Eukaryotic Transcription Initiation (Anopheles gambiae)

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dsDNATFIID553cell growthTFIIE(mRNA, snRNPs)TFIIH(recognize surface DNA geometry)Steps 1) TBP binds TATA box3TATA33TFIIFTFIIASteps 3) DNA melting by association with TFIIH3TFIIFTATA35555TFIIBTATA Box bindingproteinRNA polymerase IITFIIF(large ribosomal RNAs)TFIIHRNA pol IISteps 2) Association of TIFs and RNA polymerase55Steps 5) RNA elongation with CDT phosphorylationTATA(small stable RNAs)53TFIIDTFIIETFIIB5RNA polymerase IIIRNA polymerase I3Transcription Initiation Factors (TIFs)Gene Regulatory ProteinsPrimary RNA transcriptSteps 4) Transcription elongation by NTPs3TFIIAAgaP_AGAP008045AgaP_AGAP009209AgaP_AGAP010321AgaP_AGAP005873AgaP_AGAP008151AgaP_AGAP012397AgaP_AGAP008522AgaP_AGAP010984AgaP_AGAP002646AgaP_AGAP004370AgaP_AGAP008991AgaP_AGAP009558AgaP_AGAP010958AgaP_AGAP008417AgaP_AGAP005922AgaP_AGAP006355POLR3KAgaP_AGAP001792AgaP_AGAP007002AgaP_AGAP010064AgaP_AGAP011110AgaP_AGAP010493AgaP_AGAP003135POLR1DPOLR2KAgaP_AGAP010559AgaP_AGAP004480AgaP_AGAP003094AgaP_AGAP008393AgaP_AGAP012122POLR1AAgaP_AGAP007810AgaP_AGAP002988AgaP_AGAP011678AgaP_AGAP006573AgaP_AGAP005382AgaP_AGAP009539AgaP_AGAP003648AgaP_AGAP004254AgaP_AGAP002121AgaP_AGAP012169


In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia


GenMAPP notes 
This pathway was inferred from Homo sapiens pathway WP405(r29565) with a 90% conversion rate.

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67210view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
63238view23:46, 8 May 2013AnweshaConverted interactions to graphical lines
63237view23:41, 8 May 2013AnweshaPeriodical save, work in progress
63236view23:31, 8 May 2013AnweshaPeriodical save, work in progress
63235view23:22, 8 May 2013AnweshaOpened to convert to GPML 2013
40459view18:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
35523view13:55, 12 February 2010Thomasadded literature
35510view13:48, 12 February 2010ThomasModified description
32289view13:11, 15 August 2009MaintBotFixed text labels
31843view12:30, 14 August 2009MaintBotFixed group labels
31317view20:16, 13 August 2009MaintBotFixed text labels
30807view23:49, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
AgaP_AGAP001792GeneProduct1281323 (Entrez Gene)
AgaP_AGAP002121GeneProduct1281372 (Entrez Gene)
AgaP_AGAP002646GeneProduct1273315 (Entrez Gene)
AgaP_AGAP002988GeneProduct1272969 (Entrez Gene)
AgaP_AGAP003094GeneProduct1273770 (Entrez Gene)
AgaP_AGAP003135GeneProduct1273807 (Entrez Gene)
AgaP_AGAP003648GeneProduct1274316 (Entrez Gene)
AgaP_AGAP004254GeneProduct1274098 (Entrez Gene)
AgaP_AGAP004370GeneProduct1274516 (Entrez Gene)
AgaP_AGAP004480GeneProduct3291022 (Entrez Gene)
AgaP_AGAP005382GeneProduct1276084 (Entrez Gene)
AgaP_AGAP005873GeneProduct1276540 (Entrez Gene)
AgaP_AGAP005922GeneProduct1276589 (Entrez Gene)
AgaP_AGAP006355GeneProduct1276961 (Entrez Gene)
AgaP_AGAP006573GeneProduct1277157 (Entrez Gene)
AgaP_AGAP007002GeneProduct1270098 (Entrez Gene)
AgaP_AGAP007810GeneProduct1278148 (Entrez Gene)
AgaP_AGAP008045GeneProduct1277907 (Entrez Gene)
AgaP_AGAP008151GeneProduct1277811 (Entrez Gene)
AgaP_AGAP008393GeneProduct1277585 (Entrez Gene)
AgaP_AGAP008417GeneProduct1277560 (Entrez Gene)
AgaP_AGAP008522GeneProduct1277449 (Entrez Gene)
AgaP_AGAP008991GeneProduct1279954 (Entrez Gene)
AgaP_AGAP009209GeneProduct1280168 (Entrez Gene)
AgaP_AGAP009539GeneProduct1271371 (Entrez Gene)
AgaP_AGAP009558GeneProduct1271351 (Entrez Gene)
AgaP_AGAP010064GeneProduct1279496 (Entrez Gene)
AgaP_AGAP010321GeneProduct1278625 (Entrez Gene)
AgaP_AGAP010493GeneProduct1275232 (Entrez Gene)
AgaP_AGAP010559GeneProduct1275295 (Entrez Gene)
AgaP_AGAP010958GeneProduct1271006 (Entrez Gene)
AgaP_AGAP010984GeneProduct1270972 (Entrez Gene)
AgaP_AGAP011110GeneProduct1270814 (Entrez Gene)
AgaP_AGAP011678GeneProduct1280962 (Entrez Gene)
AgaP_AGAP012122GeneProduct1280555 (Entrez Gene)
AgaP_AGAP012169GeneProduct1280516 (Entrez Gene)
AgaP_AGAP012397GeneProduct1280317 (Entrez Gene)

Annotated Interactions

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