Non-homologous end joining (Mus musculus)

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Nhej1Ligase VPrkdcLigase VPrkdcPrkdcXrcc6Xrcc6Xrcc5Xrcc5Xrcc5Xrcc5Xrcc6PrkdcXrcc5Xrcc5Xrcc5Xrcc5Xrcc4Xrcc4Rad50Xrcc6Xrcc6Xrcc6Xrcc5Xrcc6Xrcc5Nbs1 ?PrkdcPrkdcXrcc6PrkdcPrkdcMre11aNhej1Xrcc6Xrcc6


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 91% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
69140view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67513view11:19, 26 June 2013DdiglesOntology Term : 'non-homologous end joining pathway of double-strand break repair' added !
59048view20:53, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41329view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35403view09:55, 12 February 2010MartijnVanIerselModified description
31847view12:31, 14 August 2009MaintBotFixed group labels
30822view23:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Ligase VGeneProduct
Mre11aGeneProductENSMUSG00000031928 (Ensembl Mouse)
Nbs1 ?GeneProduct
Nhej1GeneProduct75570 (Entrez Gene)
Nhej1GeneProductENSMUSG00000026162 (Ensembl Mouse)
PrkdcGeneProductENSMUSG00000022672 (Ensembl Mouse)
Rad50GeneProductENSMUSG00000020380 (Ensembl Mouse)
Xrcc4GeneProductENSMUSG00000021615 (Ensembl Mouse)
Xrcc5GeneProductENSMUSG00000026187 (Ensembl Mouse)
Xrcc6GeneProductENSMUSG00000022471 (Ensembl Mouse)

Annotated Interactions

No annotated interactions
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