ErbB signaling pathway (Mus musculus)

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+pSurvivalDG+pCell cycleprogressionDifferentiationmTor signaling pathwayPancreaticCancerCell cycle(HER2/Neu)PIP3+pDNAMAPK signalingpathway+pActivation by ErbB2overexpression (cancers)ProteinsynthesisEndometrialcancerAdhesion+pAngiogenesisDegradationCellular targets+pCell survivalNo signaling+p+p+pCalcium signaling pathway+pERBB SIGNALING PATHWAY+pGliomaAdhesionMigrationCellular targets+p+p+p+p+p(EGFR)DNANon-smallcell lungcancerDNADNAReceptor ubiquitylation+pIP3+pCa+2Metabolism+pMigration / InvasionERProliferationShc2Nrg3Erbb2BtcCdkn1aErbb2Ptk2CrkErbb3Erbb3Erbb2EgfrStat5aNrg4Erbb3Elk1Stat5aEif4ebp1Erbb4Camk2aPrkcaTgfaEregGab1MycErbb2Sos1Erbb4Erbb4Plcg1Mapk8BadHbegfArafGrb2Grb2AregNck1Nrg1Erbb2JunMap2k1Gsk3bMtorHras1EgfrEgfAkt3LOC100042150Cdkn1bSrcPik3r5Pak4Map2k7P70S6KCblcEgfrAbl1Mapk1Elk1


The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.

The ErbB protein family consists of 4 members

   * ErbB-1, also named epidermal growth factor receptor (EGFR)
   * ErbB-2, also named HER2 in humans and neu in rodents
   * ErbB-3, also named HER3 and
   * ErbB-4, also named HER4

The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


This pathway was inferred from Homo sapiens pathway WP673(r29836) with a 96% conversion rate.

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Ontology Terms



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108380view10:37, 15 December 2019Marvin M2Connected lines
108175view10:51, 29 November 2019FehrhartOntology Term : 'multiple sclerosis' added !
108174view10:50, 29 November 2019FehrhartOntology Term : 'Alzheimer's disease' added !
108173view10:50, 29 November 2019FehrhartOntology Term : 'cancer' added !
71282view04:38, 17 October 2013MaintBotRemoved buggy shape
69187view18:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
67203view10:20, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41378view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
32870view21:35, 16 September 2009MaintBotAdded xref
31324view20:18, 13 August 2009MaintBotFixed text labels
30877view00:15, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Abl1GeneProduct11350 (Entrez Gene)
Akt3GeneProduct23797 (Entrez Gene)
ArafGeneProduct11836 (Entrez Gene)
AregGeneProduct11839 (Entrez Gene)
BadGeneProduct12015 (Entrez Gene)
BtcGeneProduct12223 (Entrez Gene)
Camk2aGeneProduct12322 (Entrez Gene)
CblcGeneProduct80794 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Cdkn1bGeneProduct12576 (Entrez Gene)
CrkGeneProduct12928 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
Eif4ebp1GeneProduct13685 (Entrez Gene)
Elk1GeneProduct13712 (Entrez Gene)
Erbb2GeneProduct13866 (Entrez Gene)
Erbb3GeneProduct13867 (Entrez Gene)
Erbb4GeneProduct13869 (Entrez Gene)
EregGeneProduct13874 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
HbegfGeneProduct15200 (Entrez Gene)
Hras1GeneProduct15461 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
LOC100042150GeneProduct100042150 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k7GeneProduct26400 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
Nck1GeneProduct17973 (Entrez Gene)
Nrg1GeneProduct211323 (Entrez Gene)
Nrg3GeneProduct18183 (Entrez Gene)
Nrg4GeneProduct83961 (Entrez Gene)
Pak4GeneProduct70584 (Entrez Gene)
Pik3r5GeneProduct320207 (Entrez Gene)
Plcg1GeneProduct18803 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
Shc2GeneProduct216148 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Stat5aGeneProduct20850 (Entrez Gene)
TgfaGeneProduct21802 (Entrez Gene)

Annotated Interactions

No annotated interactions
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