Retinol metabolism (Rattus norvegicus)

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3, 4beta-caroteneCytochrome P450 family?RPE-specificPPAR pathways13,14 dehydro RALbeta-carotenebeta-caroteneRERA-binding proteinsall-trans-4-oxo dehydro RA?Liver/other organsRE + dietary lipidsROL=retinol; RAL=retinaldehyde, RA = retinoic acid, RE = retinyl ester, RPE = retinal pigment epithelium beta-carotene11-cis ROL9-cis RA9-cis ROLROL-binding proteinsBloodall-trans ROLRAL?ROLROLRE + dietary lipidsbeta-10'-apocarotenal9-cis RALall-trans RA11-cis RAL?11-cis binding proteinchylomicron?RE + dietary lipidsRENucleusNuclear receptors13,14 dehydro RAEnterocyte?13,14 dehydro ROLall-trans-4-oxo RAall-trans RALNpc1l1Adh4RaraRbp2cryptoxanthinlycopeneRxraAldh1a3Sult2b1Vitamin D3RargRdh12Rlbp1Adh1RxrgBcmo1Rdh5Aldh1a1Cyp26a1Aldh1a2beta-cryptoxanthinastaxanthinRbp7LratDhrs3canthaxanthinAldh1a2ARATRARbluteinRdh8Cyp2e1Abcg5MAPKCrabp1Scarb1Rbp4Rdh5Sult1a1LratRdh10RxrbBcdo2Rbp1Crabp2Abcg8Scarb1violaxanthinzeaxanthinLplBcmo1Cd36alpha-caroteneCyp26b1Aldh1a1RetsatAldh1a3Bcmo1Rpe65Rdh125, 16, 248, 17, 21, 242, 7, 9, 11-13, 15...141, 6, 10, 18, 20...


Description

This pathway is about carotenoid metabolism. It is mainly created by the NuGO focusteam on Carotenoid metabolism. Finally it was subject to a text mining workflow which added some additional entities.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP716(r30274) with a 76% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y; ''Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.''; Nutr Cancer, 1999 PubMed Europe PMC
  2. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG; ''Carotenoids in the human macula and whole retina.''; Invest Ophthalmol Vis Sci, 1988 PubMed Europe PMC
  3. PubMed Europe PMC
  4. Bendich A, Olson JA; ''Biological actions of carotenoids.''; FASEB J, 1989 PubMed Europe PMC
  5. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC Jr; ''Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.''; Am J Clin Nutr, 1992 PubMed Europe PMC
  6. Czeczuga-Semeniuk E, Wolczynski S, Markiewicz W; ''Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.''; Neoplasma, 2003 PubMed Europe PMC
  7. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E; ''Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol.''; Am J Clin Nutr, 1994 PubMed Europe PMC
  8. PubMed Europe PMC
  9. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL; ''Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis.''; Eur J Pediatr, 1997 PubMed Europe PMC
  10. PubMed Europe PMC
  11. PubMed Europe PMC
  12. PubMed Europe PMC
  13. Torma H, Rollman O, Binderup L, Michaelsson G; ''Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture.''; J Investig Dermatol Symp Proc, 1996 PubMed Europe PMC
  14. Hidiroglou M, Williams CJ; ''Interrelationships among liposoluble vitamins in ruminants.''; Am J Vet Res, 1986 PubMed Europe PMC
  15. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, Stacewicz-Sapuntzakis M, Mares-Perlman JA; ''Influence of using different sources of carotenoid data in epidemiologic studies.''; J Am Diet Assoc, 1996 PubMed Europe PMC
  16. PubMed Europe PMC
  17. Sies H, Stahl W, Sundquist AR; ''Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.''; Ann N Y Acad Sci, 1992 PubMed Europe PMC
  18. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr; ''Separation and identification of carotenoids and their oxidation products in the extracts of human plasma.''; Anal Chem, 1992 PubMed Europe PMC
  19. Balmer JE, Blomhoff R; ''Gene expression regulation by retinoic acid.''; J Lipid Res, 2002 PubMed Europe PMC
  20. Johansson S, Melhus H; ''Vitamin A antagonizes calcium response to vitamin D in man.''; J Bone Miner Res, 2001 PubMed Europe PMC
  21. Boosalis MG, Snowdon DA, Tully CL, Gross MD; ''Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study.''; Nutrition, 1996 PubMed Europe PMC
  22. PubMed Europe PMC
  23. Ruhl CE, Everhart JE; ''Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.''; Gastroenterology, 2003 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106955view13:41, 17 September 2019MaintBotHMDB identifier normalization
74434view06:19, 20 April 2014EgonwFixed a PubMed ID.
71769view20:30, 17 October 2013MaintBotAutomated update of data sources
69335view18:50, 8 July 2013MaintBotUpdated to 2013 gpml schema
67628view11:35, 26 June 2013DdiglesOntology Term : 'retinol metabolic pathway' added !
59818view11:06, 8 March 2013EgonwWidended label with legenda.
59805view07:22, 8 March 2013EgonwConverted the beta carotenes into DataNodes with ChEBI annotation.
48059view17:52, 1 May 2012Strandcorrected database names - hmdbid to HMDB
47781view05:51, 6 April 2012KhanspersSpecify description
41646view02:33, 2 March 2011MaintBotRemoved redundant pathway information and comments
38719view19:33, 23 September 2010AlexanderPico
34048view19:01, 9 December 2009MaintBotAutomatic update of empty xrefs
32766view18:30, 4 September 2009MaintBotModified categories
30980view00:53, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ARATGeneProduct
Abcg5GeneProduct114628 (Entrez Gene)
Abcg8GeneProduct155192 (Entrez Gene)
Adh1GeneProduct24172 (Entrez Gene)
Adh4GeneProduct29646 (Entrez Gene)
Aldh1a1GeneProduct24188 (Entrez Gene)
Aldh1a2GeneProduct116676 (Entrez Gene)
Aldh1a3GeneProduct266603 (Entrez Gene)
Bcdo2GeneProduct
Bcmo1GeneProduct114106 (Entrez Gene)
Cd36GeneProduct29184 (Entrez Gene)
Crabp1GeneProduct25061 (Entrez Gene)
Crabp2GeneProduct29563 (Entrez Gene)
Cyp26a1GeneProduct154985 (Entrez Gene)
Cyp26b1GeneProduct312495 (Entrez Gene)
Cyp2e1GeneProduct25086 (Entrez Gene)
Dhrs3GeneProduct313689 (Entrez Gene)
LplGeneProduct24539 (Entrez Gene)
LratGeneProduct64047 (Entrez Gene)
MAPKGeneProduct
Npc1l1GeneProduct432367 (Entrez Gene)
RARbGeneProduct24706 (Entrez Gene)
RaraGeneProduct24705 (Entrez Gene)
RargGeneProduct685072 (Entrez Gene)
Rbp1GeneProduct25056 (Entrez Gene)
Rbp2GeneProduct24710 (Entrez Gene)
Rbp4GeneProduct25703 (Entrez Gene)
Rbp7GeneProduct362662 (Entrez Gene)
Rdh10GeneProduct353252 (Entrez Gene)
Rdh12GeneProduct314264 (Entrez Gene)
Rdh5GeneProduct366791 (Entrez Gene)
Rdh8GeneProduct690953 (Entrez Gene)
RetsatGeneProduct246298 (Entrez Gene)
Rlbp1GeneProduct293049 (Entrez Gene)
Rpe65GeneProduct89826 (Entrez Gene)
RxraGeneProduct25271 (Entrez Gene)
RxrbGeneProduct361801 (Entrez Gene)
RxrgGeneProduct83574 (Entrez Gene)
Scarb1GeneProduct25073 (Entrez Gene)
Sult1a1GeneProduct83783 (Entrez Gene)
Sult2b1GeneProduct292915 (Entrez Gene)
Vitamin D3MetaboliteHMDB00876 (HMDB)
alpha-caroteneMetaboliteHMDB03993 (HMDB)
astaxanthinMetaboliteHMDB02204 (HMDB)
beta-caroteneMetaboliteCHEBI:17579 (ChEBI)
beta-cryptoxanthinMetaboliteHMDB02268 (HMDB)
canthaxanthinMetaboliteHMDB03154 (HMDB)
cryptoxanthinMetaboliteHMDB02268 (HMDB)
luteinMetaboliteHMDB03233 (HMDB)
lycopeneMetaboliteHMDB03000 (HMDB)
violaxanthinMetaboliteHMDB03101 (HMDB)
zeaxanthinMetaboliteHMDB02789 (HMDB)

Annotated Interactions

No annotated interactions
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