ErbB signaling pathway (Canis familiaris)

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+pMigration / InvasionAdhesionMigration+pDegradationAngiogenesisActivation by ErbB2overexpression (cancers)Cellular targetsDNAReceptor ubiquitylationCellular targets+pERmTor signaling pathwayCa+2Glioma+pProliferation+p+p+pPancreaticCancerEndometrialcancerCell cycle+pProteinsynthesis+pDGDNA+p+pAdhesion+pMetabolismDifferentiationPIP3No signaling(HER2/Neu)DNACell cycleprogression+p+pCell survivalIP3ERBB SIGNALING PATHWAY+pCalcium signaling pathwaySurvival+p+pDNA+pNon-smallcell lungcancer(EGFR)MAPK signalingpathway+pPAK4EGFRMAPK8MAPK1PTK2SHC2GAB1GRB2BTCSTAT5AEGFEGFRERBB2MAP2K1EGFRSTAT5ANCK1TGFAABL1AKT3JUNERBB3AREGERBB3NRG3GSK3BMTORERBB2HRASERBB3RPS6KB1GRB2ERBB2ERBB4ARAFMYCERBB4BADNRG1ERBB2CBLCCDKN1BCAMK2ASOS1PRKCAHBEGFNRG2PIK3R5PLCG1EIF4EBP1ERBB4SRCEREGMAP2K7ELK1NRG4ERBB2CDKN1ACRKELK1


The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.

The ErbB protein family consists of 4 members

   * ErbB-1, also named epidermal growth factor receptor (EGFR)
   * ErbB-2, also named HER2 in humans and neu in rodents
   * ErbB-3, also named HER3 and
   * ErbB-4, also named HER4

The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


This pathway was inferred from Homo sapiens pathway WP673(r29836) with a 91% conversion rate.

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Ontology Terms



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108181view10:53, 29 November 2019FehrhartOntology Term : 'multiple sclerosis' added !
108180view10:53, 29 November 2019FehrhartOntology Term : 'Alzheimer's disease' added !
108179view10:53, 29 November 2019FehrhartOntology Term : 'cancer' added !
87992view13:25, 25 July 2016SusanOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
68547view22:33, 5 July 2013MaintBotUpdated to 2013 gpml schema
40704view21:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
33985view18:33, 9 December 2009MaintBotAutomatic update of empty xrefs
31278view20:01, 13 August 2009MaintBotFixed text labels
30729view22:58, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ABL1GeneProduct491292 (Entrez Gene)
AKT3GeneProduct442964 (Entrez Gene)
ARAFGeneProduct491857 (Entrez Gene)
BADGeneProduct483763 (Entrez Gene)
BTCGeneProduct482682 (Entrez Gene)
CAMK2AGeneProduct612941 (Entrez Gene)
CBLCGeneProduct612343 (Entrez Gene)
CDKN1AGeneProduct474890 (Entrez Gene)
CDKN1BGeneProduct403429 (Entrez Gene)
EGFGeneProduct403657 (Entrez Gene)
EGFRGeneProduct404306 (Entrez Gene)
EIF4EBP1GeneProduct475590 (Entrez Gene)
ELK1GeneProduct491860 (Entrez Gene)
ERBB2GeneProduct403883 (Entrez Gene)
ERBB3GeneProduct481105 (Entrez Gene)
ERBB4GeneProduct488508 (Entrez Gene)
EREGGeneProduct611946 (Entrez Gene)
GAB1GeneProduct483808 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
HBEGFGeneProduct607007 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K7GeneProduct485004 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MTORGeneProduct478232 (Entrez Gene)
MYCGeneProduct403924 (Entrez Gene)
NCK1GeneProduct485677 (Entrez Gene)
NRG1GeneProduct482861 (Entrez Gene)
NRG2GeneProduct487158 (Entrez Gene)
NRG3GeneProduct479263 (Entrez Gene)
PAK4GeneProduct484513 (Entrez Gene)
PIK3R5GeneProduct612805 (Entrez Gene)
PLCG1GeneProduct485874 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PTK2GeneProduct475108 (Entrez Gene)
RPS6KB1GeneProduct480580 (Entrez Gene)
SHC2GeneProduct611955 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
SRCGeneProduct485864 (Entrez Gene)
STAT5AGeneProduct490968 (Entrez Gene)
TGFAGeneProduct403431 (Entrez Gene)

Annotated Interactions

No annotated interactions
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