Delta-Notch Signaling Pathway (Danio rerio)

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CYUbiquitinationICDDemethylationPlasma membraneENNUSumoylationMethylationLigand(Protein-protein interaction)DNU->CYDAccession Number: NetPath 3; cellmap:3ICDDeubiquitinationGene SymbolDesumoylationCY->NUPalmitoylationMTPMCY->NURecruitmentGolgi apparatusDeacetylationPM->CYMolecular associationCY->NUNU->CYDephosphorylationReactioin through unknown mechanisms/moleculesAcetylationGO->PMGamma secretase complexICDReceptor-- ICDIntracellular DomainGO->PMDPM->NUDPM->NUExtracellularActivationICDCY->NUAutophosphorylationERNucleusTranslocationProteolytic CleavageControlMitochondrionDPM->NUEndosomePhosphorylationPM->NUMolecule in the pathwayECCytoplasmInhibitionICDICDEnzyme complexDGONU->CYCY->NUEndoplasmic reticulumGlycosylationProteins in a complex interactionLOC564991ncor2notch3NOTCH4LOC571749pik3r2junskp2FURINSAP30RING1tp53appajag2pofut1dldnotch1bLOC100008005ep300ajag1bmef2cbegfrsmad1APH1BLOC553421LOC557176numbpsen1skp2numblNFKBIAgsk3bMAGEA1zgc:113045mapk1relamfngzgc:114200PSENENHES5smad3bjag1bjag2notch2DTX1DTX1RBX1SIN3Arelaegfhey1LOC792354dldLCKcdk2hey2LOC567335notch3fhlancor1psen2gsk3bdll4ncor1notch1bstat3MAML2NCSTNdldcul1awdr12HES6SKP1Ajag1bep300ajag2HIVEP3notch2cntfrHDAC2TLE1stat3SKP1Aher6adam10aNOTCH4zfpm1notch1bADAM17notch3dll4ncor2yy1aCNTFnotch2DKEY-265K11.4mapk3snw1NOVjak2blfngnotch1bhdac1notch1bnotch2notch1bLOC559111kat2brbpjbascl1acntn1blef1


Description

There are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric proteins and their ligands are also membrane-bound. Signaling through the Notch receptors is triggered by ligand-binding that induces cleavage of the extracellular domain by an ADAM family metalloprotease followed by a cleavage within the transmembrane domain by gamma secretase complex. The second cleavage leads to translocation of the cytosolic domain of Notch receptors into the nucleus. Notch proteins are important in lineage specification and stem cell maintenance. Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_3

Comments

GenMAPP notes 
NetPath 3; cellmap:3 - Delta-Notch Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP61(r20805) with a 76% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
68626view04:38, 6 July 2013MaintBotUpdated to 2013 gpml schema
67149view10:13, 26 June 2013Christine ChichesterOntology Term : 'Notch signaling pathway' added !
40791view22:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35715view23:20, 12 February 2010AlexanderPico
34181view21:22, 9 December 2009MaintBotAutomatic update of empty xrefs
31388view20:44, 13 August 2009MaintBotFixed text labels
31094view01:38, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM17GeneProduct
APH1BGeneProduct386808 (Entrez Gene)
CNTFGeneProduct
DKEY-265K11.4GeneProduct792900 (Entrez Gene)
DTX1GeneProduct570481 (Entrez Gene)
FURINGeneProduct569750 (Entrez Gene)
HDAC2GeneProduct
HES5GeneProduct359836 (Entrez Gene)
HES6GeneProduct373116 (Entrez Gene)
HIVEP3GeneProduct
LCKGeneProduct414333 (Entrez Gene)
LOC100008005GeneProduct100008005 (Entrez Gene)
LOC553421GeneProduct553421 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC559111GeneProduct559111 (Entrez Gene)
LOC564991GeneProduct564991 (Entrez Gene)
LOC567335GeneProduct567335 (Entrez Gene)
LOC571749GeneProduct571749 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
MAGEA1GeneProduct
MAML2GeneProduct
NCSTNGeneProduct494449 (Entrez Gene)
NFKBIAGeneProduct
NOTCH4GeneProduct
NOVGeneProduct
PSENENGeneProduct402810 (Entrez Gene)
RBX1GeneProduct449846 (Entrez Gene)
RING1GeneProduct
SAP30GeneProduct
SIN3AGeneProduct
SKP1AGeneProduct
TLE1GeneProduct
adam10aGeneProduct566044 (Entrez Gene)
appaGeneProduct58083 (Entrez Gene)
ascl1aGeneProduct30466 (Entrez Gene)
cdk2GeneProduct406715 (Entrez Gene)
cntfrGeneProduct368438 (Entrez Gene)
cntn1bGeneProduct541474 (Entrez Gene)
cul1aGeneProduct323883 (Entrez Gene)
dldGeneProduct30138 (Entrez Gene)
dll4GeneProduct563920 (Entrez Gene)
egfGeneProduct403045 (Entrez Gene)
egfrGeneProduct378478 (Entrez Gene)
ep300aGeneProduct559273 (Entrez Gene)
fhlaGeneProduct399646 (Entrez Gene)
gsk3bGeneProduct30654 (Entrez Gene)
hdac1GeneProduct192302 (Entrez Gene)
her6GeneProduct30288 (Entrez Gene)
hey1GeneProduct58008 (Entrez Gene)
hey2GeneProduct58146 (Entrez Gene)
jag1bGeneProduct140423 (Entrez Gene)
jag2GeneProduct140422 (Entrez Gene)
jak2bGeneProduct30298 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
kat2bGeneProduct563942 (Entrez Gene)
lef1GeneProduct30701 (Entrez Gene)
lfngGeneProduct30158 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
mef2cbGeneProduct798771 (Entrez Gene)
mfngGeneProduct493633 (Entrez Gene)
ncor1GeneProduct393246 (Entrez Gene)
ncor2GeneProduct561503 (Entrez Gene)
notch1bGeneProduct794892 (Entrez Gene)
notch2GeneProduct58065 (Entrez Gene)
notch3GeneProduct58066 (Entrez Gene)
numbGeneProduct692064 (Entrez Gene)
numblGeneProduct497616 (Entrez Gene)
pik3r2GeneProduct404211 (Entrez Gene)
pofut1GeneProduct403029 (Entrez Gene)
psen1GeneProduct30221 (Entrez Gene)
psen2GeneProduct58026 (Entrez Gene)
rbpjbGeneProduct563306 (Entrez Gene)
relaGeneProduct415099 (Entrez Gene)
skp2GeneProduct563708 (Entrez Gene)
smad1GeneProduct30628 (Entrez Gene)
smad3bGeneProduct326283 (Entrez Gene)
snw1GeneProduct321852 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
tp53GeneProduct30590 (Entrez Gene)
wdr12GeneProduct321652 (Entrez Gene)
yy1aGeneProduct322397 (Entrez Gene)
zfpm1GeneProduct407655 (Entrez Gene)
zgc:113045GeneProduct664768 (Entrez Gene)
zgc:114200GeneProduct559336 (Entrez Gene)

Annotated Interactions

No annotated interactions
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