Endochondral Ossification (Mus musculus)

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1, 2BMPsChondrocyte proliferationRemoval of extracellular matrixand invasion by bone cellsHypertrophyGsChondrocyte deathDyingRemoval of cartilage matrixBoneVascular invastionCartilageMineralisation?Cathepsinsand CalpainsFull differentiationintegrinsWNT signalingcanonical / non-canonicalOsteoblasticdifferentiationProliferationChondrocyte (pre)hypertrophyMmp13PrkacaBmp7Spp1MgpMef2cPthlhStat1Enpp1Adamts5Cdkn1cFrzbTgfb2PlatCst10Ptch1Cab39Ddr2Ift88Fgf2Stat5bTgfb1Col2a1Hmgcs1Growth hormoneCalm1Thyroid hormoneAlplCtslKif3aHdac4AcanTimp3ThraBmpr1aOxygenThraSlc38a2TriiodothyronineSox6Bmp6Nkx3-2PthSerpinh1IhhIgf1rPth1rVegfaSox5Mmp9Gli3Thyroid hormoneAdamts1Runx2Ptch1GhrRunx2Adamts4cAMPTNAPRunx2Igf1PlauSox9Chst11Runx3Fgf18Igf2Fgfr1Fgfr3ScinCol10a1Akt1Tgfb1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 94% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  2. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
114026view15:29, 17 December 2020Fehrhartconnected lines
107195view14:28, 17 September 2019MaintBotChEBI identifier normalization
106849view13:32, 17 September 2019MaintBotHMDB identifier normalization
87973view13:17, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72216view12:55, 27 October 2013EgonwFixed the ChEBI database name.
72176view22:19, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
69106view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
41292view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
32869view21:22, 16 September 2009MaintBotAdded xrefs
32298view13:15, 15 August 2009MaintBotFixed text labels
31870view12:38, 14 August 2009MaintBotFixed group labels
31327view20:20, 13 August 2009MaintBotFixed text labels
30897view00:23, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProduct11595 (Entrez Gene)
Adamts1GeneProduct11504 (Entrez Gene)
Adamts4GeneProduct240913 (Entrez Gene)
Adamts5GeneProduct23794 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
AlplGeneProduct11647 (Entrez Gene)
Bmp6GeneProduct12161 (Entrez Gene)
Bmp7GeneProduct12162 (Entrez Gene)
Bmpr1aGeneProduct12166 (Entrez Gene)
Cab39GeneProduct12283 (Entrez Gene)
Calm1GeneProduct12313 (Entrez Gene)
Cdkn1cGeneProduct12577 (Entrez Gene)
Chst11GeneProduct58250 (Entrez Gene)
Col10a1GeneProduct12813 (Entrez Gene)
Col2a1GeneProduct12824 (Entrez Gene)
Cst10GeneProduct58214 (Entrez Gene)
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
CtslGeneProduct13039 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
Ddr2GeneProduct18214 (Entrez Gene)
Enpp1GeneProduct18605 (Entrez Gene)
Fgf18GeneProduct14172 (Entrez Gene)
Fgf2GeneProduct14173 (Entrez Gene)
Fgfr1GeneProduct14182 (Entrez Gene)
Fgfr3GeneProduct14184 (Entrez Gene)
FrzbGeneProduct20378 (Entrez Gene)
GhrGeneProduct14600 (Entrez Gene)
Gli3GeneProduct14634 (Entrez Gene)
Growth hormoneGeneProduct
Hdac4GeneProduct208727 (Entrez Gene)
Hmgcs1GeneProduct208715 (Entrez Gene)
Ift88GeneProduct21821 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Igf1rGeneProduct16001 (Entrez Gene)
Igf2GeneProduct16002 (Entrez Gene)
IhhGeneProduct16147 (Entrez Gene)
Kif3aGeneProduct16568 (Entrez Gene)
Mef2cGeneProduct17260 (Entrez Gene)
MgpGeneProduct17313 (Entrez Gene)
Mmp13GeneProduct17386 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
Nkx3-2GeneProduct12020 (Entrez Gene)
OxygenMetaboliteHMDB0001377 (HMDB)
PlatGeneProduct18791 (Entrez Gene)
PlauGeneProduct18792 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
Ptch1GeneProduct19206 (Entrez Gene)
PthGeneProduct19226 (Entrez Gene)
Pth1rGeneProduct19228 (Entrez Gene)
PthlhGeneProduct19227 (Entrez Gene)
Runx2GeneProduct12393 (Entrez Gene)
Runx3GeneProduct12399 (Entrez Gene)
ScinGeneProduct20259 (Entrez Gene) PMID: 17097081
Serpinh1GeneProduct12406 (Entrez Gene)
Slc38a2GeneProduct67760 (Entrez Gene)
Sox5GeneProduct20678 (Entrez Gene)
Sox6GeneProduct20679 (Entrez Gene)
Sox9GeneProduct20682 (Entrez Gene)
Spp1GeneProduct20750 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
TNAPGeneProduct
Tgfb1GeneProduct21803 (Entrez Gene)
Tgfb2GeneProduct21808 (Entrez Gene)
ThraGeneProduct21833 (Entrez Gene)
Thyroid hormoneMetabolite60311 (ChEBI)
Thyroid hormoneMetaboliteT4
Timp3GeneProduct21859 (Entrez Gene)
TriiodothyronineMetabolite24864 (ChEBI)
VegfaGeneProduct22339 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions
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