Cholesterol Biosynthesis (Danio rerio)

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1-7Fatty Acid DegradationnsdhlsqleamsmolLanosterinMevalonic acid 5-pyrophosphateisopentenyl pyrophosphateidi1Squalenehmgcs1mvddhcr7CholesterolHMG-CoAcyp51Acetyl-CoAsc5dfdpsMevalonic acid-5PGeranyl-PPhmgcraLathosterol7-DehydrocholesterolfdpslssmvkDimethylallylpyrophosphatefarnesyl pyrophosphatefdft1(S)-2,3-EpoxysqualeneMevalonic acidpmvkhmgcrb


Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP197(r21093) with a 82% conversion rate.

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  1. Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, Cattanach B, Peters J, Hunsicker PR, Mallon AM, Strivens MA, Bate R, Miller W, Rhodes M, Brown SD, Herman GE; ''The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.''; Nat Genet, 1999 PubMed Europe PMC Scholia
  2. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R; ''Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  3. Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y; ''Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.''; J Biochem, 1997 PubMed Europe PMC Scholia
  4. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T; ''Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  5. Sagami H, Korenaga T, Ogura K; ''Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.''; J Biochem, 1993 PubMed Europe PMC Scholia
  6. Li L, Kaplan J; ''Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  7. Gaylor JL; ''Membrane-bound enzymes of cholesterol synthesis from lanosterol.''; Biochem Biophys Res Commun, 2002 PubMed Europe PMC Scholia


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101766view13:48, 7 November 2018EgonwReplaced a wrong CAS number of with right ChEBI identifier.
77424view08:36, 8 September 2014Mkutmonupdated gene labels
71533view19:23, 17 October 2013MaintBotAutomated update of data sources
68676view05:34, 6 July 2013MaintBotUpdated to 2013 gpml schema
67113view10:08, 26 June 2013Christine ChichesterOntology Term : 'cholesterol biosynthetic pathway' added !
40849view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35142view14:11, 11 February 2010ThomasModified description
35141view14:11, 11 February 2010Thomasmoved literature from genmapp comments to bibliography
34231view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
31962view13:05, 14 August 2009MaintBotFixed group labels
31099view01:40, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
(S)-2,3-EpoxysqualeneMetaboliteCHEBI:15441 (ChEBI)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
CholesterolMetabolite57-88-5 (CAS)
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
Geranyl-PPMetabolite6699-20-3 (CAS)
LanosterinMetabolite79-63-0 (CAS)
LathosterolMetabolite80-99-9 (CAS)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
Mevalonic acidMetabolite150-97-0 (CAS)
SqualeneMetabolite111-02-4 (CAS)
cyp51GeneProduct414331 (Entrez Gene)
dhcr7GeneProduct378446 (Entrez Gene)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
fdft1GeneProduct571911 (Entrez Gene)
fdpsGeneProduct552997 (Entrez Gene)
hmgcraGeneProductENSDARG00000052734 (Ensembl)
hmgcrbGeneProductENSDARG00000059301 (Ensembl)
hmgcs1GeneProduct394060 (Entrez Gene)
idi1GeneProduct553513 (Entrez Gene)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)
lssGeneProduct795400 (Entrez Gene)
msmolGeneProduct406662 (Entrez Gene)
mvdGeneProduct492781 (Entrez Gene)
mvkGeneProduct492477 (Entrez Gene)
nsdhlGeneProduct550369 (Entrez Gene) NAD(P) dependent steroid dehydrogenase-like
pmvkGeneProduct100003383 (Entrez Gene)
sc5dGeneProduct447891 (Entrez Gene)
sqleaGeneProduct799528 (Entrez Gene)

Annotated Interactions

No annotated interactions
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