MAPK Signaling Pathway (Homo sapiens)

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Scaffold1, 3, 4, 6-1125LegendHeteromeric G-proteinActivating mutationCalcium channelsCalcium channelsProliferation, differentiationJNK & p38 MAP kinase pathwayERK5 pathwayClassical MAP kinase PathwayMKPProliferation, differentiation,inflammationSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressProliferation, inflammation, anti-apoptosisp38Proliferation, differentiationSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDNA damagePTPJNKTRAF6MEF2CPSRFRPS6KA3PMAP2K3PELK4PRAP1APCRKIL1APDGFBAKT3ECSITMAP3K13RASGRP4MAP3K7PMAPK9PGRB2MKNK1PDUSP1STMN1PELK1PPPEGFRPPP3CBPPP3CCMAP4K1NFATC1PARRB2MAPTPRASGRP1RAP1BPCD14IKBKGBDNFDAXXMAPK10PTNFMOSSTK4MAPK14PIKBKBPPARRB1LRRK2CASP3FLNAPRKACAMAPKAPK2PTNFRSF1AMAP3K14HSPB1PZAKGNA12TGFB1MAP3K1PMAP3K2PMAXPDUSP10RASGRF2MAP4K4PDGFRBTAB1MAP3K4GADD45AWnt signaling pathwayMAP2K5CDC25BPIL1R1RAC2PRKCDPPP5CMAP2K1PPRAC1PTPN7IL1R2TAB2TGFBR1MAPK1PPPTPRRPTPN5PLA2G4DPBRAFNTRK1ATF2PMAP2K4PLPSFOSPRKCGMYCSOS2TGFB2ELK1PMAPK7PDUSP4CACNG3ApoptosisHSPA8MAPK12PMAPK8IP1IP3PPM1ACa2+VemurafenibIL1BELK4PTRAF2MAPK13PTAOK1MAP2K6PDUSP8AKT2MAPKAPK5PRASA2DUSP7PPP3R2FGFR1TGFB3PPP3CAEGFDDIT3PMAP3K6MAP3K8NGFCRKLTAOK2cAMPMAPK3PPMAPK8PNR4A1PCell cyclePRKCAATF4PNTF4PDGFAATF4PNTRK2FASLGPDGFRBPPM1BFGFR2CDC42FGFR3MP1FGFR4JUNPPSOS1JUNDPHRASRRASPPRPS6KA5PMAP3K12TP53PRRAS2PNFKB1GNG12PLA2G4CPNF1RASGRP2AKT1p53 signaling pathwayRASGRP3RASGRP4RASA1RASGRF1HSPA6Ca2+NTF3RAPGEF2Phosphatidylinositolsignaling systemPRKACBHSPA1APRKACGSTK3DUSP3MAP4K3CHUKPTGFBR2NFKB2MAP4K2RELAMAP2K7PRELBPPP3R1DUSP9NLKPDUSP2DAGDUSP16FASMKNK2PPLA2G4APNFATC3PMAP3K5MAP3K11PPTAOK3DUSP6MAP2K2PPPPP5D1MAPK11PRPS6KA4PMAPKAPK3PRAC3MAPK8IP2MAPK8IP3FLNBFLNCHSPA1BHSPA1LHSPA2MRASPNRASPKRASPRAF1PPLA2G4FPPLA2G4BPPLA2G4EPCACNG2CACNG5CACNG4CACNA2D3CACNG8CACNG7CACNG6CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1SCACNA2D1CACNB1CACNB2CACNB3CACNB4CACNG1CACNA1ICACNA1HCACNA1GCACNA2D2CACNA2D4FGF4FGF1FGF2FGF3FGF4FGF5FGF6FGF7FGF8FGF9FGF10FGF11FGF12FGF13FGF14FGF20FGF21FGF22FGF23FGF18FGF17FGF16FGF19Fibroblast growth factorsFibroblast growthfactorsPAK2PAK1