Estrogen signaling (Rattus norvegicus)

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RNA polymerase IITFIIBActivationMAPKsEREGene expressionMitochondrionInhibitionHDACsGene expression(anti apoptotic)TFIIATFIIFTFIIHTIFsTranslocationHistone Deacetylases (HDACs)+pIKKsTFIIDRNA Pol IINucleusTATA Box bindingproteinTranscription Initiation Factors (TIFs)+pTFIIE+panti apoptosisGtf2bEstradiolSrcPolr2gMapk9Polr2fMap2k1N-CoRCreb1ERCC2TbpErcc3Hdac3Polr2iTaf13Shc2Esr1HDAC5Gtf2e1Taf7Gtf2h4Hdac8Bcl2Elk1Hdac7Taf6Polr2bEsr1LOC367858Hdac2Sp1EstradiolEp300Polr2jEstradiolPolr2aTAF12Mnat1BrafPI3KPrkacaEsr1POLR2KSos1Polr2eEstradiolCrebbpEsr1Mapk1Polr2cGnb1IkbkgCcnhGtf2h3Hdac6Cyclic AMPHdac4Taf9Cdk7IlkEsr1EstradiolGtf2f2EstradiolEsr1Nfkb1Esr1Akt1Ccnd1Brca1GSABcl2Gtf2h2Esr1TbpGperTaf5NP_001101058.1Creb1Gtf2e2Hdac1EstradiolGtf2a2FosJunGtf2a2EstradiolGngt1Grb2IkbkbGtf2h1Nfkb1Sin3aMapk14POLR2HEsr1Estradiol


Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.


This pathway was inferred from Homo sapiens pathway WP712(r29739) with a 90% conversion rate.

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Ontology Terms



  1. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia
  2. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  3. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia


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106948view13:41, 17 September 2019MaintBotHMDB identifier normalization
90718view20:21, 13 December 2016KhanspersModified title
69382view18:56, 8 July 2013MaintBotUpdated to 2013 gpml schema
58949view18:15, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58517view20:00, 14 February 2013MaintBotOntology Term : 'estrogen signaling pathway' added !
58516view19:59, 14 February 2013MaintBotModified title
48265view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41697view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
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External references


View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
Bcl2GeneProduct24224 (Entrez Gene)
BrafGeneProduct114486 (Entrez Gene)
Brca1GeneProduct497672 (Entrez Gene)
Ccnd1GeneProduct58919 (Entrez Gene)
CcnhGeneProduct84389 (Entrez Gene)
Cdk7GeneProduct171150 (Entrez Gene)
Creb1GeneProduct81646 (Entrez Gene)
CrebbpGeneProduct54244 (Entrez Gene)
Cyclic AMPMetaboliteHMDB00058 (HMDB)
ERCC2GeneProduct308415 (Entrez Gene)
Elk1GeneProduct314436 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
Ercc3GeneProduct291703 (Entrez Gene)
Esr1GeneProduct24890 (Entrez Gene)
EstradiolMetaboliteHMDB00151 (HMDB)
FosGeneProduct314322 (Entrez Gene)
Gnb1GeneProduct24400 (Entrez Gene)
Gngt1GeneProduct680149 (Entrez Gene)
GperGeneProduct171104 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Gtf2a2GeneProduct83828 (Entrez Gene)
Gtf2bGeneProduct81673 (Entrez Gene)
Gtf2e1GeneProduct303918 (Entrez Gene)
Gtf2e2GeneProduct306516 (Entrez Gene)
Gtf2f2GeneProduct81674 (Entrez Gene)
Gtf2h1GeneProduct361580 (Entrez Gene)
Gtf2h2GeneProduct294693 (Entrez Gene)
Gtf2h3GeneProduct288651 (Entrez Gene)
Gtf2h4GeneProduct294236 (Entrez Gene)
HDAC5GeneProduct84580 (Entrez Gene) HDAC5; histone deacetylase 5
Hdac1GeneProduct297893 (Entrez Gene) HDAC1; histone deacetylase 1
Hdac2GeneProduct84577 (Entrez Gene) HDAC2; histone deacetylase 2
Hdac3GeneProduct84578 (Entrez Gene) HDAC3; histone deacetylase 3
Hdac4GeneProduct363287 (Entrez Gene) HDAC4; histone deacetylase 4
Hdac6GeneProduct84581 (Entrez Gene) HDAC6; histone deacetylase 6
Hdac7GeneProduct84582 (Entrez Gene) HDAC7A; histone deacetylase 7
Hdac8GeneProduct363481 (Entrez Gene) HDAC8; histone deacetylase
IkbkbGeneProductENSRNOG00000019073 (Ensembl Rat)
IkbkgGeneProductENSRNOG00000037237 (Ensembl Rat)
IlkGeneProduct170922 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LOC367858GeneProductENSRNOG00000016611 (Ensembl Rat)
Map2k1GeneProductENSRNOG00000010176 (Ensembl Rat)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk1GeneProductENSRNOG00000001849 (Ensembl Rat)
Mapk9GeneProduct50658 (Entrez Gene)
Mnat1GeneProduct266713 (Entrez Gene)
NP_001101058.1GeneProductENSRNOG00000022485 (Ensembl Rat)
Nfkb1GeneProduct81736 (Entrez Gene)
POLR2HGeneProduct498109 (Entrez Gene)
POLR2KGeneProduct309224 (Entrez Gene)
Polr2aGeneProduct363633 (Entrez Gene)
Polr2bGeneProduct289561 (Entrez Gene)
Polr2cGeneProduct361365 (Entrez Gene)
Polr2eGeneProduct690966 (Entrez Gene)
Polr2fGeneProduct83503 (Entrez Gene)
Polr2gGeneProduct117017 (Entrez Gene)
Polr2iGeneProduct292778 (Entrez Gene)
Polr2jGeneProduct288588 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
Shc2GeneProduct314612 (Entrez Gene)
Sin3aGeneProduct363067 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
Sp1GeneProduct24790 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
TAF12GeneProduct682902 (Entrez Gene)
Taf13GeneProduct310784 (Entrez Gene)
Taf5GeneProduct294018 (Entrez Gene)
Taf6GeneProduct288533 (Entrez Gene)
Taf7GeneProduct307485 (Entrez Gene)
Taf9GeneProduct373541 (Entrez Gene)
TbpGeneProduct117526 (Entrez Gene)

Annotated Interactions

No annotated interactions
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