Matrix Metalloproteinases (Canis familiaris)

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1Genes Dev 14:2123-2133EnamelysinOtherGelatinasesMatrix metalloproteinases: effectors ofMembrane-type MMPsMetalloelastaseBased on Vu & Werb (2000)MatrilysinCollagenasesInhibitorsdevelopment and normal physiology.StromelysinsPotential Inducers of TranscriptionTIMP1MMP13MMP14MMP25MMP27MMP24BSGMMP11MMP17MMP16MMP28MMP9MMP23BMMP2MMP20TCF20TIMP2MMP3MMP1MMP15MMP19MMP7MMP8MMP26MMP23ATNFTIMP3TIMP4MMP21MMP10MMP12


Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP129(r20953) with a 87% conversion rate.

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Ontology Terms



  1. Vu TH, Werb Z; ''''; , PubMed Europe PMC Scholia


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68557view22:42, 5 July 2013MaintBotUpdated to 2013 gpml schema
67450view11:03, 26 June 2013DdiglesOntology Term : 'cell-extracellular matrix signaling pathway' added !
40715view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35335view08:37, 12 February 2010Thomasrestored inferator comment
35333view08:34, 12 February 2010ThomasModified description
35332view08:34, 12 February 2010Thomasmoved reference from comments to bibliography
32261view13:01, 15 August 2009MaintBotFixed text labels
31787view12:14, 14 August 2009MaintBotFixed group labels
31288view20:06, 13 August 2009MaintBotFixed text labels
30745view23:05, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
MMP11GeneProduct486408 (Entrez Gene)
MMP12GeneProduct611789 (Entrez Gene)
MMP13GeneProduct403763 (Entrez Gene)
MMP14GeneProduct403823 (Entrez Gene)
MMP1GeneProduct489428 (Entrez Gene)
MMP15GeneProduct487257 (Entrez Gene)
MMP16GeneProduct487036 (Entrez Gene)
MMP17GeneProduct609890 (Entrez Gene)
MMP19GeneProduct606853 (Entrez Gene)
MMP20GeneProduct611829 (Entrez Gene)
MMP21GeneProduct611418 (Entrez Gene)
MMP23BGeneProduct607187 (Entrez Gene)
MMP2GeneProduct403733 (Entrez Gene)
MMP24GeneProduct485849 (Entrez Gene)
MMP25GeneProduct490046 (Entrez Gene)
MMP26GeneProduct610101 (Entrez Gene)
MMP27GeneProduct489430 (Entrez Gene)
MMP28GeneProduct491136 (Entrez Gene)
MMP3GeneProduct403445 (Entrez Gene)
MMP7GeneProduct489432 (Entrez Gene)
MMP8GeneProduct489429 (Entrez Gene)
MMP9GeneProduct403885 (Entrez Gene)
TCF20GeneProduct481224 (Entrez Gene)
TIMP1GeneProduct403816 (Entrez Gene)
TIMP2GeneProduct403633 (Entrez Gene)
TIMP3GeneProduct481289 (Entrez Gene)
TNFGeneProduct403922 (Entrez Gene)

Annotated Interactions

No annotated interactions
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