Electron Transport Chain (OXPHOS system in mitochondria) (Homo sapiens)

From WikiPathways

Revision as of 22:20, 29 April 2018 by Wpblocked (Talk | contribs)
Jump to: navigation, search
IntermembraneSpaceAssemblyComplex VATP Synthase Adenine NucleotideTranslocatorCytochrome COxidaseC subunitF1 ComplexComplex IIComplex IIIStalkSuccinate-UbiquinoneOxidoreductaseF0 ComplexNADH-UbiquinoneOxidoreductaseMatrixComplex IUncoupling ProteinComplex IVUbiquinol-Cytochrome CReductasebinds ATP Synthase betaNDUFS3COX1e-ATP5LUCRCCOX4I1ATP6ATP5J2NDUFC2SLC25A6ATPATP5IO2NDUFV2NDUFV3ATPIF1ATP5G2NDUFS2NDUFB4UQCRCYTBNDUFA8ND2Cytochrome CCOX7A3ATP5HCOX6B1COX15ATP5F1NDUFB1ND5DAP13COX2ATP5ONDUFB2FADNDUFS5NADHCOX17NDUFA1COX7A2LNDUFAB1UQCRFS1NDUFB8NDUFB9NDUFA10NDUFC1ND6COX8Ae-COX5AND1SuccinateNDUFB7H+NDUFS1FADH2UQCRHATP5A1SURF1SDHDATP5BNDUFA3ATP5JND4ATP5ETCA CycleCOX6A2H+H+ATP5DNDUFS6NDUFB5NDUFV1COX6A1UCP3NDUFA2SLC25A4COX7A2QP-CUbiquinoneNDUFA4H+SDHBUQCRC2SLC25A27NDUFS4ATP5C1COX11H+NDUFA5NDUFA6COX7BCOX5BCOX7A1ATP8NDUFA9H+UCP2ND3H+NDUFB6H2ONDUFS8UQCRC1UQCRBCOX7CATP5SNDUFB10ATP5G3NDUFS7SDHCCOX6CSLC25A14COX3NAD+e-ATP5G1SCO1UCP1ND4LNDUFA7SLC25A5SDHANDUFB3


Description

An electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set of mediating biochemical reactions. These H+ ions are used to produce adenosine triphosphate (ATP), the main energy intermediate in living organisms, as they move back across the membrane.

In mitochondria, it is the conversion of oxygen to water, NADH to NAD+ and succinate to fumarate that drives the transfer of H+ ions.

Source: Wikipedia (wikipedia:Electron_transport_chain)

Quality Tags

Ontology Terms

 

Bibliography

  1. Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landázuri MO, Enríquez JA; ''NDUFA4 is a subunit of complex IV of the mammalian electron transport chain.''; Cell Metab, 2012 PubMed Europe PMC
  2. Pitceathly RD, Rahman S, Wedatilake Y, Polke JM, Cirak S, Foley AR, Sailer A, Hurles ME, Stalker J, Hargreaves I, Woodward CE, Sweeney MG, Muntoni F, Houlden H, Taanman JW, Hanna MG; ''NDUFA4 mutations underlie dysfunction of a cytochrome c oxidase subunit linked to human neurological disease.''; Cell Rep, 2013 PubMed Europe PMC
  3. Signes A, Fernandez-Vizarra E; ''Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.''; Essays Biochem, 2018 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107324view15:29, 23 September 2019DeSlAdded general lit. ref.
107323view15:27, 23 September 2019DeSlChanged NDUFA4 from complex I to IV (according to 2 lit. refs).
106399view21:30, 28 August 2019KhanspersModified description
106195view12:09, 16 August 2019MaintBotHMDB identifier normalization
105579view06:33, 9 August 2019KhanspersModified description
98163view11:12, 31 July 2018DeSlAdded linkout to assemly PW for Complex 1
98127view15:15, 24 July 2018DeSlRemoved licence number and last modified part.
98126view15:14, 24 July 2018DeSlchanged title slightly
97390view04:58, 14 May 2018Khanspersconnected interaction
97113view22:54, 29 April 2018AlexanderPicoReverted to version '07:58, 16 November 2017' by AlexanderPico
97110view22:20, 29 April 2018WpblockedModified title
95118view14:58, 16 November 2017DeSlFixed nested groups.
89727view09:08, 29 September 2016EgonwReconnected a line and converted to interactions into graphical lines.
86860view07:29, 14 July 2016MkutmonOntology Term : 'electron transport chain pathway' added !
86853view00:43, 14 July 2016AlexanderPicoOntology Term : 'PW:0000034' removed !
86852view00:43, 14 July 2016AlexanderPicoOntology Term : 'PW:0000034' removed !
82216view19:38, 15 September 2015AlexanderPicoFixed Cytochrome C interaction
79220view13:38, 15 March 2015EgonwReplaced the HMDB H2 identifier with H+ from ChEBI.
71266view21:52, 16 October 2013MaintBotAutomated update of data sources
67189view10:18, 26 June 2013Christine ChichesterOntology Term : 'electron transport chain pathway' added !
63179view20:33, 8 May 2013MaintBotUpdating gpml version
62687view21:19, 1 May 2013MaintBotUpdated UniProt data source
45239view18:18, 7 October 2011AlexanderPicoOntology Term : 'oxidative phosphorylation pathway' added !
41171view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38660view13:52, 23 September 2010FerryJagersLinked TCA Cycle
37857view19:09, 12 July 2010Khansperschanged arrow
37856view19:06, 12 July 2010Khanspersminor layout change
35237view19:41, 11 February 2010AlexanderPicoModified description
34806view00:05, 21 January 2010KhanspersModified description
34445view18:20, 10 December 2009MaintBotAutomatic update of empty xrefs
32230view12:49, 15 August 2009MaintBotFixed text labels
31735view11:58, 14 August 2009MaintBotFixed group labels
20917view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Electron Transport Chain]] moved to [[Pathway:WP111]]: Moved to stable identifier
14979view19:48, 24 May 2008AlexanderPicominor fixes
14823view07:24, 24 May 2008AlexanderPicoConnected!
14820view07:17, 24 May 2008AlexanderPicoPeriodical save, work in progress
14818view07:07, 24 May 2008AlexanderPicoPeriodical save, work in progress
14814view06:56, 24 May 2008AlexanderPicoPeriodical save, work in progress
14811view06:46, 24 May 2008AlexanderPicoPeriodical save, work in progress
14809view06:36, 24 May 2008AlexanderPicoPeriodical save, work in progress
14807view06:25, 24 May 2008AlexanderPicoPeriodical save, work in progress
14805view06:15, 24 May 2008AlexanderPicoPeriodical save, work in progress
14802view06:05, 24 May 2008AlexanderPicoPeriodical save, work in progress
14800view05:54, 24 May 2008AlexanderPicoPeriodical save, work in progress
14797view05:44, 24 May 2008AlexanderPicoPeriodical save, work in progress
14795view05:34, 24 May 2008AlexanderPicoPeriodical save, work in progress
14793view05:26, 24 May 2008AlexanderPicoLabels fixed
14790view05:24, 24 May 2008AlexanderPicoPeriodical save, work in progress
14788view05:19, 24 May 2008AlexanderPicoGrouped
13061view11:12, 17 May 2008MaintBotautomated metabolite conversion

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATP5A1GeneProduct498 (Entrez Gene)
ATP5BGeneProduct506 (Entrez Gene)
ATP5C1GeneProduct509 (Entrez Gene)
ATP5DGeneProduct513 (Entrez Gene)
ATP5EGeneProduct514 (Entrez Gene)
ATP5F1GeneProduct515 (Entrez Gene)
ATP5G1GeneProduct516 (Entrez Gene)
ATP5G2GeneProduct517 (Entrez Gene)
ATP5G3GeneProduct518 (Entrez Gene)
ATP5HGeneProduct10476 (Entrez Gene)
ATP5IGeneProduct521 (Entrez Gene)
ATP5J2GeneProduct9551 (Entrez Gene)
ATP5JGeneProduct522 (Entrez Gene)
ATP5LGeneProduct10632 (Entrez Gene)
ATP5OGeneProduct539 (Entrez Gene)
ATP5SGeneProduct27109 (Entrez Gene)
ATP6GeneProduct4508 (Entrez Gene)
ATP8GeneProduct4509 (Entrez Gene)
ATPMetaboliteC00002 (KEGG Compound)
ATPIF1GeneProduct93974 (Entrez Gene)
COX11GeneProduct1353 (Entrez Gene)
COX1GeneProduct4512 (Entrez Gene)
COX15GeneProduct1355 (Entrez Gene)
COX17GeneProduct10063 (Entrez Gene)
COX2GeneProduct4513 (Entrez Gene)
COX3GeneProduct4514 (Entrez Gene)
COX4I1GeneProduct1327 (Entrez Gene)
COX5AGeneProduct9377 (Entrez Gene)
COX5BGeneProduct1329 (Entrez Gene)
COX6A1GeneProduct1337 (Entrez Gene)
COX6A2GeneProduct1339 (Entrez Gene)
COX6B1GeneProduct1340 (Entrez Gene)
COX6CGeneProduct1345 (Entrez Gene)
COX7A1GeneProduct1346 (Entrez Gene)
COX7A2GeneProduct1347 (Entrez Gene)
COX7A2LGeneProduct9167 (Entrez Gene)
COX7A3GeneProductO60397 (Uniprot-TrEMBL)
COX7BGeneProduct1349 (Entrez Gene)
COX7CGeneProduct1350 (Entrez Gene)
COX8AGeneProduct1351 (Entrez Gene)
CYTBGeneProduct4519 (Entrez Gene)
Cytochrome CMetaboliteC00524 (KEGG Compound)
DAP13GeneProduct55967 (Entrez Gene)
FADMetaboliteC00016 (KEGG Compound)
FADH2MetaboliteC01352 (KEGG Compound)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteHMDB02111 (HMDB)
NAD+MetaboliteC00003 (KEGG Compound)
NADHMetaboliteC00004 (KEGG Compound)
ND1GeneProduct4535 (Entrez Gene)
ND2GeneProduct4536 (Entrez Gene)
ND3GeneProduct4537 (Entrez Gene)
ND4GeneProduct4538 (Entrez Gene)
ND4LGeneProduct4539 (Entrez Gene)
ND5GeneProduct4540 (Entrez Gene)
ND6GeneProduct4541 (Entrez Gene)
NDUFA10GeneProduct4705 (Entrez Gene)
NDUFA1GeneProduct4694 (Entrez Gene)
NDUFA2GeneProduct4695 (Entrez Gene)
NDUFA3GeneProduct4696 (Entrez Gene)
NDUFA4GeneProduct4697 (Entrez Gene)
NDUFA5GeneProduct4698 (Entrez Gene)
NDUFA6GeneProduct4700 (Entrez Gene)
NDUFA7GeneProduct4701 (Entrez Gene)
NDUFA8GeneProduct4702 (Entrez Gene)
NDUFA9GeneProduct4704 (Entrez Gene)
NDUFAB1GeneProduct4706 (Entrez Gene)
NDUFB10GeneProduct4716 (Entrez Gene)
NDUFB1GeneProduct4707 (Entrez Gene)
NDUFB2GeneProduct4708 (Entrez Gene)
NDUFB3GeneProduct4709 (Entrez Gene)
NDUFB4GeneProduct4710 (Entrez Gene)
NDUFB5GeneProduct4711 (Entrez Gene)
NDUFB6GeneProduct4712 (Entrez Gene)
NDUFB7GeneProduct4713 (Entrez Gene)
NDUFB8GeneProduct4714 (Entrez Gene)
NDUFB9GeneProduct4715 (Entrez Gene)
NDUFC1GeneProduct4717 (Entrez Gene)
NDUFC2GeneProduct4718 (Entrez Gene)
NDUFS1GeneProduct4719 (Entrez Gene)
NDUFS2GeneProduct4720 (Entrez Gene)
NDUFS3GeneProduct4722 (Entrez Gene)
NDUFS4GeneProduct4724 (Entrez Gene)
NDUFS5GeneProduct4725 (Entrez Gene)
NDUFS6GeneProduct4726 (Entrez Gene)
NDUFS7GeneProduct374291 (Entrez Gene)
NDUFS8GeneProduct4728 (Entrez Gene)
NDUFV1GeneProduct4723 (Entrez Gene)
NDUFV2GeneProduct4729 (Entrez Gene)
NDUFV3GeneProduct4731 (Entrez Gene)
O2MetaboliteHMDB01377 (HMDB)
QP-CGeneProduct27089 (Entrez Gene)
SCO1GeneProduct6341 (Entrez Gene)
SDHAGeneProduct6389 (Entrez Gene)
SDHBGeneProduct6390 (Entrez Gene)
SDHCGeneProduct6391 (Entrez Gene)
SDHDGeneProduct6392 (Entrez Gene)
SLC25A14GeneProduct9016 (Entrez Gene)
SLC25A27GeneProduct9481 (Entrez Gene)
SLC25A4GeneProduct291 (Entrez Gene)
SLC25A5GeneProduct292 (Entrez Gene)
SLC25A6GeneProduct293 (Entrez Gene)
SURF1GeneProduct6834 (Entrez Gene)
SuccinateMetaboliteC00042 (KEGG Compound)
TCA CyclePathwayWP78 (WikiPathways)
UCP1GeneProduct7350 (Entrez Gene)
UCP2GeneProduct7351 (Entrez Gene)
UCP3GeneProduct7352 (Entrez Gene)
UCRCGeneProduct29796 (Entrez Gene)
UQCRGeneProduct10975 (Entrez Gene)
UQCRBGeneProduct7381 (Entrez Gene)
UQCRC1GeneProduct7384 (Entrez Gene)
UQCRC2GeneProduct7385 (Entrez Gene)
UQCRFS1GeneProduct7386 (Entrez Gene)
UQCRHGeneProduct7388 (Entrez Gene)
UbiquinoneMetaboliteHMDB02012 (HMDB)
e-MetaboliteC05359 (KEGG Compound)

Annotated Interactions

No annotated interactions

Personal tools