Alanine and aspartate metabolism (Homo sapiens)

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1L-ArgininosuccinateSuccinate2-OxosuccinamateMalonate semialdehydeAdenylosuccinateN-Acetyl-L-aspartateL-Alanyl-tRNAReductive carboxylate cycle (CO2 fixation)Urea cycle and metabolism of amino groupsHis metabolismSelenoamino acid metabolismFatty acid metabolismGlycolysis / GluconeogenesisFumarateCyanoamino acid metabolismPyrimidine metabolismGly, Ser and Thr metabolismNicotinate and nicotinamide metabolismCitrateReductive carboxylatecycle (CO2 fixation)D-Ala metabolismL-Aspartyl-tRNA (Asn)OxaloacetateL-AspartateNicotinate and nicotinamide metabolismbeta-Ala metabolism2-OxoglutarateLys biosynthesisL-Aspartyl-tRNA(Asp)D-AspartateL-Asparaginyl-tRNA(Asn)PyruvateCitrate cycle (TCA cycle)Arg and Pro metabolismProteinN-Carbamoyl-L-aspartatePantothenate and CoA biosynthesisASLGPT6.1.1.7D-Alanine4.


No description


GenMAPP notes 
Converted from rat to human using ortholog information. Link to original KEGG map: pathway?rno00252
GenMAPP remarks 
Edited by Sebastien Burel.

Quality Tags

Ontology Terms



  1. Curien G, Bastien O, Robert-Genthon M, Cornish-Bowden A, Cárdenas ML, Dumas R; ''Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters.''; Mol Syst Biol, 2009 PubMed Europe PMC Scholia
  2. Wu G; ''Intestinal mucosal amino acid catabolism.''; J Nutr, 1998 PubMed Europe PMC Scholia


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114258view13:50, 2 January 2021EgonwThree more pathways clickable
107574view05:05, 23 October 2019KhanspersModified description
107573view05:01, 23 October 2019KhanspersModified description
107115view14:19, 17 September 2019MaintBotChEBI identifier normalization
106171view12:06, 16 August 2019MaintBotHMDB identifier normalization
105875view04:49, 16 August 2019KhanspersModified description
105436view04:36, 8 August 2019KhanspersModified description
105119view22:00, 8 July 2019KhanspersModified description
102414view09:50, 23 December 2018EgonwReplaced a deleted CAS number with the active one.
94196view14:39, 25 August 2017Mkutmonadded missing metabolite identifier
92993view18:20, 21 July 2017Khanspersfixed unconnected
92992view18:17, 21 July 2017KhanspersModified description
92991view18:17, 21 July 2017Khanspersremoved GenMAPP notes
92892view18:57, 14 July 2017EgonwAdded a missing metabolite ID.
92891view18:51, 14 July 2017EgonwReplace a CAS number for a totally different compound with the ChEBI ID for L-alanine.
92890view18:51, 14 July 2017EgonwAdded a missing metabolite ID.
91240view20:15, 21 January 2017AlexanderPicoQuick edit to datanode annotation or property
89638view06:26, 22 September 2016EgonwConnected a line (the 2nd was too hard).
74147view11:26, 1 April 2014EgonwReplaced an InChI with a more traditional identifier.
71277view22:57, 16 October 2013MaintBotUpdated UniProt/TrEMBL data source
67036view09:57, 26 June 2013Christine ChichesterOntology Term : 'alanine, aspartate and glutamate metabolic pathway' added !
63140view19:17, 8 May 2013MaintBotUpdating GPML version
54702view13:23, 7 December 2012AndraRDF Tidy
53476view23:01, 7 November 2012Andra
45055view19:43, 6 October 2011AlexanderPicoadded db refs for metabolites
45039view18:57, 6 October 2011AlexanderPicoadded EC number refs
44946view12:32, 6 October 2011MartijnVanIerselOntology Term : 'amino acid metabolic pathway' added !
41117view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
38938view22:12, 24 September 2010Khanspersoverhaul of metabolites, pathway links and connectors
38933view21:50, 24 September 2010KhanspersPeriodical save, work in progress
38931view21:40, 24 September 2010KhanspersPeriodical save, work in progress
38925view21:30, 24 September 2010KhanspersPeriodical save, work in progress
38922view21:19, 24 September 2010KhanspersPeriodical save, work in progress
38921view21:09, 24 September 2010Khanspers
38826view10:24, 24 September 2010MartijnVanIersellinked pathway
38640view11:36, 23 September 2010MartijnVanIerselpathway link
35516view13:51, 12 February 2010MichielAdded ref
35424view10:53, 12 February 2010AndraAdded reference
34472view18:34, 10 December 2009MaintBotAutomatic update of empty xrefs
32205view12:40, 15 August 2009MaintBotFixed text labels
31692view11:47, 14 August 2009MaintBotFixed group labels
20905view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Alanine and aspartate metabolism KEGG]] moved to [[Pathway:WP106]]: Moved to stable identifier
14689view19:24, 23 May 2008KhanspersPeriodical save, work in progress
14686view19:14, 23 May 2008KhanspersPeriodical save, work in progress
14684view19:02, 23 May 2008Khanspersconnectors
14682view18:57, 23 May 2008Khanspersconnectors
14679view18:47, 23 May 2008KhanspersPeriodical save, work in progress
14677view18:37, 23 May 2008Khanspersconnectors
14675view18:27, 23 May 2008KhanspersConnectors
14672view18:17, 23 May 2008KhanspersPeriodical save, work in progress

External references


View all...
NameTypeDatabase referenceComment
ABATGeneProduct18 (Entrez Gene)
AGXTGeneProduct189 (Entrez Gene)
ASLGeneProduct435 (Entrez Gene)
ASPAGeneProduct443 (Entrez Gene)
ASSGeneProduct445 (Entrez Gene)
Acetyl-CoAMetabolite72-89-9 (CAS) Acetyl-CoA
CarnosineMetabolite305-84-0 (CAS) Carnosine
D-AlanineMetabolite6912-68-1 (CAS) D-Alanine
DARSGeneProduct1615 (Entrez Gene)
GAD1GeneProduct2571 (Entrez Gene)
GAD2GeneProduct2572 (Entrez Gene)
GOT1GeneProduct2805 (Entrez Gene)
GOT2GeneProduct2806 (Entrez Gene)
GPTGeneProduct2875 (Entrez Gene)
L-AlanineMetabolite6912-68-1 (CAS)
L-AsparagineMetabolite70-47-3 (CAS) L-Asparagine
MalateMetabolite617-48-1 (CAS) (S)-Malate
O-AcetylcarnitineMetabolite3040-38-8 (CAS)
PCGeneProduct5091 (Entrez Gene)
b-AlanineMetabolite6912-68-1 (CAS) beta-alanine

Annotated Interactions

No annotated interactions
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