Acetylcholine Synthesis (Bos taurus)

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1*Synaptic Cleft**Cytosol*PEMTGlycerophosphocholineCHKALOC524732CholineAcetatePDHA2PhosphatidylethanolamineACHEAcetyl CoACytidine diphosphate cholinePyruvate from GlycolysisPDHA1AcetylcholinePhosphatidylcholinePCYT1APhosphorylcholineCholine


Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.


This pathway was inferred from Homo sapiens pathway WP528(r29049) with a 50% conversion rate.

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Ontology Terms



  1. Szutowicz A, Bielarczyk H, Jankowska-Kulawy A, Pawełczyk T, Ronowska A; ''Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases.''; Neurochem Res, 2013 PubMed
  2. Blusztajn JK, Wurtman RJ; ''Choline and cholinergic neurons.''; Science, 1983 PubMed
  3. Angelini C, Baccetti B, Piomboni P, Trombino S, Aluigi MG, Stringara S, Gallus L, Falugi C; ''Acetylcholine synthesis and possible functions during sea urchin development.''; Eur J Histochem, 2004 PubMed


View all...
96211view10:47, 28 February 2018Asios OliaAdded Reference Angelini et al. 2003
96210view10:29, 28 February 2018Asios OliaAdded Reference (Szutowicz,2013)
80833view15:27, 30 June 2015Mkutmonhomology conversion
79214view19:46, 12 March 2015KhanspersReverted to version '17:59, 8 July 2013' by Khanspers
79213view19:45, 12 March 2015KhanspersReverted to version '04:09, 5 March 2015' by Khanspers
79146view05:51, 5 March 2015KhanspersModified title
79142view04:09, 5 March 2015KhanspersUpdated conversion from Hs
69053view17:59, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
67024view09:55, 26 June 2013Christine ChichesterOntology Term : 'acetylcholine metabolic pathway' added !
63461view17:18, 10 May 2013MaintBotUpdated to 2013 gpml schema
40596view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35066view11:21, 11 February 2010Thomasadded literature reference, fixed annotations
33833view00:29, 9 December 2009MaintBotAutomatic update of empty xrefs
31673view11:42, 14 August 2009MaintBotFixed group labels
30603view22:16, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
ACHEGeneProduct540446 (Entrez Gene)
AcetateMetabolite64-19-7 (CAS)
Acetyl CoAMetabolite72-89-9 (CAS)
AcetylcholineMetabolite51-84-3 (CAS)
CHKAGeneProduct514865 (Entrez Gene)
CholineMetabolite62-49-7 (CAS)
Cytidine diphosphate cholineMetaboliteHMDB01413 (HMDB)
GlycerophosphocholineMetabolite28319-77-9 (CAS)
LOC524732GeneProduct524732 (Entrez Gene)
PCYT1AGeneProduct100125779 (Entrez Gene)
PDHA1GeneProduct407109 (Entrez Gene)
PDHA2GeneProduct768012 (Entrez Gene)
PEMTGeneProduct360197 (Entrez Gene)
PhosphatidylcholineMetaboliteHMDB00564 (HMDB)
PhosphatidylethanolamineMetaboliteHMDB01222 (HMDB)
PhosphorylcholineMetaboliteHMDB01565 (HMDB)
Pyruvate from GlycolysisMetaboliteHMDB00243 (HMDB)

Annotated Interactions

No annotated interactions
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