G Protein Signaling Pathways (Canis familiaris)

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1, 2TranscriptionCellResponseG gammaG12/13GiProtein Kinase CCytoskeletalChangesGsAKAPsAdenylate CyclasesPhosphatase 2BcAMPPhosphodiesterasesTranscriptionG betaProtein Kinase AGqCellResponsePPP3CAcAMPPRKACBGNAI1Ca2+SLC9A1AKAP7GNB2PRKAR1BITPR1PRKCBPRKCHGNALPRKACGPDE8APRKCIGNG8GNG10AKAP5AKAP13GNB3PRKCQPRKCDPDE8BPDE7BPRKD3AKAP2AKAP8PDE4DPRKCAPPP3CCPDE4BRHOAAdcy6AKAP9AKAP1PDE1CADCY8PRKAR2BPRKAR1AHRASGNG5NRASAKAP10GNB1DAGGNGT2GNG3PRKACAAKAP12GNA13ADCY9ADCY7AKAP6PRKAR2APDE7APRKCZGNAI3PRKCGPDE4AGNAO1GNB5PDE1AGNAI1RRASGNGT1PRKD1GNAZGNA14ADCY2PRKCEADCY5GNAO1GNG12PDE1BGNAI2ADCY3AKAP4GNA15GNA11ADCY1PDE4CGNAQPPP3CCPLCB3CALM1GNG7KCNJ3LOC611349GNASHRASAKAP11GNA12GNG4AKAP3IP3ARHGEF1GNG11ADCY4


Description

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.

G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes.

Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP35(r20751) with a 85% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC Scholia
  2. Stryer L, Bourne HR; ''G proteins: a family of signal transducers.''; Annu Rev Cell Biol, 1986 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106056view11:57, 16 August 2019MaintBotHMDB identifier normalization
71455view19:16, 17 October 2013MaintBotAutomated update of data sources
68514view21:57, 5 July 2013MaintBotUpdated to 2013 gpml schema
67259view10:28, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway' added !
40667view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
35323view08:23, 12 February 2010ThomasModified description
35322view08:22, 12 February 2010Thomasadded literature
33959view18:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32257view12:58, 15 August 2009MaintBotFixed text labels
31779view12:11, 14 August 2009MaintBotFixed group labels
31282view20:03, 13 August 2009MaintBotFixed text labels
30734view23:01, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY1GeneProduct
ADCY2GeneProduct478624 (Entrez Gene)
ADCY3GeneProduct482994 (Entrez Gene)
ADCY4GeneProduct480271 (Entrez Gene)
ADCY5GeneProduct403859 (Entrez Gene)
ADCY7GeneProduct487289 (Entrez Gene)
ADCY8GeneProduct482045 (Entrez Gene)
ADCY9GeneProduct490031 (Entrez Gene)
AKAP10GeneProduct609073 (Entrez Gene)
AKAP11GeneProduct609431 (Entrez Gene)
AKAP12GeneProduct476246 (Entrez Gene)
AKAP13GeneProduct479032 (Entrez Gene)
AKAP1GeneProduct480567 (Entrez Gene)
AKAP2GeneProduct
AKAP3GeneProduct477719 (Entrez Gene)
AKAP4GeneProduct480917 (Entrez Gene)
AKAP5GeneProduct480354 (Entrez Gene)
AKAP6GeneProduct490644 (Entrez Gene)
AKAP7GeneProduct484128 (Entrez Gene)
AKAP8GeneProduct474362 (Entrez Gene)
AKAP9GeneProduct475224 (Entrez Gene)
ARHGEF1GeneProduct
Adcy6GeneProduct477625 (Entrez Gene)
CALM1GeneProduct480416 (Entrez Gene)
Ca2+MetaboliteHMDB00464 (HMDB)
DAGMetaboliteC00165 (Kegg Compound)
GNA11GeneProduct403914 (Entrez Gene)
GNA12GeneProduct609567 (Entrez Gene)
GNA13GeneProduct490901 (Entrez Gene)
GNA14GeneProduct484156 (Entrez Gene)
GNA15GeneProduct485063 (Entrez Gene)
GNAI1GeneProduct478227 (Entrez Gene)
GNAI2GeneProduct442957 (Entrez Gene)
GNAI3GeneProduct611810 (Entrez Gene)
GNALGeneProduct607658 (Entrez Gene)
GNAO1GeneProduct609157 (Entrez Gene)
GNAQGeneProduct403928 (Entrez Gene)
GNASGeneProduct403943 (Entrez Gene)
GNAZGeneProduct607445 (Entrez Gene)
GNB1GeneProduct403912 (Entrez Gene)
GNB2GeneProduct479733 (Entrez Gene)
GNB3GeneProduct403511 (Entrez Gene)
GNB5GeneProduct608623 (Entrez Gene)
GNG10GeneProduct
GNG11GeneProduct610002 (Entrez Gene)
GNG12GeneProduct
GNG3GeneProduct483783 (Entrez Gene)
GNG4GeneProduct607513 (Entrez Gene)
GNG5GeneProduct
GNG7GeneProduct612139 (Entrez Gene)
GNG8GeneProduct484428 (Entrez Gene)
GNGT1GeneProduct403895 (Entrez Gene)
GNGT2GeneProduct403617 (Entrez Gene)
HRASGeneProduct
HRASGeneProduct403735 (Entrez Gene)
IP3MetaboliteHMDB01143 (HMDB)
ITPR1GeneProduct476548 (Entrez Gene)
KCNJ3GeneProduct488355 (Entrez Gene)
LOC611349GeneProduct611349 (Entrez Gene)
NRASGeneProduct403872 (Entrez Gene)
PDE1AGeneProduct403652 (Entrez Gene)
PDE1BGeneProduct
PDE1CGeneProduct475272 (Entrez Gene)
PDE4AGeneProduct
PDE4BGeneProduct479540 (Entrez Gene)
PDE4CGeneProduct609938 (Entrez Gene)
PDE4DGeneProduct487221 (Entrez Gene)
PDE7AGeneProduct486975 (Entrez Gene)
PDE7BGeneProduct483996 (Entrez Gene)
PDE8AGeneProduct488752 (Entrez Gene)
PDE8BGeneProduct488939 (Entrez Gene)
PLCB3GeneProduct476034 (Entrez Gene)
PPP3CAGeneProduct403486 (Entrez Gene)
PPP3CCGeneProduct609027 (Entrez Gene)
PRKACAGeneProduct403556 (Entrez Gene)
PRKACBGeneProduct479975 (Entrez Gene)
PRKACGGeneProduct
PRKAR1AGeneProduct480459 (Entrez Gene)
PRKAR1BGeneProduct480805 (Entrez Gene)
PRKAR2AGeneProduct484774 (Entrez Gene)
PRKAR2BGeneProduct475887 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PRKCEGeneProduct609934 (Entrez Gene)
PRKCGGeneProduct484316 (Entrez Gene)
PRKCHGeneProduct490722 (Entrez Gene)
PRKCIGeneProduct478686 (Entrez Gene)
PRKCQGeneProduct478013 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PRKD1GeneProduct609091 (Entrez Gene)
PRKD3GeneProduct483036 (Entrez Gene)
RHOAGeneProduct403954 (Entrez Gene)
RRASGeneProduct476413 (Entrez Gene)
SLC9A1GeneProduct478171 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions
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