Regulation of toll-like receptor signaling pathway (Homo sapiens)

From WikiPathways

Revision as of 15:17, 5 October 2017 by DeSl (Talk | contribs)
Jump to: navigation, search
1, 2+pAutocrine / ParacrineInflammatory cytokinesJak-STAT signaling pathway-pEndosome+p+Proinflammatory+p+pMyD88-dependent pathway-Ub(anti-viral compounds)+UbeffectsNK cell)CpG DNAssRNASpecific pathwayin pDCsDownregulates+p+pCytokine--UbLPS(G-)+pImidazoquinolin+pDegradation(Neutrophil, immature DC,interactionInflammatory cytokinesChemotacticcytokine receptorLUBACMyD88-independent pathwayUnmethylatedFlagellin+peffectsT cell stimulation+p+UbMAPK signaling pathwayUbiquitin mediated proteolysis+peffectsComplement andIKK+p+p(T cell)coagulation cascades+p+p-Ub++pAntiviral effectsCostimulatory molecules+pdsRNADNAChemotacticPTPN6MAP2K3AKT2BTKFOSTIRAPIRAK3RBCK1SQSTM1STAT1NFKBIANEU1CD80MLST8RNF216IRF3PIK3CBIFNAR1IL1BCXCL9Tifahsa-mir-155CASP8CTNNAL1hsa-mir-105-1TLR1IKBKGMYD88MAPK3MYD88MAPK12PIK3CGRNF41CD86hsa-let-7eSYKMYD88CXCL11IFNA13NFKB1LY96Trim30PIK3R5OTUD5IFNA14IFNB1MAPK14TLR7CISHTICAM1IL6SOCS1TLR8IFNA6FBXW5SMAD6PELI1IRAK4IL12BRAC1TLR3MAPK9TLR4sTICAM2 (TAG)IFNA10IFNA21TLR4SIGIRRTOLLIPCCL4IFNAR2TRAF6RELASPP1ZMYND11hsa-let-7i (gene)IL12ACYLDIRAK4TRAF3LBPPLK1MAP2K7MAP3K7IP1SFTPA1IKBKEIRF5TLR2MAP3K7CCL3RIPK1IFNA1PIK3R1IKBKBPIK3CDMYD88sIFNA4TICAM2FADDApoptosisTNFMAPK8SFTPDMAP2K2IFNA5MAP3K8PELI2MAPK1RNF41IFNB1TREM1IFNB1TRAF6MAPK11IFNA17MAPK10MAP2K4CUEDC2TLR2TRAFD1CD180TLR5IRAK1CXCL10IRF7MAP3K7IP3CHUKhsa-mir-146aCHUKTLR2sCD40AKT3PELI3CD14AKT1IRAK2MAPK13CCL5IFNA2MBL2NFKB2IFNA8TBK1JUNMAP2K6MAP3K7IP2IFNA16IRAK1IL8SARM1TLR6IFNA7TRAF6hsa-let-7ehsa-mir-98TIRAPMAP2K1TNFAIP3PIK3R3RNF31TLR9PIK3R2MYD88PIK3CAUSP7NFKB1


Description

No description

Quality Tags

Ontology Terms

 

Bibliography

  1. Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S; ''Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.''; Nat Immunol, 2002 PubMed Europe PMC
  2. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S; ''Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.''; Nat Immunol, 2002 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106494view21:43, 4 September 2019KhanspersModified description
105804view22:52, 15 August 2019KhanspersModified description
103013view15:24, 31 January 2019Marvin M2Updated incorrect miRNA Ensembl IDs
96021view15:24, 15 February 2018DeSlConnected more lines, according to original PW
96017view15:07, 15 February 2018DeSlModified description
96016view15:07, 15 February 2018DeSlModified description
94748view15:17, 5 October 2017DeSlConnected as many lines as possible...
81172view13:07, 31 July 2015EgonwReplaced the ChemSpider ID for a specific compound to a ChEBI identifier for the compound class (following the two papers I just added and the Wikipedia article on imidazoquinolin).
81171view13:06, 31 July 2015EgonwAdded two papers describing the interaction of imisazoquonilines with TLR7/TLR8.
80070view18:32, 4 May 2015Khanspersremoved mouse identifier
79976view12:37, 29 April 2015Zaricorrected Id for hsa-mir-98
79550view11:15, 25 March 2015Zari
79549view11:13, 25 March 2015Zarichanged Id for tifa
77378view10:57, 1 September 2014EgonwUpdated layout, grouped noded, and fixed link to TLR7/TLR8.
77377view10:51, 1 September 2014Egonw"Anti-viral compound" has a ChEBI ID too.
77376view10:49, 1 September 2014EgonwConverted a label into a metabolite DataNode with a Chemspider identifier.
72114view23:00, 24 October 2013AlexanderPicoupdate mmu-let-7e to hsa-let-7e
72113view22:58, 24 October 2013AlexanderPicoadded missing database to xref
71388view18:42, 17 October 2013MaintBotAutomated update of data sources
70945view12:38, 17 September 2013Cloris816Periodical save, work in progress
69023view17:49, 8 July 2013MaintBotUpdated to 2013 gpml schema
59207view19:50, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
57636view08:08, 31 January 2013MaintBotReverted to version '19:11, 6 October 2011' by MaintBot
57633view04:05, 31 January 2013MaiyuPeriodical save, work in progress
45049view19:11, 6 October 2011ThomasOntology Term : 'Toll-like receptor signaling pathway' added !
41202view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
38854view18:05, 24 September 2010Khanspers
38853view18:05, 24 September 2010KhanspersChanged line types and added pathway link
36215view16:17, 9 March 2010Khansperschanged title
34714view19:03, 12 January 2010Khansperschanged pathway title
34459view18:26, 10 December 2009MaintBotAutomatic update of empty xrefs
33706view22:18, 4 December 2009MisbahNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(anti-viral compounds)MetaboliteCHEBI:22587 (ChEBI)
AKT1GeneProduct207 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT2GeneProduct208 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT3GeneProduct10000 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
ApoptosisPathwayWP254 (WikiPathways)
BTKGeneProductENSG00000010671 (Ensembl)
CASP8GeneProduct841 (Entrez Gene) Original kegg element: gene;87;hsa:841
CCL3GeneProduct6348 (Entrez Gene) Original kegg element: gene;44;hsa:6348
CCL4GeneProduct6351 (Entrez Gene) Original kegg element: gene;38;hsa:6351
CCL5GeneProduct6352 (Entrez Gene) Original kegg element: gene;58;hsa:6352
CD14GeneProduct929 (Entrez Gene) Original kegg element: gene;84;hsa:929
CD180GeneProductENSG00000134061 (Ensembl)
CD40GeneProduct958 (Entrez Gene) Original kegg element: gene;29;hsa:958
CD80GeneProduct941 (Entrez Gene) Original kegg element: gene;69;hsa:941
CD86GeneProduct942 (Entrez Gene) Original kegg element: gene;28;hsa:942
CHUKGeneProduct1147 (Entrez Gene) Original kegg element: gene;42;hsa:1147
CISHGeneProductENSG00000114737 (Ensembl)
CTNNAL1GeneProductENSG00000119326 (Ensembl)
CUEDC2GeneProductENSG00000107874 (Ensembl)
CXCL10GeneProduct3627 (Entrez Gene) Original kegg element: gene;25;hsa:3627
CXCL11GeneProduct6373 (Entrez Gene) Original kegg element: gene;23;hsa:6373
CXCL9GeneProduct4283 (Entrez Gene) Original kegg element: gene;24;hsa:4283
CYLDGeneProductENSG00000083799 (Ensembl)
FADDGeneProduct8772 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FBXW5GeneProductENSG00000159069 (Ensembl)
FOSGeneProduct2353 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA10GeneProduct3446 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProduct3447 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA1GeneProduct3439 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProduct3448 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProduct3449 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProduct3451 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProduct3452 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProduct3440 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProduct3441 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct3442 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProduct3443 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProduct3444 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProduct3445 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProduct3454 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProduct3455 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNB1GeneProduct3456 (Entrez Gene) Original kegg element: gene;1;hsa:3456
IKBKBGeneProduct3551 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKEGeneProduct9641 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProduct8517 (Entrez Gene) Original kegg element: gene;85;hsa:8517
IL12AGeneProduct3592 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProduct3593 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct3553 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProduct3569 (Entrez Gene) Original kegg element: gene;57;hsa:3569
IL8GeneProduct3576 (Entrez Gene) Original kegg element: gene;43;hsa:3576
IRAK1GeneProduct3654 (Entrez Gene) Original kegg element: gene;41;hsa:3654
IRAK2GeneProductENSG00000134070 (Ensembl)
IRAK3GeneProductENSG00000090376 (Ensembl)
IRAK4GeneProduct51135 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProduct3661 (Entrez Gene) Original kegg element: gene;67;hsa:3661
IRF5GeneProduct3663 (Entrez Gene) Original kegg element: gene;21;hsa:3663
IRF7GeneProduct3665 (Entrez Gene) Original kegg element: gene;20;hsa:3665
ImidazoquinolinMetaboliteCHEBI:38776 (ChEBI)
JUNGeneProduct3725 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LBPGeneProduct3929 (Entrez Gene) Original kegg element: gene;77;hsa:3929
LY96GeneProduct23643 (Entrez Gene) Original kegg element: gene;71;hsa:23643
MAP2K1GeneProduct5604 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K2GeneProduct5605 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K3GeneProduct5606 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K4GeneProduct6416 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP2K6GeneProduct5608 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K7GeneProduct5609 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP3K7GeneProduct6885 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAP3K7IP1GeneProduct10454 (Entrez Gene) Original kegg element: gene;59;hsa:10454
MAP3K7IP2GeneProductENSG00000055208 (Ensembl) Original kegg element: gene;59;hsa:10454
MAP3K7IP3GeneProductENSG00000157625 (Ensembl) Original kegg element: gene;61;hsa:23118
MAP3K8GeneProduct1326 (Entrez Gene) Original kegg element: gene;13;hsa:1326
MAPK10GeneProduct5602 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK11GeneProduct5600 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK12GeneProduct6300 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK13GeneProduct5603 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK14GeneProduct1432 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK1GeneProduct5594 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK3GeneProduct5595 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK8GeneProduct5599 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct5601 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MBL2GeneProductENSG00000165471 (Ensembl)
MLST8GeneProduct64223 (Entrez Gene)
MYD88GeneProduct4615 (Entrez Gene) Original kegg element: gene;47;hsa:4615
MYD88sGeneProductENSG00000172936 (Ensembl)
NEU1GeneProductENSG00000184494 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKB2GeneProduct4791 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct4792 (Entrez Gene) Original kegg element: gene;64;hsa:4792
OTUD5GeneProductENSG00000068308 (Ensembl)
PELI1GeneProductENSG00000197329 (Ensembl)
PELI2GeneProductENSG00000139946 (Ensembl)
PELI3GeneProductENSG00000174516 (Ensembl)
PIK3CAGeneProduct5290 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CBGeneProduct5291 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CDGeneProduct5293 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CGGeneProduct5294 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R1GeneProduct5295 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R2GeneProduct5296 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R3GeneProduct8503 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R5GeneProduct23533 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PLK1GeneProductENSG00000166851 (Ensembl)
PTPN6GeneProductENSG00000111679 (Ensembl)
RAC1GeneProduct5879 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RBCK1GeneProductENSG00000125826 (Ensembl)
RELAGeneProduct5970 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RIPK1GeneProduct8737 (Entrez Gene) Original kegg element: gene;17;hsa:8737
RNF216GeneProductENSG00000011275 (Ensembl)
RNF31GeneProductENSG00000092098 (Ensembl)
RNF41GeneProductENSG00000181852 (Ensembl)
SARM1GeneProductENSG00000004139 (Ensembl)
SFTPA1GeneProductENSG00000185303 (Ensembl)
SFTPDGeneProductENSG00000133661 (Ensembl)
SIGIRRGeneProductENSG00000185187 (Ensembl)
SMAD6GeneProductENSG00000137834 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
SPP1GeneProduct6696 (Entrez Gene) Original kegg element: gene;15;hsa:6696
SQSTM1GeneProductENSG00000161011 (Ensembl)
STAT1GeneProduct6772 (Entrez Gene) Original kegg element: gene;62;hsa:6772
SYKGeneProductENSG00000165025 (Ensembl)
TBK1GeneProduct29110 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TICAM1GeneProduct148022 (Entrez Gene) Original kegg element: gene;82;hsa:148022
TICAM2 (TAG)GeneProductENSG00000134970 (Ensembl)
TICAM2GeneProduct353376 (Entrez Gene) Original kegg element: gene;80;hsa:353376
TIRAPGeneProduct114609 (Entrez Gene) Original kegg element: gene;46;hsa:114609
TLR1GeneProduct7096 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR2GeneProduct7097 (Entrez Gene) Original kegg element: gene;74;hsa:7097
TLR2sGeneProductENSG00000137462 (Ensembl)
TLR3GeneProduct7098 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProduct7099 (Entrez Gene) Original kegg element: gene;79;hsa:7099
TLR4sGeneProductENSG00000136869 (Ensembl)
TLR5GeneProduct7100 (Entrez Gene) Original kegg element: gene;72;hsa:7100
TLR6GeneProduct10333 (Entrez Gene) Original kegg element: gene;76;hsa:10333
TLR7GeneProduct51284 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR8GeneProduct51311 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProduct54106 (Entrez Gene) Original kegg element: gene;78;hsa:54106
TNFGeneProduct7124 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TNFAIP3GeneProductENSG00000118503 (Ensembl)
TOLLIPGeneProduct54472 (Entrez Gene) Original kegg element: gene;81;hsa:54472
TRAF3GeneProduct7187 (Entrez Gene) Original kegg element: gene;16;hsa:7187
TRAF6GeneProduct7189 (Entrez Gene) Original kegg element: gene;9;hsa:7189
TRAFD1GeneProductENSG00000135148 (Ensembl)
TREM1GeneProductENSG00000124731 (Ensembl)
TifaGeneProductENSG00000145365 (Ensembl)
Trim30GeneProduct
USP7GeneProductENSG00000187555 (Ensembl)
ZMYND11GeneProductENSG00000015171 (Ensembl)
hsa-let-7eGeneProduct
hsa-let-7eGeneProductENSG00000198972 (Ensembl)
hsa-let-7i (gene)GeneProductENSG00000199179 (Ensembl)
hsa-mir-105-1GeneProductENSG00000207957 (Ensembl)
hsa-mir-146aGeneProductENSG00000207936 (Ensembl)
hsa-mir-155GeneProductENSG00000207795 (Ensembl)
hsa-mir-98GeneProduct407054 (Entrez Gene)

Annotated Interactions

No annotated interactions

Personal tools