Monoamine GPCRs (Bos taurus)

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AdrenergicReceptorsDopamineReceptorsSerotoninReceptorsMuscarinicAcetylcholine ReceptorsHistamineReceptorsADRA1AHTR6CHRM5ADRA1BGs PathwayADRA2AHTR1DHTR4HTR7Gq/G11 PathwayCHRM4NorepinephrineDRD2ADRA1DHTR5BADRA2BHTR1EHRH1SerotoninADRB1CHRM1Gs PathwayAcetylcholine 5HTR2BDBDRMuscarineADRB3HTR1BHRH2DRD15HTR1ADRD3DopamineCHRM2EpinephrineHTR2AADRB2DRD4HTR2CGi/Go PathwayCHRM3HistamineHTR5AADRA2C5HTR1F


Description

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: Wikipedia


Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. Monoamine neurotransmitters

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP58(80015) with a 82.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
107054view14:14, 17 September 2019MaintBotChEBI identifier normalization
105968view11:49, 16 August 2019MaintBotHMDB identifier normalization
96092view19:09, 15 February 2018KhanspersModified description
93100view15:57, 28 July 2017DeSlCHanged pubchem substance ID to Chebi for muscarine
80696view15:22, 30 June 2015Mkutmonhomology conversion
72371view09:54, 13 November 2013EgonwFixed the PubChem-substance database name.
71423view19:02, 17 October 2013MaintBotAutomated update of data sources
63444view17:08, 10 May 2013MaintBotUpdated to 2013 gpml schema
40577view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
33815view00:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32528view12:59, 17 August 2009MaintBotFixed text labels
32215view12:44, 15 August 2009MaintBotFixed text labels
31709view11:52, 14 August 2009MaintBotFixed group labels
31226view19:43, 13 August 2009MaintBotFixed text labels
30645view22:31, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
5HTR1AGeneProductENSBTAG00000040439 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3350
5HTR1FGeneProductENSBTAG00000039151 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3355
5HTR2BGeneProductENSBTAG00000039772 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3357
ADRA1AGeneProductENSBTAG00000031632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:148
ADRA1BGeneProductENSBTAG00000040253 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:147
ADRA1DGeneProductENSBTAG00000019504 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:146
ADRA2AGeneProduct
ADRA2BGeneProduct
ADRA2CGeneProduct
ADRB1GeneProductENSBTAG00000001242 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:153
ADRB2GeneProductENSBTAG00000002144 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:154
ADRB3GeneProductENSBTAG00000017981 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:155
Acetylcholine MetaboliteHMDB0000895 (HMDB)
CHRM1GeneProductENSBTAG00000011579 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1128
CHRM2GeneProductENSBTAG00000014674 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1129
CHRM3GeneProductENSBTAG00000008059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1131
CHRM4GeneProductENSBTAG00000033699 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1132
CHRM5GeneProductENSBTAG00000037985 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1133
DBDRGeneProductENSBTAG00000038606 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1816
DRD1GeneProductENSBTAG00000047719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1812
DRD2GeneProductENSBTAG00000010860 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1813
DRD3GeneProductENSBTAG00000002132 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1814
DRD4GeneProduct
DopamineMetabolite62-31-7 (CAS)
EpinephrineMetaboliteHMDB0000068 (HMDB)
Gi/Go PathwayPathwayWP35 (WikiPathways)
Gq/G11 PathwayPathwayWP35 (WikiPathways)
Gs PathwayPathwayWP35 (WikiPathways)
HRH1GeneProductENSBTAG00000001447 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3269
HRH2GeneProductENSBTAG00000044071 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3274
HTR1BGeneProductENSBTAG00000037429 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3351
HTR1DGeneProductENSBTAG00000040329 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3352
HTR1EGeneProductENSBTAG00000026580 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3354
HTR2AGeneProductENSBTAG00000013498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3356
HTR2CGeneProduct
HTR4GeneProductENSBTAG00000010837 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3360
HTR5AGeneProductENSBTAG00000002891 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3361
HTR5BGeneProduct
HTR6GeneProductENSBTAG00000007996 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3362
HTR7GeneProductENSBTAG00000008783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3363
HistamineMetabolite51-45-6 (CAS)
MuscarineMetaboliteCHEBI:7034 (ChEBI)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
SerotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
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