MAPK Signaling Pathway (Canis familiaris)

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2-101Proliferation, differentiationPhosphatidylinositolsignaling systemProliferation, inflammation, anti-apoptosisCycleMAPKKKKPTPERK5 pathwayCa2+Serum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDAGDNAMKPHeteromeric G-proteinJNKDNAMAPKKDNASerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressApoptosisDNATranscription factorsWnt signaling pathwayMAPKClassical MAP kinase PathwayDNA damagep38MAPKKKProliferation, differentiationPTPCellp53 signaling pathwayIP3LPSProliferation, differentiation,inflammationDNAJNK & p38 MAP kinase pathwayMAP3K6RPS6KA3MRASTGFBR1ATF4PRKCHTGFB1CRKNR4A1MAP3K7IP2ATF4TGFB3RAC1PTPRRPPP3CACASP2MAPK4ARRB1HSPB2mkk3MAPK8IP3MAP2K6TRAF2FASRHOXF2NFKB1DUSP5JUNfgfrRASA1MAP2K1PAK2DUSP10IL1R1HSPA8PRKCGMAPK8MAP2K4mnk1/2TNFsap1aARRB2CD14MAP2K2IL1BPDGFBPPP3R2CRKLAKT3PRKACAPPP3R1PPM1BEGFMAPK10SRFLOC480726MAP3K5IL1R2CDC25BTGFBR2IKBKBCASP8GNA12MAP3K7RAP1AMAPK6BRAFFLNASTMN1RAC2CASP6BDNFPDGFRBTP53RAP1BHRASMAPK1RASGRF2MAP3K11PAK1MAPTCASP3RASGRP4MEF2CRASGRP1IKBKGHSPB1GADD45APTPN7nfat2/4MINK1DUSP1FGF4NLKTRAF6MAPKAPK5MAPKSP1MAP3K14RAF1PTPN5DUSP7cAMPMAPK13PRKCZPPP3CBMAP4K3Sap1aCASP1GCKELK1IL1ARASA2EGFRLOC478802AKT1MAP4K4NGFPPP3CCECSITMAP3K13NRASPPP5CSOS2MAPK9MAPK12STK3PTPN5DAXXMAXCASP7NTF4PRKCDMAP3K1CDC42ACVR1CMOSTMEM37MAP3K8MAP3K4PPM1AMAP2K5GRB2NF1MAP3K12PLA2G5PTPN7MAPK14MYCDUSP4PRKCBCASP9TAOK1DDIT3DUSP6msk1/2HSPA1AFASLGJUNDTAOK2FOSMAP4K1MAPK3MAPKAPK2MAP3K7IP1PTPRRATF2TGFB2MAPK7MEKK2/3MAP2K7NTRK1AKT2PRKCDPLA2G10ACVR1B


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
 
This pathway was inferred from Homo sapiens pathway WP382(r28779) with a 86% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC
  2. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC
  3. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC
  4. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC
  5. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC
  6. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC
  7. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC
  8. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC
  9. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC
  10. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC
  11. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106039view11:56, 16 August 2019MaintBotHMDB identifier normalization
105691view21:02, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96392view09:52, 12 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95778view14:33, 19 January 2018MkutmonHomology conversion update
72089view21:25, 24 October 2013Mkutmonadded datasource for "Wnt signaling pathway", "Apoptosis" and "Cell cycle"
68578view23:04, 5 July 2013MaintBotUpdated to 2013 gpml schema
67440view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
48169view20:31, 9 May 2012MaintBotUpdating from human to fix xrefs
40736view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35663view22:26, 12 February 2010KhanspersDescription and lit refs
34012view18:42, 9 December 2009MaintBotAutomatic update of empty xrefs
32551view13:06, 17 August 2009MaintBotFixed text labels
32233view12:50, 15 August 2009MaintBotFixed text labels
31740view12:00, 14 August 2009MaintBotFixed group labels
31249view19:51, 13 August 2009MaintBotFixed text labels
30683view22:44, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACVR1BGeneProduct486537 (Entrez Gene)
ACVR1CGeneProduct488361 (Entrez Gene)
AKT1GeneProduct490878 (Entrez Gene)
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LOC478802GeneProduct478802 (Entrez Gene)
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NGFGeneProduct403402 (Entrez Gene)
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NRASGeneProduct403872 (Entrez Gene)
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PPP3CAGeneProduct403486 (Entrez Gene)
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PPP3R1GeneProduct612559 (Entrez Gene)
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RAF1GeneProduct484648 (Entrez Gene)
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RAP1BGeneProduct608981 (Entrez Gene)
RASA1GeneProduct479158 (Entrez Gene)
RASA2GeneProduct485692 (Entrez Gene)
RASGRF2GeneProduct610203 (Entrez Gene)
RASGRP1GeneProduct478255 (Entrez Gene)
RASGRP4GeneProduct484528 (Entrez Gene)
RHOXF2GeneProduct611154 (Entrez Gene)
RPS6KA3GeneProduct491768 (Entrez Gene)
SOS2GeneProduct490682 (Entrez Gene)
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Sap1aGeneProduct
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cAMPMetaboliteHMDB00058 (HMDB)
fgfrGeneProduct
mkk3GeneProduct
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nfat2/4GeneProduct
sap1aGeneProduct

Annotated Interactions

No annotated interactions
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