Metapathway biotransformation (Rattus norvegicus)
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Ddigles
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Epoxide hydrolases
Glutathione transferases
Electrophiles
Methylation
Acetylation
Cytochrome P450
Methyltransferases
Reduction
Hydrolysis
Amino acid conjugation
Aldo-keto reductases
Glucuronidation
Glutathione peroxidases
Flavin monooxygenases
Sulfotransferases
Amino acid acyl transferases
Glutathione synthetase
Nucleophiles
Glucuronosyltransferases
N-acetyltransferases
Sulfation
Oxidation
Glutathione conjugation
Glutathione reductase
Cyp19a1
CYP2C19
UGT2B4
Substrate-Aa
NP_001100974.1
Glucuronosyltransferase
Cyp7a1
AKR1C1
LOC681900
NP_001100897.1
CYP11B1
Hs3st2
UGT2B7
Substrate=O
Cyp1b1
Hs2st1
LOC690611
NP_001101226.1
CYP4F12
Sult1a1
GPX2
Gss
SULT4A1
Cyp21a1
Chst14
Cyp2e1
Ndst3_predicted
Cyp20a1
NP_001100289.1
Ugt1a1
Mgst1
Sult1a1
Gsto2
Glyat
Methyltransferase
NP_001099210.1
Substrate-SO3H
NAT1
Substrate-SG
SULT1C4
NP_001101936.1
Nat8l_predicted
NP_001102569.1
Substrate-Gl
NP_001102193.1
Gm766
Xenobiotic substrate
GPX1
NP_001100363.1
Tpmt
NP_001100901.1
AKR1C3
Ephx2
CHST12
NAT2
HS3ST3A1
CYP3A4
CYP450
GSTA4
AKR1B1
Substrate-NH2
CYP3A43
UGT2B11
Mgst2
GSTA5
GSTA2
Fmo5
Ugt2a1
Ugt2a3_predicted
Sult1a1
Cyp1a1
CYP4V2
Ugt1a2
NP_001099862.1
Kcnab1
SULT1C2
Cyp27a1
Cyp4f39_predicted
Gpx5
GSTM1
Fmo4
CYP2A13
AKR1C4
Baat
UGT2B28
CYP4F11
CYP2B6
CHSTB_RAT
Fmo2
Akr1a1
Glutathione transferase
NP_001102534.1
UGT1A7
Gstm5
NP_001101680.1
Substrate-CH3
UGT2B17
NP_001101988.1
Gstp2
Cyp51
NP_001101195.1
AKR1B10
CYP2D6
Gstt2
CYP2A6
Cyp24a1
GLYATL2
Cyp2u1
Sult1c1
Ugt1a6
CYP27B1
UGT1A10
NP_001100901.1
NP_001102065.1
GLYATL1
GSTM5
Gpx3
Hs3st1
Cyp1a2
MGC108896
Sulfotransferase
CYP2A7
CYP2J2
Cyp4f18
Aldo-keto reductase
Kcnab2
UGT1A9
Comt
Substrate-O-R
Ste
Cyp4b1
Fmo3
Chst3
Gstm3
UGT2A2
Cyp26a1
AKR1C2
Sult1a1
Gsr
Cyp7b1
HS3ST3B1
Flavin monooxygenase
LOC683774
Cyp8b1
MGC105600
Ugt1a3
MGST3
RGD1562825_predicted
Chst1
CYP4F2
Fmo1
NAT8
Gstk1
NP_001102492.1
Ugt1a5
Chst9
GSTA1
Gstt1
Kcnab3
SULT2A1
Cyp26b1
Cyp26c1_predicted
NAT6
Cyp2f2
Hnmt
LOC685402
Cyp11a1
Akr7a2
Cyp2w1_predicted
CYP2C8
LOC687052
Sult1b1
Substrate-Ac
Cyp17a1
N-acetyltransferase
Ephx1
CYP2C9
SULT1C1
Ugt1a3
GAL3ST1
ST2B1_RAT
CYP4Z1
GSTZ1
GSTA3
Amino acid acyltransferase
Ndst1
Chst2_predicted
CYP4F8
Nat9_predicted
Ndst4_predicted
Chst7
NP_001101969.1
HS6ST3
CYP2C18
Substrate-SH
Akr1d1
NP_001099351.1
CYP11B2
CYP3A5
CYP3A7
Akr7a3
Chst10
Hs3st4
UGT2B15
CYP4X1
Gsto1
CYP27C1
Gstt2
Substrate-OH
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP702(r29945)
with a 60% conversion rate.
Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
No bibliography
History
View all...
Compare
Revision
Action
Time
User
Comment
69345
view
18:52, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67457
view
11:04, 26 June 2013
Ddigles
Ontology Term : 'cellular detoxification pathway' added !
58921
view
05:10, 21 February 2013
MaintBot
Updated Ensembl and UniProt data source
58518
view
20:07, 14 February 2013
MaintBot
Modified title
41657
view
02:34, 2 March 2011
MaintBot
Removed redundant pathway information and comments
34055
view
19:04, 9 December 2009
MaintBot
Automatic update of empty xrefs
33192
view
18:08, 5 November 2009
Khanspers
Modified categories
32303
view
13:17, 15 August 2009
MaintBot
Fixed text labels
31886
view
12:42, 14 August 2009
MaintBot
Fixed group labels
31332
view
20:22, 13 August 2009
MaintBot
Fixed text labels
30952
view
00:43, 30 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
AKR1B10
GeneProduct
296972 (Entrez Gene)
AKR1B1
GeneProduct
24192 (Entrez Gene)
AKR1C1
GeneProduct
307092 (Entrez Gene)
AKR1C2
GeneProduct
AKR1C3
GeneProduct
AKR1C4
GeneProduct
Akr1a1
GeneProduct
ENSRNOG00000016727 (Ensembl)
Akr1d1
GeneProduct
ENSRNOG00000013004 (Ensembl)
Akr7a2
GeneProduct
ENSRNOG00000017780 (Ensembl)
Akr7a3
GeneProduct
ENSRNOG00000017899 (Ensembl)
Aldo-keto reductase
GeneProduct
Amino acid acyltransferase
GeneProduct
Baat
GeneProduct
ENSRNOG00000007395 (Ensembl)
CHST12
GeneProduct
304322 (Entrez Gene)
CHSTB_RAT
GeneProduct
ENSRNOG00000008885 (Ensembl)
CYP11B1
GeneProduct
500892 (Entrez Gene)
CYP11B2
GeneProduct
24294 (Entrez Gene)
CYP27B1
GeneProduct
114700 (Entrez Gene)
CYP27C1
GeneProduct
CYP2A13
GeneProduct
CYP2A6
GeneProduct
CYP2A7
GeneProduct
CYP2B6
GeneProduct
CYP2C18
GeneProduct
CYP2C19
GeneProduct
CYP2C8
GeneProduct
CYP2C9
GeneProduct
CYP2D6
GeneProduct
CYP2J2
GeneProduct
CYP3A4
GeneProduct
CYP3A43
GeneProduct
CYP3A5
GeneProduct
CYP3A7
GeneProduct
CYP450
GeneProduct
CYP4F11
GeneProduct
CYP4F12
GeneProduct
CYP4F2
GeneProduct
CYP4F8
GeneProduct
CYP4V2
GeneProduct
CYP4X1
GeneProduct
246767 (Entrez Gene)
CYP4Z1
GeneProduct
Chst10
GeneProduct
ENSRNOG00000012815 (Ensembl)
Chst14
GeneProduct
691394 (Entrez Gene)
Chst1
GeneProduct
ENSRNOG00000007989 (Ensembl)
Chst2_predicted
GeneProduct
ENSRNOG00000037453 (Ensembl)
Chst3
GeneProduct
ENSRNOG00000000572 (Ensembl)
Chst7
GeneProduct
ENSRNOG00000004258 (Ensembl)
Chst9
GeneProduct
291770 (Entrez Gene)
Comt
GeneProduct
ENSRNOG00000001889 (Ensembl)
Cyp11a1
GeneProduct
ENSRNOG00000008074 (Ensembl)
Cyp17a1
GeneProduct
ENSRNOG00000020035 (Ensembl)
Cyp19a1
GeneProduct
ENSRNOG00000000196 (Ensembl)
Cyp1a1
GeneProduct
ENSRNOG00000019500 (Ensembl)
Cyp1a2
GeneProduct
ENSRNOG00000016173 (Ensembl)
Cyp1b1
GeneProduct
ENSRNOG00000040287 (Ensembl)
Cyp20a1
GeneProduct
ENSRNOG00000017631 (Ensembl)
Cyp21a1
GeneProduct
24298 (Entrez Gene)
Cyp24a1
GeneProduct
ENSRNOG00000013062 (Ensembl)
Cyp26a1
GeneProduct
ENSRNOG00000016750 (Ensembl)
Cyp26b1
GeneProduct
ENSRNOG00000015076 (Ensembl)
Cyp26c1_predicted
GeneProduct
ENSRNOG00000030698 (Ensembl)
Cyp27a1
GeneProduct
ENSRNOG00000017188 (Ensembl)
Cyp2e1
GeneProduct
ENSRNOG00000012458 (Ensembl)
Cyp2f2
GeneProduct
ENSRNOG00000032805 (Ensembl)
Cyp2u1
GeneProduct
ENSRNOG00000011053 (Ensembl)
Cyp2w1_predicted
GeneProduct
ENSRNOG00000022355 (Ensembl)
Cyp4b1
GeneProduct
ENSRNOG00000009741 (Ensembl)
Cyp4f18
GeneProduct
ENSRNOG00000015751 (Ensembl)
Cyp4f39_predicted
GeneProduct
ENSRNOG00000029478 (Ensembl)
Cyp51
GeneProduct
ENSRNOG00000007234 (Ensembl)
Cyp7a1
GeneProduct
ENSRNOG00000009488 (Ensembl)
Cyp7b1
GeneProduct
ENSRNOG00000009730 (Ensembl)
Cyp8b1
GeneProduct
ENSRNOG00000019481 (Ensembl)
Ephx1
GeneProduct
ENSRNOG00000003515 (Ensembl)
Ephx2
GeneProduct
ENSRNOG00000017286 (Ensembl)
Flavin monooxygenase
GeneProduct
Fmo1
GeneProduct
ENSRNOG00000034191 (Ensembl)
Fmo2
GeneProduct
ENSRNOG00000003510 (Ensembl)
Fmo3
GeneProduct
ENSRNOG00000003620 (Ensembl)
Fmo4
GeneProduct
ENSRNOG00000003400 (Ensembl)
Fmo5
GeneProduct
ENSRNOG00000018076 (Ensembl)
GAL3ST1
GeneProduct
GLYATL1
GeneProduct
GLYATL2
GeneProduct
GPX1
GeneProduct
24404 (Entrez Gene)
GPX2
GeneProduct
29326 (Entrez Gene)
GSTA1
GeneProduct
GSTA2
GeneProduct
24422 (Entrez Gene)
GSTA3
GeneProduct
24421 (Entrez Gene)
GSTA4
GeneProduct
300850 (Entrez Gene)
GSTA5
GeneProduct
GSTM1
GeneProduct
24423 (Entrez Gene)
GSTM5
GeneProduct
64352 (Entrez Gene)
GSTZ1
GeneProduct
681913 (Entrez Gene)
Glucuronosyltransferase
GeneProduct
Glutathione transferase
GeneProduct
Glyat
GeneProduct
ENSRNOG00000012142 (Ensembl)
Gm766
GeneProduct
ENSRNOG00000036959 (Ensembl)
Gpx3
GeneProduct
ENSRNOG00000021809 (Ensembl)
Gpx5
GeneProduct
ENSRNOG00000018596 (Ensembl)
Gsr
GeneProduct
ENSRNOG00000014915 (Ensembl)
Gss
GeneProduct
ENSRNOG00000018964 (Ensembl)
Gstk1
GeneProduct
ENSRNOG00000016484 (Ensembl)
Gstm3
GeneProduct
ENSRNOG00000018937 (Ensembl)
Gstm5
GeneProduct
ENSRNOG00000018732 (Ensembl)
Gsto1
GeneProduct
ENSRNOG00000028746 (Ensembl)
Gsto2
GeneProduct
ENSRNOG00000012801 (Ensembl)
Gstp2
GeneProduct
ENSRNOG00000018237 (Ensembl)
Gstt1
GeneProduct
ENSRNOG00000001242 (Ensembl)
Gstt2
GeneProduct
ENSRNOG00000028188 (Ensembl)
HS3ST3A1
GeneProduct
363618 (Entrez Gene)
HS3ST3B1
GeneProduct
303218 (Entrez Gene)
HS6ST3
GeneProduct
364476 (Entrez Gene)
Hnmt
GeneProduct
ENSRNOG00000005223 (Ensembl)
Hs2st1
GeneProduct
ENSRNOG00000012549 (Ensembl)
Hs3st1
GeneProduct
ENSRNOG00000010598 (Ensembl)
Hs3st2
GeneProduct
ENSRNOG00000017659 (Ensembl)
Hs3st4
GeneProduct
ENSRNOG00000036723 (Ensembl)
Kcnab1
GeneProduct
ENSRNOG00000010422 (Ensembl)
Kcnab2
GeneProduct
ENSRNOG00000011550 (Ensembl)
Kcnab3
GeneProduct
ENSRNOG00000008480 (Ensembl)
LOC681900
GeneProduct
ENSRNOG00000014672 (Ensembl)
LOC683774
GeneProduct
ENSRNOG00000030880 (Ensembl)
LOC685402
GeneProduct
ENSRNOG00000022982 (Ensembl)
LOC687052
GeneProduct
ENSRNOG00000020743 (Ensembl)
LOC690611
GeneProduct
ENSRNOG00000013604 (Ensembl)
MGC105600
GeneProduct
ENSRNOG00000028743 (Ensembl)
MGC108896
GeneProduct
ENSRNOG00000019221 (Ensembl)
MGST3
GeneProduct
289197 (Entrez Gene)
Methyltransferase
GeneProduct
Mgst1
GeneProduct
ENSRNOG00000007743 (Ensembl)
Mgst2
GeneProduct
ENSRNOG00000013296 (Ensembl)
N-acetyltransferase
GeneProduct
NAT1
GeneProduct
116631 (Entrez Gene)
NAT2
GeneProduct
116632 (Entrez Gene)
NAT6
GeneProduct
NAT8
GeneProduct
64570 (Entrez Gene)
NP_001099210.1
GeneProduct
ENSRNOG00000027171 (Ensembl)
NP_001099351.1
GeneProduct
ENSRNOG00000039017 (Ensembl)
NP_001099862.1
GeneProduct
ENSRNOG00000000605 (Ensembl)
NP_001100289.1
GeneProduct
ENSRNOG00000005930 (Ensembl)
NP_001100363.1
GeneProduct
ENSRNOG00000010519 (Ensembl)
NP_001100897.1
GeneProduct
ENSRNOG00000016953 (Ensembl)
NP_001100901.1
GeneProduct
ENSRNOG00000021521 (Ensembl)
NP_001100974.1
GeneProduct
ENSRNOG00000022919 (Ensembl)
NP_001101195.1
GeneProduct
ENSRNOG00000011669 (Ensembl)
NP_001101226.1
GeneProduct
ENSRNOG00000008663 (Ensembl)
NP_001101680.1
GeneProduct
ENSRNOG00000014516 (Ensembl)
NP_001101936.1
GeneProduct
ENSRNOG00000038622 (Ensembl)
NP_001101969.1
GeneProduct
ENSRNOG00000011367 (Ensembl)
NP_001101988.1
GeneProduct
ENSRNOG00000021179 (Ensembl)
NP_001102065.1
GeneProduct
ENSRNOG00000010523 (Ensembl)
NP_001102193.1
GeneProduct
ENSRNOG00000007147 (Ensembl)
NP_001102492.1
GeneProduct
ENSRNOG00000011250 (Ensembl)
NP_001102534.1
GeneProduct
ENSRNOG00000001375 (Ensembl)
NP_001102569.1
GeneProduct
ENSRNOG00000014192 (Ensembl)
Nat8l_predicted
GeneProduct
ENSRNOG00000015466 (Ensembl)
Nat9_predicted
GeneProduct
ENSRNOG00000003264 (Ensembl)
Ndst1
GeneProduct
ENSRNOG00000019014 (Ensembl)
Ndst3_predicted
GeneProduct
ENSRNOG00000015781 (Ensembl)
Ndst4_predicted
GeneProduct
ENSRNOG00000009577 (Ensembl)
RGD1562825_predicted
GeneProduct
ENSRNOG00000025930 (Ensembl)
ST2B1_RAT
GeneProduct
ENSRNOG00000021046 (Ensembl)
SULT1C1
GeneProduct
SULT1C2
GeneProduct
171072 (Entrez Gene)
SULT1C4
GeneProduct
SULT2A1
GeneProduct
24912 (Entrez Gene)
SULT4A1
GeneProduct
58953 (Entrez Gene)
Ste
GeneProduct
ENSRNOG00000001957 (Ensembl)
Substrate-Aa
Metabolite
Substrate-Ac
Metabolite
Substrate-CH3
Metabolite
Substrate-Gl
Metabolite
Substrate-NH2
Metabolite
Substrate-O-R
Metabolite
Substrate-OH
Metabolite
Substrate-SG
Metabolite
Substrate-SH
Metabolite
Substrate-SO3H
Metabolite
Substrate=O
Metabolite
Sulfotransferase
GeneProduct
Sult1a1
GeneProduct
ENSRNOG00000019342 (Ensembl)
Sult1b1
GeneProduct
ENSRNOG00000001967 (Ensembl)
Sult1c1
GeneProduct
ENSRNOG00000011269 (Ensembl)
Tpmt
GeneProduct
ENSRNOG00000016468 (Ensembl)
UGT1A10
GeneProduct
UGT1A7
GeneProduct
UGT1A9
GeneProduct
396552 (Entrez Gene)
UGT2A2
GeneProduct
UGT2B11
GeneProduct
UGT2B15
GeneProduct
UGT2B17
GeneProduct
286954 (Entrez Gene)
UGT2B28
GeneProduct
UGT2B4
GeneProduct
UGT2B7
GeneProduct
Ugt1a1
GeneProduct
24861 (Entrez Gene)
Ugt1a2
GeneProduct
396527 (Entrez Gene)
Ugt1a3
GeneProduct
396551 (Entrez Gene)
Ugt1a3
GeneProduct
ENSRNOG00000018740 (Ensembl)
Ugt1a5
GeneProduct
574523 (Entrez Gene)
Ugt1a6
GeneProduct
113992 (Entrez Gene)
Ugt2a1
GeneProduct
ENSRNOG00000001973 (Ensembl)
Ugt2a3_predicted
GeneProduct
ENSRNOG00000001975 (Ensembl)
Xenobiotic substrate
Metabolite
Annotated Interactions
No annotated interactions
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