Metapathway biotransformation (Rattus norvegicus)

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Aldo-keto reductasesNucleophilesGlucuronidationSulfationElectrophilesReductionHydrolysisN-acetyltransferasesEpoxide hydrolasesGlutathione reductaseOxidationFlavin monooxygenasesAcetylationMethylationGlutathione conjugationGlutathione peroxidasesGlutathione synthetaseCytochrome P450Amino acid conjugationGlucuronosyltransferasesMethyltransferasesSulfotransferasesAmino acid acyl transferasesGlutathione transferasesLOC690611SULT1C2Fmo3Aldo-keto reductaseAKR1C1NP_001099210.1CYP3A7AKR1C4CYP2C19Kcnab3Ugt1a3CYP2C8NP_001101680.1Cyp7b1SulfotransferaseCYP2A7CYP2C9Sult1a1NP_001102065.1NP_001102534.1Akr1d1UGT2A2GssRGD1562825_predictedGSTA1GSTA2GlyatSult1c1Gpx5Cyp4f18Gstt1CYP3A5Chst9UGT2B4NP_001100897.1Sult1a1Cyp4f39_predictedCYP2J2Flavin monooxygenaseCyp2f2UGT2B28HS3ST3B1Hs2st1Hs3st2Akr7a3CYP2A6CYP2C18Kcnab2GSTM1Cyp11a1GsrGSTM5CYP4F12Cyp2e1LOC683774UGT1A7Gsto2Amino acid acyltransferaseNP_001100289.1SULT1C4CYP3A43NP_001101988.1Gstt2NP_001101969.1Cyp27a1N-acetyltransferaseChst10Fmo5Gstt2Nat9_predictedUgt1a2Fmo1Substrate-SGSubstrate-O-RAkr1a1Ugt2a3_predictedCYP3A4GSTA5ComtGSTZ1UGT2B15Gstm3AKR1B1NAT8TpmtUgt1a1NP_001102193.1Ugt1a3Akr7a2Glutathione transferaseEphx2Cyp26a1Substrate-AaSULT4A1Ugt1a5Cyp4b1Substrate-NH2NP_001101936.1CYP4V2CYP450Hs3st1NP_001100901.1Gsto1NP_001101226.1Mgst1SULT2A1NP_001100901.1Sult1a1NP_001101195.1Cyp24a1UGT2B17Fmo4Substrate-SHGstm5Substrate=OHS6ST3Fmo2CYP2D6GAL3ST1Chst2_predictedNAT6Sult1a1Chst1CYP2B6Cyp17a1Cyp20a1NP_001100363.1Cyp2u1Mgst2Substrate-GlCyp1a2Substrate-CH3LOC687052NAT1CYP27B1Gm766LOC681900NP_001099351.1Substrate-SO3HGSTA3Ugt1a6Ugt2a1CHST12GPX1AKR1C2CYP4F2GPX2Substrate-OHCHSTB_RATBaatHs3st4CYP27C1ST2B1_RATLOC685402NP_001102569.1CYP4F11Xenobiotic substrateNdst3_predictedNP_001102492.1MethyltransferaseMGST3NAT2GSTA4Gstk1Chst14Cyp19a1CYP4F8AKR1C3GLYATL2CYP4X1UGT1A9Cyp1a1Cyp26b1Sult1b1Cyp21a1UGT2B7CYP11B1Gpx3Cyp2w1_predictedHnmtSULT1C1UGT2B11Substrate-AcGLYATL1Ephx1AKR1B10NP_001100974.1Nat8l_predictedNP_001099862.1Cyp1b1Cyp51MGC105600Ndst1Cyp7a1Cyp8b1CYP2A13Gstp2HS3ST3A1CYP4Z1SteCyp26c1_predictedUGT1A10Ndst4_predictedGlucuronosyltransferaseKcnab1Chst3MGC108896Chst7CYP11B2


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP702(r29945) with a 60% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
69345view18:52, 8 July 2013MaintBotUpdated to 2013 gpml schema
67457view11:04, 26 June 2013DdiglesOntology Term : 'cellular detoxification pathway' added !
58921view05:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58518view20:07, 14 February 2013MaintBotModified title
41657view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
34055view19:04, 9 December 2009MaintBotAutomatic update of empty xrefs
33192view18:08, 5 November 2009KhanspersModified categories
32303view13:17, 15 August 2009MaintBotFixed text labels
31886view12:42, 14 August 2009MaintBotFixed group labels
31332view20:22, 13 August 2009MaintBotFixed text labels
30952view00:43, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKR1B10GeneProduct296972 (Entrez Gene)
AKR1B1GeneProduct24192 (Entrez Gene)
AKR1C1GeneProduct307092 (Entrez Gene)
AKR1C2GeneProduct
AKR1C3GeneProduct
AKR1C4GeneProduct
Akr1a1GeneProductENSRNOG00000016727 (Ensembl Rat)
Akr1d1GeneProductENSRNOG00000013004 (Ensembl Rat)
Akr7a2GeneProductENSRNOG00000017780 (Ensembl Rat)
Akr7a3GeneProductENSRNOG00000017899 (Ensembl Rat)
Aldo-keto reductaseGeneProduct
Amino acid acyltransferaseGeneProduct
BaatGeneProductENSRNOG00000007395 (Ensembl Rat)
CHST12GeneProduct304322 (Entrez Gene)
CHSTB_RATGeneProductENSRNOG00000008885 (Ensembl Rat)
CYP11B1GeneProduct500892 (Entrez Gene)
CYP11B2GeneProduct24294 (Entrez Gene)
CYP27B1GeneProduct114700 (Entrez Gene)
CYP27C1GeneProduct
CYP2A13GeneProduct
CYP2A6GeneProduct
CYP2A7GeneProduct
CYP2B6GeneProduct
CYP2C18GeneProduct
CYP2C19GeneProduct
CYP2C8GeneProduct
CYP2C9GeneProduct
CYP2D6GeneProduct
CYP2J2GeneProduct
CYP3A4GeneProduct
CYP3A43GeneProduct
CYP3A5GeneProduct
CYP3A7GeneProduct
CYP450GeneProduct
CYP4F11GeneProduct
CYP4F12GeneProduct
CYP4F2GeneProduct
CYP4F8GeneProduct
CYP4V2GeneProduct
CYP4X1GeneProduct246767 (Entrez Gene)
CYP4Z1GeneProduct
Chst10GeneProductENSRNOG00000012815 (Ensembl Rat)
Chst14GeneProduct691394 (Entrez Gene)
Chst1GeneProductENSRNOG00000007989 (Ensembl Rat)
Chst2_predictedGeneProductENSRNOG00000037453 (Ensembl Rat)
Chst3GeneProductENSRNOG00000000572 (Ensembl Rat)
Chst7GeneProductENSRNOG00000004258 (Ensembl Rat)
Chst9GeneProduct291770 (Entrez Gene)
ComtGeneProductENSRNOG00000001889 (Ensembl Rat)
Cyp11a1GeneProductENSRNOG00000008074 (Ensembl Rat)
Cyp17a1GeneProductENSRNOG00000020035 (Ensembl Rat)
Cyp19a1GeneProductENSRNOG00000000196 (Ensembl Rat)
Cyp1a1GeneProductENSRNOG00000019500 (Ensembl Rat)
Cyp1a2GeneProductENSRNOG00000016173 (Ensembl Rat)
Cyp1b1GeneProductENSRNOG00000040287 (Ensembl Rat)
Cyp20a1GeneProductENSRNOG00000017631 (Ensembl Rat)
Cyp21a1GeneProduct24298 (Entrez Gene)
Cyp24a1GeneProductENSRNOG00000013062 (Ensembl Rat)
Cyp26a1GeneProductENSRNOG00000016750 (Ensembl Rat)
Cyp26b1GeneProductENSRNOG00000015076 (Ensembl Rat)
Cyp26c1_predictedGeneProductENSRNOG00000030698 (Ensembl Rat)
Cyp27a1GeneProductENSRNOG00000017188 (Ensembl Rat)
Cyp2e1GeneProductENSRNOG00000012458 (Ensembl Rat)
Cyp2f2GeneProductENSRNOG00000032805 (Ensembl Rat)
Cyp2u1GeneProductENSRNOG00000011053 (Ensembl Rat)
Cyp2w1_predictedGeneProductENSRNOG00000022355 (Ensembl Rat)
Cyp4b1GeneProductENSRNOG00000009741 (Ensembl Rat)
Cyp4f18GeneProductENSRNOG00000015751 (Ensembl Rat)
Cyp4f39_predictedGeneProductENSRNOG00000029478 (Ensembl Rat)
Cyp51GeneProductENSRNOG00000007234 (Ensembl Rat)
Cyp7a1GeneProductENSRNOG00000009488 (Ensembl Rat)
Cyp7b1GeneProductENSRNOG00000009730 (Ensembl Rat)
Cyp8b1GeneProductENSRNOG00000019481 (Ensembl Rat)
Ephx1GeneProductENSRNOG00000003515 (Ensembl Rat)
Ephx2GeneProductENSRNOG00000017286 (Ensembl Rat)
Flavin monooxygenaseGeneProduct
Fmo1GeneProductENSRNOG00000034191 (Ensembl Rat)
Fmo2GeneProductENSRNOG00000003510 (Ensembl Rat)
Fmo3GeneProductENSRNOG00000003620 (Ensembl Rat)
Fmo4GeneProductENSRNOG00000003400 (Ensembl Rat)
Fmo5GeneProductENSRNOG00000018076 (Ensembl Rat)
GAL3ST1GeneProduct
GLYATL1GeneProduct
GLYATL2GeneProduct
GPX1GeneProduct24404 (Entrez Gene)
GPX2GeneProduct29326 (Entrez Gene)
GSTA1GeneProduct
GSTA2GeneProduct24422 (Entrez Gene)
GSTA3GeneProduct24421 (Entrez Gene)
GSTA4GeneProduct300850 (Entrez Gene)
GSTA5GeneProduct
GSTM1GeneProduct24423 (Entrez Gene)
GSTM5GeneProduct64352 (Entrez Gene)
GSTZ1GeneProduct681913 (Entrez Gene)
GlucuronosyltransferaseGeneProduct
Glutathione transferaseGeneProduct
GlyatGeneProductENSRNOG00000012142 (Ensembl Rat)
Gm766GeneProductENSRNOG00000036959 (Ensembl Rat)
Gpx3GeneProductENSRNOG00000021809 (Ensembl Rat)
Gpx5GeneProductENSRNOG00000018596 (Ensembl Rat)
GsrGeneProductENSRNOG00000014915 (Ensembl Rat)
GssGeneProductENSRNOG00000018964 (Ensembl Rat)
Gstk1GeneProductENSRNOG00000016484 (Ensembl Rat)
Gstm3GeneProductENSRNOG00000018937 (Ensembl Rat)
Gstm5GeneProductENSRNOG00000018732 (Ensembl Rat)
Gsto1GeneProductENSRNOG00000028746 (Ensembl Rat)
Gsto2GeneProductENSRNOG00000012801 (Ensembl Rat)
Gstp2GeneProductENSRNOG00000018237 (Ensembl Rat)
Gstt1GeneProductENSRNOG00000001242 (Ensembl Rat)
Gstt2GeneProductENSRNOG00000028188 (Ensembl Rat)
HS3ST3A1GeneProduct363618 (Entrez Gene)
HS3ST3B1GeneProduct303218 (Entrez Gene)
HS6ST3GeneProduct364476 (Entrez Gene)
HnmtGeneProductENSRNOG00000005223 (Ensembl Rat)
Hs2st1GeneProductENSRNOG00000012549 (Ensembl Rat)
Hs3st1GeneProductENSRNOG00000010598 (Ensembl Rat)
Hs3st2GeneProductENSRNOG00000017659 (Ensembl Rat)
Hs3st4GeneProductENSRNOG00000036723 (Ensembl Rat)
Kcnab1GeneProductENSRNOG00000010422 (Ensembl Rat)
Kcnab2GeneProductENSRNOG00000011550 (Ensembl Rat)
Kcnab3GeneProductENSRNOG00000008480 (Ensembl Rat)
LOC681900GeneProductENSRNOG00000014672 (Ensembl Rat)
LOC683774GeneProductENSRNOG00000030880 (Ensembl Rat)
LOC685402GeneProductENSRNOG00000022982 (Ensembl Rat)
LOC687052GeneProductENSRNOG00000020743 (Ensembl Rat)
LOC690611GeneProductENSRNOG00000013604 (Ensembl Rat)
MGC105600GeneProductENSRNOG00000028743 (Ensembl Rat)
MGC108896GeneProductENSRNOG00000019221 (Ensembl Rat)
MGST3GeneProduct289197 (Entrez Gene)
MethyltransferaseGeneProduct
Mgst1GeneProductENSRNOG00000007743 (Ensembl Rat)
Mgst2GeneProductENSRNOG00000013296 (Ensembl Rat)
N-acetyltransferaseGeneProduct
NAT1GeneProduct116631 (Entrez Gene)
NAT2GeneProduct116632 (Entrez Gene)
NAT6GeneProduct
NAT8GeneProduct64570 (Entrez Gene)
NP_001099210.1GeneProductENSRNOG00000027171 (Ensembl Rat)
NP_001099351.1GeneProductENSRNOG00000039017 (Ensembl Rat)
NP_001099862.1GeneProductENSRNOG00000000605 (Ensembl Rat)
NP_001100289.1GeneProductENSRNOG00000005930 (Ensembl Rat)
NP_001100363.1GeneProductENSRNOG00000010519 (Ensembl Rat)
NP_001100897.1GeneProductENSRNOG00000016953 (Ensembl Rat)
NP_001100901.1GeneProductENSRNOG00000021521 (Ensembl Rat)
NP_001100974.1GeneProductENSRNOG00000022919 (Ensembl Rat)
NP_001101195.1GeneProductENSRNOG00000011669 (Ensembl Rat)
NP_001101226.1GeneProductENSRNOG00000008663 (Ensembl Rat)
NP_001101680.1GeneProductENSRNOG00000014516 (Ensembl Rat)
NP_001101936.1GeneProductENSRNOG00000038622 (Ensembl Rat)
NP_001101969.1GeneProductENSRNOG00000011367 (Ensembl Rat)
NP_001101988.1GeneProductENSRNOG00000021179 (Ensembl Rat)
NP_001102065.1GeneProductENSRNOG00000010523 (Ensembl Rat)
NP_001102193.1GeneProductENSRNOG00000007147 (Ensembl Rat)
NP_001102492.1GeneProductENSRNOG00000011250 (Ensembl Rat)
NP_001102534.1GeneProductENSRNOG00000001375 (Ensembl Rat)
NP_001102569.1GeneProductENSRNOG00000014192 (Ensembl Rat)
Nat8l_predictedGeneProductENSRNOG00000015466 (Ensembl Rat)
Nat9_predictedGeneProductENSRNOG00000003264 (Ensembl Rat)
Ndst1GeneProductENSRNOG00000019014 (Ensembl Rat)
Ndst3_predictedGeneProductENSRNOG00000015781 (Ensembl Rat)
Ndst4_predictedGeneProductENSRNOG00000009577 (Ensembl Rat)
RGD1562825_predictedGeneProductENSRNOG00000025930 (Ensembl Rat)
ST2B1_RATGeneProductENSRNOG00000021046 (Ensembl Rat)
SULT1C1GeneProduct
SULT1C2GeneProduct171072 (Entrez Gene)
SULT1C4GeneProduct
SULT2A1GeneProduct24912 (Entrez Gene)
SULT4A1GeneProduct58953 (Entrez Gene)
SteGeneProductENSRNOG00000001957 (Ensembl Rat)
Substrate-AaMetabolite
Substrate-AcMetabolite
Substrate-CH3Metabolite
Substrate-GlMetabolite
Substrate-NH2Metabolite
Substrate-O-RMetabolite
Substrate-OHMetabolite
Substrate-SGMetabolite
Substrate-SHMetabolite
Substrate-SO3HMetabolite
Substrate=OMetabolite
SulfotransferaseGeneProduct
Sult1a1GeneProductENSRNOG00000019342 (Ensembl Rat)
Sult1b1GeneProductENSRNOG00000001967 (Ensembl Rat)
Sult1c1GeneProductENSRNOG00000011269 (Ensembl Rat)
TpmtGeneProductENSRNOG00000016468 (Ensembl Rat)
UGT1A10GeneProduct
UGT1A7GeneProduct
UGT1A9GeneProduct396552 (Entrez Gene)
UGT2A2GeneProduct
UGT2B11GeneProduct
UGT2B15GeneProduct
UGT2B17GeneProduct286954 (Entrez Gene)
UGT2B28GeneProduct
UGT2B4GeneProduct
UGT2B7GeneProduct
Ugt1a1GeneProduct24861 (Entrez Gene)
Ugt1a2GeneProduct396527 (Entrez Gene)
Ugt1a3GeneProduct396551 (Entrez Gene)
Ugt1a3GeneProductENSRNOG00000018740 (Ensembl Rat)
Ugt1a5GeneProduct574523 (Entrez Gene)
Ugt1a6GeneProduct113992 (Entrez Gene)
Ugt2a1GeneProductENSRNOG00000001973 (Ensembl Rat)
Ugt2a3_predictedGeneProductENSRNOG00000001975 (Ensembl Rat)
Xenobiotic substrateMetabolite

Annotated Interactions

No annotated interactions
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