Ganglio Sphingolipid Metabolism (Homo sapiens)

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1GD1AFuc-GM1GalNAc-GM1GM1AFuc-GD1bGQ1bAGal-GlcNAc-GM1bO-Acetylated GT3GD1aAO-Acetylated GD3GT1aAGalNAc-GM1bGM2AGD1BGal-GD1bGalNAc-GD1aB3GALT4FUT1B4GALNT1GT1aST3GAL2ST6GALNAC6ST3GAL1B3GALT4B4GALNT1GQ1bAGT3ST8SIA5B3GALST3GAL1ST8SIA5GM3GD1bB3GALT4B4GALNT1ST8SIA5LacCerST3GAL2ST8SIA1GA2GD1cGD1aB4GALNT1GM3 SynthaseB4GALNT1O-AcetylTST6GALNAC6ST3GAL2ST8SIA1ST8Sia1GD2B4GALNT1GM1aST8SIA5GQ1cST3GAL1ST6GALNAC6ST6GALNAC6O-AcetylTGA1FUT1GD3A3GALT2ST6GALNAC6ST3GAL1ST8SIA3B3GALT4B4GALNT1GT1bGT1cGT2ST8SIA5B3GALT4GP1cGM1bGM2ST3GAL2ST8SIA5ST3GAL5


Description

Sphingolipids are metabolites used to make cell-cell and cell-substratum interactions possible. This pathway describes how they are synthesized.

Quality Tags

Ontology Terms

 

Bibliography

  1. Merrill AH Jr; ''De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.''; J Biol Chem, 2002 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106690view13:00, 17 September 2019MaintBotHMDB identifier normalization
104242view15:23, 11 May 2019MaintBotRemoved the RHEA: prefix from the identifier.
103790view16:09, 7 April 2019Egonw
103789view16:06, 7 April 2019EgonwAdded two more identifiers.
103788view16:01, 7 April 2019EgonwAdded several missing identifiers.
103662view11:31, 26 March 2019EgonwRemoved an empty box and move the title a bit closer to the pathway.
103661view11:26, 26 March 2019EgonwAdded a few identifiers, and minor improvements.
94289view12:58, 31 August 2017DeSlOntology Term : 'sphingolipid biosynthetic pathway' added !
92692view18:50, 28 June 2017EgonwTwo metabolites with ID.
91044view09:12, 26 December 2016EgonwModified description
91031view08:00, 23 December 2016EgonwConverted more labels to metabolite DataNodes.
79812view16:49, 16 April 2015Mkutmonfixed unconnected lines
79262view18:22, 19 March 2015ZariChange Identifier for ST8SIA3
76323view07:56, 2 July 2014Mkutmonconnected enzymes to reactions
76322view07:37, 2 July 2014Mkutmonchanged annotation of gene products from Affy to Ensembl.
72172view22:11, 25 October 2013AlexanderPicoadded metabolite xrefs
71002view16:02, 22 September 2013EgonwConnecting dots.
69404view19:00, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
63191view20:50, 8 May 2013MaintBotUpdating gpml version
45306view20:03, 7 October 2011AlexanderPicoOntology Term : 'sphingolipid metabolic pathway' added !
41140view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
35548view14:44, 12 February 2010MichielAdded ref
34581view22:18, 21 December 2009KhanspersModified categories
33067view20:50, 11 October 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A3GALT2GeneProduct127550 (Entrez Gene)
B3GALGeneProductENSG00000172318 (Ensembl)
B3GALT4GeneProduct8705 (Entrez Gene) 2.4.1.-
B3GALT4GeneProductENSG00000235863 (Ensembl) 2.4.1.62
B4GALNT1GeneProduct2583 (Entrez Gene) 2.4.1.92
FUT1GeneProduct2523 (Entrez Gene)
Fuc-GD1bMetaboliteCHEBI:90265 (ChEBI)
Fuc-GM1MetaboliteCHEBI:90189 (ChEBI)
GA1MetaboliteHMDB04910 (HMDB)
GA2MetaboliteHMDB04898 (HMDB)
GD1AMetabolite
GD1BMetabolite
GD1aAMetabolite
GD1aMetaboliteHMDB04853 (HMDB)
GD1bMetaboliteHMDB04926 (HMDB)
GD1cMetabolite
GD2MetaboliteHMDB04925 (HMDB)
GD3MetaboliteHMDB04913 (HMDB)
GM1AMetabolite9963963 (PubChem-compound)
GM1aMetaboliteHMDB04855 (HMDB)
GM1bMetabolite53239726 (PubChem-compound)
GM2AMetabolite
GM2MetaboliteHMDB04938 (HMDB)
GM3 SynthaseGeneProductENSG00000115525 (Ensembl) 2.4.99.9
GM3MetaboliteHMDB04844 (HMDB)
GP1cMetabolite
GQ1bAMetabolite
GQ1bAMetaboliteHMDB04928 (HMDB)
GQ1cMetabolite53481235 (PubChem-compound)
GT1aMetabolite45259173 (PubChem-compound)
GT1aAMetabolite
GT1bMetaboliteHMDB04927 (HMDB)
GT1cMetabolite53481295 (PubChem-compound)
GT2Metabolite53481325 (PubChem-compound)
GT3Metabolite53481355 (PubChem-compound)
Gal-GD1bMetabolite
Gal-GlcNAc-GM1bMetabolite
GalNAc-GD1aMetabolite
GalNAc-GM1Metabolite
GalNAc-GM1bMetabolite
LacCerMetaboliteHMDB06750 (HMDB)
O-AcetylTGeneProductENSG00000169359 (Ensembl)
O-Acetylated GD3Metabolite73427362 (PubChem-compound)
O-Acetylated GT3Metabolite
ST3GAL1GeneProductENSG00000008513 (Ensembl)
ST3GAL2GeneProductENSG00000157350 (Ensembl) 2.4.99.4
ST3GAL5GeneProduct8869 (Entrez Gene)
ST6GALNAC6GeneProduct30815 (Entrez Gene)
ST6GALNAC6GeneProductENSG00000160408 (Ensembl)
ST8SIA1GeneProduct6489 (Entrez Gene)
ST8SIA1GeneProductENSG00000111728 (Ensembl) 2.4.99.8
ST8SIA3GeneProduct51046 (Entrez Gene)
ST8SIA5GeneProduct29906 (Entrez Gene)
ST8SIA5GeneProductENSG00000101638 (Ensembl)
ST8Sia1GeneProductENSG00000111728 (Ensembl) 2.4.99.8

Annotated Interactions

SourceTargetTypeDatabase referenceComment
GD1bArrowRHEA:48325 (Rhea)
GM1aFuc-GM1ArrowRHEA:48293 (Rhea)
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