Selenium metabolism Selenoproteins (Rattus norvegicus)

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2-4, 6, 7, 10...AntioxidantenzymesThyroid hormonemetabolismSecsynthesisSe transportand storagecoding regionSec tRNA[ser]secTrXSeryl-tRNA[ser](sec)AUGUnkownfunctionINORGANIC SePhosphoseryl-tRNA[ser](sec)GSHSTOPSelenocysteyl-tRNA secBody proteinsSelenium binding proteinsSeC BiosynthesisSe = Selenium, SeMet = SelenoMethionine, SeC = Selcysteine, H2Se = Selenide, GSH = gluthatione, Trx = ThioredoxinORGANIC SeProtein foldingSelenoproteinsSeCRedoxsignallingmethyl transferaseDietSeCTranscription FactorsnucleusdemethylationSBP2Gpx3SeCPstkSelenbp1SelenateSephs1RelaSBP2FosDio1Sepp1SeCNfe2l2EefsecJunH2SeSp1Pouf2f1SeleniteSepx1SelTTxnrd1Gpx2SarsSars2UGAEefsecMethylSelenol MeSeHTxnrd2SelsSeMetSp3SeleniteSelHNfkb1Cystathionine g-lyaseRpl30SclySeMetDio2SlaSelkCremSeloGpx6Sepw1Dio3SelMTXNRD3Secp43SeliSephs2SelVSBP2Txnrd2Gpx4TXNRD3Sephs2Sep15Fabp1SelenophosphateGpx1SelenateTxnrd1SEPN15, 8, 91, 5


* Comments belonging to specific genes on the Selenoprotein pathway
    • TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy.
    • Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase
    • A selenoprotein database exists at:


This pathway was inferred from Homo sapiens pathway WP28(r30051) with a 58% conversion rate.

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  1. Wang H, Zhang J, Yu H; ''Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.''; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia
  2. Ip C, Hayes C; ''Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection.''; Carcinogenesis, 1989 PubMed Europe PMC Scholia
  3. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL; ''Biosynthesis of selenocysteine on its tRNA in eukaryotes.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  4. PubMed Europe PMC Scholia
  5. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF; ''Effectiveness of selenium supplements in a low-selenium area of China.''; Am J Clin Nutr, 2005 PubMed Europe PMC Scholia
  6. Gromer S, Eubel JK, Lee BL, Jacob J; ''Human selenoproteins at a glance.''; Cell Mol Life Sci, 2005 PubMed Europe PMC Scholia
  7. Small-Howard AL, Berry MJ; ''Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes.''; Biochem Soc Trans, 2005 PubMed Europe PMC Scholia
  8. Soda K, Oikawa T, Esaki N; ''Vitamin B6 enzymes participating in selenium amino acid metabolism.''; Biofactors, 1999 PubMed Europe PMC Scholia
  9. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed Europe PMC Scholia
  10. Boosalis MG; ''The role of selenium in chronic disease.''; Nutr Clin Pract, 2008 PubMed Europe PMC Scholia
  11. PubMed Europe PMC Scholia


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106954view13:41, 17 September 2019MaintBotHMDB identifier normalization
71766view20:30, 17 October 2013MaintBotAutomated update of data sources
71291view16:56, 17 October 2013MaintBotAutomated update of data sources
69327view18:49, 8 July 2013MaintBotUpdated to 2013 gpml schema
67633view11:36, 26 June 2013DdiglesOntology Term : 'selenoamino acid metabolic pathway' added !
62842view05:03, 3 May 2013MaintBotUpdated UniProt data source
58918view04:52, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41638view02:33, 2 March 2011MaintBotRemoved redundant pathway information and comments
34041view18:59, 9 December 2009MaintBotAutomatic update of empty xrefs
32307view13:19, 15 August 2009MaintBotFixed text labels
31894view12:44, 14 August 2009MaintBotFixed group labels
31335view20:23, 13 August 2009MaintBotFixed text labels
30974view00:51, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CremGeneProduct25620 (Entrez Gene)
Cystathionine g-lyaseGeneProduct
Dio1GeneProduct25430 (Entrez Gene)
Dio2GeneProduct65162 (Entrez Gene)
Dio3GeneProduct29475 (Entrez Gene)
EefsecGeneProduct500255 (Entrez Gene)
Fabp1GeneProduct24360 (Entrez Gene)
FosGeneProductENSRNOG00000008015 (Ensembl Rat)
Gpx1GeneProduct24404 (Entrez Gene)
Gpx2GeneProduct29326 (Entrez Gene)
Gpx3GeneProduct64317 (Entrez Gene)
Gpx4GeneProduct29328 (Entrez Gene)
Gpx6GeneProduct259233 (Entrez Gene)
JunGeneProductENSRNOG00000026293 (Ensembl Rat)
MethylSelenol MeSeHMetabolite
Nfe2l2GeneProduct83619 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
RelaGeneProduct309165 (Entrez Gene)
Rpl30GeneProduct64640 (Entrez Gene)
SEPN1GeneProduct362624 (Entrez Gene)
Sars2GeneProduct292759 (Entrez Gene)
SarsGeneProduct266975 (Entrez Gene)
SclyGeneProduct363285 (Entrez Gene)
SeCMetaboliteHMDB03288 (HMDB)
SeMetMetaboliteHMDB03966 (HMDB)
Secp43GeneProduct65241 (Entrez Gene)
SelMGeneProduct498398 (Entrez Gene)
SelTGeneProduct365802 (Entrez Gene)
SelVGeneProduct499113 (Entrez Gene)
Selenbp1GeneProduct140927 (Entrez Gene)
SelenophosphateMetaboliteHMDB06407 (HMDB)
SeliGeneProduct362713 (Entrez Gene)
SelkGeneProduct290549 (Entrez Gene)
SeloGeneProduct315216 (Entrez Gene)
SelsGeneProduct286900 (Entrez Gene)
Sep15GeneProduct113922 (Entrez Gene)
Sephs1GeneProduct291314 (Entrez Gene)
Sephs2GeneProduct308993 (Entrez Gene)
Sepp1GeneProduct29360 (Entrez Gene)
Sepw1GeneProduct25545 (Entrez Gene)
Sepx1GeneProduct685059 (Entrez Gene)
SlaGeneProduct338477 (Entrez Gene)
Sp1GeneProduct24790 (Entrez Gene)
Sp3GeneProduct367846 (Entrez Gene)
TXNRD3GeneProduct297437 (Entrez Gene)
Txnrd1GeneProduct58819 (Entrez Gene)
Txnrd2GeneProduct50551 (Entrez Gene)

Annotated Interactions

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