Osteoclast Signaling (Homo sapiens)

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1OsteoclastOsteoclast activationPDGF-BB complexBoneRANK ligandType 1 interferon receptorH+H+ ATPaseIFN-bH+TRPVPDGFBOPGNa+/H+ transporterTRAPRANKH+H+b3 integrinOsteopontinCa2+MAPK8Na+PiCathepsin KTRAPCathepsin KNa+AIMP2H+PDGFBOGR1Ca2+


Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass.

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  1. Boyle WJ, Simonet WS, Lacey DL; ''Osteoclast differentiation and activation.''; Nature, 2003 PubMed Europe PMC


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106572view21:19, 6 September 2019KhanspersModified description
106216view12:11, 16 August 2019MaintBotHMDB identifier normalization
105767view19:37, 15 August 2019KhanspersModified description
97823view15:29, 9 June 2018EgonwUndo revision 97754 by [[Special:Contributions/Jessev1993|Jessev1993]] ([[User talk:Jessev1993|Talk]]) Text cannot be copied from other websites.
97754view13:18, 7 June 2018Jessev1993Modified description
97753view13:17, 7 June 2018Jessev1993added references
88602view20:04, 11 August 2016Mkutmonfix unconnected lines
81176view13:30, 31 July 2015EgonwPubChem-compound ID for H+ (hydron) instead of the hydrogen radical.
78593view14:51, 7 January 2015MaintBotadded missing graphIds
72135view08:17, 25 October 2013EgonwAdded an identifier for Pi.
68910view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67557view11:25, 26 June 2013DdiglesOntology Term : 'signaling pathway pertinent to development' added !
59108view22:20, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48235view05:51, 17 May 2012MaintBotUpdating PubChem xrefs
48213view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45320view20:10, 7 October 2011KhanspersOntology Term : 'signaling pathway' added !
45318view20:08, 7 October 2011KhanspersOntology Term : 'osteoclast' added !
43865view23:57, 9 August 2011Samuel SklarSpecify description
43864view23:56, 9 August 2011Samuel SklarPeriodical save, work in progress
41056view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39760view07:33, 17 January 2011AlexanderPicomore specific title
38787view00:25, 24 September 2010AlexanderPico
38786view00:24, 24 September 2010AlexanderPico
38785view00:22, 24 September 2010AlexanderPico
38784view00:21, 24 September 2010AlexanderPicoSpecify description
38783view00:20, 24 September 2010AlexanderPico
38781view00:18, 24 September 2010AlexanderPicoSpecify description
38780view00:15, 24 September 2010AlexanderPicobeautification
20697view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Osteoclasts]] moved to [[Pathway:WP12]]: Moved to stable identifier
14749view22:51, 23 May 2008EhsiaoConnected
10392view02:54, 25 January 2008AlexanderPicoadded id for na+/h+ transporter
10391view02:46, 25 January 2008AlexanderPicoupdated identifiers and data types
10390view02:41, 25 January 2008AlexanderPicoupdating identifiers and data types
10358view03:01, 23 January 2008AlexanderPicoModified categories
10335view01:33, 23 January 2008EhsiaoGPML Import (Author=Grant Yang)

External references


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NameTypeDatabase referenceComment
AIMP2GeneProductENSG00000106305 (Ensembl)
Ca2+Metabolite271 (PubChem-compound)
Cathepsin KProtein1513 (Entrez Gene)
H+ ATPaseProtein9550 (Entrez Gene)
H+Metabolite1038 (PubChem-compound)
IFN-bProtein3456 (Entrez Gene)
MAPK8GeneProductENSG00000107643 (Ensembl)
Na+/H+ transporterProtein6548 (Entrez Gene)
Na+MetaboliteHMDB00588 (HMDB)
OGR1Protein8111 (Entrez Gene)
OPGProtein4982 (Entrez Gene)
OsteopontinProtein6696 (Entrez Gene)
PDGFBProtein5155 (Entrez Gene)
PiMetaboliteCHEBI:35780 (ChEBI)
RANK ligandProtein8600 (Entrez Gene)
RANKProtein8792 (Entrez Gene)
TRAPProtein54 (Entrez Gene)
TRPVProtein56302 (Entrez Gene)
Type 1 interferon receptorProtein3454 (Entrez Gene)
b3 integrinProtein3690 (Entrez Gene)

Annotated Interactions

No annotated interactions

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