" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2081.3166666666666" CenterY="1673.3166666666666" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02664"/>
+
     <Xref Database="HMDB" ID="HMDB02664" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Kynurenine" GraphId="bc30c" Type="Metabolite">
   <DataNode TextLabel="Kynurenine" GraphId="bc30c" Type="Metabolite">
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
-
     <Graphics CenterX="1033.6666666666667" CenterY="1645.3166666666666" Width="71.33333333333326" Height="21.333333333333314" ZOrder="32770" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1033.6666666666667" CenterY="1645.3166666666666" Width="71.33333333333326" Height="21.333333333333314" ZOrder="32770" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00684"/>
+
     <Xref Database="HMDB" ID="HMDB00684" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTR" GraphId="fba72" Type="Protein">
   <DataNode TextLabel="MTR" GraphId="fba72" Type="Protein">
Line 319: Line 323:
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>c2d</BiopaxRef>
-
     <Graphics CenterX="496.3333333333333" CenterY="1568.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="496.3333333333333" CenterY="1568.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4548"/>
+
     <Xref Database="Entrez Gene" ID="4548" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TRXR1" GraphId="e3880" Type="Protein" GroupRef="e0614">
   <DataNode TextLabel="TRXR1" GraphId="e3880" Type="Protein" GroupRef="e0614">
     <Comment>EC 1.8.1.9</Comment>
     <Comment>EC 1.8.1.9</Comment>
     <Comment>Selenoprotein-thioredoxin reductase 1</Comment>
     <Comment>Selenoprotein-thioredoxin reductase 1</Comment>
-
     <Graphics CenterX="1332.0" CenterY="283.8333333333333" Width="78.66666666666667" Height="17.0" ZOrder="32774" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1332.0" CenterY="283.8333333333333" Width="78.66666666666667" Height="17.0" ZOrder="32774" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="7296"/>
+
     <Xref Database="Entrez Gene" ID="7296" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CBS" GraphId="c4433" Type="Protein">
   <DataNode TextLabel="CBS" GraphId="c4433" Type="Protein">
Line 333: Line 337:
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
-
     <Graphics CenterX="329.3333333333333" CenterY="1726.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32776" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="329.3333333333333" CenterY="1726.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32776" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="875"/>
+
     <Xref Database="Entrez Gene" ID="875" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Iodine" GraphId="c80df" Type="Metabolite">
   <DataNode TextLabel="Iodine" GraphId="c80df" Type="Metabolite">
     <BiopaxRef>e0b</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
-
     <Graphics CenterX="2930.0" CenterY="2297.833333333333" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32778" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="2930.0" CenterY="2297.833333333333" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32778" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="Wikidata" ID="Q1103"/>
+
     <Xref Database="Wikidata" ID="Q1103" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Iodine" GraphId="df988" Type="Metabolite">
   <DataNode TextLabel="Iodine" GraphId="df988" Type="Metabolite">
     <BiopaxRef>e0b</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
-
     <Graphics CenterX="2874.0" CenterY="490.8333333333331" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32778" FontSize="10" Valign="Middle" Color="009933"/>
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-
     <Xref Database="Wikidata" ID="Q1103"/>
+
     <Xref Database="Wikidata" ID="Q1103" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="KMO" GraphId="cc807" Type="Protein">
   <DataNode TextLabel="KMO" GraphId="cc807" Type="Protein">
Line 350: Line 354:
     <Comment>kynurenine 3-hydroxylase</Comment>
     <Comment>kynurenine 3-hydroxylase</Comment>
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
-
     <Graphics CenterX="1100.3333333333333" CenterY="1590.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32780" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="1100.3333333333333" CenterY="1590.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32780" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="8564"/>
+
     <Xref Database="Entrez Gene" ID="8564" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="R-Triiodothyronine (rT3)" GraphId="a5609" Type="Metabolite">
   <DataNode TextLabel="R-Triiodothyronine (rT3)" GraphId="a5609" Type="Metabolite">
Line 357: Line 361:
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>c37</BiopaxRef>
     <BiopaxRef>c37</BiopaxRef>
-
     <Graphics CenterX="2810.5" CenterY="2351.3166666666666" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2810.5" CenterY="2351.3166666666666" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="28774"/>
+
     <Xref Database="ChEBI" ID="28774" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Triiodothyronine (T3)" GraphId="af9f8" Type="Metabolite">
   <DataNode TextLabel="Triiodothyronine (T3)" GraphId="af9f8" Type="Metabolite">
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
-
     <Graphics CenterX="2703.5" CenterY="434.14999999999986" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="2703.5" CenterY="434.14999999999986" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="18258"/>
+
     <Xref Database="ChEBI" ID="18258" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="15-HETE" GraphId="b2775" Type="Metabolite">
   <DataNode TextLabel="15-HETE" GraphId="b2775" Type="Metabolite">
Line 370: Line 374:
     <BiopaxRef>b30</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
     <BiopaxRef>d95</BiopaxRef>
     <BiopaxRef>d95</BiopaxRef>
-
     <Graphics CenterX="2546.0" CenterY="851.3166666666667" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2546.0" CenterY="851.3166666666667" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03876"/>
+
     <Xref Database="HMDB" ID="HMDB03876" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thyroxine (T4)" GraphId="c4512" Type="Metabolite">
   <DataNode TextLabel="Thyroxine (T4)" GraphId="c4512" Type="Metabolite">
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
-
     <Graphics CenterX="2703.5" CenterY="543.15" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2703.5" CenterY="543.15" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="30660"/>
+
     <Xref Database="ChEBI" ID="30660" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-HPETE" GraphId="ce455" Type="Metabolite">
   <DataNode TextLabel="5-HPETE" GraphId="ce455" Type="Metabolite">
Line 384: Line 388:
     <BiopaxRef>fad</BiopaxRef>
     <BiopaxRef>fad</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
-
     <Graphics CenterX="2198.0" CenterY="944.3166666666667" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2198.0" CenterY="944.3166666666667" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01193"/>
+
     <Xref Database="HMDB" ID="HMDB01193" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5,6-Epoxytetraene" GraphId="cfc2b" Type="Metabolite">
   <DataNode TextLabel="5,6-Epoxytetraene" GraphId="cfc2b" Type="Metabolite">
     <BiopaxRef>d95</BiopaxRef>
     <BiopaxRef>d95</BiopaxRef>
-
     <Graphics CenterX="2702.0" CenterY="851.3166666666667" Width="94.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2702.0" CenterY="851.3166666666667" Width="94.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="KEGG Compound" ID="C14815"/>
+
     <Xref Database="KEGG Compound" ID="C14815" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="R-Triiodothyronine (rT3)" GraphId="d8e2a" Type="Metabolite">
   <DataNode TextLabel="R-Triiodothyronine (rT3)" GraphId="d8e2a" Type="Metabolite">
Line 396: Line 400:
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
-
     <Graphics CenterX="2703.5" CenterY="652.1499999999999" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="2703.5" CenterY="652.1499999999999" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="28774"/>
+
     <Xref Database="ChEBI" ID="28774" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="15-HETE" GraphId="d985f" Type="Metabolite">
   <DataNode TextLabel="15-HETE" GraphId="d985f" Type="Metabolite">
     <Comment>15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid</Comment>
     <Comment>15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid</Comment>
     <BiopaxRef>b30</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
-
     <Graphics CenterX="2496.0" CenterY="2349.3166666666666" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="2496.0" CenterY="2349.3166666666666" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03876"/>
+
     <Xref Database="HMDB" ID="HMDB03876" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Triiodothyronine (T3)" GraphId="e744d" Type="Metabolite">
   <DataNode TextLabel="Triiodothyronine (T3)" GraphId="e744d" Type="Metabolite">
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>c37</BiopaxRef>
     <BiopaxRef>c37</BiopaxRef>
-
     <Graphics CenterX="2976.5" CenterY="2417.3166666666666" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="2976.5" CenterY="2417.3166666666666" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="18258"/>
+
     <Xref Database="ChEBI" ID="18258" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-HETE" GraphId="e8b87" Type="Metabolite">
   <DataNode TextLabel="5-HETE" GraphId="e8b87" Type="Metabolite">
Line 416: Line 420:
     <BiopaxRef>fad</BiopaxRef>
     <BiopaxRef>fad</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
-
     <Graphics CenterX="2199.0" CenterY="2472.3166666666666" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2199.0" CenterY="2472.3166666666666" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB11134"/>
+
     <Xref Database="HMDB" ID="HMDB11134" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thyroxine (T4)" GraphId="ea35e" Type="Metabolite">
   <DataNode TextLabel="Thyroxine (T4)" GraphId="ea35e" Type="Metabolite">
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>c37</BiopaxRef>
     <BiopaxRef>c37</BiopaxRef>
-
     <Graphics CenterX="2891.5" CenterY="2381.3166666666666" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="2891.5" CenterY="2381.3166666666666" Width="117.0" Height="16.69999999999999" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="30660"/>
+
     <Xref Database="ChEBI" ID="30660" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-HETE" GraphId="eea23" Type="Metabolite">
   <DataNode TextLabel="5-HETE" GraphId="eea23" Type="Metabolite">
Line 430: Line 434:
     <BiopaxRef>fad</BiopaxRef>
     <BiopaxRef>fad</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
-
     <Graphics CenterX="2199.0" CenterY="1024.3166666666666" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2199.0" CenterY="1024.3166666666666" Width="62.0" Height="16.7" ZOrder="32782" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB11134"/>
+
     <Xref Database="HMDB" ID="HMDB11134" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="fbaf7" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="fbaf7" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="748.1666666666666" CenterY="1665.8166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
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-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB00217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MPO" GraphId="c7ac2" Type="Protein">
   <DataNode TextLabel="MPO" GraphId="c7ac2" Type="Protein">
Line 445: Line 449:
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
-
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     <Graphics CenterX="706.3333333333334" CenterY="1130.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4353"/>
+
     <Xref Database="Entrez Gene" ID="4353" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Catalase" GraphId="cf958" Type="Protein">
   <DataNode TextLabel="Catalase" GraphId="cf958" Type="Protein">
Line 452: Line 456:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>de0</BiopaxRef>
     <BiopaxRef>de0</BiopaxRef>
-
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     <Graphics CenterX="1157.3333333333333" CenterY="1142.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="847"/>
+
     <Xref Database="Entrez Gene" ID="847" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MPO" GraphId="faa3d" Type="Protein">
   <DataNode TextLabel="MPO" GraphId="faa3d" Type="Protein">
Line 459: Line 463:
     <Comment>Myeloperoxidase</Comment>
     <Comment>Myeloperoxidase</Comment>
     <BiopaxRef>c2b</BiopaxRef>
     <BiopaxRef>c2b</BiopaxRef>
-
     <Graphics CenterX="675.3333333333334" CenterY="2374.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="675.3333333333334" CenterY="2374.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4353"/>
+
     <Xref Database="Entrez Gene" ID="4353" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Uric acid" GraphId="e6791" Type="Metabolite">
   <DataNode TextLabel="Uric acid" GraphId="e6791" Type="Metabolite">
     <BiopaxRef>f84</BiopaxRef>
     <BiopaxRef>f84</BiopaxRef>
     <BiopaxRef>f4e</BiopaxRef>
     <BiopaxRef>f4e</BiopaxRef>
-
     <Graphics CenterX="446.0" CenterY="2130.6666666666665" Width="56.0" Height="17.0" ZOrder="32788" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="446.0" CenterY="2130.6666666666665" Width="56.0" Height="17.0" ZOrder="32788" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00289"/>
+
     <Xref Database="HMDB" ID="HMDB00289" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cysteine" GraphId="e5057" Type="Metabolite">
   <DataNode TextLabel="Cysteine" GraphId="e5057" Type="Metabolite">
-
     <Graphics CenterX="142.0" CenterY="1779.8333333333333" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="142.0" CenterY="1779.8333333333333" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00574"/>
+
     <Xref Database="HMDB" ID="HMDB00574" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Factor VII" GraphId="a2e9b" Type="Protein">
   <DataNode TextLabel="Factor VII" GraphId="a2e9b" Type="Protein">
Line 477: Line 481:
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>d29</BiopaxRef>
     <BiopaxRef>d29</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="2155"/>
+
     <Xref Database="Entrez Gene" ID="2155" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thrombin" GraphId="a85a9" Type="Protein">
   <DataNode TextLabel="Thrombin" GraphId="a85a9" Type="Protein">
Line 485: Line 489:
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
-
     <Graphics CenterX="2529.8166666666666" CenterY="1948.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="2529.8166666666666" CenterY="1948.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2147"/>
+
     <Xref Database="Entrez Gene" ID="2147" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="tPA" GraphId="bd650" Type="Protein">
   <DataNode TextLabel="tPA" GraphId="bd650" Type="Protein">
Line 492: Line 496:
     <Comment>plasminogen activator, tissue</Comment>
     <Comment>plasminogen activator, tissue</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2693.8166666666666" CenterY="2023.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="2693.8166666666666" CenterY="2023.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="5327"/>
+
     <Xref Database="Entrez Gene" ID="5327" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="tPA" GraphId="bf4fe" Type="Protein">
   <DataNode TextLabel="tPA" GraphId="bf4fe" Type="Protein">
Line 499: Line 503:
     <Comment>plasminogen activator, tissue</Comment>
     <Comment>plasminogen activator, tissue</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2693.8166666666666" CenterY="2127.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="2693.8166666666666" CenterY="2127.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="5327"/>
+
     <Xref Database="Entrez Gene" ID="5327" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAI-1" GraphId="d6714" Type="Protein">
   <DataNode TextLabel="PAI-1" GraphId="d6714" Type="Protein">
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2843.8166666666666" CenterY="2127.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="5054"/>
+
     <Xref Database="Entrez Gene" ID="5054" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PLG" GraphId="e063c" Type="Protein">
   <DataNode TextLabel="PLG" GraphId="e063c" Type="Protein">
Line 512: Line 516:
     <Comment>Plasminogen</Comment>
     <Comment>Plasminogen</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2497.8166666666666" CenterY="2389.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="5340"/>
+
     <Xref Database="Entrez Gene" ID="5340" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thrombin" GraphId="e223c" Type="Protein">
   <DataNode TextLabel="Thrombin" GraphId="e223c" Type="Protein">
Line 520: Line 524:
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
-
     <Graphics CenterX="2497.8166666666666" CenterY="2436.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="2497.8166666666666" CenterY="2436.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2147"/>
+
     <Xref Database="Entrez Gene" ID="2147" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Factor VII" GraphId="e887f" Type="Protein">
   <DataNode TextLabel="Factor VII" GraphId="e887f" Type="Protein">
Line 528: Line 532:
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>d29</BiopaxRef>
     <BiopaxRef>d29</BiopaxRef>
-
     <Graphics CenterX="2498.8166666666666" CenterY="2479.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="2498.8166666666666" CenterY="2479.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2155"/>
+
     <Xref Database="Entrez Gene" ID="2155" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PLG" GraphId="ea7fa" Type="Protein">
   <DataNode TextLabel="PLG" GraphId="ea7fa" Type="Protein">
Line 535: Line 539:
     <Comment>Plasminogen</Comment>
     <Comment>Plasminogen</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2529.8166666666666" CenterY="2023.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="2529.8166666666666" CenterY="2023.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="5340"/>
+
     <Xref Database="Entrez Gene" ID="5340" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAI-1" GraphId="f4722" Type="Protein">
   <DataNode TextLabel="PAI-1" GraphId="f4722" Type="Protein">
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2843.8166666666666" CenterY="2023.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2843.8166666666666" CenterY="2023.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="5054"/>
+
     <Xref Database="Entrez Gene" ID="5054" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GGT1" GraphId="f74ca" Type="Protein">
   <DataNode TextLabel="GGT1" GraphId="f74ca" Type="Protein">
Line 548: Line 552:
     <Comment>gamma-glutamyltransferase 1</Comment>
     <Comment>gamma-glutamyltransferase 1</Comment>
     <BiopaxRef>cf6</BiopaxRef>
     <BiopaxRef>cf6</BiopaxRef>
-
     <Graphics CenterX="2659.8166666666666" CenterY="1328.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="2659.8166666666666" CenterY="1328.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2678"/>
+
     <Xref Database="Entrez Gene" ID="2678" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 4" GraphId="fd41c" Type="Protein" GroupRef="afe71">
   <DataNode TextLabel="GPX 4" GraphId="fd41c" Type="Protein" GroupRef="afe71">
     <Comment>EC 1.11.1.12</Comment>
     <Comment>EC 1.11.1.12</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 4</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 4</Comment>
-
     <Graphics CenterX="1162.5" CenterY="893.0833333333334" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32794" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1162.5" CenterY="893.0833333333334" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32794" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2879"/>
+
     <Xref Database="Entrez Gene" ID="2879" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TRXR2" GraphId="adb0f" Type="Protein" GroupRef="e0614">
   <DataNode TextLabel="TRXR2" GraphId="adb0f" Type="Protein" GroupRef="e0614">
     <Comment>EC 1.8.1.9</Comment>
     <Comment>EC 1.8.1.9</Comment>
     <Comment>Selenoprotein-thioredoxin reductase 2</Comment>
     <Comment>Selenoprotein-thioredoxin reductase 2</Comment>
-
     <Graphics CenterX="1332.0" CenterY="296.8333333333333" Width="78.66666666666667" Height="17.0" ZOrder="32796" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1332.0" CenterY="296.8333333333333" Width="78.66666666666667" Height="17.0" ZOrder="32796" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="10587"/>
+
     <Xref Database="Entrez Gene" ID="10587" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Xantine oxidase" GraphId="d17e4" Type="Protein">
   <DataNode TextLabel="Xantine oxidase" GraphId="d17e4" Type="Protein">
Line 568: Line 572:
     <BiopaxRef>f4e</BiopaxRef>
     <BiopaxRef>f4e</BiopaxRef>
     <BiopaxRef>e0f</BiopaxRef>
     <BiopaxRef>e0f</BiopaxRef>
-
     <Graphics CenterX="344.5" CenterY="722.8333333333334" Width="87.0" Height="19.0" ZOrder="32798" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="344.5" CenterY="722.8333333333334" Width="87.0" Height="19.0" ZOrder="32798" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="7498"/>
+
     <Xref Database="Entrez Gene" ID="7498" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRDX5" GraphId="cb3e2" Type="Protein" GroupRef="c1ae6">
   <DataNode TextLabel="PRDX5" GraphId="cb3e2" Type="Protein" GroupRef="c1ae6">
     <Comment>EC 1.11.1.15</Comment>
     <Comment>EC 1.11.1.15</Comment>
     <Comment>peroxiredoxin 5</Comment>
     <Comment>peroxiredoxin 5</Comment>
-
     <Graphics CenterX="1124.8166666666666" CenterY="517.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32800" FontSize="10" Valign="Middle" Color="999998"/>
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     <Graphics CenterX="1124.8166666666666" CenterY="517.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32800" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="25824"/>
+
     <Xref Database="Entrez Gene" ID="25824" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="H2O2" GraphId="e47b0" Type="Metabolite">
   <DataNode TextLabel="H2O2" GraphId="e47b0" Type="Metabolite">
     <Comment>Hydrogen peroxide</Comment>
     <Comment>Hydrogen peroxide</Comment>
-
     <Graphics CenterX="958.0" CenterY="1082.0" Width="80.0" Height="30.0" ZOrder="32802" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="958.0" CenterY="1082.0" Width="80.0" Height="30.0" ZOrder="32802" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03125"/>
+
     <Xref Database="HMDB" ID="HMDB03125" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALOX5" GraphId="aaa29" Type="Protein">
   <DataNode TextLabel="ALOX5" GraphId="aaa29" Type="Protein">
Line 590: Line 594:
     <BiopaxRef>ade</BiopaxRef>
     <BiopaxRef>ade</BiopaxRef>
     <BiopaxRef>fb5</BiopaxRef>
     <BiopaxRef>fb5</BiopaxRef>
-
     <Graphics CenterX="2191.8166666666666" CenterY="800.1499999999999" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32804" FontSize="10" Valign="Middle" Color="999999"/>
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     <Graphics CenterX="2191.8166666666666" CenterY="800.1499999999999" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32804" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="240"/>
+
     <Xref Database="Entrez Gene" ID="240" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALOX15B" GraphId="b544e" Type="Protein">
   <DataNode TextLabel="ALOX15B" GraphId="b544e" Type="Protein">
Line 598: Line 602:
     <BiopaxRef>b30</BiopaxRef>
     <BiopaxRef>b30</BiopaxRef>
     <BiopaxRef>c82</BiopaxRef>
     <BiopaxRef>c82</BiopaxRef>
-
     <Graphics CenterX="2362.8166666666666" CenterY="718.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32804" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="2362.8166666666666" CenterY="718.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32804" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="247"/>
+
     <Xref Database="Entrez Gene" ID="247" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Copper" GraphId="db9da" Type="Metabolite">
   <DataNode TextLabel="Copper" GraphId="db9da" Type="Metabolite">
-
     <Graphics CenterX="820.0" CenterY="2212.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32806" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="820.0" CenterY="2212.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32806" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00657"/>
+
     <Xref Database="HMDB" ID="HMDB00657" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Uric acid" GraphId="ab5b9" Type="Metabolite">
   <DataNode TextLabel="Uric acid" GraphId="ab5b9" Type="Metabolite">
     <BiopaxRef>f84</BiopaxRef>
     <BiopaxRef>f84</BiopaxRef>
     <BiopaxRef>f4e</BiopaxRef>
     <BiopaxRef>f4e</BiopaxRef>
-
     <Graphics CenterX="460.0" CenterY="793.6666666666666" Width="56.0" Height="17.0" ZOrder="32808" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="460.0" CenterY="793.6666666666666" Width="56.0" Height="17.0" ZOrder="32808" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00289"/>
+
     <Xref Database="HMDB" ID="HMDB00289" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Vitamin B12" GraphId="dbe9f" Type="Metabolite">
   <DataNode TextLabel="Vitamin B12" GraphId="dbe9f" Type="Metabolite">
     <BiopaxRef>c7a</BiopaxRef>
     <BiopaxRef>c7a</BiopaxRef>
     <BiopaxRef>a64</BiopaxRef>
     <BiopaxRef>a64</BiopaxRef>
-
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+
     <Graphics CenterX="496.8333333333333" CenterY="1639.8166666666666" Width="61.666666666666664" Height="17.7" ZOrder="32810" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB02174"/>
+
     <Xref Database="HMDB" ID="HMDB02174" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5,10-Methylene-THF" GraphId="d35e0" Type="Metabolite">
   <DataNode TextLabel="5,10-Methylene-THF" GraphId="d35e0" Type="Metabolite">
     <Comment>5,10-Methylenetetrahydrofolate</Comment>
     <Comment>5,10-Methylenetetrahydrofolate</Comment>
-
     <Graphics CenterX="786.9916666666667" CenterY="1612.3166666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="786.9916666666667" CenterY="1612.3166666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01533"/>
+
     <Xref Database="HMDB" ID="HMDB01533" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelR" GraphId="c4fa0" Type="Protein">
   <DataNode TextLabel="SelR" GraphId="c4fa0" Type="Protein">
Line 627: Line 631:
     <BiopaxRef>aff</BiopaxRef>
     <BiopaxRef>aff</BiopaxRef>
     <BiopaxRef>af9</BiopaxRef>
     <BiopaxRef>af9</BiopaxRef>
-
     <Graphics CenterX="1270.4833333333333" CenterY="1514.4833333333333" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32814" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1270.4833333333333" CenterY="1514.4833333333333" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32814" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="51734"/>
+
     <Xref Database="Entrez Gene" ID="51734" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Tryptophan" GraphId="eb9ae" Type="Metabolite">
   <DataNode TextLabel="Tryptophan" GraphId="eb9ae" Type="Metabolite">
     <BiopaxRef>d0b</BiopaxRef>
     <BiopaxRef>d0b</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
-
     <Graphics CenterX="1495.6666666666667" CenterY="1313.3166666666666" Width="71.33333333333326" Height="21.333333333333314" ZOrder="32816" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1495.6666666666667" CenterY="1313.3166666666666" Width="71.33333333333326" Height="21.333333333333314" ZOrder="32816" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00929"/>
+
     <Xref Database="HMDB" ID="HMDB00929" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-methyl-THF" GraphId="c6bbe" Type="Metabolite">
   <DataNode TextLabel="5-methyl-THF" GraphId="c6bbe" Type="Metabolite">
     <Comment>5-methyltetrahydrofolate</Comment>
     <Comment>5-methyltetrahydrofolate</Comment>
-
     <Graphics CenterX="614.325" CenterY="1612.3166666666666" Width="82.65" Height="21.366666666666674" ZOrder="32818" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="614.325" CenterY="1612.3166666666666" Width="82.65" Height="21.366666666666674" ZOrder="32818" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01396"/>
+
     <Xref Database="HMDB" ID="HMDB01396" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD3" GraphId="cecee" Type="Protein" GroupRef="ae815">
   <DataNode TextLabel="SOD3" GraphId="cecee" Type="Protein" GroupRef="ae815">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
-
     <Graphics CenterX="893.15" CenterY="999.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="893.15" CenterY="999.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="6649"/>
+
     <Xref Database="Entrez Gene" ID="6649" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRDX1" GraphId="ad556" Type="Protein" GroupRef="c1ae6">
   <DataNode TextLabel="PRDX1" GraphId="ad556" Type="Protein" GroupRef="c1ae6">
     <Comment>EC 1.11.1.15</Comment>
     <Comment>EC 1.11.1.15</Comment>
     <Comment>peroxiredoxin 1</Comment>
     <Comment>peroxiredoxin 1</Comment>
-
     <Graphics CenterX="1124.8166666666666" CenterY="460.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32822" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="1124.8166666666666" CenterY="460.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32822" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="5052"/>
+
     <Xref Database="Entrez Gene" ID="5052" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RFK" GraphId="faed3" Type="Protein">
   <DataNode TextLabel="RFK" GraphId="faed3" Type="Protein">
Line 657: Line 661:
     <Comment>riboflavin kinase</Comment>
     <Comment>riboflavin kinase</Comment>
     <BiopaxRef>a22</BiopaxRef>
     <BiopaxRef>a22</BiopaxRef>
-
     <Graphics CenterX="249.33333333333334" CenterY="960.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32824" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="249.33333333333334" CenterY="960.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32824" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="55312"/>
+
     <Xref Database="Entrez Gene" ID="55312" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="H2O" GraphId="ad687" Type="Metabolite">
   <DataNode TextLabel="H2O" GraphId="ad687" Type="Metabolite">
     <Comment>Glutathione disulfide</Comment>
     <Comment>Glutathione disulfide</Comment>
-
     <Graphics CenterX="1274.0" CenterY="1083.0" Width="80.0" Height="30.0" ZOrder="32826" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1274.0" CenterY="1083.0" Width="80.0" Height="30.0" ZOrder="32826" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02111"/>
+
     <Xref Database="HMDB" ID="HMDB02111" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 3" GraphId="cfea7" Type="Protein" GroupRef="afe71">
   <DataNode TextLabel="GPX 3" GraphId="cfea7" Type="Protein" GroupRef="afe71">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
-
     <Graphics CenterX="1162.5" CenterY="878.3833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1162.5" CenterY="878.3833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2878"/>
+
     <Xref Database="Entrez Gene" ID="2878" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Niacinamide" GraphId="cc97b" Type="Metabolite">
   <DataNode TextLabel="Niacinamide" GraphId="cc97b" Type="Metabolite">
-
     <Graphics CenterX="1496.3166666666666" CenterY="1023.3039193632117" Width="70.70000000000005" Height="21.333333333333314" ZOrder="32830" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1496.3166666666666" CenterY="1023.3039193632117" Width="70.70000000000005" Height="21.333333333333314" ZOrder="32830" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01406"/>
+
     <Xref Database="HMDB" ID="HMDB01406" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CTH" GraphId="bed9f" Type="Protein">
   <DataNode TextLabel="CTH" GraphId="bed9f" Type="Protein">
Line 679: Line 683:
     <Comment>cystathionase</Comment>
     <Comment>cystathionase</Comment>
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
-
     <Graphics CenterX="205.33333333333334" CenterY="1726.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32832" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="205.33333333333334" CenterY="1726.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32832" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="1491"/>
+
     <Xref Database="Entrez Gene" ID="1491" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PNPO" GraphId="cbf20" Type="Protein">
   <DataNode TextLabel="PNPO" GraphId="cbf20" Type="Protein">
Line 686: Line 690:
     <Comment>pyridoxamine 5'-phosphate oxidase</Comment>
     <Comment>pyridoxamine 5'-phosphate oxidase</Comment>
     <BiopaxRef>ddc</BiopaxRef>
     <BiopaxRef>ddc</BiopaxRef>
-
     <Graphics CenterX="991.6666666666666" CenterY="1371.4833333333333" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32834" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="991.6666666666666" CenterY="1371.4833333333333" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32834" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="55163"/>
+
     <Xref Database="Entrez Gene" ID="55163" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Heme" GraphId="ca7e6" Type="Metabolite">
   <DataNode TextLabel="Heme" GraphId="ca7e6" Type="Metabolite">
Line 695: Line 699:
     <BiopaxRef>d18</BiopaxRef>
     <BiopaxRef>d18</BiopaxRef>
     <BiopaxRef>b53</BiopaxRef>
     <BiopaxRef>b53</BiopaxRef>
-
     <Graphics CenterX="1338.3166666666666" CenterY="1142.3166666666666" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32836" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1338.3166666666666" CenterY="1142.3166666666666" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32836" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03178"/>
+
     <Xref Database="HMDB" ID="HMDB03178" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="ca100" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="ca100" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="1291.5" CenterY="448.98333333333335" Width="51.0" Height="14.7" ZOrder="32838" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1291.5" CenterY="448.98333333333335" Width="51.0" Height="14.7" ZOrder="32838" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB00221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Lipoic acid" GraphId="c8e06" Type="Metabolite">
   <DataNode TextLabel="Lipoic acid" GraphId="c8e06" Type="Metabolite">
     <BiopaxRef>abc</BiopaxRef>
     <BiopaxRef>abc</BiopaxRef>
-
     <Graphics CenterX="1131.9833333333333" CenterY="2130.65" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32840" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1131.9833333333333" CenterY="2130.65" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32840" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01451"/>
+
     <Xref Database="HMDB" ID="HMDB01451" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Manganese" GraphId="a37df" Type="Metabolite">
   <DataNode TextLabel="Manganese" GraphId="a37df" Type="Metabolite">
-
     <Graphics CenterX="766.0000000000001" CenterY="2180.5" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32842" FontSize="10" Valign="Middle" Color="009833"/>
+
     <Graphics CenterX="766.0000000000001" CenterY="2180.5" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32842" FontSize="10" Valign="Middle" Color="009833" />
-
     <Xref Database="HMDB" ID="HMDB01333"/>
+
     <Xref Database="HMDB" ID="HMDB01333" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="bb0ab" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="bb0ab" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="487.3333333333333" CenterY="1021.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32844" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="487.3333333333333" CenterY="1021.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32844" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01248"/>
+
     <Xref Database="HMDB" ID="HMDB01248" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Methionine sulfoxide" GraphId="af991" Type="Metabolite">
   <DataNode TextLabel="Methionine sulfoxide" GraphId="af991" Type="Metabolite">
     <BiopaxRef>aff</BiopaxRef>
     <BiopaxRef>aff</BiopaxRef>
-
     <Graphics CenterX="1148.0" CenterY="1493.5" Width="110.0" Height="30.0" ZOrder="32846" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1148.0" CenterY="1493.5" Width="110.0" Height="30.0" ZOrder="32846" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02005"/>
+
     <Xref Database="HMDB" ID="HMDB02005" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Dehydroascorbic acid" GraphId="a473b" Type="Metabolite">
   <DataNode TextLabel="Dehydroascorbic acid" GraphId="a473b" Type="Metabolite">
     <BiopaxRef>f97</BiopaxRef>
     <BiopaxRef>f97</BiopaxRef>
     <BiopaxRef>ec4</BiopaxRef>
     <BiopaxRef>ec4</BiopaxRef>
-
     <Graphics CenterX="893.9833333333333" CenterY="2136.65" Width="112.03333333333333" Height="21.366666666666667" ZOrder="32848" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="893.9833333333333" CenterY="2136.65" Width="112.03333333333333" Height="21.366666666666667" ZOrder="32848" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="17242"/>
+
     <Xref Database="ChEBI" ID="17242" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Leukotriene A4" GraphId="d431b" Type="Metabolite">
   <DataNode TextLabel="Leukotriene A4" GraphId="d431b" Type="Metabolite">
     <BiopaxRef>e71</BiopaxRef>
     <BiopaxRef>e71</BiopaxRef>
     <BiopaxRef>f5f</BiopaxRef>
     <BiopaxRef>f5f</BiopaxRef>
-
     <Graphics CenterX="2362.6666666666665" CenterY="944.3166666666667" Width="79.33333333333333" Height="20.7" ZOrder="32850" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2362.6666666666665" CenterY="944.3166666666667" Width="79.33333333333333" Height="20.7" ZOrder="32850" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01337"/>
+
     <Xref Database="HMDB" ID="HMDB01337" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="b96ba" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="b96ba" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="1217.5" CenterY="2112.3166666666666" Width="51.0" Height="14.7" ZOrder="32852" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1217.5" CenterY="2112.3166666666666" Width="51.0" Height="14.7" ZOrder="32852" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB00221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="fd89b" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="fd89b" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="357.3333333333333" CenterY="839.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32856" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="357.3333333333333" CenterY="839.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32856" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01248"/>
+
     <Xref Database="HMDB" ID="HMDB01248" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="THF" GraphId="e2c9a" Type="Metabolite">
   <DataNode TextLabel="THF" GraphId="e2c9a" Type="Metabolite">
     <Comment>Tetrahydrofolic acid</Comment>
     <Comment>Tetrahydrofolic acid</Comment>
-
     <Graphics CenterX="615.325" CenterY="1524.3166666666666" Width="82.64999999999999" Height="21.366666666666788" ZOrder="32858" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="615.325" CenterY="1524.3166666666666" Width="82.64999999999999" Height="21.366666666666788" ZOrder="32858" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01846"/>
+
     <Xref Database="HMDB" ID="HMDB01846" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Hydroxykynurenine" GraphId="fa566" Type="Metabolite">
   <DataNode TextLabel="Hydroxykynurenine" GraphId="fa566" Type="Metabolite">
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
-
     <Graphics CenterX="1182.5" CenterY="1645.3166666666666" Width="97.0" Height="21.333333333333314" ZOrder="32860" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1182.5" CenterY="1645.3166666666666" Width="97.0" Height="21.333333333333314" ZOrder="32860" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00732"/>
+
     <Xref Database="HMDB" ID="HMDB00732" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folic acid" GraphId="aa67f" Type="Metabolite">
   <DataNode TextLabel="Folic acid" GraphId="aa67f" Type="Metabolite">
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>c2d</BiopaxRef>
-
     <Graphics CenterX="672.0" CenterY="2165.65" Width="62.0" Height="20.033333333333335" ZOrder="32862" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="672.0" CenterY="2165.65" Width="62.0" Height="20.033333333333335" ZOrder="32862" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00121"/>
+
     <Xref Database="HMDB" ID="HMDB00121" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="c9ee6" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="c9ee6" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="1379.1666666666667" CenterY="449.48333333333335" Width="50.333333333333336" Height="15.7" ZOrder="32864" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1379.1666666666667" CenterY="449.48333333333335" Width="50.333333333333336" Height="15.7" ZOrder="32864" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB00217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="f48db" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="f48db" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="669.5" CenterY="1665.3166666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="669.5" CenterY="1665.3166666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB00221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Selenium" GraphId="ac66d" Type="Metabolite">
   <DataNode TextLabel="Selenium" GraphId="ac66d" Type="Metabolite">
     <BiopaxRef>e72</BiopaxRef>
     <BiopaxRef>e72</BiopaxRef>
-
     <Graphics CenterX="1634.0" CenterY="2515.0" Width="190.0" Height="42.0" ZOrder="32868" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1634.0" CenterY="2515.0" Width="190.0" Height="42.0" ZOrder="32868" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01349"/>
+
     <Xref Database="HMDB" ID="HMDB01349" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Selenium" GraphId="ea38d" Type="Metabolite">
   <DataNode TextLabel="Selenium" GraphId="ea38d" Type="Metabolite">
     <BiopaxRef>e72</BiopaxRef>
     <BiopaxRef>e72</BiopaxRef>
-
     <Graphics CenterX="1862.0" CenterY="55.0" Width="190.0" Height="42.0" ZOrder="32868" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1862.0" CenterY="55.0" Width="190.0" Height="42.0" ZOrder="32868" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01349"/>
+
     <Xref Database="HMDB" ID="HMDB01349" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelK" GraphId="b3ed6" Type="Protein">
   <DataNode TextLabel="SelK" GraphId="b3ed6" Type="Protein">
     <Comment>Selenoprotein-selenoprotein K</Comment>
     <Comment>Selenoprotein-selenoprotein K</Comment>
     <BiopaxRef>af0</BiopaxRef>
     <BiopaxRef>af0</BiopaxRef>
-
     <Graphics CenterX="1795.4833333333333" CenterY="765.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32870" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1795.4833333333333" CenterY="765.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32870" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="58515"/>
+
     <Xref Database="Entrez Gene" ID="58515" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Sep15" GraphId="fca10" Type="Protein">
   <DataNode TextLabel="Sep15" GraphId="fca10" Type="Protein">
Line 792: Line 796:
     <BiopaxRef>a89</BiopaxRef>
     <BiopaxRef>a89</BiopaxRef>
     <BiopaxRef>f4c</BiopaxRef>
     <BiopaxRef>f4c</BiopaxRef>
-
     <Graphics CenterX="976.4833333333333" CenterY="685.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32870" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="976.4833333333333" CenterY="685.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32870" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="9403"/>
+
     <Xref Database="Entrez Gene" ID="9403" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 6" GraphId="b59a0" Type="Protein" GroupRef="afe71">
   <DataNode TextLabel="GPX 6" GraphId="b59a0" Type="Protein" GroupRef="afe71">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 6</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 6</Comment>
-
     <Graphics CenterX="1162.5" CenterY="907.7833333333332" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32872" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1162.5" CenterY="907.7833333333332" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32872" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="257202"/>
+
     <Xref Database="Entrez Gene" ID="257202" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GSH" GraphId="a9d07" Type="Metabolite">
   <DataNode TextLabel="GSH" GraphId="a9d07" Type="Metabolite">
     <Comment>Glutathione</Comment>
     <Comment>Glutathione</Comment>
     <BiopaxRef>bc0</BiopaxRef>
     <BiopaxRef>bc0</BiopaxRef>
-
     <Graphics CenterX="1079.0" CenterY="2177.5" Width="80.0" Height="30.0" ZOrder="32874" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1079.0" CenterY="2177.5" Width="80.0" Height="30.0" ZOrder="32874" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00125"/>
+
     <Xref Database="HMDB" ID="HMDB00125" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Nicotinamidase" GraphId="d1714" Type="Protein">
   <DataNode TextLabel="Nicotinamidase" GraphId="d1714" Type="Protein">
     <Comment>Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3 GO:0008936</Comment>
     <Comment>Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3 GO:0008936</Comment>
     <BiopaxRef>d0b</BiopaxRef>
     <BiopaxRef>d0b</BiopaxRef>
-
     <Graphics CenterX="1447.3333333333333" CenterY="981.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32876" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="1447.3333333333333" CenterY="981.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32876" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Enzyme Nomenclature" ID="3.5.1.19"/>
+
     <Xref Database="Enzyme Nomenclature" ID="3.5.1.19" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Calcium" GraphId="b044b" Type="Metabolite">
   <DataNode TextLabel="Calcium" GraphId="b044b" Type="Metabolite">
     <BiopaxRef>f5f</BiopaxRef>
     <BiopaxRef>f5f</BiopaxRef>
-
     <Graphics CenterX="2177.0" CenterY="878.8333333333331" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32878" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="2177.0" CenterY="878.8333333333331" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32878" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00464"/>
+
     <Xref Database="HMDB" ID="HMDB00464" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Methionine" GraphId="e297e" Type="Metabolite">
   <DataNode TextLabel="Methionine" GraphId="e297e" Type="Metabolite">
     <BiopaxRef>aff</BiopaxRef>
     <BiopaxRef>aff</BiopaxRef>
-
     <Graphics CenterX="628.0" CenterY="2214.8166666666666" Width="72.0" Height="30.0" ZOrder="32880" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="628.0" CenterY="2214.8166666666666" Width="72.0" Height="30.0" ZOrder="32880" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00696"/>
+
     <Xref Database="HMDB" ID="HMDB00696" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Manganese" GraphId="c2267" Type="Metabolite">
   <DataNode TextLabel="Manganese" GraphId="c2267" Type="Metabolite">
-
     <Graphics CenterX="878.0000000000001" CenterY="853.4999999999999" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833"/>
+
     <Graphics CenterX="878.0000000000001" CenterY="853.4999999999999" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833" />
-
     <Xref Database="HMDB" ID="HMDB01333"/>
+
     <Xref Database="HMDB" ID="HMDB01333" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="c0b2d" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="c0b2d" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="1217.5" CenterY="980.3166666666667" Width="51.0" Height="14.7" ZOrder="32884" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1217.5" CenterY="980.3166666666667" Width="51.0" Height="14.7" ZOrder="32884" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB00221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folic acid" GraphId="c7921" Type="Metabolite">
   <DataNode TextLabel="Folic acid" GraphId="c7921" Type="Metabolite">
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>c2d</BiopaxRef>
-
     <Graphics CenterX="703.0" CenterY="1823.65" Width="62.0" Height="20.033333333333335" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="703.0" CenterY="1823.65" Width="62.0" Height="20.033333333333335" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00121"/>
+
     <Xref Database="HMDB" ID="HMDB00121" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FMN" GraphId="a0653" Type="Metabolite">
   <DataNode TextLabel="FMN" GraphId="a0653" Type="Metabolite">
     <Comment>Flavin Mononucleotide</Comment>
     <Comment>Flavin Mononucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="921.3333333333334" CenterY="1466.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32890" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="921.3333333333334" CenterY="1466.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32890" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01520"/>
+
     <Xref Database="HMDB" ID="HMDB01520" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Selenocysteine" GraphId="cc5e0" Type="Metabolite">
   <DataNode TextLabel="Selenocysteine" GraphId="cc5e0" Type="Metabolite">
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a3f</BiopaxRef>
     <BiopaxRef>a3f</BiopaxRef>
-
     <Graphics CenterX="1661.15" CenterY="671.15" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32892" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1661.15" CenterY="671.15" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32892" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03288"/>
+
     <Xref Database="HMDB" ID="HMDB03288" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Selenide" GraphId="e5648" Type="Metabolite">
   <DataNode TextLabel="Selenide" GraphId="e5648" Type="Metabolite">
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a3f</BiopaxRef>
     <BiopaxRef>a3f</BiopaxRef>
-
     <Graphics CenterX="2128.15" CenterY="479.15" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32892" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2128.15" CenterY="479.15" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32892" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="15076"/>
+
     <Xref Database="ChEBI" ID="15076" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Selenophosphate" GraphId="f4293" Type="Metabolite">
   <DataNode TextLabel="Selenophosphate" GraphId="f4293" Type="Metabolite">
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a3f</BiopaxRef>
     <BiopaxRef>a3f</BiopaxRef>
-
     <Graphics CenterX="1948.15" CenterY="479.15" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32892" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1948.15" CenterY="479.15" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32892" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="16144"/>
+
     <Xref Database="ChEBI" ID="16144" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cysteine" GraphId="bc332" Type="Metabolite">
   <DataNode TextLabel="Cysteine" GraphId="bc332" Type="Metabolite">
-
     <Graphics CenterX="178.0" CenterY="2213.8166666666666" Width="72.0" Height="30.0" ZOrder="32894" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="178.0" CenterY="2213.8166666666666" Width="72.0" Height="30.0" ZOrder="32894" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00574"/>
+
     <Xref Database="HMDB" ID="HMDB00574" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Leukotriene C4" GraphId="c28d2" Type="Metabolite">
   <DataNode TextLabel="Leukotriene C4" GraphId="c28d2" Type="Metabolite">
     <BiopaxRef>f5f</BiopaxRef>
     <BiopaxRef>f5f</BiopaxRef>
     <BiopaxRef>cf6</BiopaxRef>
     <BiopaxRef>cf6</BiopaxRef>
-
     <Graphics CenterX="2363.6666666666665" CenterY="1293.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32896" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2363.6666666666665" CenterY="1293.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32896" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01198"/>
+
     <Xref Database="HMDB" ID="HMDB01198" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Leukotriene C4" GraphId="ff750" Type="Metabolite">
   <DataNode TextLabel="Leukotriene C4" GraphId="ff750" Type="Metabolite">
-
     <Graphics CenterX="2363.6666666666665" CenterY="2142.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32896" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2363.6666666666665" CenterY="2142.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32896" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01198"/>
+
     <Xref Database="HMDB" ID="HMDB01198" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 3" GraphId="c10cb" Type="Protein">
   <DataNode TextLabel="GPX 3" GraphId="c10cb" Type="Protein">
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
     <BiopaxRef>f4a</BiopaxRef>
     <BiopaxRef>f4a</BiopaxRef>
-
     <Graphics CenterX="1012.5" CenterY="2218.15" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32898" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1012.5" CenterY="2218.15" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32898" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2878"/>
+
     <Xref Database="Entrez Gene" ID="2878" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Dehydroascorbic acid" GraphId="f14eb" Type="Metabolite">
   <DataNode TextLabel="Dehydroascorbic acid" GraphId="f14eb" Type="Metabolite">
     <BiopaxRef>f97</BiopaxRef>
     <BiopaxRef>f97</BiopaxRef>
-
     <Graphics CenterX="1122.9833333333333" CenterY="245.65" Width="112.03333333333333" Height="21.366666666666667" ZOrder="32900" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1122.9833333333333" CenterY="245.65" Width="112.03333333333333" Height="21.366666666666667" ZOrder="32900" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="17242"/>
+
     <Xref Database="ChEBI" ID="17242" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 2" GraphId="b036c" Type="Protein" GroupRef="afe71">
   <DataNode TextLabel="GPX 2" GraphId="b036c" Type="Protein" GroupRef="afe71">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 2</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 2</Comment>
-
     <Graphics CenterX="1162.5" CenterY="863.6833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32902" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1162.5" CenterY="863.6833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32902" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2877"/>
+
     <Xref Database="Entrez Gene" ID="2877" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelP" GraphId="d929a" Type="Protein">
   <DataNode TextLabel="SelP" GraphId="d929a" Type="Protein">
     <Comment>Selenoprotein-selenoprotein P</Comment>
     <Comment>Selenoprotein-selenoprotein P</Comment>
     <BiopaxRef>f1e</BiopaxRef>
     <BiopaxRef>f1e</BiopaxRef>
-
     <Graphics CenterX="1826.4833333333333" CenterY="2199.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32904" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1826.4833333333333" CenterY="2199.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32904" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="6414"/>
+
     <Xref Database="Entrez Gene" ID="6414" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Trx-S2" GraphId="b3e60" Type="Protein">
   <DataNode TextLabel="Trx-S2" GraphId="b3e60" Type="Protein">
Line 903: Line 907:
     <BiopaxRef>f1f</BiopaxRef>
     <BiopaxRef>f1f</BiopaxRef>
     <BiopaxRef>f97</BiopaxRef>
     <BiopaxRef>f97</BiopaxRef>
-
     <Graphics CenterX="1260.65" CenterY="413.65" Width="69.36666666666666" Height="21.366666666666667" ZOrder="32906" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1260.65" CenterY="413.65" Width="69.36666666666666" Height="21.366666666666667" ZOrder="32906" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="7295"/>
+
     <Xref Database="Entrez Gene" ID="7295" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Ascorbic acid" GraphId="fca86" Type="Metabolite">
   <DataNode TextLabel="Ascorbic acid" GraphId="fca86" Type="Metabolite">
     <BiopaxRef>ec4</BiopaxRef>
     <BiopaxRef>ec4</BiopaxRef>
-
     <Graphics CenterX="562.3333333333334" CenterY="2129.8333333333335" Width="80.0" Height="24.333333333333332" ZOrder="32908" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="562.3333333333334" CenterY="2129.8333333333335" Width="80.0" Height="24.333333333333332" ZOrder="32908" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="ChEBI" ID="29073"/>
+
     <Xref Database="ChEBI" ID="29073" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Lipoic acid" GraphId="a81a0" Type="Metabolite">
   <DataNode TextLabel="Lipoic acid" GraphId="a81a0" Type="Metabolite">
     <BiopaxRef>abc</BiopaxRef>
     <BiopaxRef>abc</BiopaxRef>
-
     <Graphics CenterX="1238.9833333333333" CenterY="584.65" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32910" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1238.9833333333333" CenterY="584.65" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32910" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01451"/>
+
     <Xref Database="HMDB" ID="HMDB01451" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRDX4" GraphId="d85f9" Type="Protein" GroupRef="c1ae6">
   <DataNode TextLabel="PRDX4" GraphId="d85f9" Type="Protein" GroupRef="c1ae6">
     <Comment>EC 1.11.1.15</Comment>
     <Comment>EC 1.11.1.15</Comment>
     <Comment>peroxiredoxin 4</Comment>
     <Comment>peroxiredoxin 4</Comment>
-
     <Graphics CenterX="1124.8166666666666" CenterY="503.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32912" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="1124.8166666666666" CenterY="503.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32912" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="10549"/>
+
     <Xref Database="Entrez Gene" ID="10549" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 1" GraphId="ef54e" Type="Protein" GroupRef="afe71">
   <DataNode TextLabel="GPX 1" GraphId="ef54e" Type="Protein" GroupRef="afe71">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 1</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 1</Comment>
-
     <Graphics CenterX="1162.5" CenterY="848.9833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32914" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1162.5" CenterY="848.9833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32914" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="2876"/>
+
     <Xref Database="Entrez Gene" ID="2876" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="cc501" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="cc501" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="1379.1666666666667" CenterY="619.4833333333333" Width="50.333333333333336" Height="15.7" ZOrder="32916" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1379.1666666666667" CenterY="619.4833333333333" Width="50.333333333333336" Height="15.7" ZOrder="32916" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB00217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Homocysteine" GraphId="a4680" Type="Metabolite">
   <DataNode TextLabel="Homocysteine" GraphId="a4680" Type="Metabolite">
-
     <Graphics CenterX="394.0" CenterY="2214.8166666666666" Width="72.0" Height="30.0" ZOrder="32918" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="394.0" CenterY="2214.8166666666666" Width="72.0" Height="30.0" ZOrder="32918" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00742"/>
+
     <Xref Database="HMDB" ID="HMDB00742" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ROS" GraphId="bed05" Type="Metabolite">
   <DataNode TextLabel="ROS" GraphId="bed05" Type="Metabolite">
Line 961: Line 965:
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>e3f</BiopaxRef>
     <BiopaxRef>e3f</BiopaxRef>
-
     <Graphics CenterX="684.3166666666667" CenterY="762.7622139764998" Width="70.70000000000005" Height="20.857761286332618" ZOrder="32920" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="684.3166666666667" CenterY="762.7622139764998" Width="70.70000000000005" Height="20.857761286332618" ZOrder="32920" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="26523"/>
+
     <Xref Database="ChEBI" ID="26523" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RNS" GraphId="c0e80" Type="Metabolite">
   <DataNode TextLabel="RNS" GraphId="c0e80" Type="Metabolite">
Line 969: Line 973:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
-
     <Graphics CenterX="970.3166666666667" CenterY="1293.3333333333333" Width="70.70000000000005" Height="30.0" ZOrder="32920" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="970.3166666666667" CenterY="1293.3333333333333" Width="70.70000000000005" Height="30.0" ZOrder="32920" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="CHEBI:62764"/>
+
     <Xref Database="ChEBI" ID="CHEBI:62764" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="d3a67" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="d3a67" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="1291.5" CenterY="618.9833333333333" Width="51.0" Height="14.7" ZOrder="32922" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1291.5" CenterY="618.9833333333333" Width="51.0" Height="14.7" ZOrder="32922" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB00221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Vitamin B12" GraphId="f28e8" Type="Metabolite">
   <DataNode TextLabel="Vitamin B12" GraphId="f28e8" Type="Metabolite">
     <BiopaxRef>c7a</BiopaxRef>
     <BiopaxRef>c7a</BiopaxRef>
     <BiopaxRef>a64</BiopaxRef>
     <BiopaxRef>a64</BiopaxRef>
-
     <Graphics CenterX="496.8333333333333" CenterY="2214.8166666666666" Width="61.666666666666664" Height="17.7" ZOrder="32924" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="496.8333333333333" CenterY="2214.8166666666666" Width="61.666666666666664" Height="17.7" ZOrder="32924" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB02174"/>
+
     <Xref Database="HMDB" ID="HMDB02174" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFR" GraphId="ef1e3" Type="Protein">
   <DataNode TextLabel="MTHFR" GraphId="ef1e3" Type="Protein">
Line 987: Line 991:
     <Comment>5,10-methylenetetrahydrofolate reductase</Comment>
     <Comment>5,10-methylenetetrahydrofolate reductase</Comment>
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>c2d</BiopaxRef>
-
     <Graphics CenterX="704.0" CenterY="1704.1666666666665" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="704.0" CenterY="1704.1666666666665" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="4524"/>
+
     <Xref Database="Entrez Gene" ID="4524" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Homocysteine" GraphId="ec17c" Type="Metabolite">
   <DataNode TextLabel="Homocysteine" GraphId="ec17c" Type="Metabolite">
     <BiopaxRef>d29</BiopaxRef>
     <BiopaxRef>d29</BiopaxRef>
-
     <Graphics CenterX="394.0" CenterY="1779.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="394.0" CenterY="1779.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00742"/>
+
     <Xref Database="HMDB" ID="HMDB00742" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelH" GraphId="b83ab" Type="Protein">
   <DataNode TextLabel="SelH" GraphId="b83ab" Type="Protein">
Line 999: Line 1,003:
     <BiopaxRef>ae3</BiopaxRef>
     <BiopaxRef>ae3</BiopaxRef>
     <BiopaxRef>ffd</BiopaxRef>
     <BiopaxRef>ffd</BiopaxRef>
-
     <Graphics CenterX="959.4833333333333" CenterY="578.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="959.4833333333333" CenterY="578.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="280636"/>
+
     <Xref Database="Entrez Gene" ID="280636" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SPS2" GraphId="c35a9" Type="Protein">
   <DataNode TextLabel="SPS2" GraphId="c35a9" Type="Protein">
Line 1,007: Line 1,011:
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>cbc</BiopaxRef>
     <BiopaxRef>cbc</BiopaxRef>
-
     <Graphics CenterX="2038.4833333333333" CenterY="401.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="2038.4833333333333" CenterY="401.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="22928"/>
+
     <Xref Database="Entrez Gene" ID="22928" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelO" GraphId="d27a3" Type="Protein">
   <DataNode TextLabel="SelO" GraphId="d27a3" Type="Protein">
Line 1,014: Line 1,018:
     <Comment>Unknown function</Comment>
     <Comment>Unknown function</Comment>
     <BiopaxRef>c06</BiopaxRef>
     <BiopaxRef>c06</BiopaxRef>
-
     <Graphics CenterX="1523.4833333333333" CenterY="217.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1523.4833333333333" CenterY="217.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="83642"/>
+
     <Xref Database="Entrez Gene" ID="83642" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelN" GraphId="d86b0" Type="Protein">
   <DataNode TextLabel="SelN" GraphId="d86b0" Type="Protein">
Line 1,022: Line 1,026:
     <BiopaxRef>b76</BiopaxRef>
     <BiopaxRef>b76</BiopaxRef>
     <BiopaxRef>d6f</BiopaxRef>
     <BiopaxRef>d6f</BiopaxRef>
-
     <Graphics CenterX="1802.4833333333333" CenterY="441.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1802.4833333333333" CenterY="441.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="57190"/>
+
     <Xref Database="Entrez Gene" ID="57190" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DIO2" GraphId="d9bd5" Type="Protein">
   <DataNode TextLabel="DIO2" GraphId="d9bd5" Type="Protein">
Line 1,031: Line 1,035:
     <BiopaxRef>e0b</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
     <BiopaxRef>f5c</BiopaxRef>
     <BiopaxRef>f5c</BiopaxRef>
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     <Graphics CenterX="2516.483333333333" CenterY="481.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
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     <Graphics CenterX="2516.483333333333" CenterY="481.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="1734"/>
+
     <Xref Database="Entrez Gene" ID="1734" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelT" GraphId="da423" Type="Protein">
   <DataNode TextLabel="SelT" GraphId="da423" Type="Protein">
Line 1,038: Line 1,042:
     <BiopaxRef>c06</BiopaxRef>
     <BiopaxRef>c06</BiopaxRef>
     <BiopaxRef>c83</BiopaxRef>
     <BiopaxRef>c83</BiopaxRef>
-
     <Graphics CenterX="2083.483333333333" CenterY="534.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
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     <Graphics CenterX="2083.483333333333" CenterY="534.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="51714"/>
+
     <Xref Database="Entrez Gene" ID="51714" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelM" GraphId="de905" Type="Protein">
   <DataNode TextLabel="SelM" GraphId="de905" Type="Protein">
Line 1,046: Line 1,050:
     <BiopaxRef>a4a</BiopaxRef>
     <BiopaxRef>a4a</BiopaxRef>
     <BiopaxRef>fb2</BiopaxRef>
     <BiopaxRef>fb2</BiopaxRef>
-
     <Graphics CenterX="1737.4833333333333" CenterY="390.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
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     <Graphics CenterX="1737.4833333333333" CenterY="390.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="140606"/>
+
     <Xref Database="Entrez Gene" ID="140606" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelP" GraphId="e3718" Type="Protein">
   <DataNode TextLabel="SelP" GraphId="e3718" Type="Protein">
Line 1,055: Line 1,059:
     <BiopaxRef>e2d</BiopaxRef>
     <BiopaxRef>e2d</BiopaxRef>
     <BiopaxRef>b77</BiopaxRef>
     <BiopaxRef>b77</BiopaxRef>
-
     <Graphics CenterX="1826.4833333333333" CenterY="526.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
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     <Graphics CenterX="1826.4833333333333" CenterY="526.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="6414"/>
+
     <Xref Database="Entrez Gene" ID="6414" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DIO3" GraphId="e586f" Type="Protein">
   <DataNode TextLabel="DIO3" GraphId="e586f" Type="Protein">
Line 1,063: Line 1,067:
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
-
     <Graphics CenterX="2517.483333333333" CenterY="652.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
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     <Graphics CenterX="2517.483333333333" CenterY="652.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="1735"/>
+
     <Xref Database="Entrez Gene" ID="1735" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DIO1" GraphId="f09fb" Type="Protein">
   <DataNode TextLabel="DIO1" GraphId="f09fb" Type="Protein">
Line 1,071: Line 1,075:
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>a53</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
     <BiopaxRef>e0b</BiopaxRef>
-
     <Graphics CenterX="2517.483333333333" CenterY="569.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
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     <Graphics CenterX="2517.483333333333" CenterY="569.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="1733"/>
+
     <Xref Database="Entrez Gene" ID="1733" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelV" GraphId="f8b44" Type="Protein">
   <DataNode TextLabel="SelV" GraphId="f8b44" Type="Protein">
Line 1,078: Line 1,082:
     <Comment>Unknown function</Comment>
     <Comment>Unknown function</Comment>
     <BiopaxRef>c06</BiopaxRef>
     <BiopaxRef>c06</BiopaxRef>
-
     <Graphics CenterX="1679.4833333333333" CenterY="217.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
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     <Graphics CenterX="1679.4833333333333" CenterY="217.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="348303"/>
+
     <Xref Database="Entrez Gene" ID="348303" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelI" GraphId="fad0c" Type="Protein">
   <DataNode TextLabel="SelI" GraphId="fad0c" Type="Protein">
Line 1,085: Line 1,089:
     <Comment>Unknown function</Comment>
     <Comment>Unknown function</Comment>
     <BiopaxRef>c06</BiopaxRef>
     <BiopaxRef>c06</BiopaxRef>
-
     <Graphics CenterX="1609.4833333333333" CenterY="255.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
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     <Graphics CenterX="1609.4833333333333" CenterY="255.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="85465"/>
+
     <Xref Database="Entrez Gene" ID="85465" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelS" GraphId="fe319" Type="Protein">
   <DataNode TextLabel="SelS" GraphId="fe319" Type="Protein">
Line 1,093: Line 1,097:
     <BiopaxRef>a05</BiopaxRef>
     <BiopaxRef>a05</BiopaxRef>
     <BiopaxRef>d42</BiopaxRef>
     <BiopaxRef>d42</BiopaxRef>
-
     <Graphics CenterX="1355.4833333333333" CenterY="1328.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1355.4833333333333" CenterY="1328.15" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32930" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="55829"/>
+
     <Xref Database="Entrez Gene" ID="55829" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD1" GraphId="e9bbd" Type="Protein" GroupRef="ae815">
   <DataNode TextLabel="SOD1" GraphId="e9bbd" Type="Protein" GroupRef="ae815">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 1, soluble</Comment>
     <Comment>superoxide dismutase 1, soluble</Comment>
-
     <Graphics CenterX="893.15" CenterY="971.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32932" FontSize="10" Valign="Middle" Color="999998"/>
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     <Graphics CenterX="893.15" CenterY="971.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32932" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="6647"/>
+
     <Xref Database="Entrez Gene" ID="6647" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="ee8f2" Type="Metabolite">
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="ee8f2" Type="Metabolite">
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
-
     <Graphics CenterX="1137.3333333333333" CenterY="1416.1666666666667" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933"/>
+
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-
     <Xref Database="HMDB" ID="HMDB01491"/>
+
     <Xref Database="HMDB" ID="HMDB01491" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Serine" GraphId="b2e47" Type="Metabolite">
   <DataNode TextLabel="Serine" GraphId="b2e47" Type="Metabolite">
-
     <Graphics CenterX="301.0" CenterY="1829.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="301.0" CenterY="1829.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00187"/>
+
     <Xref Database="HMDB" ID="HMDB00187" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Iron" GraphId="beae1" Type="Metabolite">
   <DataNode TextLabel="Iron" GraphId="beae1" Type="Metabolite">
     <BiopaxRef>f5f</BiopaxRef>
     <BiopaxRef>f5f</BiopaxRef>
-
     <Graphics CenterX="2128.0" CenterY="2242.833333333333" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32938" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="2128.0" CenterY="2242.833333333333" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32938" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="Wikidata" ID="Q26840996"/>
+
     <Xref Database="Wikidata" ID="Q26840996" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Hypoxanthine" GraphId="b33c7" Type="Metabolite">
   <DataNode TextLabel="Hypoxanthine" GraphId="b33c7" Type="Metabolite">
-
     <Graphics CenterX="231.0" CenterY="793.6666666666666" Width="82.0" Height="18.0" ZOrder="32940" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="231.0" CenterY="793.6666666666666" Width="82.0" Height="18.0" ZOrder="32940" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00157"/>
+
     <Xref Database="HMDB" ID="HMDB00157" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRDX3" GraphId="e9631" Type="Protein" GroupRef="c1ae6">
   <DataNode TextLabel="PRDX3" GraphId="e9631" Type="Protein" GroupRef="c1ae6">
     <Comment>EC 1.11.1.15</Comment>
     <Comment>EC 1.11.1.15</Comment>
     <Comment>peroxiredoxin 3</Comment>
     <Comment>peroxiredoxin 3</Comment>
-
     <Graphics CenterX="1124.8166666666666" CenterY="488.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32942" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="1124.8166666666666" CenterY="488.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32942" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="10935"/>
+
     <Xref Database="Entrez Gene" ID="10935" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GSR" GraphId="d554b" Type="Protein">
   <DataNode TextLabel="GSR" GraphId="d554b" Type="Protein">
Line 1,130: Line 1,134:
     <Comment>glutathione reductase</Comment>
     <Comment>glutathione reductase</Comment>
     <BiopaxRef>f38</BiopaxRef>
     <BiopaxRef>f38</BiopaxRef>
-
     <Graphics CenterX="1253.3333333333333" CenterY="1021.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32944" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="1253.3333333333333" CenterY="1021.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32944" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="2936"/>
+
     <Xref Database="Entrez Gene" ID="2936" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1" GraphId="a0196" Type="Protein">
   <DataNode TextLabel="APOA1" GraphId="a0196" Type="Protein">
     <Comment>apolipoprotein A-I</Comment>
     <Comment>apolipoprotein A-I</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="493.3333333333333" CenterY="1231.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="493.3333333333333" CenterY="1231.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="335"/>
+
     <Xref Database="Entrez Gene" ID="335" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOB" GraphId="a4395" Type="Protein">
   <DataNode TextLabel="APOB" GraphId="a4395" Type="Protein">
     <Comment>apolipoprotein B</Comment>
     <Comment>apolipoprotein B</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="247.33333333333334" CenterY="1463.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="247.33333333333334" CenterY="1463.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="338"/>
+
     <Xref Database="Entrez Gene" ID="338" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDLR" GraphId="a53eb" Type="Protein">
   <DataNode TextLabel="LDLR" GraphId="a53eb" Type="Protein">
     <Comment>low density lipoprotein receptor</Comment>
     <Comment>low density lipoprotein receptor</Comment>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
-
     <Graphics CenterX="596.3333333333334" CenterY="995.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="596.3333333333334" CenterY="995.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3949"/>
+
     <Xref Database="Entrez Gene" ID="3949" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL" GraphId="afaae" Type="Metabolite">
   <DataNode TextLabel="VLDL" GraphId="afaae" Type="Metabolite">
Line 1,155: Line 1,159:
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
     <Graphics CenterX="168.33333333333334" CenterY="1492.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="168.33333333333334" CenterY="1492.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39027"/>
+
     <Xref Database="ChEBI" ID="39027" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDL" GraphId="b142a" Type="Metabolite">
   <DataNode TextLabel="LDL" GraphId="b142a" Type="Metabolite">
Line 1,165: Line 1,169:
     <BiopaxRef>a40</BiopaxRef>
     <BiopaxRef>a40</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
-
     <Graphics CenterX="595.3333333333334" CenterY="1096.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="595.3333333333334" CenterY="1096.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39026"/>
+
     <Xref Database="ChEBI" ID="39026" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA4" GraphId="b5726" Type="Protein">
   <DataNode TextLabel="SAA4" GraphId="b5726" Type="Protein">
Line 1,172: Line 1,176:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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+
     <Graphics CenterX="306.3333333333333" CenterY="1252.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="6291"/>
+
     <Xref Database="Entrez Gene" ID="6291" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SRB1" GraphId="b6a04" Type="Protein">
   <DataNode TextLabel="SRB1" GraphId="b6a04" Type="Protein">
     <Comment>scavenger receptor class B, member 1</Comment>
     <Comment>scavenger receptor class B, member 1</Comment>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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+
     <Graphics CenterX="102.33333333333333" CenterY="1351.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="949"/>
+
     <Xref Database="Entrez Gene" ID="949" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ABCA1" GraphId="bb745" Type="Protein">
   <DataNode TextLabel="ABCA1" GraphId="bb745" Type="Protein">
Line 1,185: Line 1,189:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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+
     <Graphics CenterX="405.3333333333333" CenterY="1351.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="19"/>
+
     <Xref Database="Entrez Gene" ID="19" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cholesterol" GraphId="bcf2e" Type="Metabolite">
   <DataNode TextLabel="Cholesterol" GraphId="bcf2e" Type="Metabolite">
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="572.3333333333334" CenterY="2427.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="572.3333333333334" CenterY="2427.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00067"/>
+
     <Xref Database="HMDB" ID="HMDB00067" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1-NO2Tyr" GraphId="c2d04" Type="Protein">
   <DataNode TextLabel="APOA1-NO2Tyr" GraphId="c2d04" Type="Protein">
     <Comment>Nitrotyrosinated apolipoprotein A-I</Comment>
     <Comment>Nitrotyrosinated apolipoprotein A-I</Comment>
     <BiopaxRef>c65</BiopaxRef>
     <BiopaxRef>c65</BiopaxRef>
-
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+
     <Graphics CenterX="786.9916666666667" CenterY="1241.3166666666666" Width="86.01666666666667" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="335"/>
+
     <Xref Database="Entrez Gene" ID="335" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACT" GraphId="c4d7d" Type="Protein">
   <DataNode TextLabel="ACT" GraphId="c4d7d" Type="Protein">
Line 1,205: Line 1,209:
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>e11</BiopaxRef>
     <BiopaxRef>e11</BiopaxRef>
-
     <Graphics CenterX="729.3333333333334" CenterY="2290.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="729.3333333333334" CenterY="2290.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="12"/>
+
     <Xref Database="Entrez Gene" ID="12" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL" GraphId="c57e3" Type="Metabolite">
   <DataNode TextLabel="HDL" GraphId="c57e3" Type="Metabolite">
     <Comment>high-density lipoprotein</Comment>
     <Comment>high-density lipoprotein</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="572.3333333333334" CenterY="1283.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="572.3333333333334" CenterY="1283.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39025"/>
+
     <Xref Database="ChEBI" ID="39025" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL-TAG" GraphId="cb970" Type="Metabolite">
   <DataNode TextLabel="VLDL-TAG" GraphId="cb970" Type="Metabolite">
Line 1,218: Line 1,222:
     <Comment>Triglyceride transport</Comment>
     <Comment>Triglyceride transport</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="297.3333333333333" CenterY="2277.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="297.3333333333333" CenterY="2277.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="47776"/>
+
     <Xref Database="ChEBI" ID="47776" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FMN" GraphId="ce4a7" Type="Metabolite">
   <DataNode TextLabel="FMN" GraphId="ce4a7" Type="Metabolite">
     <Comment>Flavin Mononucleotide</Comment>
     <Comment>Flavin Mononucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="354.3333333333333" CenterY="1021.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="354.3333333333333" CenterY="1021.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01520"/>
+
     <Xref Database="HMDB" ID="HMDB01520" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA2" GraphId="ce7eb" Type="Protein">
   <DataNode TextLabel="SAA2" GraphId="ce7eb" Type="Protein">
Line 1,231: Line 1,235:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
     <Graphics CenterX="156.33333333333334" CenterY="1252.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="156.33333333333334" CenterY="1252.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="6289"/>
+
     <Xref Database="Entrez Gene" ID="6289" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL-C" GraphId="cf0a6" Type="Metabolite">
   <DataNode TextLabel="HDL-C" GraphId="cf0a6" Type="Metabolite">
Line 1,238: Line 1,242:
     <Comment>Cholesterol transport</Comment>
     <Comment>Cholesterol transport</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="493.3333333333333" CenterY="1395.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="493.3333333333333" CenterY="1395.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="47775"/>
+
     <Xref Database="ChEBI" ID="47775" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TAG" GraphId="d0575" Type="Metabolite">
   <DataNode TextLabel="TAG" GraphId="d0575" Type="Metabolite">
Line 1,245: Line 1,249:
     <Comment>Triacylglycerol</Comment>
     <Comment>Triacylglycerol</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="168.33333333333334" CenterY="1565.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="168.33333333333334" CenterY="1565.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="17855"/>
+
     <Xref Database="ChEBI" ID="17855" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACT" GraphId="d3b5a" Type="Protein">
   <DataNode TextLabel="ACT" GraphId="d3b5a" Type="Protein">
Line 1,254: Line 1,258:
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>e11</BiopaxRef>
     <BiopaxRef>e11</BiopaxRef>
-
     <Graphics CenterX="596.3333333333334" CenterY="921.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="596.3333333333334" CenterY="921.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="12"/>
+
     <Xref Database="Entrez Gene" ID="12" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1" GraphId="d4079" Type="Protein">
   <DataNode TextLabel="APOA1" GraphId="d4079" Type="Protein">
     <Comment>apolipoprotein A-I</Comment>
     <Comment>apolipoprotein A-I</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="419.3333333333333" CenterY="2427.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="419.3333333333333" CenterY="2427.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="335"/>
+
     <Xref Database="Entrez Gene" ID="335" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL" GraphId="d595a" Type="Metabolite">
   <DataNode TextLabel="HDL" GraphId="d595a" Type="Metabolite">
     <Comment>high-density lipoprotein</Comment>
     <Comment>high-density lipoprotein</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="666.3333333333334" CenterY="2427.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="666.3333333333334" CenterY="2427.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39025"/>
+
     <Xref Database="ChEBI" ID="39025" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL-C" GraphId="d5f27" Type="Metabolite">
   <DataNode TextLabel="HDL-C" GraphId="d5f27" Type="Metabolite">
     <Comment>high-density lipoprotein cholesterol</Comment>
     <Comment>high-density lipoprotein cholesterol</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="496.3333333333333" CenterY="2427.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="496.3333333333333" CenterY="2427.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="47775"/>
+
     <Xref Database="ChEBI" ID="47775" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA1" GraphId="d7661" Type="Protein">
   <DataNode TextLabel="SAA1" GraphId="d7661" Type="Protein">
Line 1,279: Line 1,283:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
     <Graphics CenterX="80.33333333333333" CenterY="1252.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="80.33333333333333" CenterY="1252.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="6288"/>
+
     <Xref Database="Entrez Gene" ID="6288" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA3" GraphId="da7bf" Type="Protein">
   <DataNode TextLabel="SAA3" GraphId="da7bf" Type="Protein">
Line 1,286: Line 1,290:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
     <Graphics CenterX="230.33333333333334" CenterY="1252.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="230.33333333333334" CenterY="1252.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="6290"/>
+
     <Xref Database="Entrez Gene" ID="6290" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOB" GraphId="dd437" Type="Protein">
   <DataNode TextLabel="APOB" GraphId="dd437" Type="Protein">
     <Comment>apolipoprotein B</Comment>
     <Comment>apolipoprotein B</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="229.33333333333334" CenterY="2255.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="229.33333333333334" CenterY="2255.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="338"/>
+
     <Xref Database="Entrez Gene" ID="338" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL" GraphId="dd4fd" Type="Metabolite">
   <DataNode TextLabel="VLDL" GraphId="dd4fd" Type="Metabolite">
Line 1,299: Line 1,303:
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
     <Graphics CenterX="279.3333333333333" CenterY="2348.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="279.3333333333333" CenterY="2348.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39027"/>
+
     <Xref Database="ChEBI" ID="39027" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="oxLDL" GraphId="de60a" Type="Metabolite">
   <DataNode TextLabel="oxLDL" GraphId="de60a" Type="Metabolite">
Line 1,308: Line 1,312:
     <BiopaxRef>a9f</BiopaxRef>
     <BiopaxRef>a9f</BiopaxRef>
     <BiopaxRef>a40</BiopaxRef>
     <BiopaxRef>a40</BiopaxRef>
-
     <Graphics CenterX="470.3333333333333" CenterY="2314.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="470.3333333333333" CenterY="2314.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="CHEBI:60151"/>
+
     <Xref Database="ChEBI" ID="CHEBI:60151" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL/APOA1" GraphId="e97d6" Type="Metabolite">
   <DataNode TextLabel="HDL/APOA1" GraphId="e97d6" Type="Metabolite">
Line 1,315: Line 1,319:
     <Comment>ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles</Comment>
     <Comment>ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="493.3333333333333" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="493.3333333333333" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39025"/>
+
     <Xref Database="ChEBI" ID="39025" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL/SAA" GraphId="e9c9c" Type="Metabolite">
   <DataNode TextLabel="HDL/SAA" GraphId="e9c9c" Type="Metabolite">
Line 1,324: Line 1,328:
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
     <Graphics CenterX="187.33333333333334" CenterY="1323.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="187.33333333333334" CenterY="1323.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39025"/>
+
     <Xref Database="ChEBI" ID="39025" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cholesterol" GraphId="eb3d6" Type="Metabolite">
   <DataNode TextLabel="Cholesterol" GraphId="eb3d6" Type="Metabolite">
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="572.3333333333334" CenterY="1351.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="572.3333333333334" CenterY="1351.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00067"/>
+
     <Xref Database="HMDB" ID="HMDB00067" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="oxLDL" GraphId="ee0d9" Type="Metabolite">
   <DataNode TextLabel="oxLDL" GraphId="ee0d9" Type="Metabolite">
Line 1,339: Line 1,343:
     <BiopaxRef>a40</BiopaxRef>
     <BiopaxRef>a40</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
-
     <Graphics CenterX="595.3333333333334" CenterY="1184.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="595.3333333333334" CenterY="1184.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="CHEBI:60151"/>
+
     <Xref Database="ChEBI" ID="CHEBI:60151" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TAG" GraphId="f0bc8" Type="Metabolite">
   <DataNode TextLabel="TAG" GraphId="f0bc8" Type="Metabolite">
Line 1,346: Line 1,350:
     <Comment>Triacylglycerol</Comment>
     <Comment>Triacylglycerol</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="286.3333333333333" CenterY="2318.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="286.3333333333333" CenterY="2318.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="17855"/>
+
     <Xref Database="ChEBI" ID="17855" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDL" GraphId="f2302" Type="Metabolite">
   <DataNode TextLabel="LDL" GraphId="f2302" Type="Metabolite">
Line 1,355: Line 1,359:
     <BiopaxRef>a9f</BiopaxRef>
     <BiopaxRef>a9f</BiopaxRef>
     <BiopaxRef>a40</BiopaxRef>
     <BiopaxRef>a40</BiopaxRef>
-
     <Graphics CenterX="470.3333333333333" CenterY="2356.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="470.3333333333333" CenterY="2356.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39026"/>
+
     <Xref Database="ChEBI" ID="39026" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL-TAG" GraphId="f5683" Type="Metabolite">
   <DataNode TextLabel="VLDL-TAG" GraphId="f5683" Type="Metabolite">
Line 1,362: Line 1,366:
     <Comment>Triglyceride transport</Comment>
     <Comment>Triglyceride transport</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="247.33333333333334" CenterY="1611.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="247.33333333333334" CenterY="1611.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="47776"/>
+
     <Xref Database="ChEBI" ID="47776" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL/APOB" GraphId="ff642" Type="Metabolite">
   <DataNode TextLabel="VLDL/APOB" GraphId="ff642" Type="Metabolite">
Line 1,369: Line 1,373:
     <Comment>The VLDL is produced in the liver, contains one molecule of apoB100</Comment>
     <Comment>The VLDL is produced in the liver, contains one molecule of apoB100</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="247.33333333333334" CenterY="1531.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="247.33333333333334" CenterY="1531.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="39027"/>
+
     <Xref Database="ChEBI" ID="39027" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O2" GraphId="ba6f9" Type="Metabolite">
   <DataNode TextLabel="O2" GraphId="ba6f9" Type="Metabolite">
     <BiopaxRef>d63</BiopaxRef>
     <BiopaxRef>d63</BiopaxRef>
-
     <Graphics CenterX="1628.0" CenterY="1089.0" Width="80.0" Height="30.0" ZOrder="32948" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1628.0" CenterY="1089.0" Width="80.0" Height="30.0" ZOrder="32948" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01377"/>
+
     <Xref Database="HMDB" ID="HMDB01377" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="c1b4b" Type="Metabolite">
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="c1b4b" Type="Metabolite">
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
-
     <Graphics CenterX="1183.3333333333333" CenterY="2243.8166666666666" Width="114.0" Height="30.0" ZOrder="32950" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1183.3333333333333" CenterY="2243.8166666666666" Width="114.0" Height="30.0" ZOrder="32950" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01491"/>
+
     <Xref Database="HMDB" ID="HMDB01491" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-OHdG" GraphId="affc1" Type="Metabolite">
   <DataNode TextLabel="8-OHdG" GraphId="affc1" Type="Metabolite">
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <BiopaxRef>be4</BiopaxRef>
     <BiopaxRef>be4</BiopaxRef>
-
     <Graphics CenterX="958.3333333333334" CenterY="1868.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="958.3333333333334" CenterY="1868.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03333"/>
+
     <Xref Database="HMDB" ID="HMDB03333" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-OHdG" GraphId="c5114" Type="Metabolite">
   <DataNode TextLabel="8-OHdG" GraphId="c5114" Type="Metabolite">
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <BiopaxRef>be4</BiopaxRef>
     <BiopaxRef>be4</BiopaxRef>
-
     <Graphics CenterX="958.3333333333334" CenterY="2178.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="958.3333333333334" CenterY="2178.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03333"/>
+
     <Xref Database="HMDB" ID="HMDB03333" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="ff44e" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="ff44e" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="840.3333333333334" CenterY="1675.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="840.3333333333334" CenterY="1675.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01248"/>
+
     <Xref Database="HMDB" ID="HMDB01248" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PRDX2" GraphId="afe0d" Type="Protein" GroupRef="c1ae6">
   <DataNode TextLabel="PRDX2" GraphId="afe0d" Type="Protein" GroupRef="c1ae6">
     <Comment>EC 1.11.1.15</Comment>
     <Comment>EC 1.11.1.15</Comment>
     <Comment>peroxiredoxin 2</Comment>
     <Comment>peroxiredoxin 2</Comment>
-
     <Graphics CenterX="1124.8166666666666" CenterY="474.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32954" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="1124.8166666666666" CenterY="474.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32954" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="7001"/>
+
     <Xref Database="Entrez Gene" ID="7001" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ADP" GraphId="bfa7a" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="bfa7a" Type="Metabolite">
     <Comment>Adenosine diphosphate</Comment>
     <Comment>Adenosine diphosphate</Comment>
-
     <Graphics CenterX="453.0" CenterY="1051.9833333333333" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="453.0" CenterY="1051.9833333333333" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB01341"/>
+
     <Xref Database="HMDB" ID="HMDB01341" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Leukotriene D4" GraphId="c48de" Type="Metabolite">
   <DataNode TextLabel="Leukotriene D4" GraphId="c48de" Type="Metabolite">
     <BiopaxRef>cf6</BiopaxRef>
     <BiopaxRef>cf6</BiopaxRef>
-
     <Graphics CenterX="2458.6666666666665" CenterY="1293.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32958" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2458.6666666666665" CenterY="1293.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32958" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03080"/>
+
     <Xref Database="HMDB" ID="HMDB03080" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Leukotriene D4" GraphId="edda5" Type="Metabolite">
   <DataNode TextLabel="Leukotriene D4" GraphId="edda5" Type="Metabolite">
-
     <Graphics CenterX="2458.6666666666665" CenterY="2143.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32958" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2458.6666666666665" CenterY="2143.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32958" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03080"/>
+
     <Xref Database="HMDB" ID="HMDB03080" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Copper" GraphId="a1433" Type="Metabolite">
   <DataNode TextLabel="Copper" GraphId="a1433" Type="Metabolite">
-
     <Graphics CenterX="870.0" CenterY="885.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="870.0" CenterY="885.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00657"/>
+
     <Xref Database="HMDB" ID="HMDB00657" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Chlorine" GraphId="b5519" Type="Metabolite">
   <DataNode TextLabel="Chlorine" GraphId="b5519" Type="Metabolite">
-
     <Graphics CenterX="1049.0" CenterY="1107.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1049.0" CenterY="1107.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00492"/>
+
     <Xref Database="HMDB" ID="HMDB00492" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Chlorine" GraphId="c6e4f" Type="Metabolite">
   <DataNode TextLabel="Chlorine" GraphId="c6e4f" Type="Metabolite">
-
     <Graphics CenterX="1003.0" CenterY="2312.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1003.0" CenterY="2312.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00492"/>
+
     <Xref Database="HMDB" ID="HMDB00492" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cystathionine" GraphId="bee4c" Type="Metabolite">
   <DataNode TextLabel="Cystathionine" GraphId="bee4c" Type="Metabolite">
-
     <Graphics CenterX="260.0" CenterY="1778.5" Width="72.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="260.0" CenterY="1778.5" Width="72.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00099"/>
+
     <Xref Database="HMDB" ID="HMDB00099" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="d9733" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="d9733" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="1229.3333333333333" CenterY="1699.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32964" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1229.3333333333333" CenterY="1699.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32964" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01248"/>
+
     <Xref Database="HMDB" ID="HMDB01248" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD2" GraphId="af4b3" Type="Protein" GroupRef="ae815">
   <DataNode TextLabel="SOD2" GraphId="af4b3" Type="Protein" GroupRef="ae815">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 2, mitochondrial</Comment>
     <Comment>superoxide dismutase 2, mitochondrial</Comment>
-
     <Graphics CenterX="893.15" CenterY="985.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32966" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="893.15" CenterY="985.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32966" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="6648"/>
+
     <Xref Database="Entrez Gene" ID="6648" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Dihydrolipoate" GraphId="ac3f4" Type="Metabolite">
   <DataNode TextLabel="Dihydrolipoate" GraphId="ac3f4" Type="Metabolite">
     <BiopaxRef>abc</BiopaxRef>
     <BiopaxRef>abc</BiopaxRef>
     <BiopaxRef>a2e</BiopaxRef>
     <BiopaxRef>a2e</BiopaxRef>
-
     <Graphics CenterX="1424.9833333333333" CenterY="584.65" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32968" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1424.9833333333333" CenterY="584.65" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32968" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB12210"/>
+
     <Xref Database="HMDB" ID="HMDB12210" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Serine" GraphId="a7d41" Type="Metabolite">
   <DataNode TextLabel="Serine" GraphId="a7d41" Type="Metabolite">
-
     <Graphics CenterX="301.0" CenterY="2187.8166666666666" Width="72.0" Height="21.33333333333337" ZOrder="32970" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="301.0" CenterY="2187.8166666666666" Width="72.0" Height="21.33333333333337" ZOrder="32970" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00187"/>
+
     <Xref Database="HMDB" ID="HMDB00187" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="b39da" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="b39da" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="1302.1666666666667" CenterY="980.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32972" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1302.1666666666667" CenterY="980.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32972" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB00217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ATP" GraphId="c50a9" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="c50a9" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
-
     <Graphics CenterX="215.49166666666667" CenterY="1052.9833333333333" Width="51.0" Height="14.7" ZOrder="32974" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="215.49166666666667" CenterY="1052.9833333333333" Width="51.0" Height="14.7" ZOrder="32974" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00538"/>
+
     <Xref Database="HMDB" ID="HMDB00538" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Zinc" GraphId="d4f38" Type="Metabolite">
   <DataNode TextLabel="Zinc" GraphId="d4f38" Type="Metabolite">
-
     <Graphics CenterX="1270.0" CenterY="2192.8166666666666" Width="56.666666666666664" Height="25.0" ZOrder="32976" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1270.0" CenterY="2192.8166666666666" Width="56.666666666666664" Height="25.0" ZOrder="32976" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01303"/>
+
     <Xref Database="HMDB" ID="HMDB01303" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="e0652" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="e0652" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="1139.1666666666667" CenterY="1692.8166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32980" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1139.1666666666667" CenterY="1692.8166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32980" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB00217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GSSG" GraphId="e48d3" Type="Metabolite">
   <DataNode TextLabel="GSSG" GraphId="e48d3" Type="Metabolite">
     <Comment>Glutathione disulfide</Comment>
     <Comment>Glutathione disulfide</Comment>
-
     <Graphics CenterX="1332.0" CenterY="949.0" Width="80.0" Height="30.0" ZOrder="32982" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1332.0" CenterY="949.0" Width="80.0" Height="30.0" ZOrder="32982" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00656"/>
+
     <Xref Database="HMDB" ID="HMDB00656" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="c15fb" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="c15fb" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="1067.5" CenterY="1691.3166666666666" Width="51.0" Height="14.7" ZOrder="32984" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1067.5" CenterY="1691.3166666666666" Width="51.0" Height="14.7" ZOrder="32984" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00221"/>
+
     <Xref Database="HMDB" ID="HMDB00221" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Zinc" GraphId="a48e8" Type="Metabolite">
   <DataNode TextLabel="Zinc" GraphId="a48e8" Type="Metabolite">
-
     <Graphics CenterX="1270.0" CenterY="1568.8333333333333" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1270.0" CenterY="1568.8333333333333" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01303"/>
+
     <Xref Database="HMDB" ID="HMDB01303" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Niacin" GraphId="a602e" Type="Metabolite">
   <DataNode TextLabel="Niacin" GraphId="a602e" Type="Metabolite">
-
     <Graphics CenterX="1391.3166666666666" CenterY="1023.65" Width="70.70000000000005" Height="21.333333333333314" ZOrder="32988" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="1391.3166666666666" CenterY="1023.65" Width="70.70000000000005" Height="21.333333333333314" ZOrder="32988" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB01488"/>
+
     <Xref Database="HMDB" ID="HMDB01488" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Leukotriene B4" GraphId="a9b63" Type="Metabolite">
   <DataNode TextLabel="Leukotriene B4" GraphId="a9b63" Type="Metabolite">
     <BiopaxRef>e71</BiopaxRef>
     <BiopaxRef>e71</BiopaxRef>
     <BiopaxRef>f5f</BiopaxRef>
     <BiopaxRef>f5f</BiopaxRef>
-
     <Graphics CenterX="2273.6666666666665" CenterY="2142.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32990" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2273.6666666666665" CenterY="2142.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32990" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01085"/>
+
     <Xref Database="HMDB" ID="HMDB01085" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Leukotriene B4" GraphId="f74e0" Type="Metabolite">
   <DataNode TextLabel="Leukotriene B4" GraphId="f74e0" Type="Metabolite">
     <BiopaxRef>e71</BiopaxRef>
     <BiopaxRef>e71</BiopaxRef>
-
     <Graphics CenterX="2273.6666666666665" CenterY="1293.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32990" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2273.6666666666665" CenterY="1293.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32990" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01085"/>
+
     <Xref Database="HMDB" ID="HMDB01085" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Quinolinic Acid" GraphId="a2e6b" Type="Metabolite">
   <DataNode TextLabel="Quinolinic Acid" GraphId="a2e6b" Type="Metabolite">
     <BiopaxRef>d0b</BiopaxRef>
     <BiopaxRef>d0b</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
-
     <Graphics CenterX="1496.325" CenterY="1169.65" Width="81.35" Height="21.333333333333314" ZOrder="32992" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1496.325" CenterY="1169.65" Width="81.35" Height="21.333333333333314" ZOrder="32992" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00232"/>
+
     <Xref Database="HMDB" ID="HMDB00232" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PMP" GraphId="a9cb3" Type="Metabolite">
   <DataNode TextLabel="PMP" GraphId="a9cb3" Type="Metabolite">
     <Comment>Pyridoxamine 5'-phosphate</Comment>
     <Comment>Pyridoxamine 5'-phosphate</Comment>
-
     <Graphics CenterX="876.3166666666667" CenterY="1416.3166666666666" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32994" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="876.3166666666667" CenterY="1416.3166666666666" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32994" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01555"/>
+
     <Xref Database="HMDB" ID="HMDB01555" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO" GraphId="a760e" Type="Metabolite">
   <DataNode TextLabel="NO" GraphId="a760e" Type="Metabolite">
Line 1,521: Line 1,525:
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
-
     <Graphics CenterX="1109.3333333333333" CenterY="1192.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1109.3333333333333" CenterY="1192.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03378"/>
+
     <Xref Database="HMDB" ID="HMDB03378" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O3" GraphId="da39a" Type="Metabolite">
   <DataNode TextLabel="O3" GraphId="da39a" Type="Metabolite">
     <Comment>ozone</Comment>
     <Comment>ozone</Comment>
-
     <Graphics CenterX="854.3333333333334" CenterY="1150.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="854.3333333333334" CenterY="1150.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="25812"/>
+
     <Xref Database="ChEBI" ID="25812" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO" GraphId="dbec3" Type="Metabolite">
   <DataNode TextLabel="NO" GraphId="dbec3" Type="Metabolite">
Line 1,533: Line 1,537:
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
-
     <Graphics CenterX="1111.3333333333333" CenterY="2356.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1111.3333333333333" CenterY="2356.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB03378"/>
+
     <Xref Database="HMDB" ID="HMDB03378" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HNO2" GraphId="e2d67" Type="Metabolite">
   <DataNode TextLabel="HNO2" GraphId="e2d67" Type="Metabolite">
     <Comment>Nitrous acid</Comment>
     <Comment>Nitrous acid</Comment>
-
     <Graphics CenterX="1195.3333333333333" CenterY="1235.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1195.3333333333333" CenterY="1235.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="25567"/>
+
     <Xref Database="ChEBI" ID="25567" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO2" GraphId="ee480" Type="Metabolite">
   <DataNode TextLabel="NO2" GraphId="ee480" Type="Metabolite">
     <Comment>Nitrogen dioxide</Comment>
     <Comment>Nitrogen dioxide</Comment>
-
     <Graphics CenterX="1192.3333333333333" CenterY="1192.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1192.3333333333333" CenterY="1192.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="33101"/>
+
     <Xref Database="ChEBI" ID="33101" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HOCl" GraphId="f16d6" Type="Metabolite">
   <DataNode TextLabel="HOCl" GraphId="f16d6" Type="Metabolite">
     <Comment>Hypochlorite</Comment>
     <Comment>Hypochlorite</Comment>
-
     <Graphics CenterX="958.0387027688543" CenterY="1150.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="958.0387027688543" CenterY="1150.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01050"/>
+
     <Xref Database="HMDB" ID="HMDB01050" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="cd332" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="cd332" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="1302.1666666666667" CenterY="2125.3166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32998" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="1302.1666666666667" CenterY="2125.3166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32998" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00217"/>
+
     <Xref Database="HMDB" ID="HMDB00217" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GSH" GraphId="e572e" Type="Metabolite">
   <DataNode TextLabel="GSH" GraphId="e572e" Type="Metabolite">
Line 1,561: Line 1,565:
     <BiopaxRef>e71</BiopaxRef>
     <BiopaxRef>e71</BiopaxRef>
     <BiopaxRef>ae3</BiopaxRef>
     <BiopaxRef>ae3</BiopaxRef>
-
     <Graphics CenterX="1079.0" CenterY="946.5" Width="80.0" Height="30.0" ZOrder="33000" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1079.0" CenterY="946.5" Width="80.0" Height="30.0" ZOrder="33000" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00125"/>
+
     <Xref Database="HMDB" ID="HMDB00125" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="sICAM-1" GraphId="a1471" Type="Protein">
   <DataNode TextLabel="sICAM-1" GraphId="a1471" Type="Protein">
Line 1,569: Line 1,573:
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>cd0</BiopaxRef>
     <BiopaxRef>cd0</BiopaxRef>
-
     <Graphics CenterX="1679.8166666666666" CenterY="2152.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1679.8166666666666" CenterY="2152.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3383"/>
+
     <Xref Database="Entrez Gene" ID="3383" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="D-dimer" GraphId="a7107" Type="Protein">
   <DataNode TextLabel="D-dimer" GraphId="a7107" Type="Protein">
Line 1,576: Line 1,580:
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
-
     <Graphics CenterX="2361.8166666666666" CenterY="2058.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2361.8166666666666" CenterY="2058.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="" ID=""/>
+
     <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL10" GraphId="a8632" Type="Protein">
   <DataNode TextLabel="IL10" GraphId="a8632" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>b77</BiopaxRef>
     <BiopaxRef>b77</BiopaxRef>
-
     <Graphics CenterX="1429.8166666666666" CenterY="2248.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1429.8166666666666" CenterY="2248.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3458"/>
+
     <Xref Database="Entrez Gene" ID="3458" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TNFa" GraphId="aa73c" Type="Protein">
   <DataNode TextLabel="TNFa" GraphId="aa73c" Type="Protein">
Line 1,591: Line 1,595:
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e3f</BiopaxRef>
     <BiopaxRef>e3f</BiopaxRef>
-
     <Graphics CenterX="1429.8166666666666" CenterY="1705.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1429.8166666666666" CenterY="1705.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="7124"/>
+
     <Xref Database="Entrez Gene" ID="7124" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HbA1c" GraphId="ab76c" Type="Protein">
   <DataNode TextLabel="HbA1c" GraphId="ab76c" Type="Protein">
Line 1,598: Line 1,602:
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2634.8166666666666" CenterY="2401.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2634.8166666666666" CenterY="2401.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="" ID=""/>
+
     <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IFNg" GraphId="abc88" Type="Protein">
   <DataNode TextLabel="IFNg" GraphId="abc88" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>f5c</BiopaxRef>
     <BiopaxRef>f5c</BiopaxRef>
-
     <Graphics CenterX="1430.8166666666666" CenterY="2282.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1430.8166666666666" CenterY="2282.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3458"/>
+
     <Xref Database="Entrez Gene" ID="3458" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALB" GraphId="ae520" Type="Protein">
   <DataNode TextLabel="ALB" GraphId="ae520" Type="Protein">
     <Comment>albumin</Comment>
     <Comment>albumin</Comment>
     <BiopaxRef>c31</BiopaxRef>
     <BiopaxRef>c31</BiopaxRef>
-
     <Graphics CenterX="2514.8166666666666" CenterY="1591.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2514.8166666666666" CenterY="1591.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="213"/>
+
     <Xref Database="Entrez Gene" ID="213" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INS" GraphId="b220a" Type="Protein">
   <DataNode TextLabel="INS" GraphId="b220a" Type="Protein">
Line 1,619: Line 1,623:
     <BiopaxRef>c53</BiopaxRef>
     <BiopaxRef>c53</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
-
     <Graphics CenterX="2218.8166666666666" CenterY="2319.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2218.8166666666666" CenterY="2319.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3630"/>
+
     <Xref Database="Entrez Gene" ID="3630" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Fibrin" GraphId="b2cc7" Type="Protein">
+
   <DataNode TextLabel="Fibrin" GraphId="b491c" Type="Metabolite">
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2361.8166666666666" CenterY="1994.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2361.8166666666666" CenterY="1994.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc33" />
-
     <Xref Database="Wikidata" ID="Q27205"/>
+
     <Xref Database="Wikidata" ID="Q27205" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL1B" GraphId="b9f06" Type="Protein">
   <DataNode TextLabel="IL1B" GraphId="b9f06" Type="Protein">
Line 1,633: Line 1,637:
     <BiopaxRef>da2</BiopaxRef>
     <BiopaxRef>da2</BiopaxRef>
     <BiopaxRef>e2d</BiopaxRef>
     <BiopaxRef>e2d</BiopaxRef>
-
     <Graphics CenterX="1429.8166666666666" CenterY="1740.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1429.8166666666666" CenterY="1740.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3553"/>
+
     <Xref Database="Entrez Gene" ID="3553" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INSR" GraphId="bddef" Type="Protein">
   <DataNode TextLabel="INSR" GraphId="bddef" Type="Protein">
Line 1,640: Line 1,644:
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>e66</BiopaxRef>
     <BiopaxRef>e66</BiopaxRef>
-
     <Graphics CenterX="2218.8166666666666" CenterY="1629.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2218.8166666666666" CenterY="1629.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3643"/>
+
     <Xref Database="Entrez Gene" ID="3643" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HBB" GraphId="bf8e2" Type="Protein">
   <DataNode TextLabel="HBB" GraphId="bf8e2" Type="Protein">
     <Comment>hemoglobin, beta</Comment>
     <Comment>hemoglobin, beta</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2512.8166666666666" CenterY="1551.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2512.8166666666666" CenterY="1551.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3043"/>
+
     <Xref Database="Entrez Gene" ID="3043" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TNFa" GraphId="c376b" Type="Protein">
   <DataNode TextLabel="TNFa" GraphId="c376b" Type="Protein">
     <Comment>tumor necrosis factor (TNF superfamily, member 2)</Comment>
     <Comment>tumor necrosis factor (TNF superfamily, member 2)</Comment>
     <BiopaxRef>d42</BiopaxRef>
     <BiopaxRef>d42</BiopaxRef>
-
     <Graphics CenterX="1429.8166666666666" CenterY="2361.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1429.8166666666666" CenterY="2361.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="7124"/>
+
     <Xref Database="Entrez Gene" ID="7124" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CRP" GraphId="c3834" Type="Protein">
   <DataNode TextLabel="CRP" GraphId="c3834" Type="Protein">
Line 1,661: Line 1,665:
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>e0e</BiopaxRef>
     <BiopaxRef>e0e</BiopaxRef>
-
     <Graphics CenterX="1675.8166666666666" CenterY="1211.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1675.8166666666666" CenterY="1211.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="1401"/>
+
     <Xref Database="Entrez Gene" ID="1401" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrin" GraphId="c4a3d" Type="Protein">
   <DataNode TextLabel="Fibrin" GraphId="c4a3d" Type="Protein">
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2363.8166666666666" CenterY="2304.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2363.8166666666666" CenterY="2304.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Wikidata" ID="Q27205"/>
+
     <Xref Database="Wikidata" ID="Q27205" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL1B" GraphId="c8c76" Type="Protein">
   <DataNode TextLabel="IL1B" GraphId="c8c76" Type="Protein">
     <Comment>interleukin 1, beta</Comment>
     <Comment>interleukin 1, beta</Comment>
     <BiopaxRef>d42</BiopaxRef>
     <BiopaxRef>d42</BiopaxRef>
-
     <Graphics CenterX="1429.8166666666666" CenterY="2335.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1429.8166666666666" CenterY="2335.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3553"/>
+
     <Xref Database="Entrez Gene" ID="3553" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IFNg" GraphId="caffc" Type="Protein">
   <DataNode TextLabel="IFNg" GraphId="caffc" Type="Protein">
Line 1,681: Line 1,685:
     <BiopaxRef>e2d</BiopaxRef>
     <BiopaxRef>e2d</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
-
     <Graphics CenterX="1429.8166666666666" CenterY="1836.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1429.8166666666666" CenterY="1836.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3458"/>
+
     <Xref Database="Entrez Gene" ID="3458" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="sICAM-1" GraphId="cf4c8" Type="Protein">
   <DataNode TextLabel="sICAM-1" GraphId="cf4c8" Type="Protein">
Line 1,689: Line 1,693:
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>cd0</BiopaxRef>
     <BiopaxRef>cd0</BiopaxRef>
-
     <Graphics CenterX="1679.8166666666666" CenterY="2002.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1679.8166666666666" CenterY="2002.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3383"/>
+
     <Xref Database="Entrez Gene" ID="3383" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CCL2" GraphId="d147c" Type="Protein">
   <DataNode TextLabel="CCL2" GraphId="d147c" Type="Protein">
Line 1,696: Line 1,700:
     <BiopaxRef>b77</BiopaxRef>
     <BiopaxRef>b77</BiopaxRef>
     <BiopaxRef>e3f</BiopaxRef>
     <BiopaxRef>e3f</BiopaxRef>
-
     <Graphics CenterX="1236.8166666666666" CenterY="1995.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1236.8166666666666" CenterY="1995.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="6347"/>
+
     <Xref Database="Entrez Gene" ID="6347" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INS" GraphId="d58ca" Type="Protein">
   <DataNode TextLabel="INS" GraphId="d58ca" Type="Protein">
Line 1,706: Line 1,710:
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
     <Graphics CenterX="2218.8166666666666" CenterY="1529.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2218.8166666666666" CenterY="1529.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3630"/>
+
     <Xref Database="Entrez Gene" ID="3630" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL10" GraphId="dd0e9" Type="Protein">
   <DataNode TextLabel="IL10" GraphId="dd0e9" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>b77</BiopaxRef>
     <BiopaxRef>b77</BiopaxRef>
-
     <Graphics CenterX="1429.8166666666666" CenterY="1874.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
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     <Graphics CenterX="1429.8166666666666" CenterY="1874.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3458"/>
+
     <Xref Database="Entrez Gene" ID="3458" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALB" GraphId="e2257" Type="Protein">
   <DataNode TextLabel="ALB" GraphId="e2257" Type="Protein">
     <Comment>albumin</Comment>
     <Comment>albumin</Comment>
     <BiopaxRef>c31</BiopaxRef>
     <BiopaxRef>c31</BiopaxRef>
-
     <Graphics CenterX="2514.8166666666666" CenterY="2201.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
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     <Graphics CenterX="2514.8166666666666" CenterY="2201.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="213"/>
+
     <Xref Database="Entrez Gene" ID="213" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FLAP" GraphId="e262a" Type="Protein">
   <DataNode TextLabel="FLAP" GraphId="e262a" Type="Protein">
     <Comment>arachidonate 5-lipoxygenase-activating protein</Comment>
     <Comment>arachidonate 5-lipoxygenase-activating protein</Comment>
     <BiopaxRef>f43</BiopaxRef>
     <BiopaxRef>f43</BiopaxRef>
-
     <Graphics CenterX="1845.8166666666666" CenterY="874.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
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     <Graphics CenterX="1845.8166666666666" CenterY="874.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="241"/>
+
     <Xref Database="Entrez Gene" ID="241" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL6" GraphId="eaaa4" Type="Protein">
   <DataNode TextLabel="IL6" GraphId="eaaa4" Type="Protein">
Line 1,732: Line 1,736:
     <BiopaxRef>ed1</BiopaxRef>
     <BiopaxRef>ed1</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
-
     <Graphics CenterX="1429.8166666666666" CenterY="1788.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
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     <Graphics CenterX="1429.8166666666666" CenterY="1788.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3569"/>
+
     <Xref Database="Entrez Gene" ID="3569" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CCL2" GraphId="eb649" Type="Protein">
   <DataNode TextLabel="CCL2" GraphId="eb649" Type="Protein">
Line 1,739: Line 1,743:
     <BiopaxRef>b77</BiopaxRef>
     <BiopaxRef>b77</BiopaxRef>
     <BiopaxRef>e3f</BiopaxRef>
     <BiopaxRef>e3f</BiopaxRef>
-
     <Graphics CenterX="1236.8166666666666" CenterY="2325.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
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     <Graphics CenterX="1236.8166666666666" CenterY="2325.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="6347"/>
+
     <Xref Database="Entrez Gene" ID="6347" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL6" GraphId="ef76d" Type="Protein">
   <DataNode TextLabel="IL6" GraphId="ef76d" Type="Protein">
     <Comment>interleukin 6 (interferon, beta 2)</Comment>
     <Comment>interleukin 6 (interferon, beta 2)</Comment>
     <BiopaxRef>f5c</BiopaxRef>
     <BiopaxRef>f5c</BiopaxRef>
-
     <Graphics CenterX="1429.8166666666666" CenterY="2309.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="1429.8166666666666" CenterY="2309.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3569"/>
+
     <Xref Database="Entrez Gene" ID="3569" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrinogen" GraphId="f2509" Type="Protein">
   <DataNode TextLabel="Fibrinogen" GraphId="f2509" Type="Protein">
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
-
     <Graphics CenterX="2363.8166666666666" CenterY="2378.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2363.8166666666666" CenterY="2378.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="" ID=""/>
+
     <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Fibrinogen" GraphId="f3dd1" Type="Protein">
+
   <DataNode TextLabel="Fibrinogen" GraphId="f3dd1" Type="Protein" GroupRef="e46d6">
-
    <BiopaxRef>af4</BiopaxRef>
+
     <Graphics CenterX="2361.8166666666666" CenterY="1888.4445736434102" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Graphics CenterX="2361.8166666666666" CenterY="1910.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Xref Database="" ID="" />
-
     <Xref Database="" ID=""/>
+
   </DataNode>
   </DataNode>
   <DataNode TextLabel="D-dimer" GraphId="f6b17" Type="Protein">
   <DataNode TextLabel="D-dimer" GraphId="f6b17" Type="Protein">
Line 1,762: Line 1,765:
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
-
     <Graphics CenterX="2363.8166666666666" CenterY="2242.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2363.8166666666666" CenterY="2242.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="" ID=""/>
+
     <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HBA1" GraphId="f710f" Type="Protein">
   <DataNode TextLabel="HBA1" GraphId="f710f" Type="Protein">
     <Comment>hemoglobin, alpha 1</Comment>
     <Comment>hemoglobin, alpha 1</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2512.8166666666666" CenterY="1495.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2512.8166666666666" CenterY="1495.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="Entrez Gene" ID="3039"/>
+
     <Xref Database="Entrez Gene" ID="3039" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HbA1c" GraphId="fcf18" Type="Protein">
   <DataNode TextLabel="HbA1c" GraphId="fcf18" Type="Protein">
Line 1,775: Line 1,778:
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2632.8166666666666" CenterY="1523.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
+
     <Graphics CenterX="2632.8166666666666" CenterY="1523.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
-
     <Xref Database="" ID=""/>
+
     <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SelW" GraphId="a3dd8" Type="Protein">
   <DataNode TextLabel="SelW" GraphId="a3dd8" Type="Protein">
Line 1,783: Line 1,786:
     <BiopaxRef>dd0</BiopaxRef>
     <BiopaxRef>dd0</BiopaxRef>
     <BiopaxRef>fb6</BiopaxRef>
     <BiopaxRef>fb6</BiopaxRef>
-
     <Graphics CenterX="1745.8166666666666" CenterY="809.4833333333333" Width="88.66666666666674" Height="17.700000000000045" ZOrder="33004" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1745.8166666666666" CenterY="809.4833333333333" Width="88.66666666666674" Height="17.700000000000045" ZOrder="33004" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="6415"/>
+
     <Xref Database="Entrez Gene" ID="6415" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Riboflavin" GraphId="d3307" Type="Metabolite">
   <DataNode TextLabel="Riboflavin" GraphId="d3307" Type="Metabolite">
     <BiopaxRef>ca9</BiopaxRef>
     <BiopaxRef>ca9</BiopaxRef>
-
     <Graphics CenterX="149.31666666666666" CenterY="1021.3166666666667" Width="70.7" Height="21.333333333333346" ZOrder="33006" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="149.31666666666666" CenterY="1021.3166666666667" Width="70.7" Height="21.333333333333346" ZOrder="33006" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00244"/>
+
     <Xref Database="HMDB" ID="HMDB00244" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD3" GraphId="c6bd2" Type="Protein">
   <DataNode TextLabel="SOD3" GraphId="c6bd2" Type="Protein">
Line 1,795: Line 1,798:
     <Comment>superoxide dismutase 3, extracellular</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
     <BiopaxRef>ae2</BiopaxRef>
     <BiopaxRef>ae2</BiopaxRef>
-
     <Graphics CenterX="716.15" CenterY="2128.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33008" FontSize="10" Valign="Middle" Color="999998"/>
+
     <Graphics CenterX="716.15" CenterY="2128.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33008" FontSize="10" Valign="Middle" Color="999998" />
-
     <Xref Database="Entrez Gene" ID="6649"/>
+
     <Xref Database="Entrez Gene" ID="6649" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TRXR1" GraphId="b6504" Type="Protein">
   <DataNode TextLabel="TRXR1" GraphId="b6504" Type="Protein">
     <Comment>Selenoprotein-thioredoxin reductase 1</Comment>
     <Comment>Selenoprotein-thioredoxin reductase 1</Comment>
     <BiopaxRef>f1f</BiopaxRef>
     <BiopaxRef>f1f</BiopaxRef>
-
     <Graphics CenterX="1438.0" CenterY="2189.8333333333335" Width="78.66666666666667" Height="17.0" ZOrder="33010" FontSize="10" Valign="Middle" Color="ff0000"/>
+
     <Graphics CenterX="1438.0" CenterY="2189.8333333333335" Width="78.66666666666667" Height="17.0" ZOrder="33010" FontSize="10" Valign="Middle" Color="ff0000" />
-
     <Xref Database="Entrez Gene" ID="7296"/>
+
     <Xref Database="Entrez Gene" ID="7296" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Ascorbate" GraphId="f643c" Type="Metabolite">
   <DataNode TextLabel="Ascorbate" GraphId="f643c" Type="Metabolite">
     <BiopaxRef>ec4</BiopaxRef>
     <BiopaxRef>ec4</BiopaxRef>
     <BiopaxRef>f97</BiopaxRef>
     <BiopaxRef>f97</BiopaxRef>
-
     <Graphics CenterX="1122.9833333333333" CenterY="379.65" Width="112.03333333333333" Height="21.366666666666667" ZOrder="33012" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1122.9833333333333" CenterY="379.65" Width="112.03333333333333" Height="21.366666666666667" ZOrder="33012" FontSize="10" Valign="Middle" />
-
     <Xref Database="ChEBI" ID="38290"/>
+
     <Xref Database="ChEBI" ID="38290" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O2-“" GraphId="d1e46" Type="Metabolite">
   <DataNode TextLabel="O2-“" GraphId="d1e46" Type="Metabolite">
     <Comment>Superoxide</Comment>
     <Comment>Superoxide</Comment>
-
     <Graphics CenterX="849.4798072510325" CenterY="1082.0" Width="44.95961450206505" Height="18.0" ZOrder="33014" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="849.4798072510325" CenterY="1082.0" Width="44.95961450206505" Height="18.0" ZOrder="33014" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02168"/>
+
     <Xref Database="HMDB" ID="HMDB02168" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Xanthine" GraphId="fbb37" Type="Metabolite">
   <DataNode TextLabel="Xanthine" GraphId="fbb37" Type="Metabolite">
-
     <Graphics CenterX="341.0" CenterY="793.6666666666666" Width="56.0" Height="17.0" ZOrder="33016" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="341.0" CenterY="793.6666666666666" Width="56.0" Height="17.0" ZOrder="33016" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00292"/>
+
     <Xref Database="HMDB" ID="HMDB00292" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Calcium" GraphId="eddfc" Type="Metabolite">
   <DataNode TextLabel="Calcium" GraphId="eddfc" Type="Metabolite">
     <BiopaxRef>f5f</BiopaxRef>
     <BiopaxRef>f5f</BiopaxRef>
-
     <Graphics CenterX="2024.0" CenterY="2244.15" Width="56.666666666666664" Height="21.333333333333314" ZOrder="33018" FontSize="10" Valign="Middle" Color="009933"/>
+
     <Graphics CenterX="2024.0" CenterY="2244.15" Width="56.666666666666664" Height="21.333333333333314" ZOrder="33018" FontSize="10" Valign="Middle" Color="009933" />
-
     <Xref Database="HMDB" ID="HMDB00464"/>
+
     <Xref Database="HMDB" ID="HMDB00464" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Kynureninase" GraphId="c9f82" Type="Protein">
   <DataNode TextLabel="Kynureninase" GraphId="c9f82" Type="Protein">
     <Comment>EC 3.7.1.3</Comment>
     <Comment>EC 3.7.1.3</Comment>
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
-
     <Graphics CenterX="1337.3333333333333" CenterY="1200.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="33020" FontSize="10" Valign="Middle" Color="999999"/>
+
     <Graphics CenterX="1337.3333333333333" CenterY="1200.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="33020" FontSize="10" Valign="Middle" Color="999999" />
-
     <Xref Database="Entrez Gene" ID="8942"/>
+
     <Xref Database="Entrez Gene" ID="8942" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Methionine" GraphId="d77b8" Type="Metabolite">
   <DataNode TextLabel="Methionine" GraphId="d77b8" Type="Metabolite">
     <BiopaxRef>aff</BiopaxRef>
     <BiopaxRef>aff</BiopaxRef>
-
     <Graphics CenterX="628.0" CenterY="1493.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="628.0" CenterY="1493.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB00696"/>
+
     <Xref Database="HMDB" ID="HMDB00696" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ADP" GraphId="dcdd4" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="dcdd4" Type="Metabolite">
     <Comment>Adenosine diphosphate</Comment>
     <Comment>Adenosine diphosphate</Comment>
-
     <Graphics CenterX="291.0" CenterY="1052.9833333333333" Width="51.0" Height="14.7" ZOrder="33024" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="291.0" CenterY="1052.9833333333333" Width="51.0" Height="14.7" ZOrder="33024" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB01341"/>
+
     <Xref Database="HMDB" ID="HMDB01341" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Trx-(SH)2" GraphId="aa8a1" Type="Protein">
   <DataNode TextLabel="Trx-(SH)2" GraphId="aa8a1" Type="Protein">
Line 1,844: Line 1,847:
     <BiopaxRef>abc</BiopaxRef>
     <BiopaxRef>abc</BiopaxRef>
     <BiopaxRef>f1f</BiopaxRef>
     <BiopaxRef>f1f</BiopaxRef>
-
     <Graphics CenterX="1399.65" CenterY="413.65" Width="69.36666666666666" Height="21.366666666666667" ZOrder="33026" FontSize="10" Valign="Middle" Color="fccc00"/>
+
     <Graphics CenterX="1399.65" CenterY="413.65" Width="69.36666666666666" Height="21.366666666666667" ZOrder="33026" FontSize="10" Valign="Middle" Color="fccc00" />
-
     <Xref Database="Entrez Gene" ID="7295"/>
+
     <Xref Database="Entrez Gene" ID="7295" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Nitrotyrosine" GraphId="a3827" Type="Metabolite">
   <DataNode TextLabel="Nitrotyrosine" GraphId="a3827" Type="Metabolite">
     <BiopaxRef>f11</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
-
     <Graphics CenterX="855.1666666666666" CenterY="1290.6666666666667" Width="89.0" Height="18.0" ZOrder="33028" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="855.1666666666666" CenterY="1290.6666666666667" Width="89.0" Height="18.0" ZOrder="33028" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01904"/>
+
     <Xref Database="HMDB" ID="HMDB01904" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ONOO-/ONOOH" GraphId="ed886" Type="Metabolite">
   <DataNode TextLabel="ONOO-/ONOOH" GraphId="ed886" Type="Metabolite">
     <Comment>Peroxynitrite</Comment>
     <Comment>Peroxynitrite</Comment>
-
     <Graphics CenterX="1114.1666666666667" CenterY="1235.0" Width="89.0" Height="18.0" ZOrder="33028" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="1114.1666666666667" CenterY="1235.0" Width="89.0" Height="18.0" ZOrder="33028" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02179"/>
+
     <Xref Database="HMDB" ID="HMDB02179" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Nitrotyrosine" GraphId="f6e0b" Type="Metabolite">
   <DataNode TextLabel="Nitrotyrosine" GraphId="f6e0b" Type="Metabolite">
     <BiopaxRef>f11</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
-
     <Graphics CenterX="855.1666666666666" CenterY="2291.6666666666665" Width="89.0" Height="18.0" ZOrder="33028" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="855.1666666666666" CenterY="2291.6666666666665" Width="89.0" Height="18.0" ZOrder="33028" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB01904"/>
+
     <Xref Database="HMDB" ID="HMDB01904" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ATP" GraphId="cdd46" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="cdd46" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
-
     <Graphics CenterX="381.4916666666667" CenterY="1052.9833333333333" Width="51.0" Height="14.7" ZOrder="33030" FontSize="10" Valign="Middle" Color="ffff00"/>
+
     <Graphics CenterX="381.4916666666667" CenterY="1052.9833333333333" Width="51.0" Height="14.7" ZOrder="33030" FontSize="10" Valign="Middle" Color="ffff00" />
-
     <Xref Database="HMDB" ID="HMDB00538"/>
+
     <Xref Database="HMDB" ID="HMDB00538" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Leukotriene E4" GraphId="a9427" Type="Metabolite">
   <DataNode TextLabel="Leukotriene E4" GraphId="a9427" Type="Metabolite">
-
     <Graphics CenterX="2660.6666666666665" CenterY="2254.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="33032" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="2660.6666666666665" CenterY="2254.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="33032" FontSize="10" Valign="Middle" />
-
     <Xref Database="HMDB" ID="HMDB02200"/>
+
     <Xref Database="HMDB" ID="HMDB02200" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Leukotriene E4" GraphId="b73ed" Type="Metabolite">
   <DataNode TextLabel="Leukotriene E4" GraphId="b73ed" Type="Metabolite">
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   <DataNode TextLabel="Glucose" GraphId="c8be1" Type="Metabolite">
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