Oxidation by Cytochrome P450 (Canis familiaris)

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1Cytochrome P450 genesSubstrateCYB5R4CYP4F12O2CP2E1_CANFACYP4F8NB5R3_CANFACYP11A1CYP4F2CYP4X1CYP20A1CYP4Z1SubstrateFe2+Q3HTU0_CANFAQ70DT1_CANFACYP2C8CYP8B1CP2BB_CANFACYP3A5CYB5R1CYP4F22CYP4A22NADHCYP24A1CYP4V2CYP2S1CYB5BCYP39A1SubstrateCYP2J2activated O2CYP2A7CYP26C1CYP26A1CYP2C19CYP7A1Fe2+CYP2C9CYP27C1CYP46A1Q3HTU0_CANFACYB5R2CYP2R1CYPCYB5ACYP2C18CYP7B1CYP17A1SubstrateNADP+CYP2U1CYB5BCYP26B1Q2EFX8_CANFACYP1B1CYP2G1PH2ONAD+CYP3A7CYP27A1Fe2+CYP4A11CYP51A1CYP3A43CYPCP1A1_CANFACYPNADPHCYPCYPCYP2A6O2CP21A_CANFACYP2W1SubstrateCYP51A1CYB5AFe2+CYP3A4CYP4F3Fe3+CP1A2_CANFAFe3+Substrate-OHCYP4F11CP19A_CANFAFe3+CYP2A13CYP2F1CYB5ACYP27B1CYP4B1Fe3+CYB5B


Description

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP43(r29608) with a 62% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996

History

View all...
CompareRevisionActionTimeUserComment
107093view14:17, 17 September 2019MaintBotChEBI identifier normalization
88269view14:34, 1 August 2016FehrhartOntology Term : 'hepatocyte' added !
88268view14:34, 1 August 2016FehrhartOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
88267view14:33, 1 August 2016FehrhartOntology Term : 'xenobiotics biodegradation pathway' added !
74166view09:55, 2 April 2014EgonwUpdated the PubChem-compound data source.
73518view23:31, 29 January 2014KhanspersModified title
71487view19:19, 17 October 2013MaintBotAutomated update of data sources
68592view23:18, 5 July 2013MaintBotUpdated to 2013 gpml schema
58855view23:35, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40752view21:54, 1 March 2011MaintBotRemoved redundant pathway information and comments
34025view18:46, 9 December 2009MaintBotAutomatic update of empty xrefs
31804view12:19, 14 August 2009MaintBotFixed group labels
30763view23:13, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CP19A_CANFAGeneProductENSCAFG00000015338 (Ensembl)
CP1A1_CANFAGeneProductENSCAFG00000017937 (Ensembl)
CP1A2_CANFAGeneProductENSCAFG00000017941 (Ensembl)
CP21A_CANFAGeneProductENSCAFG00000000712 (Ensembl)
CP2BB_CANFAGeneProductENSCAFG00000005052 (Ensembl)
CP2E1_CANFAGeneProductENSCAFG00000013318 (Ensembl)
CYB5AGeneProductENSCAFG00000000026 (Ensembl)
CYB5BGeneProductENSCAFG00000003865 (Ensembl)
CYB5R1GeneProductENSCAFG00000010350 (Ensembl)
CYB5R2GeneProductENSCAFG00000006769 (Ensembl)
CYB5R4GeneProductENSCAFG00000002967 (Ensembl)
CYPGeneProduct
CYP11A1GeneProductENSCAFG00000017888 (Ensembl)
CYP17A1GeneProductENSCAFG00000010279 (Ensembl)
CYP1B1GeneProductENSCAFG00000006164 (Ensembl)
CYP20A1GeneProductENSCAFG00000012765 (Ensembl)
CYP24A1GeneProductENSCAFG00000011839 (Ensembl)
CYP26A1GeneProduct
CYP26B1GeneProductENSCAFG00000009005 (Ensembl)
CYP26C1GeneProductENSCAFG00000007574 (Ensembl)
CYP27A1GeneProductENSCAFG00000014943 (Ensembl)
CYP27B1GeneProductENSCAFG00000000287 (Ensembl)
CYP27C1GeneProductENSCAFG00000004542 (Ensembl)
CYP2A13GeneProduct484494 (Entrez Gene)
CYP2A6GeneProduct
CYP2A7GeneProduct
CYP2C18GeneProduct
CYP2C19GeneProduct
CYP2C8GeneProduct
CYP2C9GeneProduct
CYP2F1GeneProductENSCAFG00000023821 (Ensembl)
CYP2G1PGeneProduct
CYP2J2GeneProductENSCAFG00000018871 (Ensembl)
CYP2R1GeneProductENSCAFG00000008504 (Ensembl)
CYP2S1GeneProductENSCAFG00000005049 (Ensembl)
CYP2U1GeneProductENSCAFG00000011203 (Ensembl)
CYP2W1GeneProductENSCAFG00000011551 (Ensembl)
CYP39A1GeneProductENSCAFG00000002026 (Ensembl)
CYP3A4GeneProduct
CYP3A43GeneProduct
CYP3A5GeneProduct
CYP3A7GeneProduct
CYP46A1GeneProductENSCAFG00000017838 (Ensembl)
CYP4A11GeneProduct610385 (Entrez Gene)
CYP4A22GeneProduct
CYP4B1GeneProductENSCAFG00000004097 (Ensembl)
CYP4F11GeneProductENSCAFG00000023401 (Ensembl)
CYP4F12GeneProductENSCAFG00000023401 (Ensembl)
CYP4F22GeneProductENSCAFG00000023053 (Ensembl)
CYP4F2GeneProductENSCAFG00000023401 (Ensembl)
CYP4F3GeneProduct
CYP4F8GeneProduct
CYP4V2GeneProductENSCAFG00000007384 (Ensembl)
CYP4X1GeneProductENSCAFG00000023824 (Ensembl)
CYP4Z1GeneProduct
CYP51A1GeneProductENSCAFG00000001945 (Ensembl)
CYP7A1GeneProductENSCAFG00000007098 (Ensembl)
CYP7B1GeneProductENSCAFG00000007246 (Ensembl)
CYP8B1GeneProductENSCAFG00000005370 (Ensembl)
Fe2+Metabolite29033 (ChEBI)
Fe3+Metabolite29034 (ChEBI)
H2OMetabolite
NAD+Metabolite15846 (ChEBI)
NADHMetabolite16908 (ChEBI)
NADP+Metabolite18009 (ChEBI)
NADPHMetabolite16474 (ChEBI)
NB5R3_CANFAGeneProductENSCAFG00000000953 (Ensembl)
O2Metabolite977 (PubChem-compound)
Q2EFX8_CANFAGeneProductENSCAFG00000013467 (Ensembl)
Q3HTU0_CANFAGeneProductENSCAFG00000001285 (Ensembl)
Q70DT1_CANFAGeneProductENSCAFG00000000980 (Ensembl)
SubstrateGeneProduct
Substrate-OHGeneProduct
activated O2Metabolite

Annotated Interactions

No annotated interactions
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