Cholesterol Biosynthesis (Danio rerio)

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1-7Fatty Acid DegradationDimethylallylpyrophosphatefarnesyl pyrophosphateidi1HMGCRGeranyl-PP(S)-2,3-EpoxysqualeneAcetyl-CoAMevalonic acid 5-pyrophosphateCholesteroldhcr77-Dehydrocholesterolzgc:171801fdpshmgcs1LanosterinSC4MOLHMG-CoAisopentenyl pyrophosphatesc5dlssMevalonic acidfdpszgc:162701Squalenezgc:103473zgc:100824nsdhlMevalonic acid-5PLathosterolfdft1cyp51


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP197(r21093) with a 82% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, Cattanach B, Peters J, Hunsicker PR, Mallon AM, Strivens MA, Bate R, Miller W, Rhodes M, Brown SD, Herman GE; ''The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.''; Nat Genet, 1999 PubMed Europe PMC
  2. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R; ''Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC
  3. Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y; ''Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.''; J Biochem, 1997 PubMed Europe PMC
  4. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T; ''Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.''; J Biol Chem, 2003 PubMed Europe PMC
  5. Sagami H, Korenaga T, Ogura K; ''Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.''; J Biochem, 1993 PubMed Europe PMC
  6. Li L, Kaplan J; ''Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.''; J Biol Chem, 1996 PubMed Europe PMC
  7. Gaylor JL; ''Membrane-bound enzymes of cholesterol synthesis from lanosterol.''; Biochem Biophys Res Commun, 2002 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
101766view13:48, 7 November 2018EgonwReplaced a wrong CAS number of with right ChEBI identifier.
77424view08:36, 8 September 2014Mkutmonupdated gene labels
71533view19:23, 17 October 2013MaintBotAutomated update of data sources
68676view05:34, 6 July 2013MaintBotUpdated to 2013 gpml schema
67113view10:08, 26 June 2013Christine ChichesterOntology Term : 'cholesterol biosynthetic pathway' added !
40849view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35142view14:11, 11 February 2010ThomasModified description
35141view14:11, 11 February 2010Thomasmoved literature from genmapp comments to bibliography
34231view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
31962view13:05, 14 August 2009MaintBotFixed group labels
31099view01:40, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(S)-2,3-EpoxysqualeneMetabolite9029-62-3 (CAS)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
Acetyl-CoAMetabolite
CholesterolMetabolite57-88-5 (CAS)
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
Geranyl-PPMetabolite6699-20-3 (CAS)
HMG-CoAMetabolite
HMGCRGeneProduct
LanosterinMetabolite79-63-0 (CAS)
LathosterolMetabolite80-99-9 (CAS)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
Mevalonic acidMetabolite150-97-0 (CAS)
SC4MOLGeneProduct406662 (Entrez Gene)
SqualeneMetabolite111-02-4 (CAS)
cyp51GeneProduct414331 (Entrez Gene)
dhcr7GeneProduct378446 (Entrez Gene)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
fdft1GeneProduct571911 (Entrez Gene)
fdpsGeneProduct552997 (Entrez Gene)
hmgcs1GeneProduct394060 (Entrez Gene)
idi1GeneProduct553513 (Entrez Gene)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)
lssGeneProduct795400 (Entrez Gene)
nsdhlGeneProduct550369 (Entrez Gene) NAD(P) dependent steroid dehydrogenase-like
sc5dGeneProduct447891 (Entrez Gene)
zgc:100824GeneProduct492781 (Entrez Gene)
zgc:103473GeneProduct492477 (Entrez Gene)
zgc:162701GeneProduct100003383 (Entrez Gene)
zgc:171801GeneProduct799528 (Entrez Gene)

Annotated Interactions

No annotated interactions
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