AMP-activated protein kinase (AMPK) signaling (Homo sapiens)

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Low glucose,Hypoxia, Ischemia,Heat shockMetforminAMP kinaseExerciseFatty Acid OxidationPRKACGINSAKT1GeneProductSTRADATorc2ACC1PGC-1AMPKy2INSReEF2CAMKK2PRKACBLKB1CalciumHNF4AAMPKy1AMPKa1CPT1C (brain)Malonyl-CoAGEFmTORAMPKa2AMPKb1GlucoseeEF2KAMPKb2CPT1A (liver)CPT1B (muscle)LeptinGLUT4CAMKK1GeneProductGYS2 (liver)RaptorPFK2ACC2GYS1(muscle)MEF2BPLCB1PIK3CBAMPKy3AdiponectinSTRADB


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  1. Fu A, Screaton RA; ''Using kinomics to delineate signaling pathways: control of CRTC2/TORC2 by the AMPK family.''; Cell Cycle, 2008 PubMed Europe PMC Scholia
  2. Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N; ''Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  3. Shaw RJ; ''LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.''; Acta Physiol (Oxf), 2009 PubMed Europe PMC Scholia
  4. Holmes BF, Sparling DP, Olson AL, Winder WW, Dohm GL; ''Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase.''; Am J Physiol Endocrinol Metab, 2005 PubMed Europe PMC Scholia
  5. Cheng A, Saltiel AR; ''More TORC for the gluconeogenic engine.''; Bioessays, 2006 PubMed Europe PMC Scholia
  6. Findlay GM, Harrington LS, Lamb RF; ''TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?''; Curr Opin Genet Dev, 2005 PubMed Europe PMC Scholia
  7. Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N; ''4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  8. Viana R, Aguado C, Esteban I, Moreno D, Viollet B, Knecht E, Sanz P; ''Role of AMP-activated protein kinase in autophagy and proteasome function.''; Biochem Biophys Res Commun, 2008 PubMed Europe PMC Scholia
  9. Lee WJ, Kim M, Park HS, Kim HS, Jeon MJ, Oh KS, Koh EH, Won JC, Kim MS, Oh GT, Yoon M, Lee KU, Park JY; ''AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1.''; Biochem Biophys Res Commun, 2006 PubMed Europe PMC Scholia
  10. Hong YH, Varanasi US, Yang W, Leff T; ''AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  11. Hue L, Beauloye C, Marsin AS, Bertrand L, Horman S, Rider MH; ''Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways.''; J Mol Cell Cardiol, 2002 PubMed Europe PMC Scholia
  12. Inoki K, Zhu T, Guan KL; ''TSC2 mediates cellular energy response to control cell growth and survival.''; Cell, 2003 PubMed Europe PMC Scholia
  13. Halse R, Fryer LG, McCormack JG, Carling D, Yeaman SJ; ''Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase.''; Diabetes, 2003 PubMed Europe PMC Scholia
  14. Carling D, Hardie DG; ''The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  15. Murgia M, Jensen TE, Cusinato M, Garcia M, Richter EA, Schiaffino S; ''Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle.''; J Physiol, 2009 PubMed Europe PMC Scholia
  16. Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF, Van den Berghe G, Carling D, Hue L; ''Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia.''; Curr Biol, 2000 PubMed Europe PMC Scholia


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121114view07:59, 9 February 2022EgonwMade three pathways clickable
116516view10:54, 7 May 2021EweitzModified title
106688view13:00, 17 September 2019MaintBotHMDB identifier normalization
105868view23:29, 15 August 2019KhanspersModified description
105428view04:29, 8 August 2019KhanspersModified description
105427view04:28, 8 August 2019KhanspersModified description
98156view17:59, 27 July 2018AlexanderPicoOntology Term : 'signaling pathway' added !
90259view20:18, 27 October 2016AlexanderPicoupdated vesicle and pathway node glyphs
90018view19:27, 8 October 2016AlexanderPicoModified description
89800view11:29, 6 October 2016Mkutmonfixed special characters in description
86073view08:47, 29 June 2016MirellaKalafatiModified title
79471view11:56, 23 March 2015ZariChanded ID for STRADA gene
78804view09:11, 31 January 2015EgonwConnected dots.
75220view21:45, 9 May 2014Khanspersconnected interactions
73193view10:42, 10 January 2014Mkutmonupdated layout
71709view20:01, 17 October 2013MaintBotremoved data source from nodes without identifier
69892view19:03, 11 July 2013AlexanderPicoModified title
68209view00:52, 2 July 2013JeangonPeriodical save, work in progress
67040view09:58, 26 June 2013Christine ChichesterOntology Term : 'adenosine monophosphate-activated protein kinase (AMPK) signaling pathway' added !
63159view20:18, 8 May 2013MaintBotUpdating GPML version
60818view17:38, 28 March 2013MaintBotOntology Term : 'ATP biosynthetic pathway' added !
59114view22:25, 21 February 2013MaintBotUpdated Ensembl data source
44950view12:34, 6 October 2011MartijnVanIerselOntology Term : 'AMPK signaling pathway' added !
43615view14:06, 8 July 2011AdrienDefayadd DATABASE name for some Pathway Link
42309view17:22, 16 March 2011KhanspersReverted to version '23:18, 1 March 2011' by Khanspers
42306view16:01, 15 March 2011Frances55muscle growth
41064view23:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
38943view22:54, 24 September 2010KhanspersSpecify description
33370view14:34, 30 November 2009MaintBotRemoved group label
33329view12:12, 24 November 2009AndraRemoved reference
33328view11:55, 24 November 2009AndraAdd reference
33179view17:41, 5 November 2009KhanspersModified categories
32864view13:52, 16 September 2009SusanModified description
32862view13:24, 16 September 2009SusanAdding literature
32861view12:52, 16 September 2009SusanSpecify description
32860view11:52, 16 September 2009SusanAdding genes
32859view08:48, 16 September 2009SusanSpecify description
32858view08:17, 16 September 2009SusanAdding genes and references
32853view12:17, 15 September 2009SusanAdding PI3 kinase
32852view11:54, 15 September 2009SusanPeriodical save, work in progress
32851view10:02, 15 September 2009SusanSpecify description
32850view09:56, 15 September 2009SusanAdding genes
32849view09:40, 15 September 2009SusanAdding genes
32848view09:33, 15 September 2009SusanPeriodical save, work in progress
32847view09:22, 15 September 2009SusanPeriodical save, work in progress
32846view09:11, 15 September 2009SusanAdding genes
32845view09:09, 15 September 2009SusanPeriodical save, work in progress
32834view11:24, 14 September 2009SusanNew pathway

External references


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NameTypeDatabase referenceComment
ACC1GeneProduct31 (Entrez Gene)
ACC2GeneProduct32 (Entrez Gene)
AKT1GeneProductENSG00000142208 (Ensembl Human)
AMPKa1GeneProduct5562 (Entrez Gene)
AMPKa2GeneProduct5563 (Entrez Gene)
AMPKb1GeneProduct5564 (Entrez Gene)
AMPKb2GeneProduct5565 (Entrez Gene)
AMPKy1GeneProduct5571 (Entrez Gene)
AMPKy2GeneProduct51422 (Entrez Gene)
AMPKy3GeneProduct53632 (Entrez Gene)
AdiponectinMetabolite9370 (Entrez Gene)
CAMKK1GeneProductENSG00000004660 (Ensembl Human)
CAMKK2GeneProductENSG00000110931 (Ensembl Human)
CPT1A (liver)GeneProduct1374 (Entrez Gene)
CPT1B (muscle)GeneProduct1375 (Entrez Gene)
CPT1C (brain)GeneProduct126129 (Entrez Gene)
CalciumMetaboliteHMDB00464 (HMDB)
GEFGeneProductENSG00000125520 (Ensembl Human)
GLUT4GeneProduct6517 (Entrez Gene)
GYS1(muscle)GeneProductENSG00000104812 (Ensembl Human)
GYS2 (liver)GeneProductENSG00000111713 (Ensembl Human)
GlucoseMetaboliteHMDB00122 (HMDB)
HNF4AGeneProductENSG00000101076 (Ensembl Human)
INSRGeneProductENSG00000171105 (Ensembl Human)
LKB1GeneProductENSG00000118046 (Ensembl Human)
MEF2BGeneProductENSG00000064489 (Ensembl Human)
Malonyl-CoAMetaboliteHMDB01175 (HMDB)
PFK2GeneProduct5209 (Entrez Gene)
PGC-1GeneProductENSG00000155846 (Ensembl Human)
PIK3CBGeneProduct5291 (Entrez Gene)
PLCB1GeneProductENSG00000182621 (Ensembl Human)
PRKACBGeneProduct5567 (Entrez Gene)
PRKACGGeneProduct5568 (Entrez Gene)
RaptorGeneProduct57521 (Entrez Gene)
STRADAGeneProductENSG00000125695 (Ensembl Human)
STRADBGeneProductENSG00000082146 (Ensembl Human)
Torc2GeneProduct200186 (Entrez Gene)
eEF2GeneProduct1938 (Entrez Gene)
eEF2KGeneProductENSG00000103319 (Ensembl Human)
mTORGeneProduct2475 (Entrez Gene)

Annotated Interactions

No annotated interactions

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