Androgen receptor signaling pathway (Homo sapiens)

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1-7MTGolgi appparatusENMolecular associationERCY->NUAndrogen IndependentCytoplasmCY->NUPDMolecule in the pathwayDephosphorylationPRecruitmentNucleusUbiquitinationDPReactions through unknown mechanisms/moleculesDReceptorDeSumoylationMethylationGlycosylationProteins in a complex interactionNUPhosphorylationDInhibitionSumoylationAcetylationLigandEnzyme complexPPalmitoylationDeacetylationDemethylationEndoplasmic reticulumAutophosphorylationCYGOAndrogen IndependentControlTranslocationPMitochondrionECPMProteolytic CleavageExtracellularDActivation(Protein-protein interaction)EndosomeAccession Number: NetPath 2; cellmap:2Gene SymbolCY->NUPlasma membraneDeubiquitinationCY->NUAndrogen (T/DHT)TGIFTMF1CASP7GAPDHCAV1UBE3ASP1HDAC1CDC2MMP1NCOA2ARCDK7FHL2CASP3PIAS3CCNHJUNAKT1TBPIPGTF2F2NRIP1HMGB2MAP2K1PA2G4SENP1CTNNB1CDK9GHRNR3C1HRMT1L2PNRC1FLNASVILMAPK1IL6STCOX5BESR2PNRC1TGFB1I1RNF4BRCA1ESR1AESCASP8HSPA1ACTDP1RAC3UBE2IJUNRUNX2SIN3ANCOA1STAT3ETV5APPLNCOA4MAPK1AKT1PIAS1GTF2F1NR2C2SLC25A4EP300TP53PIAS2PAK6NSD1NR0B2IL6BAG1SMAD4RCHY1RANARSRCRAFCCNE1SPDEFMDM2PXNNR0B1CDC25BGTF2H1RASATF2RUNX1SRISNF2LUXTCASP1ARESR1GHBPFLNACDC37ZNF278SRYEGFRCALRMYST2PLAGL1HMGB1YWHAHPCAFSTUB1ARRANBP9NR5A1SMAD3HRMT1L2NR3C1RB1PTENHIPK3RNF14RCHY1CREBBPNCOA3NCOR2RB1IGFIPOU2F2PIAS4CCND1HTATIPARRELAPOU2F1


"The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module." Source:


GenMAPP notes 
NetPath:2; cellmap:2 - Androgen Receptor Signaling Pathway. The Androgen Receptor signaling pathway was kindly reviewed by Liying Zhang and William Gerald. This cancer signaling pathway is available at Cancer Cell Map ( and NetPath ( and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (, PandeyLab at Johns Hopkins University ( and Institute of Bioinformatics ( If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks;

Quality Tags

Ontology Terms



  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia


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115904view09:19, 20 March 2021EgonwCopied the NetPath paper into the literature list
115899view08:07, 20 March 2021EgonwModified description
108320view20:48, 6 December 2019L DupuisConverted interactions to graphical lines in legend
105881view04:52, 16 August 2019KhanspersModified description
105528view06:00, 9 August 2019KhanspersModified description
79958view12:55, 28 April 2015ZariChanged label for Actin polymerization because it is process not protein
79277view21:48, 19 March 2015ZariAdded Identifier for TGIF1
78526view10:29, 7 January 2015MaintBotadded missing graphIds
72130view07:56, 25 October 2013Mkutmonadded datasource to SIN3A and PIAS2
71364view18:36, 17 October 2013MaintBotAutomated update of data sources
63142view19:17, 8 May 2013MaintBotUpdating GPML version
53243view19:04, 1 November 2012RobertbaertschAdd gene id to RLN1
47971view14:16, 23 April 2012NetPathModified description
47970view14:14, 23 April 2012NetPathModified description
44951view12:35, 6 October 2011MartijnVanIerselOntology Term : 'androgen signaling pathway' added !
44596view20:59, 21 September 2011KhanspersModified categories
44595view20:59, 21 September 2011KhanspersModified description
44594view20:58, 21 September 2011KhanspersUpdating content to NetSlim
44118view20:49, 24 August 2011KhanspersReverted to version '23:17, 1 March 2011' by Khanspers
44046view23:41, 22 August 2011KhanspersModified description
44045view23:39, 22 August 2011KhanspersUpdating pathway from NetSlim
41063view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
35667view22:37, 12 February 2010AlexanderPicoModified description
35427view11:00, 12 February 2010AndraAdded references
35299view23:19, 11 February 2010NsalomonisModified description
20973view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Androgen-Receptor NetPath 2]] moved to [[Pathway:WP138]]: Moved to stable identifier
7902view13:46, 7 January 2008MaintBot[[Pathway:Human:Androgen-Receptor NetPath 2]] moved to [[Pathway:Homo sapiens:Androgen-Receptor NetPath 2]]: Renaming species
7576view16:01, 18 December 2007MaintBotfixed category names
7195view12:33, 4 November 2007MaintBotAdded categories to GPML
6294view22:17, 22 May 2007A.Pandeygpml file for [[Human:Androgen-Receptor_NetPath_2]]

External references


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NameTypeDatabase referenceComment
AESGeneProduct166 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
APPLGeneProduct26060 (Entrez Gene)
ARGeneProduct367 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
BAG1GeneProduct573 (Entrez Gene)
BRCA1GeneProduct672 (Entrez Gene)
CALRGeneProduct811 (Entrez Gene)
CASP1GeneProduct834 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP7GeneProduct840 (Entrez Gene)
CASP8GeneProduct841 (Entrez Gene)
CAV1GeneProduct857 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNHGeneProduct902 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDC2GeneProduct983 (Entrez Gene)
CDC37GeneProduct11140 (Entrez Gene)
CDK7GeneProduct1022 (Entrez Gene)
CDK9GeneProduct1025 (Entrez Gene)
COX5BGeneProduct1329 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CTDP1GeneProduct9150 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
ESR1GeneProduct2099 (Entrez Gene)
ESR2GeneProduct2100 (Entrez Gene)
ETV5GeneProduct2119 (Entrez Gene)
FHL2GeneProduct2274 (Entrez Gene)
FLNAGeneProduct2316 (Entrez Gene)
GAPDHGeneProduct2597 (Entrez Gene)
GHRGeneProduct2690 (Entrez Gene)
GTF2F1GeneProduct2962 (Entrez Gene)
GTF2F2GeneProduct2963 (Entrez Gene)
GTF2H1GeneProduct2965 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
HIPK3GeneProduct10114 (Entrez Gene)
HMGB1GeneProduct3146 (Entrez Gene)
HMGB2GeneProduct3148 (Entrez Gene)
HRMT1L2GeneProduct3276 (Entrez Gene)
HSPA1AGeneProduct3303 (Entrez Gene)
HTATIPGeneProduct10524 (Entrez Gene)
IGFIGeneProduct3479 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6STGeneProduct3572 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MMP1GeneProduct4312 (Entrez Gene)
MYST2GeneProduct11143 (Entrez Gene)
NCOA1GeneProduct8648 (Entrez Gene)
NCOA2GeneProduct10499 (Entrez Gene)
NCOA3GeneProduct8202 (Entrez Gene)
NCOA4GeneProduct8031 (Entrez Gene)
NCOR2GeneProduct9612 (Entrez Gene)
NR0B1GeneProduct190 (Entrez Gene)
NR0B2GeneProduct8431 (Entrez Gene)
NR2C2GeneProduct7182 (Entrez Gene)
NR3C1GeneProduct2908 (Entrez Gene)
NR5A1GeneProduct2516 (Entrez Gene)
NRIP1GeneProduct8204 (Entrez Gene)
NSD1GeneProduct64324 (Entrez Gene)
PA2G4GeneProduct5036 (Entrez Gene)
PAK6GeneProduct56924 (Entrez Gene)
PCAFGeneProduct8850 (Entrez Gene)
PIAS1GeneProduct8554 (Entrez Gene)
PIAS2GeneProduct9063 (Entrez Gene)
PIAS3GeneProduct10401 (Entrez Gene)
PIAS4GeneProduct51588 (Entrez Gene)
PLAGL1GeneProduct5325 (Entrez Gene)
PNRC1GeneProduct10957 (Entrez Gene)
POU2F1GeneProduct5451 (Entrez Gene)
POU2F2GeneProduct5452 (Entrez Gene)
PTENGeneProduct5728 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
RAC3GeneProduct5881 (Entrez Gene)
RAFGeneProduct5894 (Entrez Gene)
RANGeneProduct5901 (Entrez Gene)
RANBP9GeneProduct10048 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RCHY1GeneProduct25898 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RNF14GeneProduct9604 (Entrez Gene)
RNF4GeneProduct6047 (Entrez Gene)
RUNX1GeneProduct861 (Entrez Gene)
RUNX2GeneProduct860 (Entrez Gene)
SENP1GeneProduct29843 (Entrez Gene)
SIN3AGeneProduct25942 (Entrez Gene)
SLC25A4GeneProduct291 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
SPDEFGeneProduct25803 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
SRISNF2LGeneProduct23132 (Entrez Gene)
SRYGeneProduct6736 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STUB1GeneProduct10273 (Entrez Gene)
SVILGeneProduct6840 (Entrez Gene)
TBPIPGeneProduct29893 (Entrez Gene)
TGFB1I1GeneProduct7041 (Entrez Gene)
TGIFGeneProduct7050 (Entrez Gene)
TMF1GeneProduct7110 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
UBE2IGeneProduct7329 (Entrez Gene)
UBE3AGeneProduct7337 (Entrez Gene)
UXTGeneProduct8409 (Entrez Gene)
YWHAHGeneProduct7533 (Entrez Gene)
ZNF278GeneProduct23598 (Entrez Gene)

Annotated Interactions

No annotated interactions
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