Pentose Phosphate Pathway (Anopheles gambiae)

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++NucleotideBiosynthesis+(Hexose Monophosphosphate ShuntGlycolysis/Gluconeogenesisor Phosphogluconate Pathway)+AgaP_AGAP010866Ribose-5-PhosphateTKTTKTErythrose-4-Phosphate6-PhosphogluconateSedoheptulose-7-Phosphate6-Phosphonoglucono-delta-lactoneFructose-6-PhosphateGlyceraldehyde-3-phosphateG6PDFructose-6-PhosphateAgaP_AGAP004197Glyceraldehyde-3-phosphateAgaP_AGAP011457AgaP_AGAP011800Glucose-6-PhosphateRibulose-5-PhosphateXylulose-5-PhosphateAgaP_AGAP005080


The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. This metabolic pathway is parallel to glycolysis. It generates NADPH and pentoses (5-carbon sugars) as well as ribose 5-phosphate, the last one a precursor for the synthesis of nucleotides. While it does involve oxidation of glucose, its primary role is anabolic rather than catabolic. The pathway is especially important in erythrocytes. There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars.


GenMAPP notes 
D. Voet & J.G. Voet (1990) Biochemistry, John Wiley & Sons, New York, pp. 577-583.
This pathway was inferred from Homo sapiens pathway WP134(r30180) with a 62% conversion rate.

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105893view11:25, 16 August 2019MkutmonHMDB identifier normalization
97762view13:28, 7 June 2018TeacupModified description
95102view03:44, 15 November 2017LawsonAdded gene ID for G6PD GeneProduct
88296view15:22, 1 August 2016FehrhartOntology Term : 'pentose phosphate pathway' added !
68438view19:11, 5 July 2013MaintBotUpdated to 2013 gpml schema
40469view18:47, 1 March 2011MaintBotRemoved redundant pathway information and comments
32286view13:10, 15 August 2009MaintBotFixed text labels
31838view12:28, 14 August 2009MaintBotFixed group labels
31314view20:15, 13 August 2009MaintBotFixed text labels
30800view23:45, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
6-PhosphogluconateMetaboliteHMDB0001316 (HMDB)
6-Phosphonoglucono-delta-lactoneMetaboliteHMDB0001127 (HMDB)
AgaP_AGAP004197GeneProduct1274031 (Entrez Gene)
AgaP_AGAP005080GeneProduct1274761 (Entrez Gene)
AgaP_AGAP010866GeneProduct1271093 (Entrez Gene)
AgaP_AGAP011457GeneProduct3291340 (Entrez Gene)
AgaP_AGAP011800GeneProduct1280848 (Entrez Gene)
Erythrose-4-PhosphateMetaboliteHMDB0001321 (HMDB)
Fructose-6-PhosphateMetabolite643-13-0 (CAS)
Fructose-6-PhosphateMetaboliteHMDB0000124 (HMDB)
G6PDGeneProductAGAP012678 (Ensembl Mosquito)
Glucose-6-PhosphateMetabolite59-56-3 (CAS)
Glyceraldehyde-3-phosphateMetaboliteHMDB0001112 (HMDB)
Ribose-5-PhosphateMetabolite3615-55-2 (CAS)
Ribulose-5-PhosphateMetabolite4151-19-3 (CAS)
Sedoheptulose-7-PhosphateMetabolite2646-35-7 (CAS)
Xylulose-5-PhosphateMetabolite60802-29-1 (CAS)

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