Endochondral Ossification (Danio rerio)

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1, 2Removal of extracellular matrixand invasion by bone cellsDyingChondrocyte (pre)hypertrophyBoneChondrocyte proliferationGsintegrinsCartilageCathepsinsand CalpainsBMPsChondrocyte deathWNT signalingcanonical / non-canonicalHypertrophyProliferationVascular invastionOsteoblasticdifferentiationMineralisationRemoval of cartilage matrix?Full differentiationCarminerintgfb2hdac4kif3aPLAUPTCHrunx2aadamts1TGFB1pth1rankx3.2TIMP3FGF2CALM1fgfr1aLOC566764Thyroid hormonepthlhPTCH1cdkn1cCOL10A1vegfabLOC564254gli3chst11Aggrecanrunx2awu:fi36g12stat1aTriiodothyroninesi:ch211-132p20.4si:ch211-142e24.2OxygenGrowth hormoneLOC792354LOC565053STAT5IHHOsteopontinIGF1Rift88SERPINH1cAMPrunx3igf1cab39runx2asox5Thyroid hormonesox6LOC556380PTHADAMTS4mmp9BMPR1Actsl1abmp7bhmgcs1TGFBIfrzbfgfr3ghraLOC100149108mef2cbFGF18zgc:158799sox9aTHRATHRATNAPbmp6MGPcol2a1aIGF2


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 62% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC
  2. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107099view14:18, 17 September 2019MaintBotChEBI identifier normalization
106081view11:59, 16 August 2019MaintBotHMDB identifier normalization
87976view13:18, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72213view12:52, 27 October 2013Egonw
72173view22:16, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
68643view04:57, 6 July 2013MaintBotUpdated to 2013 gpml schema
40811view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
34199view21:28, 9 December 2009MaintBotAutomatic update of empty xrefs
32342view13:34, 15 August 2009MaintBotFixed text labels
31958view13:04, 14 August 2009MaintBotFixed group labels
31389view20:45, 13 August 2009MaintBotFixed text labels
31095view01:39, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAMTS4GeneProduct
AggrecanGeneProduct
BMPR1AGeneProduct58145 (Entrez Gene)
CALM1GeneProduct
COL10A1GeneProduct558919 (Entrez Gene)
CarminerinGeneProduct
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
FGF18GeneProduct
FGF2GeneProduct404231 (Entrez Gene)
Growth hormoneGeneProduct
IGF1RGeneProduct
IGF2GeneProduct
IHHGeneProduct
LOC100149108GeneProduct100149108 (Entrez Gene)
LOC556380GeneProduct556380 (Entrez Gene)
LOC564254GeneProduct564254 (Entrez Gene)
LOC565053GeneProduct565053 (Entrez Gene)
LOC566764GeneProduct566764 (Entrez Gene) PMID: 17097081
LOC792354GeneProduct792354 (Entrez Gene)
MGPGeneProduct402937 (Entrez Gene)
OsteopontinGeneProduct
OxygenMetaboliteHMDB01377 (HMDB)
PLAUGeneProduct
PTCHGeneProduct
PTCH1GeneProduct
PTHGeneProduct
SERPINH1GeneProduct
STAT5GeneProduct
TGFB1GeneProduct359834 (Entrez Gene)
TGFBIGeneProduct321421 (Entrez Gene)
THRAGeneProduct
TIMP3GeneProduct
TNAPGeneProduct
Thyroid hormoneMetabolite60311 (ChEBI)
Thyroid hormoneMetaboliteT4
TriiodothyronineMetabolite24864 (ChEBI)
adamts1GeneProduct565145 (Entrez Gene)
bmp6GeneProduct503761 (Entrez Gene)
bmp7bGeneProduct557567 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)
cab39GeneProduct415235 (Entrez Gene)
cdkn1cGeneProduct399483 (Entrez Gene)
chst11GeneProduct404232 (Entrez Gene)
col2a1aGeneProduct562496 (Entrez Gene)
ctsl1aGeneProduct321453 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
fgfr1aGeneProduct30705 (Entrez Gene)
fgfr3GeneProduct58129 (Entrez Gene)
frzbGeneProduct30119 (Entrez Gene)
ghraGeneProduct100001424 (Entrez Gene)
gli3GeneProduct403042 (Entrez Gene)
hdac4GeneProduct568877 (Entrez Gene)
hmgcs1GeneProduct394060 (Entrez Gene)
ift88GeneProduct321855 (Entrez Gene)
igf1GeneProduct114433 (Entrez Gene)
kif3aGeneProduct550267 (Entrez Gene)
mef2cbGeneProduct798771 (Entrez Gene)
mmp9GeneProduct406397 (Entrez Gene)
nkx3.2GeneProduct337865 (Entrez Gene)
pth1raGeneProduct30629 (Entrez Gene)
pthlhGeneProduct554221 (Entrez Gene)
runx2aGeneProduct405784 (Entrez Gene)
runx3GeneProduct58127 (Entrez Gene)
si:ch211-132p20.4GeneProduct566537 (Entrez Gene)
si:ch211-142e24.2GeneProduct562399 (Entrez Gene)
sox5GeneProduct567413 (Entrez Gene)
sox6GeneProduct567154 (Entrez Gene)
sox9aGeneProduct60641 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
tgfb2GeneProduct369194 (Entrez Gene)
vegfabGeneProduct558154 (Entrez Gene)
wu:fi36g12GeneProduct100006896 (Entrez Gene)
zgc:158799GeneProduct564064 (Entrez Gene)

Annotated Interactions

No annotated interactions
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