Monoamine GPCRs (Canis familiaris)

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HistamineReceptorsGq/G11 PathwayAdrenergicReceptorsGs PathwayGs PathwayDopamineReceptorsGi/Go PathwayMuscarinicAcetylcholine ReceptorsSerotoninReceptorsDRD5HTR4ADRA2AHTR2ANorepinephrineADRB1HTR5AADRA1AHistamineADRA1BHTR2BADRA1DEpinephrineHTR1DHTR5BHTR7DRD1DRD4HTR6SerotoninADRB2ADRA2BHTR1ACHRM3HTR1FAcetylcholine DRD2CHRM1DopamineCHRM4HTR2CHTR1BADRB3MuscarineHTR1EADRA2CHRH2DRD3CHRM5CHRM2HRH1


G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: Wikipedia

Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. Monoamine neurotransmitters


This pathway was inferred from Homo sapiens pathway WP58(r20799) with a 72% conversion rate.

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106064view11:57, 16 August 2019MaintBotHMDB identifier normalization
98236view12:36, 14 August 2018EgonwReplace a PubChem SID with a PubChem CID.
96089view19:08, 15 February 2018KhanspersModified description
87856view11:54, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
87855view11:53, 25 July 2016ElisaOntology Term : 'G protein mediated signaling pathway' added !
74179view15:43, 2 April 2014EgonwUpdated the PubChem-substance data source.
71458view19:16, 17 October 2013MaintBotAutomated update of data sources
68523view22:07, 5 July 2013MaintBotUpdated to 2013 gpml schema
40677view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
33967view18:27, 9 December 2009MaintBotAutomatic update of empty xrefs
32270view13:04, 15 August 2009MaintBotFixed text labels
31803view12:19, 14 August 2009MaintBotFixed group labels
31298view20:10, 13 August 2009MaintBotFixed text labels
30762view23:12, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ADRA1AGeneProduct403866 (Entrez Gene)
ADRA1BGeneProduct403962 (Entrez Gene)
ADRA1DGeneProduct552897 (Entrez Gene)
ADRA2AGeneProduct486888 (Entrez Gene)
ADRA2BGeneProduct611658 (Entrez Gene)
ADRA2CGeneProduct488793 (Entrez Gene)
ADRB1GeneProduct493972 (Entrez Gene)
ADRB2GeneProduct403910 (Entrez Gene)
ADRB3GeneProduct442979 (Entrez Gene)
Acetylcholine MetaboliteHMDB00895 (HMDB)
CHRM1GeneProduct483776 (Entrez Gene)
CHRM2GeneProduct403858 (Entrez Gene)
CHRM3GeneProduct403827 (Entrez Gene)
CHRM4GeneProduct611314 (Entrez Gene)
CHRM5GeneProduct487472 (Entrez Gene)
DRD1GeneProduct489110 (Entrez Gene)
DRD2GeneProduct403701 (Entrez Gene)
DRD3GeneProduct487984 (Entrez Gene)
DRD4GeneProduct448805 (Entrez Gene)
DRD5GeneProduct488824 (Entrez Gene)
EpinephrineMetaboliteHMDB00068 (HMDB)
HRH1GeneProduct403813 (Entrez Gene)
HRH2GeneProduct403812 (Entrez Gene)
HTR1AGeneProduct487230 (Entrez Gene)
HTR1BGeneProduct403741 (Entrez Gene)
HTR1DGeneProduct403963 (Entrez Gene)
HTR1EGeneProduct481907 (Entrez Gene)
HTR2AGeneProduct403882 (Entrez Gene)
HTR2BGeneProduct403881 (Entrez Gene)
HTR2CGeneProduct450240 (Entrez Gene)
HTR4GeneProduct489198 (Entrez Gene)
HTR5AGeneProduct482814 (Entrez Gene)
HTR6GeneProduct487402 (Entrez Gene)
HTR7GeneProduct477762 (Entrez Gene)
MuscarineMetabolite9676 (PubChem-substance)
NorepinephrineMetaboliteHMDB00216 (HMDB)

Annotated Interactions

No annotated interactions
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