Bone Morphogenic Protein (BMP) Signalling and Regulation (Homo sapiens)

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"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into the nucleus where they interact with other transcription factors, such as Runx2 in osteoblasts." (Chen 2004)

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Ontology Terms



  1. Chen D, Zhao M, Mundy GR; ''Bone morphogenetic proteins.''; Growth Factors, 2004 PubMed Europe PMC Scholia


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106344view21:33, 21 August 2019KhanspersModified description
105545view06:09, 9 August 2019KhanspersModified description
86082view11:26, 29 June 2016MirellaKalafatiModified title
74390view22:37, 15 April 2014KhanspersChanged OSE2 binding site rectangle to label
73562view19:52, 1 February 2014AlexanderPicoCorrecting designation of BMPR1B as a GeneProduct rather than a Pathway data node
69901view19:29, 11 July 2013AlexanderPicoModified title
68904view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
59105view22:20, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
44981view14:27, 6 October 2011MartijnVanIerselOntology Term : 'BMP signaling pathway ' added !
42559view18:50, 4 April 2011BabikerosmanPeriodical save, work in progress
42558view18:40, 4 April 2011BabikerosmanPeriodical save, work in progress
41051view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
39169view17:28, 26 October 2010VfunariPeriodical save, work in progress
38973view18:02, 25 September 2010AlexanderPicoModified description
38972view18:00, 25 September 2010AlexanderPicooverhaul
38955view00:33, 25 September 2010Khanspers
38954view00:32, 25 September 2010KhanspersAdded nucleus, changed line types
33373view14:35, 30 November 2009MaintBotRemoved group label
33180view17:42, 5 November 2009KhanspersModified categories
33113view12:21, 19 October 2009AndraNew pathway

External references


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NameTypeDatabase referenceComment
BMP2GeneProductENSG00000125845 (Ensembl)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BMPR1BGeneProductENSG00000138696 (Ensembl)
BMPR2GeneProduct659 (Entrez Gene)
NOGGeneProductENSG00000183691 (Ensembl)
RUNX2GeneProductENSG00000124813 (Ensembl)
SMAD1GeneProductENSG00000170365 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SMAD6GeneProductENSG00000137834 (Ensembl)
SMURF1GeneProductENSG00000198742 (Ensembl)
TOB1GeneProductENSG00000141232 (Ensembl)
TOB2GeneProductENSG00000183864 (Ensembl)

Annotated Interactions

No annotated interactions

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