IL-6 Signaling Pathway (Canis familiaris)

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AutophosphorylationEndosomeDReceptorDeacetylationDCY->EN(Protein-Protein interaction)DephosphorylationUbiquitinationDeubiquitinationDEnzyme complexInhibitionAccession Number: NetPath 18DNucleusMolecule in the pathwayComplex formationPlasma membraneDCY->NUDSumoylationPhosphorylationEarly EndosomesReactions through unknown mechanisms/moleculesDemethylationPalmitoylationCY->NUDMolecular associationPMProteins in a complex interactionEndoplasmic reticulumDGene SymbolGlycosylationDMethylationECDCY->NUDGolgi apparatusNUERDControlDActivationENMTGODTranslocationCytoplasmLigandCY->NUDesumoylationCY->NUCYExtracellularProteolytic cleavageCY->NUAcetylationRecruitmentMitochondrionSTAT3NLKLYNPPP2R3BPIK3R1CASP9PXNPPP2CBJAK2BTKFOXO4PPP2CASTAT3FESFYNGAB1EIF2ASTAT1PPP2R1AIL6RSGK1STAT5AMAPK3HNF1AEIF4ESTAT1CASP3PPP2R5BHCKSTAT3MAP2K6PTK2MAP2K2PPP2R5DSOCS3NFKB1MAPK8CDK9MAP2K1STAT1HRASSHC1CREBBPARRAC1STAT3EP300CEBPBCDK5STAT3STAT3AKT1RPS6KB1STAT3MAPK14ERBB3PTK2BPTPN11STAT3PPP2R1BFOXO3APPP2R4FOSPRKCDMAP3K7PPP2R3AGAB2PPP2R5EGSK3BCDK5R1STAT1JAK1CEBPBMAPKAPK2MAPTFGRDAXXPPP2R2BSTAT5BTYK2RAF1BMXPPP2R5CVAV1NCOA1GRB2SOS1JUNTECIL6STRPS6KA2NFKB1BADSGK1PLCG1PPP2R5AIL6STIL6IL6PPP2R2CPIK3R2MAP3K7MAP2K4HSPB1INPPL1PPP2R2ACD40MAP3K4RB1FOXO1ERBB2LOC487309MAPK1IL6RMAPK14EIF4EBP1LOC480438INPP5D


Description

No description

Comments

GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP364(r28142) with a 91% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
86937view13:07, 15 July 2016MkutmonOntology Term : 'interleukin-6 signaling pathway' added !
68562view22:47, 5 July 2013MaintBotUpdated to 2013 gpml schema
40720view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
33999view18:38, 9 December 2009MaintBotAutomatic update of empty xrefs
32542view13:03, 17 August 2009MaintBotFixed text labels
31240view19:48, 13 August 2009MaintBotFixed text labels
30663view22:37, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
ARGeneProduct403588 (Entrez Gene)
BADGeneProduct483763 (Entrez Gene)
BMXGeneProduct491750 (Entrez Gene)
BTKGeneProduct492019 (Entrez Gene)
CASP3GeneProduct403567 (Entrez Gene)
CASP9GeneProduct487432 (Entrez Gene)
CD40GeneProduct403469 (Entrez Gene)
CDK5GeneProduct475537 (Entrez Gene)
CDK5R1GeneProduct491154 (Entrez Gene)
CDK9GeneProduct491325 (Entrez Gene)
CEBPBGeneProduct
CREBBPGeneProduct479866 (Entrez Gene)
DAXXGeneProduct474873 (Entrez Gene)
EIF2AGeneProduct477112 (Entrez Gene)
EIF4EGeneProduct487870 (Entrez Gene)
EIF4EBP1GeneProduct475590 (Entrez Gene)
EP300GeneProduct
ERBB2GeneProduct403883 (Entrez Gene)
ERBB3GeneProduct481105 (Entrez Gene)
FESGeneProduct609483 (Entrez Gene)
FGRGeneProduct487341 (Entrez Gene)
FOSGeneProduct490792 (Entrez Gene)
FOXO1GeneProduct477295 (Entrez Gene)
FOXO3AGeneProduct
FOXO4GeneProduct491946 (Entrez Gene)
FYNGeneProduct475032 (Entrez Gene)
GAB1GeneProduct483808 (Entrez Gene)
GAB2GeneProduct485167 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
HCKGeneProduct485828 (Entrez Gene)
HNF1AGeneProduct486303 (Entrez Gene)
HRASGeneProduct
HSPB1GeneProduct403979 (Entrez Gene)
IL6GeneProduct403985 (Entrez Gene)
IL6RGeneProduct612271 (Entrez Gene)
IL6STGeneProduct403545 (Entrez Gene)
INPP5DGeneProduct
INPPL1GeneProduct485209 (Entrez Gene)
JAK1GeneProduct442952 (Entrez Gene)
JAK2GeneProduct484185 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
LOC480438GeneProduct480438 (Entrez Gene)
LOC487309GeneProduct487309 (Entrez Gene)
LYNGeneProduct477886 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAP2K4GeneProduct489508 (Entrez Gene)
MAP2K6GeneProduct480454 (Entrez Gene)
MAP3K4GeneProduct476262 (Entrez Gene)
MAP3K7GeneProduct474996 (Entrez Gene)
MAPK14GeneProduct403856 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MAPKAPK2GeneProduct490263 (Entrez Gene)
MAPTGeneProduct480488 (Entrez Gene)
NCOA1GeneProduct475684 (Entrez Gene)
NFKB1GeneProduct442859 (Entrez Gene)
NLKGeneProduct491160 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PLCG1GeneProduct485874 (Entrez Gene)
PPP2CAGeneProduct403608 (Entrez Gene)
PPP2CBGeneProduct482873 (Entrez Gene)
PPP2R1AGeneProduct484335 (Entrez Gene)
PPP2R1BGeneProduct479444 (Entrez Gene)
PPP2R2AGeneProduct477374 (Entrez Gene)
PPP2R2BGeneProduct478053 (Entrez Gene)
PPP2R2CGeneProduct610262 (Entrez Gene)
PPP2R3AGeneProduct485672 (Entrez Gene)
PPP2R3BGeneProduct607103 (Entrez Gene)
PPP2R4GeneProduct491303 (Entrez Gene)
PPP2R5AGeneProduct490280 (Entrez Gene)
PPP2R5BGeneProduct483755 (Entrez Gene)
PPP2R5CGeneProduct480436 (Entrez Gene)
PPP2R5DGeneProduct481806 (Entrez Gene)
PPP2R5EGeneProduct480349 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PTK2GeneProduct475108 (Entrez Gene)
PTK2BGeneProduct486102 (Entrez Gene)
PTPN11GeneProduct477488 (Entrez Gene)
PXNGeneProduct486299 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RB1GeneProduct476915 (Entrez Gene)
RPS6KA2GeneProduct612448 (Entrez Gene)
RPS6KB1GeneProduct480580 (Entrez Gene)
SGK1GeneProduct403647 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT3GeneProduct490967 (Entrez Gene)
STAT5AGeneProduct490968 (Entrez Gene)
STAT5BGeneProduct490969 (Entrez Gene)
TECGeneProduct482140 (Entrez Gene)
TYK2GeneProduct476714 (Entrez Gene)
VAV1GeneProduct485016 (Entrez Gene)

Annotated Interactions

No annotated interactions
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