Target Of Rapamycin (TOR) Signaling (Homo sapiens)

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mTORC2ribosome biogenesisCytoskeletal dynamicsInsulin signalingAmino acidsautophagyAmino acid transportermTORC1mRNA translationSurvivalRPS6KB1PRR5RRAGAPRR5LRRAGCPRKCAMLST8AKT1S1MTORMTORRRAGDMLST8RPTORULK1TSC2RapamycinFKBP1ATSC1AKT1ULK2RHEBRRAGBULK3RICTORMAPKAP1EIF4EBP1


Description

No description

Quality Tags

Ontology Terms

 

Bibliography

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  1. Inoki K, Guan KL; ''Complexity of the TOR signaling network.''; Trends Cell Biol, 2006 PubMed Europe PMC
  2. Yang Q, Guan KL; ''Expanding mTOR signaling.''; Cell Res, 2007 PubMed Europe PMC
  3. Corradetti MN, Guan KL; ''Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?''; Oncogene, 2006 PubMed Europe PMC
  4. Sancak Y, Sabatini DM; ''Rag proteins regulate amino-acid-induced mTORC1 signalling.''; Biochem Soc Trans, 2009 PubMed Europe PMC
  5. Wullschleger S, Loewith R, Hall MN; ''TOR signaling in growth and metabolism.''; Cell, 2006 PubMed Europe PMC
  6. Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, Rantanen V, Wessig C, van Deijk AL, Smit AB, Verheijen MH, Rüegg MA, Hall MN, Suter U; ''mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.''; Cell Rep, 2014 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106444view23:34, 28 August 2019KhanspersModified description
105496view05:50, 8 August 2019KhanspersModified description
94755view15:33, 5 October 2017Mkutmonfix unconnected line
90258view20:01, 27 October 2016AlexanderPicoupdated compartment and graphical object types
86079view10:06, 29 June 2016MirellaKalafatiModified title
82750view03:25, 27 October 2015Jlw9added components of myelination pathway
82749view03:15, 27 October 2015Jlw9Periodical save, work in progress
82748view02:55, 27 October 2015Jlw9Periodical save, work in progress
82747view02:45, 27 October 2015Jlw9Periodical save, work in progress
82219view02:39, 16 September 2015AlexanderPicoclarified interactions for biopax conversion
70031view01:57, 12 July 2013AlexanderPicoModified title
69007view17:46, 8 July 2013MaintBotUpdated to 2013 gpml schema
61698view23:24, 16 April 2013MaintBotremoved data source without identifer
60230view20:12, 14 March 2013EgonwReplaced PubChem-substance with PubChem-compound.
60227view20:10, 14 March 2013EgonwAnnotated 'amino acid' with an ChEBI entry.
59195view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
48241view06:07, 17 May 2012MaintBotUpdating PubChem xrefs
45081view20:42, 6 October 2011KhanspersOntology Term : 'insulin signaling pathway' added !
45080view20:41, 6 October 2011KhanspersOntology Term : 'AMPK signaling pathway' added !
45078view20:40, 6 October 2011KhanspersOntology Term : 'mTOR signaling pathway' added !
41181view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38698view19:08, 23 September 2010AlexanderPicopathway nodes
38691view18:26, 23 September 2010AlexanderPicoadded pathway nodes; altered labels for conditions and phenotypes
36157view16:59, 3 March 2010Pieter GiesbertzSpecify description
36156view15:53, 3 March 2010Pieter GiesbertzModified categories
36155view15:48, 3 March 2010Pieter GiesbertzSpecify description
36140view12:31, 3 March 2010Pieter GiesbertzSpecify description
36139view12:15, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36138view11:44, 3 March 2010Pieter GiesbertzModified description
36137view11:41, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36095view10:09, 3 March 2010Pieter GiesbertzAdded literature
36042view09:17, 3 March 2010Pieter GiesbertzSpecify description
36041view09:06, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36040view08:35, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36039view16:22, 2 March 2010Pieter GiesbertzSpecify description
36038view16:19, 2 March 2010Pieter GiesbertzSpecify description
36037view16:17, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36035view16:06, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36032view15:40, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36031view15:17, 2 March 2010Pieter GiesbertzSpecify description
36030view15:10, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36029view15:00, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36026view12:55, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36025view12:39, 2 March 2010Pieter GiesbertzSpecify description
36024view12:34, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36023view12:14, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36022view12:04, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36021view12:00, 2 March 2010Pieter GiesbertzSpecify description
36020view11:54, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36019view11:47, 2 March 2010Pieter GiesbertzSpecify description

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl Human)
AKT1S1GeneProductENSG00000204673 (Ensembl Human)
EIF4EBP1GeneProductENSG00000187840 (Ensembl Human)
FKBP1AGeneProductENSG00000088832 (Ensembl Human)
MAPKAP1GeneProductENSG00000119487 (Ensembl Human)
MLST8GeneProductENSG00000167965 (Ensembl Human)
MTORGeneProductENSG00000198793 (Ensembl Human)
PRKCAGeneProductENSG00000154229 (Ensembl Human)
PRR5GeneProductENSG00000186654 (Ensembl Human)
PRR5LGeneProductENSG00000135362 (Ensembl Human)
RHEBGeneProductENSG00000106615 (Ensembl Human)
RICTORGeneProductENSG00000164327 (Ensembl Human)
RPS6KB1GeneProductENSG00000108443 (Ensembl Human)
RPTORGeneProductENSG00000141564 (Ensembl Human)
RRAGAGeneProductENSG00000155876 (Ensembl Human)
RRAGBGeneProductENSG00000083750 (Ensembl Human)
RRAGCGeneProductENSG00000116954 (Ensembl Human)
RRAGDGeneProductENSG00000025039 (Ensembl Human)
RapamycinMetabolite7847818 (PubChem)
TSC1GeneProductENSG00000165699 (Ensembl Human)
TSC2GeneProductENSG00000103197 (Ensembl Human)
ULK1GeneProductENSG00000177169 (Ensembl Human)
ULK2GeneProductENSG00000083290 (Ensembl Human)
ULK3GeneProductENSG00000140474 (Ensembl Human)

Annotated Interactions

No annotated interactions

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