Nucleotide-binding Oligomerization Domain (NOD) pathway (Homo sapiens)

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(Modified description)
Current revision (21:27, 12 September 2019) (view source)
(Modified description)
 
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   <Comment Source="WikiPathways-description">The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori.
   <Comment Source="WikiPathways-description">The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori.
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This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP1433 CPTAC Assay Portal].</Comment>
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Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1433 CPTAC Assay Portal]</Comment>
   <BiopaxRef>a0c</BiopaxRef>
   <BiopaxRef>a0c</BiopaxRef>
   <Graphics BoardWidth="1144.0" BoardHeight="767.0"/>
   <Graphics BoardWidth="1144.0" BoardHeight="767.0"/>

Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
106666view21:27, 12 September 2019KhanspersModified description
105761view19:33, 15 August 2019KhanspersModified description
86035view12:30, 28 June 2016EveloModified title
86034view12:30, 28 June 2016EveloModified title
83527view16:44, 20 November 2015JmeliusCorrect outdated id
80018view17:37, 30 April 2015Zaricorrected ID for NDUFA13, NAIP
68991view17:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
59191view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45352view20:29, 7 October 2011KhanspersModified description
45351view20:27, 7 October 2011KhanspersOntology Term : 'NOD-like receptor signaling pathway' added !
41168view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38800view07:16, 24 September 2010Thomaslinked to NF-kB signaling
35545view14:20, 12 February 2010MichielModified description
35541view14:18, 12 February 2010MichielModified description
35538view14:17, 12 February 2010MichielAdded refs
34887view00:28, 2 February 2010KhanspersModified categories
33214view22:38, 5 November 2009MisbahPeriodical save, work in progress
33213view22:04, 5 November 2009MisbahPeriodical save, work in progress
33212view21:39, 5 November 2009MisbahPeriodical save, work in progress
33211view21:29, 5 November 2009MisbahPeriodical save, work in progress
33210view20:57, 5 November 2009MisbahNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/b/b2/WP1433_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/b/b2/WP1433_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106666)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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