Wnt Signaling Pathway and Pluripotency (Rattus norvegicus)

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4TR: Transcriptional Regulation+pPluripotencyPromotes DifferentiationProtein Kinase CPhosphorylated beta-cateninPP2Abeta-cateninTcf/Lef-126S Proteasome DegradationTRApoptosisTcf/Lef-1Wnt ReceptorsTRbeta-cateninFrizzled LigandsDifferentiationStabilized beta-cateninRecruitment to UnknownUbiquitin Conjugating EnzymeTR+pCytoskeletonIQ1TRBIO+pUbiquitin Taggedbeta-cateninTcf/Lef-1NucleusPromotes 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_predictedFoxd3Ppp2r2c


This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining

Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.


This pathway was inferred from Homo sapiens pathway WP399(r29616) with a 94% conversion rate.

Quality Tags

Ontology Terms



  1. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  2. ''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html
  3. Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMed Europe PMC Scholia
  4. Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia


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71793view20:33, 17 October 2013MaintBotAutomated update of data sources
69412view19:01, 8 July 2013MaintBotUpdated to 2013 gpml schema
67756view11:59, 26 June 2013DdiglesOntology Term : 'canonical Wnt signaling pathway' added !
58963view18:38, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
47764view05:14, 6 April 2012Khanspersupdated xref
47763view05:13, 6 April 2012Khanspersupdated xref
41733view02:39, 2 March 2011MaintBotRemoved redundant pathway information and comments
34108view19:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32304view13:18, 15 August 2009MaintBotFixed text labels
31888view12:42, 14 August 2009MaintBotFixed group labels
31333view20:23, 13 August 2009MaintBotFixed text labels
30957view00:45, 30 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
ApcGeneProduct24205 (Entrez Gene)
Axin1GeneProduct79257 (Entrez Gene)
Axin2GeneProduct29134 (Entrez Gene)
Ccnd1GeneProduct58919 (Entrez Gene)
Ccnd2GeneProduct64033 (Entrez Gene)
Ccnd3GeneProduct25193 (Entrez Gene)
Cd44GeneProduct25406 (Entrez Gene)
CrebbpGeneProduct54244 (Entrez Gene)
Csnk1eGeneProduct58822 (Entrez Gene)
Ctbp1GeneProduct29382 (Entrez Gene)
Ctbp2GeneProduct81717 (Entrez Gene)
Ctnnb1GeneProduct84353 (Entrez Gene)
Ctnnd1GeneProduct311163 (Entrez Gene)
DVL2GeneProduct303251 (Entrez Gene)
Dvl1GeneProduct83721 (Entrez Gene)
Dvl3GeneProduct303811 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
FZD3GeneProduct266715 (Entrez Gene)
FZD7GeneProduct301440 (Entrez Gene)
Fbxw2GeneProduct311881 (Entrez Gene)
Fosl1GeneProduct25445 (Entrez Gene)
Foxd3GeneProductENSRNOG00000009021 (Ensembl Rat)
Fzd1GeneProduct58868 (Entrez Gene)
Fzd2GeneProduct64512 (Entrez Gene)
Fzd4GeneProduct64558 (Entrez Gene)
Fzd5GeneProduct317674 (Entrez Gene)
Fzd6GeneProduct282581 (Entrez Gene)
Fzd8GeneProduct364754 (Entrez Gene)
Fzd9GeneProduct266608 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
Gstt2GeneProduct29487 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LOC679869GeneProductENSRNOG00000013993 (Ensembl Rat)
LdlrGeneProduct300438 (Entrez Gene)
Lef1GeneProduct161452 (Entrez Gene)
Lrp5GeneProduct293649 (Entrez Gene)
Lrp6GeneProduct312781 (Entrez Gene)
Map3k7GeneProduct313121 (Entrez Gene)
Mapk10GeneProduct25272 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
Mmp7GeneProduct25335 (Entrez Gene)
MycGeneProduct24577 (Entrez Gene)
NanogGeneProduct414065 (Entrez Gene)
NfyaGeneProductENSRNOG00000012702 (Ensembl Rat)
Nkd1GeneProduct364952 (Entrez Gene)
Nkd2GeneProduct308068 (Entrez Gene)
NlkGeneProduct497961 (Entrez Gene)
Pafah1b1GeneProduct83572 (Entrez Gene)
PlauGeneProduct25619 (Entrez Gene)
Pou5f1GeneProduct294562 (Entrez Gene)
PpardGeneProduct25682 (Entrez Gene)
Ppm1jGeneProductENSRNOG00000012481 (Ensembl Rat)
Ppp2caGeneProduct24672 (Entrez Gene)
Ppp2cbGeneProduct24673 (Entrez Gene)
Ppp2r1aGeneProduct117281 (Entrez Gene)
Ppp2r1bGeneProduct315648 (Entrez Gene)
Ppp2r2aGeneProduct117104 (Entrez Gene)
Ppp2r2bGeneProduct60660 (Entrez Gene)
Ppp2r2cGeneProduct117256 (Entrez Gene)
Ppp2r3aGeneProduct363122 (Entrez Gene)
Ppp2r4GeneProduct362102 (Entrez Gene)
Ppp2r5cGeneProduct691318 (Entrez Gene)
Ppp2r5eGeneProduct299147 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
PrkcdGeneProduct170538 (Entrez Gene)
PrkceGeneProduct29340 (Entrez Gene)
PrkchGeneProduct81749 (Entrez Gene)
PrkciGeneProduct84006 (Entrez Gene)
PrkcqGeneProduct85420 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
Prkd1GeneProduct85421 (Entrez Gene)
Racgap1GeneProduct315298 (Entrez Gene)
RhoaGeneProduct117273 (Entrez Gene)
Sox2GeneProduct499593 (Entrez Gene)
Tcf3GeneProduct312451 (Entrez Gene)
Tcf7_predictedGeneProductENSRNOG00000005872 (Ensembl Rat)
Tp53GeneProduct24842 (Entrez Gene)
Wnt10aGeneProduct316527 (Entrez Gene)
Wnt10bGeneProduct315294 (Entrez Gene)
Wnt11GeneProduct140584 (Entrez Gene) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
Wnt1GeneProduct24881 (Entrez Gene)
Wnt16GeneProduct500047 (Entrez Gene)
Wnt2GeneProduct114487 (Entrez Gene)
Wnt2bGeneProduct116466 (Entrez Gene)
Wnt3GeneProduct24882 (Entrez Gene)
Wnt3aGeneProduct303181 (Entrez Gene)
Wnt4GeneProduct84426 (Entrez Gene)
Wnt5aGeneProduct64566 (Entrez Gene)
Wnt5bGeneProduct282582 (Entrez Gene)
Wnt6GeneProduct316526 (Entrez Gene)
Wnt7aGeneProduct114850 (Entrez Gene)
Wnt7bGeneProduct315196 (Entrez Gene)
Wnt9bGeneProduct303586 (Entrez Gene)
Zbtb33GeneProduct501506 (Entrez Gene)

Annotated Interactions

No annotated interactions
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