mRNA Processing (Bos taurus)

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1RNA helicase(2b)CFIheterogeneous nuclear ribonucleoproteinsU2 snRNPsAAUAAAexon 1AGUAccessory ProteinsSpt5Additional SR proteinsAGYYYYFormation of pre-mRNPsU4:U5:U6 tri-snRNP complexexon 2snRNP Sm core complexAAAAAAA(2)SR-phosphatasesright click on blue text for detailed informationCstFU2 snRNPSR-proteinspre-mRNA3CF IU1SR protein phosphatasesmRNA 3'-end processingsnRNP Sm core complex(1)mRNA CappingRnmt (methyltransferase)exon 1AGAPolr2asplicing factor SF3B5snRNP Sm core complexAGFormation of the Spliceosomal E complex5exon 15mRNA splice site selectionFormation of pre-mRNPs3U4/U6CPSF335CAYYYYU5exon 1Regulation ofAlternative Splicing3Formation of the Spliceosomal B complex3SR-proteins5exon 2Additional Factors(3)Internal methylation of mRNAU1 snRNPPoly(A) polInternal methylation of mRNASR protein kinasesUGFormation of the Spliceosomal B complexU1 snRNP55Formation of the Spliceosomal C complex5exon 2U4 snRNPPoly(A)-binding protein IIFormation of the Spliceosomal A complexmRNA polyadenylationSR-binding sitesPASR-repressor proteinsexon 23Cleavage of mRNA at the 3'-endU2YYYYPutative Alternative SplicingRegulatorsU6splicesome associated helicasesCap BindingYYYY5Serine/Argenine Rich Proteins(SR)iPoU6 snRNP3Processing of Intron-Containing Pre-mRNARNA helicase AKinases Phosphorylating RS domains?AGNote: New participating members shown at each stepFormation of the Spliceosomal E complexSR-kinases5SF3b14bhnRNP regulatorsmRNA splicing (major pathway)Formation of the active Spliceosomal C complexSR-proteinsdegradedAG3exon 2U2AFCPSFUGU5Rngtt (capping enzyme)hnRNPsCF IIMisc.5 G capU5 snRNPFormation of the Spliceosomal A complexU2 snRNPAAGPrimary RNA transcriptP-3U2AFSR-binding sites5Additional FactorsMethylation of mRNAPisplicing factor SF3APoly(A) polymerase alphaA(2c)Cleavage at the 3'-Splice-Site and Exon LigationYYYYmRNA cappingexon 1(2a)CstFintronLariat Formation and 5'-Splice Site CleavageA5exon 23exon 165Poly(A)pb IIRNAi pathwayAdditional FactorsU4YYYYCF II3SRSF3METTL3DHX38DHX15CPSF4SNRPFEFTUD2SF3B1DNAJC8CSTF1TRA2BRBM5PCBP2PABPN1SNRPD1PRPF40ACLP1RBMXU2CLK1PRPF3SRSF1SFPQNHP2L1FUSIP1DDX20SF3B3SNRPNU2AF1PRPF6CLK2SPOPSMC1APHF5ASNRNP40CUGBP1FUSIP1SRSF6SNRPEDHX16HNRPLDHX9SRPK2SNRPD2HNRNPH1HNRNPKSFRS4LSM7SUGP2SREK1HNRPDCELF2LSM2SNRPA1ATPPTBP1PRPF4PRPF18LSM2CPSF1GMPU1 snRNACDC40SNRPD3SF3B4HNRNPUSUPT5HHNRPMPRPF8SFRS5SNRPGSF3A1SNRPABRUNOL4HNRPH2CLK4PSKH1RBM17SF4NCBP2SFSWAPHNRNPABCSTF3U4 snRNAXRN2SNRPNDDX1NONORNGTTSRRM1HNRPA3P1PTBP2YBX1CLASRPSRPK1TXNL4ASRSF2PRPF4CSTF2TRNPS1NUDT21HRMT1L2SNRPB2POLR2AHNRNPRSF3A2CD2BP2NHP2L1RBM39RNMTNXF1DHX8HNRNPA2B1NHP2L1SF3B5HRMT1L1PAPOLAHNRNPA1CDC40SNRNP70SF3A3PRPF4BCLK3TMED10U2AF2CPSF3NCBP1SFRS9SRSF7DICER1HNRPCPRPF8Rnu6PPM1GFUSSF3B2U5 snRNACPSF2CSTF2SNRPBSRP54


Description

This process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA).

The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' polyadenylation, and RNA splicing, which occur in the cell nucleus before the RNA is translated.

5' Capping: Capping of the pre-mRNA involves the addition of 7-methylguanosine (m7G) to the 5' end. The cap protects the 5' end of the primary RNA transcript from attack by ribonucleases that have specificity to the 3'5' phosphodiester bonds.

3' Processing: The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 200 adenine residues to form a poly(A) tail. As the poly(A) tails is synthesised, it binds multiple copies of poly(A) binding protein, which protects the 3'end from ribonuclease digestion.

Splicing: RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule.

Description adapted from Wikipedia: http://en.wikipedia.org/wiki/Post-transcriptional_modification

Pathway adapted from http://www.reactome.org.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP411(79980) with a 94.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Carmody SR, Wente SR; ''mRNA nuclear export at a glance.''; J Cell Sci, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95764view14:18, 19 January 2018MkutmonHomology conversion update
80888view15:29, 30 June 2015Mkutmonhomology conversion
71421view19:02, 17 October 2013MaintBotAutomated update of data sources
67492view11:08, 26 June 2013DdiglesOntology Term : 'spliceosome pathway' added !
63389view00:03, 10 May 2013MaintBotUpdated to 2013 gpml schema
48124view05:41, 9 May 2012KhanspersUpdating from human to fix xref duplication
40562view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
35238view19:44, 11 February 2010Khanspersupdated xrefs
35235view19:37, 11 February 2010KhanspersModified description
33800view00:16, 9 December 2009MaintBotAutomatic update of empty xrefs
32497view12:47, 17 August 2009MaintBotFixed text labels
32189view12:34, 15 August 2009MaintBotFixed text labels
31663view11:39, 14 August 2009MaintBotFixed group labels
31195view19:31, 13 August 2009MaintBotFixed text labels
30592view22:13, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
BRUNOL4GeneProductENSBTAG00000004940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56853
CD2BP2GeneProductENSBTAG00000015486 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10421
CDC40GeneProductENSBTAG00000000409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51362
CELF2GeneProductENSBTAG00000008937 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10659
CLASRPGeneProductENSBTAG00000013697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11129
CLK1GeneProductENSBTAG00000005408 (Ensembl)
  • PMID: 15010457: Inhibitor John C. Bell, PhD

    Professor, Depts. of Medicine and Biochemistry, Microbiology & Immunology University of Ottawa Career Scientist, Ottawa Regional Cancer Centre Associate Scientist, The Ottawa Hospital Research Institute Telephone: 613-737-7700 ext 6893 Fax: 613-247-3524 Email: John.Bell@orcc.on.ca The control of pre-mRNA splicing by the Clk kinase family

    We are studying a family of kinases which we believe provide an interface between intracellular signaling networks and the post-transcriptional mechanism of mRNA splicing. We are performing a structure:function analysis of the three Clk family members to identify domains in the three proteins which are involved in regulating splicing. Using homologous recombination we are generating null strains of mice which are lacking one, two or all three Clk genes. The Clk kinases all possess dual specificity kinase activity and yeast expression systems are being used to produce large amounts of the kinase to perform a detailed analysis of the sites of serine, threonine and tyrosine autophosphorylation within the kinase.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1195
CLK2GeneProductENSBTAG00000014393 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1196
CLK3GeneProductENSBTAG00000007304 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1198
CLK4GeneProductENSBTAG00000019414 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57396
CLP1GeneProductENSBTAG00000006493 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10978
CPSF1GeneProductENSBTAG00000008355 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29894
CPSF2GeneProductENSBTAG00000010227 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53981
CPSF3GeneProductENSBTAG00000019735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51692
CPSF4GeneProductENSBTAG00000002090 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10898
CSTF1GeneProductENSBTAG00000006639 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1477
CSTF2GeneProductENSBTAG00000003547 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1478
CSTF2TGeneProductENSBTAG00000018406 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23283
CSTF3GeneProductENSBTAG00000008617 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1479
CUGBP1GeneProductENSBTAG00000002520 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10658
DDX1GeneProductENSBTAG00000009906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1653
DDX20GeneProductENSBTAG00000018717 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11218
DHX15GeneProductENSBTAG00000008896 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1665
DHX16GeneProductENSBTAG00000006960 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8449
DHX38GeneProductENSBTAG00000013265 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9785
DHX8GeneProductENSBTAG00000008339 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1659
DHX9GeneProductENSBTAG00000019821 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1660
DICER1GeneProductENSBTAG00000012852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23405
DNAJC8GeneProductENSBTAG00000018385 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22826
EFTUD2GeneProductENSBTAG00000013526 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9343
FUSGeneProductENSBTAG00000005757 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2521
FUSIP1GeneProductENSBTAG00000008072 (Ensembl)
  • FUSI MOUSE PMID: 11684676
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10772
GMPMetabolite85-32-5 (CAS)
HNRNPA1GeneProductENSBTAG00000001553 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3178
HNRNPA2B1GeneProductENSBTAG00000005726 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3181
HNRNPABGeneProductENSBTAG00000013627 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3182
HNRNPH1GeneProductENSBTAG00000009389 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3187
HNRNPKGeneProductENSBTAG00000021131 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3190
HNRNPRGeneProductENSBTAG00000016578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10236
HNRNPUGeneProductENSBTAG00000007606 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3192
HNRPA3P1GeneProduct
HNRPCGeneProduct
HNRPDGeneProductENSBTAG00000013952 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3184
HNRPH2GeneProductENSBTAG00000007499 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3188
HNRPLGeneProductENSBTAG00000001055 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3191
HNRPMGeneProductENSBTAG00000021039 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4670
HRMT1L1GeneProductENSBTAG00000005503 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3275
HRMT1L2GeneProductENSBTAG00000001357 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3276
LSM2GeneProductENSBTAG00000005634 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57819
LSM7GeneProductENSBTAG00000004521 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51690
METTL3GeneProductENSBTAG00000015148 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56339
NCBP1GeneProductENSBTAG00000009732 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4686
NCBP2GeneProductENSBTAG00000008873 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22916
NHP2L1GeneProductENSBTAG00000006104 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4809
NONOGeneProductENSBTAG00000012152 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4841
NUDT21GeneProductENSBTAG00000010207 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11051
NXF1GeneProductENSBTAG00000009488 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10482
PABPN1GeneProductENSBTAG00000006884 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8106
PAPOLAGeneProductENSBTAG00000004054 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10914
PCBP2GeneProduct
PHF5AGeneProductENSBTAG00000006423 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84844
POLR2AGeneProductENSBTAG00000046765 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5430
PPM1GGeneProductENSBTAG00000019522 (Ensembl)
  • PMID: 12773558
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5496
PRPF18GeneProductENSBTAG00000017244 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8559
PRPF3GeneProductENSBTAG00000013946 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9129
PRPF40AGeneProductENSBTAG00000048151 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55660
PRPF4BGeneProductENSBTAG00000002086 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8899
PRPF4GeneProductENSBTAG00000004571 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9128
PRPF6GeneProductENSBTAG00000011656 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:24148
PRPF8GeneProductENSBTAG00000011488 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10594
PSKH1GeneProductENSBTAG00000018037 (Ensembl)
  • PMID: 12466556
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5681
PTBP1GeneProductENSBTAG00000045828 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5725
PTBP2GeneProductENSBTAG00000008809 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:58155
RBM17GeneProductENSBTAG00000021951 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84991
RBM39GeneProductENSBTAG00000003949 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9584
RBM5GeneProductENSBTAG00000006330 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10181
RBMXGeneProductENSBTAG00000013308 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27316
RNGTTGeneProductENSBTAG00000002725 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8732
RNMTGeneProductENSBTAG00000009142 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8731
RNPS1GeneProductENSBTAG00000009969 (Ensembl)
  • PMID: 14729963
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10921
Rnu6RnaGenBank sequence: M10329
SF3A1GeneProductENSBTAG00000003390 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10291
SF3A2GeneProductENSBTAG00000025452 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8175
SF3A3GeneProductENSBTAG00000007299 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10946
SF3B1GeneProductENSBTAG00000008915 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23451
SF3B2GeneProductENSBTAG00000002778 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10992
SF3B3GeneProductENSBTAG00000010627 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23450
SF3B4GeneProductENSBTAG00000026365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10262
SF3B5GeneProductENSBTAG00000009795 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83443
SF4GeneProductENSBTAG00000006116 (Ensembl)
  • inferred from: SURP 2, G patch protein, UniProt:O60378
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57794
SFPQGeneProductENSBTAG00000016328 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6421
SFRS4GeneProductENSBTAG00000013309 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6429
SFRS5GeneProductENSBTAG00000011596 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6430
SFRS9GeneProductENSBTAG00000012792 (Ensembl)
  • PMID: 12738786, PMID: 12024014 (associated with hnRNP A1 splicing)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8683
SFSWAPGeneProductENSBTAG00000000439 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6433
SMC1AGeneProductENSBTAG00000017761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8243
SNRNP40GeneProductENSBTAG00000016817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9410
SNRNP70GeneProductENSBTAG00000001996 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6625
SNRPA1GeneProductENSBTAG00000013593 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6627
SNRPAGeneProductENSBTAG00000009077 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6626
SNRPB2GeneProductENSBTAG00000027506 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6629
SNRPBGeneProductENSBTAG00000001038 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6628
SNRPD1GeneProductENSBTAG00000012376 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6632
SNRPD2GeneProductENSBTAG00000012177 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6633
SNRPD3GeneProductENSBTAG00000021262 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6634
SNRPEGeneProductENSBTAG00000039066 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6635
SNRPFGeneProductENSBTAG00000016271 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6636
SNRPGGeneProductENSBTAG00000034506 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6637
SNRPNGeneProductENSBTAG00000008251 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6638
SPOPGeneProductENSBTAG00000005824 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8405
SREK1GeneProductENSBTAG00000007321 (Ensembl)
  • PMID: 14559993. SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and alternative splicing. These functions were most consistent with the model in which SRrp86 functions by interacting with and thereby modulating the activity of target proteins. To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry. We show that SRrp86 interacts with all of the core SR proteins, as well as a subset of other splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72. In contrast to previous results that showed activation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of SRrp86. Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:140890
SRP54GeneProductENSBTAG00000019085 (Ensembl)
  • PMID: 14729963
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6729
SRPK1GeneProductENSBTAG00000016838 (Ensembl)
  • PMID: 12773558
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6732
SRPK2GeneProductENSBTAG00000002175 (Ensembl)
  • PMID: 12773558
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6733
SRRM1GeneProductENSBTAG00000013772 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10250
SRSF1GeneProductENSBTAG00000014766 (Ensembl)
  • Antagonist splicing factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6426
SRSF2GeneProductENSBTAG00000018258 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6427
SRSF3GeneProductENSBTAG00000040006 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6428
SRSF6GeneProductENSBTAG00000008527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6431
SRSF7GeneProductENSBTAG00000014891 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6432
SUGP2GeneProductENSBTAG00000013288 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10147
SUPT5HGeneProductENSBTAG00000010467 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6829
TMED10GeneProductENSBTAG00000005694 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10972
TRA2BGeneProductENSBTAG00000001697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6434
TXNL4AGeneProductENSBTAG00000013587 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10907
U1 snRNARnaGenBank sequence: J00645
U2AF1GeneProductENSBTAG00000011645 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7307
U2AF2GeneProductENSBTAG00000002830 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11338
U2GeneProductENSBTAG00000036659 (Ensembl)
  • GenBank sequence: K00027
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6066
U4 snRNARnaGenBank sequence: M10328, M18004
U5 snRNARnaGenBank sequence: AB021173
XRN2GeneProductENSBTAG00000011304 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22803
YBX1GeneProductENSBTAG00000017368 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4904

Annotated Interactions

No annotated interactions
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