Integrin-mediated Cell Adhesion (Bos taurus)

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21F-actinF-actinIntegrin alphaPAKp130 Cascell motilityPAKITGAECMC3GCAPNcell proliferationcell maintenanceERKcell maintenancePI3KCAPNMEKITGBRAFIntegrin betaRAC2SEPP1RAP1BITGALPAK4RAPGEF1MAPK6SHC1PIK3R2PAK2ITGA2BMAPK7TNS1ITGA6VCLARHGEF7ITGADPXNPAK6ITGB7AKT2MAP2K2ACTNITGB2GIT2ITGB1CAPN2PAK1PTK2MAP2K5CAPN5CAPN9HRASITGB8MYLK2AKT3PI5KITGA2ITGA3BRAFMAPK1CAPN3Phosphatidylinositolsignaling systemCAV1RHOMAP2K1RAC3DOCK1SRCITGB4PTK2VAV3MAPK10CAPN6GRB2bta-mir-34cITGA5ITGB6SORBS1ITGA9ITGB5CAV3PDPK1CDC42SRCMYOCAPN10ILKTLN1RAC1CAPN1MAPK4ITGA7PAK3ITGA11MAP2K6ZYXp110CRKMYPNINTB3CAV2ITGAXITGAMMAP2K3ITGA10ITGA8ROCK1BCAR1MAPK12ITGAVVAV2CAPN7ROCK2ARAFFYNCAPNS1SOS1ITGAEITGA4CSKVASPCAPN11RAP1ARAF1SHC3AKT1ITGA1


Description

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP185(80036) with a 92.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hermeking H; ''The miR-34 family in cancer and apoptosis.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia
  2. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
80667view15:21, 30 June 2015Mkutmonhomology conversion
71411view19:01, 17 October 2013MaintBotAutomated update of data sources
67399view10:56, 26 June 2013DdiglesOntology Term : 'integrin mediated signaling pathway' added !
63354view22:22, 9 May 2013MaintBotUpdated to 2013 gpml schema
62704view23:17, 1 May 2013MaintBotUpdated UniProt data source
40528view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
35601view15:45, 12 February 2010ThomasModified description
35594view15:42, 12 February 2010Thomasadded literature
33770view00:06, 9 December 2009MaintBotAutomatic update of empty xrefs
31701view11:50, 14 August 2009MaintBotFixed group labels
30638view22:28, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTNGeneProduct
AKT1GeneProductENSBTAG00000017636 (Ensembl)
  • AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
AKT2GeneProductENSBTAG00000001400 (Ensembl)
  • AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:208
AKT3GeneProductENSBTAG00000017788 (Ensembl)
  • AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10000
ARAFGeneProductENSBTAG00000005039 (Ensembl)
  • ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:369
ARHGEF7GeneProductENSBTAG00000020726 (Ensembl)
  • ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8874
BCAR1GeneProductENSBTAG00000012002 (Ensembl)
  • BCAR1; breast cancer anti-estrogen resistance 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9564
BRAFGeneProductENSBTAG00000021761 (Ensembl)
  • BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CAPN10GeneProductENSBTAG00000002809 (Ensembl)
  • CAPN10; calpain 10 [EC:3.4.22.17
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11132
CAPN11GeneProductENSBTAG00000021066 (Ensembl)
  • CAPN11; calpain 11 [EC:3.4.22.17]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11131
CAPN1GeneProductENSBTAG00000010230 (Ensembl)
  • CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:823
CAPN2GeneProductENSBTAG00000012778 (Ensembl)
  • CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:824
CAPN3GeneProductENSBTAG00000008868 (Ensembl)
  • CAPN3; calpain 3 (p94) [EC:3.4.22.17]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:825
CAPN5GeneProductENSBTAG00000005034 (Ensembl)
  • CAPN5; calpain
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:726
CAPN6GeneProductENSBTAG00000000828 (Ensembl)
  • CAPN6; calpain 6 [EC:3.4.22.17]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:827
CAPN7GeneProductENSBTAG00000006479 (Ensembl)
  • CAPN7; calpain 7 [EC:3.4.22.17
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23473
CAPN9GeneProductCAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
CAPNS1GeneProductENSBTAG00000014872 (Ensembl)
  • CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:826
CAV1GeneProductENSBTAG00000017869 (Ensembl)
  • CAV1; caveolin 1 caveolae protein 22kD
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:857
CAV2GeneProductENSBTAG00000045584 (Ensembl)
  • CAV2; caveolin 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:858
CAV3GeneProductENSBTAG00000022699 (Ensembl)
  • CAV3; caveolin 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:859
CDC42GeneProductENSBTAG00000001700 (Ensembl)
  • CDC42; cell division cycle 42 (GTP binding protein 25kD)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
CRKGeneProductENSBTAG00000005665 (Ensembl)
  • CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
CSKGeneProductENSBTAG00000021424 (Ensembl)
  • CSK; c-src tyrosine kinase [EC:2.7.1.112]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1445
DOCK1GeneProductENSBTAG00000031890 (Ensembl)
  • DOCK1; dedicator of cyto-kinesis
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1793
FYNGeneProductENSBTAG00000011851 (Ensembl)
  • FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
GIT2GeneProductENSBTAG00000006506 (Ensembl)
  • GIT2; G protein-coupled receptor kinase-interactor 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9815
GRB2GeneProductENSBTAG00000004736 (Ensembl)
  • GRB2; growth factor receptor-bound protein 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
ILKGeneProductENSBTAG00000000696 (Ensembl)
  • ILK; integrin-linked kinase [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3611
INTB3GeneProductENSBTAG00000009987 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
ITGA10GeneProductENSBTAG00000008373 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8515
ITGA11GeneProductENSBTAG00000008380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22801
ITGA1GeneProductENSBTAG00000016525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3672
ITGA2BGeneProductENSBTAG00000008165 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3674
ITGA2GeneProductENSBTAG00000019289 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3673
ITGA3GeneProductENSBTAG00000019498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3675
ITGA4GeneProductENSBTAG00000009256 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3676
ITGA5GeneProductENSBTAG00000013745 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3678
ITGA6GeneProductENSBTAG00000017266 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655
ITGA7GeneProductENSBTAG00000012897 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3679
ITGA8GeneProductENSBTAG00000007602 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8516
ITGA9GeneProductENSBTAG00000016566 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3680
ITGADGeneProductENSBTAG00000019524 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3681
ITGAEGeneProductENSBTAG00000015264 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3682
ITGALGeneProductENSBTAG00000007103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3683
ITGAMGeneProductENSBTAG00000047238 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3684
ITGAVGeneProductENSBTAG00000019929 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3685
ITGAXGeneProduct
ITGB1GeneProductENSBTAG00000015910 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688
ITGB2GeneProductENSBTAG00000017060 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3689
ITGB4GeneProductENSBTAG00000018169 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691
ITGB5GeneProductENSBTAG00000013755 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3693
ITGB6GeneProductENSBTAG00000009080 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3694
ITGB7GeneProductENSBTAG00000018993 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3695
ITGB8GeneProductENSBTAG00000003709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3696
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)
  • MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)
  • MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K3GeneProductENSBTAG00000010576 (Ensembl)
  • MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K5GeneProductENSBTAG00000000218 (Ensembl)
  • MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607
MAP2K6GeneProductENSBTAG00000001609 (Ensembl)
  • MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAPK10GeneProductENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
MAPK12GeneProductENSBTAG00000019574 (Ensembl)
  • MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6300
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
  • MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK4GeneProductENSBTAG00000009907 (Ensembl)
  • MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596
MAPK6GeneProductENSBTAG00000005865 (Ensembl)
  • MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5597
MAPK7GeneProductENSBTAG00000001014 (Ensembl)
  • MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598
MYLK2GeneProductENSBTAG00000014930 (Ensembl)
  • MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85366
MYOGeneProduct
MYPNGeneProductENSBTAG00000017509 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138347
PAK1GeneProductENSBTAG00000010191 (Ensembl)
  • PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
PAK2GeneProductENSBTAG00000047856 (Ensembl)
  • PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5062
PAK3GeneProductENSBTAG00000015670 (Ensembl)
  • PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5063
PAK4GeneProductENSBTAG00000013958 (Ensembl)
  • PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10298
PAK6GeneProductENSBTAG00000019076 (Ensembl)
  • PAK6; p21(CDKN1A)-activated kinase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56924
PDPK1GeneProductENSBTAG00000034436 (Ensembl)
  • PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
PI5KGeneProduct
PIK3R2GeneProduct
  • PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
  • HomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PTK2GeneProductENSBTAG00000009578 (Ensembl)
  • PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
PXNGeneProductENSBTAG00000018108 (Ensembl)
  • PXN; paxillin
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5829
Phosphatidylinositol signaling systemPathway
RAC1GeneProductENSBTAG00000009233 (Ensembl)
  • RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAC2GeneProductENSBTAG00000011043 (Ensembl)
  • RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5880
RAC3GeneProductENSBTAG00000022927 (Ensembl)
  • RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5881
RAF1GeneProductENSBTAG00000045748 (Ensembl)
  • RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RAP1AGeneProductENSBTAG00000014710 (Ensembl)
  • RAP1A; RAP1A member of RAS oncogene family
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RAP1BGeneProductENSBTAG00000008967 (Ensembl)
  • RAP1B; RAP1B member of RAS oncogene family
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908
RAPGEF1GeneProductENSBTAG00000020791 (Ensembl)
  • GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889
RHOGeneProductENSBTAG00000001310 (Ensembl)
  • RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6010
ROCK1GeneProductENSBTAG00000008403 (Ensembl)
  • ROCK1; Rho-associated coiled-coil containing protein kinase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093
ROCK2GeneProductENSBTAG00000005847 (Ensembl)
  • ROCK2; Rho-associated coiled-coil containing protein kinase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9475
SEPP1GeneProductSEPP1; selenoprotein P plasma
SHC1GeneProductENSBTAG00000019838 (Ensembl)
  • SHC1; SHC (Src homology 2 domain containing) transforming protein 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SHC3GeneProductENSBTAG00000011375 (Ensembl)
  • SHC3; neuronal Sh
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53358
SORBS1GeneProductENSBTAG00000002880 (Ensembl)
  • SH3D5; SH3-domain protein 5 (ponsin
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10580
SOS1GeneProductENSBTAG00000011643 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SRCGeneProductENSBTAG00000008938 (Ensembl)
  • SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
TLN1GeneProductENSBTAG00000025868 (Ensembl)
  • TLN1; talin 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7094
TNS1GeneProductENSBTAG00000002485 (Ensembl)
  • TNS; tensi
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7145
VASPGeneProductENSBTAG00000019604 (Ensembl)
  • VASP; vasodilator-stimulated phosphoprotein
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7408
VAV2GeneProductENSBTAG00000004511 (Ensembl)
  • VAV2; vav 2 oncogene
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7410
VAV3GeneProductENSBTAG00000031575 (Ensembl)
  • VAV3; vav 3 oncogene
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10451
VCLGeneProductENSBTAG00000021879 (Ensembl)
  • VCL; vinculin
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7414
ZYXGeneProductENSBTAG00000017970 (Ensembl)
  • ZYX; zyxin
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7791
bta-mir-34cGeneProductENSBTAG00000029991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207562
p110GeneProduct

Annotated Interactions

No annotated interactions
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